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The Basal Level Ethylene Response is Important to the Wall and Endomembrane Structure in the Hypocotyl Cells of Etiolated Arabidopsis Seedlings

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Journal of Integrative Plant Biology 2012年第7期54卷 434-455页

作者： Chan Xu xiaoyan gao Xiaobin Sun Chi-Kuang Wen National KeyLaboratory of Plant Molecular Genetics and National Center for Plant Gene Research(Shanghai) Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences300 Fenglin RdShanghai 200032China Shanghai Applied Protein Technology ShanghaiChina

The sub-cellular events that occur during the ethylene-modulated cell elongation were characterized by examining the ultra-structure of etiolated Arabidopsis seedling hypocotyl cells. Preventing the basal level ethylene response facilitated cell elongation, and the cells exhibited wall loosening and separation phenotype. Nearby the wall separation sites were frequently associated with an increase in the cortical rough endoplasmic reticulum （rER） membranes, the presence of paramural bodies, and the circular Golgi formation. The cortical rER proliferation and circular Golgi phenotype were reverted by the protein biosynthesis inhibitor cycloheximide. The cortical rER membranes were longer when the ethylene response was prevented and shortened with elevated ethylene responses. Proteomic changes between wild type and the ethylene-insensitive mutant ethylene insensitive2 （ein2） seedling hypocotyls indicated that distinct subsets of proteins involving endomembrane trafficking, remodeling, and wall modifications were differentially expressed. FM4-64 staining supported the proteomic changes, which indicated reduced endocytosis activity with alleviation of the ethylene response. The basal level ethylene response has an important role in endomembrane trafficking, biological materials transport and maintenance of the endomembrane organization. It is possible that endomembrane alterations may partly associate with the wall modifications, though the biological significance of the alterations should be addressed in future studies.

关键词： ER proliferation cell walls circular Golgi endomembrane trafficking ethylene.

Rhubarb ameliorates cognitive dysfunction in a rat model of Alzheimer’s disease through regulation of the intestinal microbiome

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Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 234-243页

作者： Huizhen Zhao Demin gao xiaoyan gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Objective:To determine the mechanism whereby rhubarb(Rheum tanguticum *** BALF.)may ameliorate cognitive dysfunction through regulation of the intestinal ***:We used a rat model of human microbiome-associated(HMA)-AD to characterize the therapeutic effect of rhubarb on cognitive dysfunction by assessing learning and spatial memory,tissue pathology,and neurotransmitter expression in brain ***,16S rRNA gene sequencing was used to analyze the intestinal microbial composition of the rats before and after rhubarb intervention,to determine whether changes in the intestinal microbiome might underpin the beneficial effect of rhubarb on cognitive ***:Morris water maze experiments showed that the learning and spatial memory of HMAAD rats were improved after rhubarb *** of brain sections showed that rhubarb had a protective effect on neurons in the brain tissue of HMA-AD *** tissue neurotransmitter analysis showed that rhubarb significantly reduces the 5-hydorxytryptamine concentration in the hippocampus of HMA-AD rats(P Z.0013).Furthermore,rhubarb affected the abundance of the Lachnospiraceae_NK4A136_group and Lactobacillus in the large ***:This study suggests that rhubarb ameliorates cognitive dysfunction in rats with HMA-AD by regulating the abundance of beneficial bacteria,which likely affects the concentration of 5-hydorxytryptamine in the hippocampus.

关键词： Rhubarb Intestinal microbiome Alzheimer’s disease Cognitive function 5-hydroxytryptamine

Corydalis Rhizoma as a model for herb-derived trace metabolites exploration:A cross-mapping strategy involving multiple doses and samples

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Journal of Pharmaceutical Analysis 2021年第3期11卷 308-319页

作者： Chanjuan Yu Fengyun Wang Xinyue Liu Jiayan Miao Siqi Tang Qin Jiang Xudong Tang xiaoyan gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488PR China Gastroenterology Department Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091PR China

Deciphering the metabolites of multiple components in herbal medicine has far-reaching significance for revealing pharmacodynamic ***,most chemical components of herbal medicine are secondary metabolites with low content whose in vivo metabolites are close to trace amounts,making it difficult to achieve comprehensive detection and *** this paper,an efficient strategy was proposed:herb-derived metabolites were predicted according to the structural characteristics and metabolic reactions of chemical constituents in Corydalis Rhizoma and chemical structure screening tables for metabolites were *** fragmentation patterns were summarized from representative standards combining with specific cleavage behaviors to deduce structures of *** abundance plays an important role in compound identification,and high ion abundance can improve identification *** types of metabolites in different biological samples were very similar,but their ion abundance might be ***,for trace metabolites in biological samples,we used the following two methods to process:metabolites of high dose herbal extract were analyzed to characterize those of clinical dose herbal extracts in the same biological samples;cross-mapping of different biological samples was applied to identify trace metabolites based on the fact that a metabolite has different ion abundance in different biological *** with not using this strategy,44 more metabolites of clinical dose herbal extract were *** study improved the depth,breadth,and accuracy of current methods for herb-derived metabolites characterization.

