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大直径盾构隧道工程施工风险分析及施工措施

城市建筑 2024年第14期21卷 205-208,232页

作者：李祥钰郭靖赵越孙小力王亦嘉中建八局轨道交通建设有限公司

当前,我国正处于城市建设中的高速发展时期,随着房地产行业的迅速发展,城市基础配套设施建设,尤其是地铁隧道相关设施需求量迅速增大。国内外盾构隧道施工技术在近年来正在向大深度、大断面、长距离的方向发展。由于大直径盾构隧道工程... 详细信息

当前,我国正处于城市建设中的高速发展时期,随着房地产行业的迅速发展,城市基础配套设施建设,尤其是地铁隧道相关设施需求量迅速增大。国内外盾构隧道施工技术在近年来正在向大深度、大断面、长距离的方向发展。由于大直径盾构隧道工程具有大尺寸断面、复杂地质条件等特点,其施工技术要求和难度也大大提高。结合我国大直径盾构隧道施工现状,围绕其施工技术展开分析和探讨,总结大直径盾构施工过程中的重难点,并针对重难点提出施工措施,促进大直径盾构隧道工程相关领域的发展,为类似工程提供借鉴。

关键词：大直径盾构隧道重难点施工措施

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Induced neuronal differentiation of neural stem cells by a combination of cytokines One-step versus two-step methods

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Neural Regeneration Research 2009年第11期4卷 814-821页

作者： xiaoli sun Xue Chen Tianyi Zhang Zhenglin Jiang Weiwei Lin Ying Yuan XiaodongWang Department of Histology and Embryology Medical School of Nantong University Nantong 226001 Jiangsu Province China Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China Jiangsu Province Key Laboratory of Neuroregeneration Nantong 226001 Jiangsu Province China

BACKGROUND： A combination of basic fibroblast growth factor （bFGF）, platelet-derived growth factor （PDGF）, human heregulin-beta-1, beta-mercaptoethanol retinoic acid and forskolin has been reported to induce the differentiation of rat bone marrow stromal cells into myelinating Schwann-like cells. OBJECTIVE： To investigate the inducing effects of a combination of bFGF, PDGF, human heregulin-beta-1, beta-mercaptoethanol retinoic acid and forskolin on neural stem cell differentiation by one- and two-step methods. DESIGN, TIME AND SETTING： A cytobiology experiment was performed at the Department of Histology and Embryology, Medical School of Nantong University, and Jiangsu Province Key Laboratory of Neuroregeneration, China, between August 2005 and January 2007. MATERIALS： A total of 30 healthy Sprague Dawley rat embryos at gestational days 14-16 were selected, bFGF, PDGF, human heregulin-beta-t, beta-mercaptoethanol, retinoic acid, and forskolin were purchased from Sigma, USA. METHODS： Passage 3 rat neural stem cells were cultured by a one-step method in serum-free medium plus 10 ng/m/bFGF, 5 ng/mL PDGF, 200 ng/mL heregulin-beta-1,35 ng/mL all-trans retinoic acid, and 5 pmol/L forskolin or by a two-step method in serum-free medium plus 35 ng/m/ all-trans retinoic acid for 72 hours, followed by serum-free medium plus 10 ng/mL bFGF, 5 ng/mL PDGF, 200 ng/mL heregulin-beta-t and 5 μmol/L forskolin. The control condition consisted of 10% fetal bovine serum alone or 20 ng/mL bFGF alone. MAIN OUTCOME MEASURES： Differentiated cells were identified by immunocytochemical staining for microtubule associate protein-2 （MAP2） and St 00 protein. Geometric parameters and sodium ion currents of the differentiated cells were measured by image analysis and whole-cell patch-clamp techniques, respectively. RESULTS： Compared with the two-step culture method, neuronal-like cells exhibited longer processes and a similar appearance to mature neurons using the one-step method. The percentage of

关键词： neural stem cells differentiation neuron cytokines whole-cell patch-clamp

Introduction to Wireless Endogenous Security and Safety:Problems, Attributes, Structures and Functions

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China Communications 2021年第9期18卷 88-99页

作者： Liang Jin Xiaoyan Hu Yangming Lou Zhou Zhong xiaoli sun Huiming Wang Jiangxing Wu PLA Strategic Support Force Information Engineering University Zhengzhou 450002China Xi’an Jiaotong University Xi’an710049China Purple Mountain Laboratories:Networking Communications and SecurityNanjing 211111China

The information security and functional safety are fundamental issues of wireless communications *** endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety *** paper introduces the concept of wireless endogenous security from the following four ***,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless *** that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed.

