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Frontiers of Materials Science 2024年第1期18卷 71-83页

作者： Hang Zhang Shu Cai Huanlin Zhang Lei Ling You Zuo Hao Tian Tengfei Meng Guohua Xu xiaogang Bao Mintao Xue Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin UniversityTianjin 300072China Department of Orthopedic Surgery Spine CenterChangzheng HospitalNaval Medical UniversityShanghai 200003China

The coating-modified magnesium(Mg)alloys exhibit controllable corrosion resistance,but the insufficient antibacterial performance limits their clinical applications as degradable *** coatings show excellent performance in terms of both corrosion resistance and inhibition of bacterial adhesion and *** this work,a hydroxyapatite(HA)/palmitic acid(PA)superhydrophobic composite coating was fabricated on the Mg alloy by the hydrothermal technique and immersion *** HA/PA composite coating showed superhydrophobicity with a contact angle of 153°and a sliding angle of 2°.The coated Mg alloy exhibited excellent corrosion resistance in the simulated body fluid,with high polarization resistance(77.10 kΩ·cm^(2))and low corrosion current density((0.491±0.015)μA·cm^(-2)).Meanwhile,the antibacterial efficiency of the composite coating was over 98% against *** and *** in different *** results indicate that the construction of such superhydrophobic composite coating(HA/PA)on the Mg alloy can greatly improve the corrosion resistance of Mg alloy implants within the human body and avoid bacterial infection during the initial stages of implantation.

关键词： superhydrophobic coating hydroxyapatite corrosion resistance antibacterial

Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

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Chinese Herbal Medicines 2024年第1期16卷 56-69页

作者： Wenxian Zhang Fusen Yang Qikai Yan Jiahui Li xiaogang Zhang Yiwei Jiang Jianye Dai Affiliated Hospital of Gansu University of Traditional Chinese Medicine Lanzhou 730000China School of Pharmacy Lanzhou UniversityLanzhou 730000China Xi’an Hospital of Traditional Chinese Medicine Xi’an 710021China

As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine(TCM). In the early stage of fracture healing,the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α(HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms,in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.

关键词： fracture healing hypoxia hypoxia inducible factor-1α traditional chinese medicine molecular mechanism

祁连山植物共有种沿海拔梯度的叶片化学计量特征

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Journal of Plant Ecology 2024年第1期17卷 78-93页

作者： Shuyan Hong Jie Chen Asim Biswas Jianjun Cao xiaogang Dong College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China School of Environmental Sciences University of GuelphGuelphON N1G 2W1Canada Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Northwest Normal UniversityLanzhou 730070China

研究不同海拔地区植物共有种叶片化学计量的变化及其影响因素和适应策略,对于理解全球环境变化中的生物地球化学循环具有重要意义。在本研究中,我们测量了中国西北部祁连山5个海拔高度(海拔2400-3200 m,间隔200 m)的土壤有机碳和养分浓... 详细信息

研究不同海拔地区植物共有种叶片化学计量的变化及其影响因素和适应策略,对于理解全球环境变化中的生物地球化学循环具有重要意义。在本研究中,我们测量了中国西北部祁连山5个海拔高度(海拔2400-3200 m,间隔200 m)的土壤有机碳和养分浓度,以及植物共有种的叶片化学计量,以期能更好地了解山区植物共有种如何对海拔变化表现出适应性反应及未来潜在的环境变化如何影响其叶片功能。研究结果表明,随海拔高度的增加,植物共有种叶片C:N:P化学计量的变化不同。在不同的海拔梯度上,年平均气温(MAT)、土壤全磷(STP)、年平均降水量(MAP)、土壤含水量(SWC)和土壤硝态氮(NO3-N)是影响植物共有种叶片元素浓度的主要因素。而叶片化学计量比主要由MAT、MAP和土壤全氮(STN)决定。MAT和MAP对植物共有种叶片元素浓度和叶化学计量比均有显著影响。研究区植物生长主要受到磷的限制。研究结果不仅凸显了植物的可塑性生存策略,还有助于加深我们对植物叶片化学计量学的理解,建立单个植物物种和植物群落与共有种之间的联系。

关键词：地形因子海拔梯度常见植物种类叶片化学计量祁连山

簸箕柳×三蕊柳种特异性KASP标记开发及种间杂交子代鉴别

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林业科学 2024年第4期60卷 119-126页

作者：戴晓港魏铭辰林木遗传育种全国重点实验室、南方现代林业协同创新中心、林木遗传与生物技术教育部重点实验室、江苏省林木遗传和高效培育重点实验室、南京林业大学林学院南京210037

