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Do neural precursor cells exist in a distal neurogenic region following cerebral hemorrhage?

Neural Regeneration Research 2010年第5期5卷 325-330页

作者： Chaoxian Yang Ling Zhou Li Deng xiaoqing gao Department of Neurobiology Luzhou Medical College Luzhou 646000 Sichuan Province China Department of Endocrinology Affiliated Hospital of Luzhou Medical College Luzhou 646000 Sichuan Province China

BACKGROUND： Cerebral injury in adult mammals can induce neural precursor cells （NPCs） to proliferate and migrate towards the focal zone, but it is unclear whether endogenous NPCs can migrate towards regions distal to the hemorrhagic focus or whether NPCs differentiate in the peripheral hemorrhagic region. OBJECTIVE： To investigate the distribution of endogenous NPCs in different brain regions of rats with experimental cerebral hemorrhage, as well as NPC proliferation and differentiation with time. DESIGN, TIME AND SE＇B＇ING： A randomized, controlled animal experiment was performed at the Department of Neurobiology, Luzhou Medical College, between January 2007 and October 2008. MATERIALS： Bromodeoxyuridine （BrdU） was purchased from Roche, Germany. Mouse anti-rat BrdU monoclonal antibody, rabbit anti-nestin polyclonal antibody, rabbit anti-neuron specific enolase （NSE） polyclonal antibody were purchased from Wuhan Boster, China. Rabbit anti-glial fibrillary acidic protein （GFAP） polyclonal antibody was purchased from Sigma, USA. METHODS： Thirty-five adult Sprague Dawley rats were randomly divided into three groups：（1） cerebral hemorrhage group （n = 25）, rats were stereotaxically administered 50 p L autologous arterial blood via the dorsal caudate putamen to induce cerebral hemorrhage; （2） sham-surgery group （n = 5）, rats underwent surgery but did not receive blood injection; （3） blank control group （n = 5）, rats received no surgery and blood administration. At 2 hours after surgery, all rats were intraperitoneally administered BrdU. MAIN OUTCOME MEASURES： Distribution and proliferation of BrdU-positive cells were observed by immunohistochemical staining. BrdU-positive cell differentiation into neurons and glial cells in the peripheral hemorrhagic region was detected by double-label immunofluorescence. RESULTS： Immunohistochemistry results revealed that BrdU-positive cells existed not only in the peripheral hemorrhagic region, such as the subependymal layer and hippoca

关键词： rats cerebral hemorrhage neural precursor cells differentiation distal neuroyenic region distal neurogenic region

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An overview of the policies and models of integrated development for solar and wind power generation in China

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Research in Cold and Arid Regions 2023年第3期15卷 122-131页

作者： LiWei Yang xiaoqing gao ZhenChao Li Key Laboratory of Land Surface Progress and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Under the goal of “Carbon Emission Peak and Carbon Neutralization”, the integrated development between various industries and renewable energy(photovoltaic, wind power) is of great significance in China. This paper summarizes the relevant policies, integration schemes and typical cases of the integrated development between renewable energy and other industries. First, the development status of wind and solar generation in China is introduced. Second, we summarize the relevant policies issued by the National Development and Reform Commission, National Energy Administration and other departments to promote the integrated development in photovoltaic and wind power generation in China. Third, eight kinds of photovoltaic three-dimensional development models are described, including “photovoltaic + agriculture, industry, environmental protection, transportation, architecture, communication, hydrogen and ecology”. Fourth, eight kinds of wind power threedimensional development models are summarized, including “Offshore wind power + marine ranch, marine energy, marine tourism, marine oil and gas, hydrogen, communication, Energy Island” and “Onshore wind power+ courtyard”. In the future, the promotion and application of the above integrated development projects will be accelerated. This overview aims to provide reference for the design in photovoltaic and wind energy systems and help potential investors to make decisions.

关键词： Renewable energy Solar PV Wind power Policies Integrated development

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Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation

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Neural Regeneration Research 2014年第1期9卷 33-40页

作者： Jie Du xiaoqing gao Li Deng Nengbin Chang Huailin Xiong Yu Zheng Department of Physiology West China School of Preclinical and Forensic MedicineSichuan University Department of Anatomy Luzhou Medical College Research Center for Preclinical Medicine Luzhou Medical CollegeLuzhou Department of Anatomy Luzhou Medical CollegeLuzhou

Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic acid and epidermal growth factor. Cell viability, micro- tubule-associated protein 2-positive cell ratio, and the expression levels of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43 protein in the su- pernatant were significantly higher in glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells compared with empty virus plasmid-transfected bone marrow mes- enchymal stem cells. Furthermore, microtubule-associated protein 2, glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein743 mRNA levels in cell pellets were statistically higher in glial cell line-derived neurotrophic factor/bone marrow mesen- chymal stem cells compared with empty virus plasmid-transfected bone marrow mesenchymal stem cells. These results suggest that glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells have a higher rate of induction into neuron-like cells, and this enhanced differentiation into neuron-like cells may be associated with up-regulated expression of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43.