关键词： wireless communication endogenous security information security functional safety

Optogenetic control of GGGGCC repeat-containing RNA phase transition

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Fundamental Research 2022年第6期2卷 843-850页

作者： Xiong Li Shengyi Lu Boxun Lu xiaoli sun State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Biomedical SciencesSchool of Life SciencesFudan UniversityShanghai 200438China Shanghai Xuhui Central Hospital Zhongshan-Xuhui HospitalFudan UniversityShanghai 200031China

The GGGGCC(G_(4)C_(2))hexanucleotide repeat expansion in the C9ORF72 gene is a major cause of both hereditary amyotrophic lateral sclerosis and familial frontotemporal *** studies have shown that G_(4)C_(2)hexanucleotide repeat-containing RNA transcripts((G_(4)C_(2))_(n)RNA)could go through liquid-liquid phase separation to form RNA foci,which may elicit ***,the direct causality between these abnormal RNA foci and neuronal toxicity remains to be *** we introduce an optogenetic control system that can induce the assembly and phase separation of(G_(4)C_(2))_(n)RNA foci with blue light illumination in human cells,by fusing a specific(G_(4)C_(2))_(n)RNA binding protein as the linker domain to Cry2,a protein that oligomerizes in response to blue *** results demonstrate that a higher number of G_(4)C_(2)repeats have the potential to be induced into more RNA foci in the *** spontaneous and induced RNA foci display liquid-like properties according to FRAP *** simulation shows strong consistency with the experimental results and supports the effect of our system to promote the propensity of(G_(4)C_(2))_(n)RNA towards phase *** system can thus be used to investigate whether(G_(4)C_(2))_(n)RNA foci would disrupt normal cellular processes and lead to pathological phenotypes relevant to repeat expansion disorders.

关键词： RNA aggregates Liquid-liquid phase separation Optogenetics Chromosome 9 open reading frame 72(C9ORF72 )Amyotrophic lateral sclerosis

基于RAGE、VCAM-1表达变化的抗静脉血栓方抗大鼠深静脉血栓研究

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甘肃科学学报 2024年第3期36卷 37-43页

作者：孙小丽洪冉仲瑞雪周霞万军西南交通大学生命科学与工程学院四川成都610031 四川省骨科医院四川成都610041

为探究基于晚期糖基化终末产物受体(RAGE)和血管细胞粘附分子1(VCAM-1)表达变化的抗静脉血栓方对深静脉血栓(DVT)大鼠抗血栓的影响,将30只SD大鼠随机分为空白组、模型组、假手术组、阳性药组和中药组,采用下腔静脉狭窄法建立大鼠DVT模... 详细信息

为探究基于晚期糖基化终末产物受体(RAGE)和血管细胞粘附分子1(VCAM-1)表达变化的抗静脉血栓方对深静脉血栓(DVT)大鼠抗血栓的影响,将30只SD大鼠随机分为空白组、模型组、假手术组、阳性药组和中药组,采用下腔静脉狭窄法建立大鼠DVT模型。中药组给予抗静脉血栓方汤剂4.48 g/100 g;阳性药组给予复方丹参片0.023 g/100 g;其余组灌胃等体积生理盐水,1次/d。灌胃7 d后,取腹主动脉血1~2 mL,取下腔静脉标本。ELISA检测大鼠血清中RAGE和VCAM-1的表达水平,HE染色观察血管形态改变,免疫组化、WB和PCR检测各组大鼠RAGE和VCAM-1的表达变化。结果显示:模型组大鼠内膜损伤严重,有血栓形成,血管壁有炎性细胞浸润;模型组大鼠血清RAGE和VCAM-1的含量均显著高于中药组和阳性药组,而中药组和阳性药组大鼠血管组织中RAGE和VCAM-1的表达均降低;与假手术组相比,模型组大鼠中的RAGE、VCAM-1的蛋白和mRNA表达均显著增加,药物治疗后,中药组与阳性药组RAGE\,VCAM-1的蛋白和mRNA表达均显著降低。研究表明排除手术创伤影响,抗静脉血栓方可能是通过减少RAGE、VCAM-1的表达从而减少DVT模型大鼠静脉血栓的形成。

关键词：深静脉血栓抗静脉血栓方晚期糖基化终末产物受体血管细胞黏附分子1

“双碳”背景下基于科研成果转化导向的产教融合协同育人模式探索与实践——以福建师范大学资源循环科学与工程专业为例

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再生资源与循环经济 2024年第8期17卷 11-14页

作者：冯云珠钱庆荣孙晓丽薛珲福建师范大学科学技术处福建福州350117 福建师范大学环境与资源学院、碳中和现代产业学院福建福州350007

在双碳背景下,产教融合协同育人的战略意义愈发凸显,是培养新时代具备未来视野和创新能力人才的关键路径。在分析目前产教融合协同育人存在问题的基础上,介绍了福建师范大学资源循环科学与工程专业在加强校企党建共建、形成校企培养人... 详细信息

在双碳背景下,产教融合协同育人的战略意义愈发凸显,是培养新时代具备未来视野和创新能力人才的关键路径。在分析目前产教融合协同育人存在问题的基础上,介绍了福建师范大学资源循环科学与工程专业在加强校企党建共建、形成校企培养人才合力、校企协同促进科研成果转化和完善考核激励评价机制等方面深化产教融合协同育人模式的探索与实践,以期推动产教融合育人模式的创新与发展,为培养适应双碳时代需求的高素质人才提供有力支撑。