【目的】开发簸箕柳和三蕊柳种特异性KASP引物,为开展簸箕柳和三蕊柳杂交选育速生、抗虫新种质的真实性鉴定提供参考。【方法】利用簸箕柳和三蕊柳重测序数据,开展全基因组SNP位点分析,筛选出种特异性的SNP位点并设计KASP引物,利用SeqHu... 详细信息

【目的】开发簸箕柳和三蕊柳种特异性KASP引物,为开展簸箕柳和三蕊柳杂交选育速生、抗虫新种质的真实性鉴定提供参考。【方法】利用簸箕柳和三蕊柳重测序数据,开展全基因组SNP位点分析,筛选出种特异性的SNP位点并设计KASP引物,利用SeqHunter2检测设计引物在簸箕柳中的通用性,并利用簸箕柳和三蕊柳自然群体材料对合成的引物进行实验验证,筛选出簸箕柳和三蕊柳种特异性KASP引物,并对它们的杂交子代进行真实性鉴别。【结果】将三蕊柳和簸箕柳重测序的数据比对到三蕊柳基因组,共获得个6598144个SNPs。经过筛选,最终在簸箕柳中检测到674144个和三蕊柳相比为纯合突变的位点。从每条染色体上随机选取100个位点用于KASP引物设计,在1900个SNPs位点中,750个SNP位点可以成功设计出KASP引物。从每条染色体上选取2组,共选取38组引物,通过SeqHunter2检测得到11组引物在簸箕柳中是通用的。利用簸箕柳和三蕊柳自然群体DNA对合成的10组通用引物进行种内保守和种间差异性检测,获得4组在簸箕柳、三蕊柳和种间杂交子代中聚类明显的引物。引物Stri08_82809、Stri14_11602、Stri14_12274和Stri17_10731在簸箕柳自然群体中分别扩增出纯合G/G、T/T、A/A和T/T位点,在三蕊柳自然群体分别扩增出纯合A/A、C/C、G/G和C/C位点,而在真实杂交子代中分别扩增出G/A、T/C、A/G和T/C杂合位点。利用上述4组引物对簸箕柳×三蕊柳的杂交子代进行鉴定,发现在31个杂交子代中,29个个体扩增出杂合位点,说明同时遗传了2个亲本的特征位点,为真实的种间杂交子代。有2个个体扩增的位点为纯合且和母本相同,说明这2个子代为簸箕柳花粉污染的子代。【结论】本研究获得了簸箕柳和三蕊柳种间特异性KASP标记4组,可以准确快速的开展簸箕柳和三蕊柳种间杂交子代的真实性鉴别,为进一步簸箕柳和三蕊柳种间杂交及回交创制抗虫新品种提供了技术支持。

关键词：簸箕柳三蕊柳种间杂交物种特异性KASP引物种间杂交分子鉴别

Numerical studies for plasmas of a linear plasma device HIT-PSI with geometry modified SOLPS-ITER

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Chinese Physics B 2024年第3期33卷 503-508页

作者：王敏聂秋月黄韬王晓钢张彦杰 School of Physics Harbin Institute of TechnologyHarbin 150001China School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001China MOE (Ministry of Education) Key Laboratory of Materials Modification by Laser Ionand Electron BeamsSchool of PhysicsDalian Institute of TechnologyDalian 116024China

The HIT-PSI is a linear plasma device built for physically simulating the high heat flux environment of future reactor divertors to test/develop advanced target plate *** this study,the geometry-modified SOLPS-ITER program is employed to examine the effects of the magnetic field strength and neutral pressure in the device on the heat flux experienced by the target plate of the HIT-PSI *** findings of the numerical simulation indicate a positive correlation between the magnetic field strength and the heat flux ***,there is a negative correlation observed between the heat flux density and the neutral *** the magnetic field strength at the axis exceeds 1 tesla and the neutral pressure falls below 10 Pa,the HIT-PSI has the capability to attain a heat flux of 10 MW·m-2 at the target *** simulation results offer a valuable point of reference for subsequent experiments at HIT-PSI.