关键词： nerve regeneration bone marrow mesenchymal stem cells cell differentiation neu-ron-like cells glial cell line-derived neurotrophic factor recombinant adenovirus vector transfection retinoic acid epidermal growth factor nerve growth factor growth-associated protein-43 neuralregeneration

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Ultra-stable silica-coated chiral Au-nanorod assemblies： Core-shell nanostructures with enhanced chiroptical properties

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Nano Research 2016年第2期9卷 451-457页

作者： Bing Han Lin Shi xiaoqing gao Jun Guo Ke Hou Yonglong Zheng Zhiyong Tang Laboratory of Nanomaterials National Center for Nanoscience and Technology Beijing 100190 China

Chiral nano-assemblies with amplified optical activity have attracted particular interest for their potential application in photonics, sensing and catalysis. Yet it still remains a great challenge to realize their real applications because of the instability of these assembled nanostructures. Herein, we demonstrate a facile and efficient method to fabricate ultra-stable chiral nanostructures with strong chiroptical properties. In these novel chiral nanostructures, side-by-side assembly of chiral cysteine-modified gold nanorods serves as the core while mesoporous silica acts as the shell. The chiral core-shell nanostructures exhibit an evident plasmonic circular dichroism （CD） response originating from the chiral core. Impressively, such plasmonic CD signals can be easily manipulated by changing the number as well as the aspect ratio of Au nanorods in the assemblies located at the core. In addition, because of the stabilization effect of silica shells, the chiroptical performance of these core-shell nanostructures is significantly improved in different chemical environments.

关键词： chiral core-shell nanostructure plasmonic circular dichroism gold nanorods self-assembly high stability

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Study on the atmospheric heat engine efficiency and heat source characteristics of the Qinghai-Tibet Plateau in summer

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Science China Earth Sciences 2024年第1期67卷 117-133页

作者： Yujie LI xiaoqing gao Yaoming MA Zeyong HU Zhenchao LI Liwei YANG Xiao JIN Xiyin ZHOU Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions of Chinese Academy of Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Tianjin Key Laboratory for Oceanic Meteorology Tianjin Institute of Meteorological ScienceTianjin 300074China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

There are many types of atmospheric heat engines in land-air *** accurate definition,calculation and interpretation of the efficiency of atmospheric heat engines are key to understanding energy transfer and transformation of landair *** atmosphere over the Qinghai-Tibet Plateau(QTP)in summer can be regarded as a positive heat *** study of the heat engine efficiency is helpful to better understand land-air interaction and thermal-dynamic processes on the *** also provides a new perspective to explain the impact of the QTP on the climate of China,East Asia and even the *** this paper,we used MOD08 and ERA5 reanalysis data to calculate the atmospheric heat engine efficiency,surface heat source and atmospheric heat source on the QTP in summer(May to September)from 2000 to *** average atmospheric heat engine efficiency on the QTP in summer from 2000 to 2020 varies between 1.2%and 1.5%,which is less than 1.6%;the heat engine efficiency in summer is higher than that in June,July and August;the Qaidam Basin is the region with the highest atmospheric heat engine efficiency,followed by the western *** mean surface heat source on the QTP in summer from 2000 to 2020 is 96.0 W m^(−2),the atmospheric heat source is 90.7 W m^(−2),and the release of precipitation condensation latent heat is the most important component of the atmospheric heat source on the QTP in *** is a strong and significant positive correlation between the atmospheric heat engine efficiency and the surface heat source on the QTP in *** precipitation condensation latent heat is the most important component of the atmospheric heat source in summer and can reflect the precipitation *** is a strong and significant negative correlation between the atmospheric heat engine efficiency and the atmospheric heat source on the QTP in summer.