关键词： Alkaloid Characteristic fragment Corydalis yanhusuo In vivo metabolism Metabolite

Design and Implementation of Peer-to-Peer Service Routing Algorithm

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Journal of Software Engineering and Applications 2015年第11期8卷 575-580页

作者： xiaoyan gao Department of Computer Science North China Institute of Science and Technology Beijing China

Due to the lack of QoS (quality of service) guarantee in current Peer-to-Peer services routing network, it is difficult to apply Peer-to-Peer network to business successfully. Therefore, a service guarantee routing model is proposed in this paper, and an ant colony algorithm is designed for this routing model. Finally, the experimental analysis of the Peer-to-Peer services routing algorithm is presented. The experimental result shows the effectiveness of the service routing algorithm.

关键词： Peer-to-Peer Services Routing Ant Colony Algorithm

Sufficiency and Wolfe Type Duality for Nonsmooth Multiobjective Programming Problems

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Advances in Pure Mathematics 2018年第8期8卷 755-763页

作者： Gang An xiaoyan gao College of Science Xi’an Shiyou University Xi’an China College of Science Xi’an University of Science and Technology Xi’an China

In this paper, a class of nonsmooth multiobjective programming problems is considered. We introduce the new concept of invex of order??type II for nondifferentiable locally Lipschitz functions using the tools of Clarke subdifferential. The new functions are used to derive the sufficient optimality condition for a class of nonsmooth multiobjective programming problems. Utilizing the sufficient optimality conditions, weak and strong duality theorems are established for Wolfe type duality model.

关键词： Multiobjective Programming Optimality Condition Locally Lipschitz Function Wolfe Type Dual Problem

Engineered Hybrid Materials with Smart Surfaces for Effective Mitigation of Petroleum-Originated Pollutants

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Engineering 2021年第10期7卷 1492-1503页

作者： Nisar Ali Muhammad Bilal Adnan Khan Farman Ali Mohamad Nasir Mohamad Ibrahim xiaoyan gao Shizhong Zhang Kun Hong Hafiz MNIqbal Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province National and Local Joint Engineering Research Center for Deep Utilization Technology of Rock-salt ResourceFaculty of Chemical EngineeringHuaiyin Institute of TechnologyHuaian 223003China School of Life Science and Food Engineering Huaiyin Institute of TechnologyHuaian 223003China Institute of Chemical Sciences University of PeshawarPeshawar 25120Pakistan Department of Chemistry Hazara UniversityMansehra 21300Pakistan School of Engineering and Sciences School of Chemical SciencesUniversiti Sains MalaysiaPenang 11800Malaysia School of Engineering and Sciences Tecnologico de MonterreyMonterrey 64849Mexico

The generation and controlled or uncontrolled release of hydrocarbon-contaminated industrial wastewater effluents to water matrices are a major environmental *** contaminated water comes to surface in the form of stable emulsions,which sometimes require different techniques to mitigate or separate *** the crude emulsions and hydrocarbon-contaminated wastewater effluents contain suspended solids,oil/grease,organic matter,toxic elements,salts,and recalcitrant *** treatment of crude oil emulsions has been one of the most important challenges due to the complex nature and the substantial amount of generated ***,the recovery of oil from waste will help meet the increasing demand for oil and its *** this context,functional nanostructured materials with smart surfaces and switchable wettability properties have gained increasing attention because of their excellent performance in the separation of oil–water *** improvements in the design,composition,morphology,and fine-tuning of polymeric nanostructured materials have resulted in enhanced demulsification ***,we reviewed the environmental impacts of crude oil emulsions and hydrocarbon-contaminated wastewater *** effective treatments by smart polymeric nanostructured materials with wettability properties have been stated with suitable *** fundamental mechanisms underpinning the efficient separation of oil–water emulsions are discussed with suitable examples along with the future perspectives of smart materials.

关键词： Emulsion Hydrocarbon-contamination Environment impacts Hybrid nanomaterials Oil-water separation Wastewater treatment

The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang Feng Chuanjia Zhai Xuejiao Li Yulian Shi Xiang Li Miao Li Ying Wang Gan Luo xiaoyan gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

Analysis of Ethical Problems in China＇s Engineering Activities and Countermeasures

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Meteorological and Environmental Research 2018年第2期9卷 37-38,46页

作者： Li Cici gao xiaoyan Zhejiang Institute of Communications Hangzhou 311112 China

Engineering ethics is generated from the research on ethical issues caused by engineering activities. The development of engineering ethics in China was compared with that of European countries and the United States. Problems such as non-standard evaluation of registered engineers,weak ethical awareness,and lack of scientific understanding in engineering activities were discussed. Establishing and improving the system of registered engineers,strengthening education in engineering ethics,and promoting public participation will be the only way for the development of engineering ethics in China.

关键词： Engineering activities Engineering ethics Ethical issues Countermeasures

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2325-2327页

作者： Zubiao Niu Zhengrong Zhang xiaoyan gao Peng Du Jingjing Lu Bohua Yan Chenxi Wang You Zheng Hongyan Huang Qiang Sun Laboratory of Cell Engineering Institute of BiotechnologyResearch Unit of Cell Death MechanismChinese Academy of Medical Sciences2020RU009BeijingChina Department of Oncology Beijing Shijiton Hospital of Capital Medical UniversityBeijingChina

Dear Editor,According to the World Health Organization(WHO),as of March 8,2021,the pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)had infected more than 116 million patients with coronavirus disease 2019(COVID-19)(https://***).The high infectivity of SARS-CoV-2 is largely attributable to the unique sequence composition of its spike(S)glycoprotein.

关键词： acute respiratory glycoprotein