关键词：双碳背景科研成果转化产教融合协同育人

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倾斜摄影实景三维数据质量控制研究与实践

城市勘测 2024年第4期 129-132页

作者：孙晓丽郭巧林崔涛吕悦马啸山东正元数字城市建设有限公司山东烟台264670 山东港通工程管理咨询有限公司山东烟台264001

基于倾斜摄影实景三维数据的质量控制和评价研究主要集中在三维模型数据的质量检查和等级评价两个方面,对生产技术流程中的质量控制节点方面研究较少,通过将关键质量节点控制方法应用于阿勒泰实景三维数据的生产过程中,得到错误频次降低... 详细信息

基于倾斜摄影实景三维数据的质量控制和评价研究主要集中在三维模型数据的质量检查和等级评价两个方面,对生产技术流程中的质量控制节点方面研究较少,通过将关键质量节点控制方法应用于阿勒泰实景三维数据的生产过程中,得到错误频次降低,精度提升的效果。期待出台规范化的三维模型质检评定规范,促进质检部门和从业者优化过程质量控制方法,提升实景三维数据质量,促进实景三维城市建设的高质量发展。

关键词：倾斜摄影实景三维数据质量控制阿勒泰市

Carbon and hydrogen isotopic compositions and their evolutions of gases generated by herbaceous swamp peat at different thermal maturity stages

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Chinese Science Bulletin 2011年第13期56卷 1383-1389页

作者： DUAN Yi ZHANG xiaoli sun Tao WU BaoXiang HE JinXian XU Li Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences Lanzhou 730000 China

Coalbed methane (CBM) accumulation models include continuous gas accumulation and staged gas ***,studied on the geochemical characteristics and indices to evaluate staged accumulation CBM are *** study for the first time obtained the carbon and hydrogen isotopic compositions of methane and ethane generated at different evolution stages using thermal simulation of samples prepared by treating an herbaceous swamp peat at different *** results showed that the carbon isotopic compositions of methane and ethane were obviously affected by the thermal evolution level of the starting sample,while the hydrogen isotopic compositions were closely related to the maturity of *** carbon and hydrogen isotopic compositions of gases generated by coal-forming organic matter with Ro values from 1.2%,1.7%,2.4%,3.2% and 3.7% to 5.2% were *** relationship between Ro values and the carbon and hydrogen isotopic compositions of gases generated by coal-forming organic matter at different evolution stages as well as the carbon or hydrogen isotopic relationships between methane and ethane were *** results provide a scientific basis for studying the genesis of CBM generated at different maturity intervals and understanding the geochemical characteristics of staged accumulation *** results were applied to a case study on CBM from the southern Qinshui basin,and it was found that the CBM accumulated after the Middle Jurassic and was characteristic of staged gas *** is consistent with the result of geological studies,and further showed that the results of thermal simulation experiments are very important for evaluating the genesis of natural CBM.

关键词：碳同位素组成氢同位素成熟阶段气体泥炭沼泽草本地球化学特征

中药灌肠联合多西环素、甲硝唑治疗合并慢性子宫内膜炎的不孕患者的临床研究

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中国当代医药 2024年第10期31卷 84-87,109页

作者：关心怡赵春梅鲁敏纪淑玲孙小丽广东省妇幼保健院妇科广东广州510000

目的探讨中药灌肠联合多西环素、甲硝唑对合并慢性子宫内膜炎(CE)的不孕患者治疗效果及辅助生育结局影响。方法选取2021年6月至2022年5月广东省妇幼保健院收治的80例合并CE的不孕患者,采用随机数字表法将其分为治疗组和对照组,每组各40... 详细信息

目的探讨中药灌肠联合多西环素、甲硝唑对合并慢性子宫内膜炎(CE)的不孕患者治疗效果及辅助生育结局影响。方法选取2021年6月至2022年5月广东省妇幼保健院收治的80例合并CE的不孕患者,采用随机数字表法将其分为治疗组和对照组,每组各40例。对照组采用多西环素、甲硝唑治疗,治疗组在此基础上加用中药灌肠治疗。比较两组患者治疗前后的疗效。结果两组患者的临床总有效率、子宫内膜形态疗效、妊娠结局、气虚乏力积分比较,差异无统计学意义(P>0.05)。治疗组治疗后的下腹坠痛积分、月经不调积分、白带异常积分、面色萎黄积分、脉沉细积分、血管阻力指数(RI)和血流搏动指数(PI)均低于对照组,差异有统计学意义(P<0.05)。另外,治疗组治疗后的内膜厚度、血流指数(FI)、子宫内膜病理组织疗效均高于对照组,差异有统计学意义(P<0.05)。结论CE合并不孕患者采取中药灌肠联合多西环素、甲硝唑治疗可有效提升临床疗效,改善中医证候,提高辅助生育成功率。

关键词：不孕慢性子宫内膜炎中药灌肠多西环素甲硝唑