关键词： Qinghai-Tibet Plateau Climate change Land-air system Atmospheric heat engine Heat source on the Qinghai-Tibet Plateau

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Spatial and temporal patterns of solar radiation in China from 1957 to 2016

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Research in Cold and Arid Regions 2022年第1期14卷 68-78页

作者： PeiDu Li xiaoqing gao JunXia Jiang LiWei Yang YuJie Li Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China

Solar energy is clean and renewable energy that plays an important role in mitigating impacts of environmental problems and climate *** radiation received on the earth's surface determines the efficiency of power generation and the location and layout of photovoltaic *** this paper,the average daily solar radiation of 77 stations in China from 1957 to 2016 was analyzed in terms of spatial and temporal *** results indicate that Xinjiang,the Qinghai-Tibet Plateau,North,Central and East China show a decreasing trend with an average of 2.54×10^(−3)MJ/(m^(2)⋅10a),while Northwest and Northeast China are basically stabilized,and Southwest China shows a clear increasing trend with an average increase of 1.79×10^(−3)MJ/(m^(2)⋅10a).The average daily solar radiation in summer and winter in China from 1957 to 2016 was 18.74 MJ/m^(2)and 9.09 MJ/m^(2),*** for spring in Northwest,East and South China,and summer in northeast China,the average daily solar radiation in all other regions show a downward trend.A critical point for the change is 1983 in the average daily solar ***,large-scale(25−30 years)oscillation changes are more obvious,while small-scale(5−10 years)changes are stable and have a global *** average daily solar radiation shows an increasing-decreasing gradient from west to east,which can be divided into three areas west of 80°E,80°E−100°E and east of 100°*** average daily solar radiation was 2.07 MJ/m^(2)in the 1980s,and that in 1990s lower than that in the 1960s and the *** average daily solar radiation has rebounded in the 21st century,but overall it is still lower than the average daily solar radiation from 1957 to 2016(13.87 MJ/m^(2)).

关键词： average daily solar radiation temporal variability spatial distribution characteristics China

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Variation characteristics and prediction of pollutant concentration during winter in Lanzhou New District, China

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Research in Cold and Arid Regions 2020年第5期12卷 317-328页

作者： DongYu Jia XiaoXia Li xiaoqing gao LiWei Yang College of Geography and Environmental Engineering Lanzhou City UniversityLanzhouGansu 730070China Northwest Regional Climate Center/Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province/Key Open Laboratory of Arid Climatic Change and Disaster of China Meteorological Administration/Institute of Arid Meteorology LanzhouGansu 730020China Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions/Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhouGansu 730000China

PM2.5 and PM10 were the main air pollutants during winter in Lanzhou New District,*** this paper,WRF model output combined with hourly monitoring data of pollutant concentration was used to analyze characteristics of the concentration change and to study the relationship between meteorological elements and PM10/PM2.5 in Lanzhou New District in January,***,the concentration changes of PM2.5 and PM10 were predicted by wavelet analysis combined with BP neural *** results show that:(1)Due to the cold front process in winter,PM2.5 was negatively correlated with the water vapor mixing ***10 was positively correlated with air temperature and negatively correlated with air pressure.(2)There was an inversion layer in the atmosphere near the high value day of PM2.5 and PM10,the surface was controlled by low pressure,low wind speed,and the situation of low value day of PM2.5 was the *** the day of high value of PM10,the air temperature below 600 hPa was higher,and the wind speed near the surface was also higher.(3)Wavelet analysis combined with BP(Back Propagation)neural network had a good prediction effect on PM2.5,which could basically reflect the hourly change of PM2.5 ***,the simulation effect of PM10 was poor,and the input parameters of surrounding pollutants should be added to improve the prediction effect.

关键词： PM2.5 PM10 WRF Wavelet neural network Lanzhou New District

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Comparative study of surface energy and land-surface parameters in different climate zones in Northwest China

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Research in Cold and Arid Regions 2019年第4期11卷 283-294页

作者： JiaXi Yang ZhenChao Li Ye Yu ZhiYuan Zheng XuHong Hou xiaoqing gao 无 Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100875China Center for Monsoon and Environment Research Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSchool of Atmospheric SciencesSun Yat-Sen UniversityGuangzhouGuangdong 510000China Pingliang Land Surface Process and Severe Weather Research Station Chinese Academy of SciencesPingliangGansu 730000China

Based on observational data of arid,semi-arid and semi-humid areas in Northwest China,the characteristics of surface-wa ter heat transfer and land-surface parameters were compared and *** results show that the annual mean net radi ation was largest in the semi-humid area,followed by the semi-arid area,and then the arid area:77.72 W/m^2,67.73 W/m^2,and 55.47 W/m^2,*** annual mean sensible heat flux was largest in the arid area,followed by the semi-arid and semi-humid areas,while latent heat flux showed the *** annual mean sensible heat flux in arid,semi-arid,and semi-humid areas was 85.7 W/m^2,37.59 W/m^2,and 27.55 W/m^2,*** annual mean latent heat flux was 0 W/m^2,26.08 W/m^2,and 51.19 W/m2,*** annual mean soil-heat flux at the 5-cm soil layer in arid,semi-arid,and semi-humid areas was 1.00 W/m^2,0.82 W/m^2,and 1.25 W/m^2,*** annual mean surface albedo was larg est in the arid area,followed by the semi-humid area;and the smallest was in the semi-arid area:0.24,0.21,and 0.18,re *** annual mean Bowen ratio in the semi-arid area was about 2.06,and that in semi-humid area was about *** annual mean soil thermal conductivity in the arid,semi-arid,and semi-humid areas was 0.26 W/(m k),1.15 W/(m k),and 1.20 W/(m k),respectively.

关键词： surface energy land-surface parameters different climate zones Northwest China

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Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease

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Science China Chemistry 2022年第10期65卷 1911-1920页

作者： Xiuxiu Wang Jing Zhao Weiwei Wang Meiru Lu Aihua Qu Maozhong Sun xiaoqing gao Chen Chen Hua Kuang Chuanlai Xu Liguang Xu International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhou 325001China

The misfolding and aggregation ofα-synuclein(α-syn)is closely associated with Parkinson’s disease(PD).Here,chiral dimanganese trioxide(Mn_(2)O_(3))nanoparticles(NPs)were prepared for PD treatment enhanced by a noninvasive electromagnetic field(MF).The affinity constants of D-NPs towardα-syn monomer(mono)orα-syn fibril were 3.5 times or 5.2 times higher,respectively,than those of L-NPs,and the mechanical force generated by NPs under a MF further promoted the interaction between NPs andα-syn to amplify the difference between L-NPs and *** the synergy effect of the preferentially affinity ability and MF-induced mechanical forces,D-NPs exhibited a better inhibitory efficiency onα-syn fibrillization than ***,after differentially cellular uptake of L-/D-NPs via the caveolin-mediated pathway,as reactive oxygen species(ROS)-scavengers,D-NPs possess higher efficiency in decreasing intracellular ROS level than L-NPs to provide higher cytoprotective efficiency to neuron *** vivo data showed that after treatment with D-NPs under a MF for 60 days,α-syn concentration in the cerebrospinal fluid of PD mice decreased 81%,while dopamine level in the brain of PD mice increased *** findings indicated the potential of utilizing the synergic interplay of chiral NPs and MF for treating disease and opened a new path to explore the nanoscale chirality for regulating the biological effect.

关键词： electromagnetic field chiral dimanganese trioxide nanoparticles mitigate Parkinson’s Disease

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EST-derived microsatellites in P seudosciaena crocea and their applicability to related species

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Acta Oceanologica Sinica 2010年第6期29卷 83-91页

作者： YE Hua WANG xiaoqing gao Tianxiang WANG Zhiyong College of Animal Science and Technology Hunan Agricultural University Changsha 410128 China Key Laboratory of Science and Technology for Aquaculture and Food Safety Fisheries College/Fisheries Biotechnology Institute Jimei University Xiamen 361021 China Key Laboratory of Mariculture Ministry of Education Ocean University of China Qingdao 266003 China

Simple sequence repeat （SSR） markers were obtained for the large yellow croaker Pseudosciaena crocea using 1 205 expressed sequences tags （ESTs） from the NCBI *** for 48 ESTSSR loci were designed and screened with 30 *** specimens captured from Guanjingyang sea area in Fujian Province of *** of the loci were polymorphic,which were amplified with 3 to 11 alleles per locus and the mean of *** observed and expected heterozygosity per locus ranged from 0.091 to 0.844 （mean 0.544） and from 0.118 to 0.892 （mean 0.644）,*** information content （PIC） ranged from 0.115 to 0.866 （mean 0.593）.The results for cross-species amplification of the 16 large yellow croaker EST-SSRs on ***,***,***,*** and *** revealed that 14,12,11,7 and 6 loci were successfully amplified with 1 to 10 alleles with an average of 4.5 per locus,respectively,which are suitable for population genetics studies of these species and useful for phylogenetic relationship analysis among these ***,this study provides a set of type I markers for population genetics studies and genome mapping for large yellow croaker and its closely related species.

关键词： Pseudosciaena crocea EST-SSRs genetic diversity cross-species amplification

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