关键词： HIT-PSI heat flux linear plasma SOLPS-ITER device

Epistasis-aware genome-wide association studies provide insights into the efficient breeding of high-yield and high-quality rice

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Journal of Integrative Agriculture 2024年第8期23卷 2541-2556页

作者： xiaogang He Zirong Li Sicheng Guo Xingfei Zheng Chunhai Liu Zijie Liu Yongxin Li Zheming Yuan Lanzhi Li Hunan Engineering&Technology Research Center for Agricultural Big Data Analysis&Decision-making/College of Plant Protection Hunan Agricultural UniversityChangsha 410128China Hubei Key Laboratory of Food Crop Germplasm and Genetic Improvement/Food Crop Institute Hubei Academy of Agricultural SciencesWuhan 430064China

Marker-assisted selection(MAS)and genomic selection(GS)breeding have greatly improved the efficiency of rice *** to the influences of epistasis and gene pleiotropy,ensuring the actual breeding effect of MAS and GS is still a difficult challenge to *** this study,113 indica rice varieties(V)and their 565 testcross hybrids(TC)were used as the materials to investigate the genetic basis of 12 quality traits and nine agronomic *** original traits and general combining ability of the parents,as well as the original traits and midparent heterosis of TC,were subjected to genome-wide association *** total,381 primary significantly associated loci(SAL)and 1,759 secondary SALs that had epistatic interactions with these primary SALs were *** these loci,322 candidate genes located within or nearby the SALs were screened,204 of which were cloned genes.A total of 39 MAS molecular modules that are beneficial for trait improvement were identified by pyramiding the superior haplotypes of candidate genes and desirable epistatic alleles of the secondary *** the SALs were used to construct genetic networks,in which 91 pleiotropic loci were ***,we estimated the accuracy of genomic prediction in the parent V and TC by incorporating either no SALs,primary SALs,secondary SALs or epistatic effect SALs as *** the prediction accuracies of the four models were generally not significantly different in the TC dataset,the incorporation of primary SALs,secondary SALs,and epistatic effect SALs significantly improved the prediction accuracies of 5(26%),3(16%),and 11(58%)traits in the V dataset,*** results suggested that SALs and epistatic effect SALs identified based on an additive genotype can provide considerable predictive power for the parental *** also provide insights into the genetic basis of complex traits and valuable information for molecular breeding in rice.

关键词： rice genome-wide association study epistasis gene pleiotropy maker-associated selection genome selection

肃北五个庙石窟北朝遗迹考述——五个庙石窟研究之一

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敦煌研究 2024年第3期 50-62页

作者：张小刚敦煌研究院考古研究所甘肃敦煌736200

肃北五个庙石窟的西夏壁画在敦煌石窟艺术中颇具特色,但是这个石窟群的始建年代并不是西夏时期,而是可以追溯到敦煌石窟营建的早期阶段。五个庙石窟现存6个有壁画的编号洞窟,在这些洞窟内都保留着一些北朝时期的建筑和造像遗迹。这些遗... 详细信息

肃北五个庙石窟的西夏壁画在敦煌石窟艺术中颇具特色,但是这个石窟群的始建年代并不是西夏时期,而是可以追溯到敦煌石窟营建的早期阶段。五个庙石窟现存6个有壁画的编号洞窟,在这些洞窟内都保留着一些北朝时期的建筑和造像遗迹。这些遗迹与敦煌莫高窟和西千佛洞北朝石窟遗存既存在相似性,又有其独特之处。

关键词：肃北五个庙石窟敦煌石窟北朝壁画

Jiaohong pills attenuate neuroinflammation and amyloid-βprotein-induced cognitive deficits by modulating the mitogen-activated protein kinase/nuclear factor kappa-B pathway

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Animal Models and Experimental Medicine 2024年第3期7卷 222-233页

作者： Hong Zhang Weiyan Cai Lijinchuan Dong Qing Yang Qi Li Qingsen Ran Li Liu Yajie Wang Yujie Li xiaogang Weng Xiaoxin Zhu Ying Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina

Background:Jiaohong pills(JHP)consist of Pericarpium Zanthoxyli(PZ)and Radix Rehmanniae,two herbs that have been extensively investigated over many years due to their potential protective effects against cognitive decline and memory ***,the precise mechanisms underlying the beneficial effects remain ***,research studies were conducted to investigate and validate the therapeutic effects of JHP on Alzheimer's ***:BV-2 cell inflammation was induced by *** mice were administered amyloid-β(Aβ).Behavioral experiments were used to evaluate learning and memory *** levels of nitric oxide(NO),tumor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β),and interleukin-10(IL-10)were detected using enzymelinked immunosorbent assay(ELISA).The protein expressions of inducible nitric oxide synthase(iNOS)and the phosphorylation level of mitogen-activated protein kinase(MAPK)and nuclear factor kappa-B(NF-κB)were detected using Western *** staining was used to detect neuronal ***:The results demonstrated that an alcoholic extract of PZ significantly decreased the levels of NO,IL-1β,TNF-α,and iNOS;increased the expression level of IL-10;and significantly decreased the phosphorylation levels of MAPK and NF-κ*** inhibitory effects were further confirmed in the AD mouse ***,JHP improved learning and memory function in AD mice,reduced neuronal damage,and enriched the Nissl bodies in the ***,IL-1βand TNF-αin the cortex were significantly downregulated after JHP administration,whereas IL-10showed increased ***:It was found that JHP reduced neuroinflammatory response in AD mice by targeting the MAPK/NF-κB signaling pathway.

关键词： amyloid-β(Aβ)protein BV2 neuroinflammation Pericarpium Zanthoxyli Radix Rehmanniae

2023年大地测量学领域自然科学基金项目申请与资助分析

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武汉大学学报（信息科学版） 2024年第3期49卷 426-433页

作者：程惠红宋小刚国家自然科学基金委员会地球科学部北京100085 中国地震局地质研究所地震动力学国家重点实验室北京100029

介绍了大地测量学领域2023年度国家自然科学基金各类项目的申请、评审和资助等情况,从研究方向、依托单位等角度对申请项目进行了统计分析,并对关键词进行了词云分析。2023年度集中受理项目申请共计534项,较2022年度增加了3.1%。截至202... 详细信息

介绍了大地测量学领域2023年度国家自然科学基金各类项目的申请、评审和资助等情况,从研究方向、依托单位等角度对申请项目进行了统计分析,并对关键词进行了词云分析。2023年度集中受理项目申请共计534项,较2022年度增加了3.1%。截至2023年10月底,共116项项目获得资助。关键词词云分析结果显示,大地测量学科当前的研究热点仍主要围绕GNSS(global navigation satellite system)、InSAR(interferometric synthetic aperture radar)和北斗卫星导航系统3种支撑技术展开,卫星精密定位、定轨、导航及应用、InSAR技术及应用以及青藏高原物质迁移和气候变化研究是目前热点研究领域。

关键词：自然科学基金大地测量学项目申请项目资助

Efficient and Stable Inverted Perovskite Solar Modules Enabled by Solid-Liquid Two-Step Film Formation

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Nano-Micro Letters 2024年第9期16卷 571-582页

作者： Juan Zhang Xiaofei Ji Xiaoting Wang Liujiang Zhang Leyu Bi Zhenhuang Su Xingyu Gao Wenjun Zhang Lei Shi Guoqing Guan Abuliti Abudula xiaogang Hao Liyou Yang Qiang Fu Alex K.‑Y.Jen Linfeng Lu Graduate School of Science and Technology Hirosaki University3‑BunkyochoHirosaki 036‑8561Japan Department of Materials Science and Engineering Department of ChemistryHong Kong Institute for Clean EnergyCity University of Hong Kong KowloonHong Kong 999077People’s Republic of China The Interdisciplinary Research Center Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210People’s Republic of China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai201204People’s Republic of China JINNENG Clean Energy Technology Ltd. Jinzhong 030300ShanxiPeople’s Republic of China Hangzhou Zhongneng Photoelectricity Technology Co. Ltd.Hangzhou 310018People’s Republic of China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China Institute of Regional Innovation Hirosaki University3‑BunkyochoHirosaki 036‑8561Japan

A considerable efficiency gap exists between large-area perovskite solar modules and small-area perovskite solar *** control of forming uniform and large-area film and perovskite crystallization is still the main obstacle restricting the efficiency of *** this work,we adopted a solid-liquid two-step film formation technique,which involved the evaporation of a lead iodide film and blade coating of an organic ammonium halide solution to prepare perovskite *** method possesses the advantages of integrating vapor deposition and solution methods,which could apply to substrates with different roughness and avoid using toxic solvents to achieve a more uniform,large-area perovskite ***,modification of the NiO_(x)/perovskite buried interface and introduction of Urea additives were utilized to reduce interface recombination and regulate perovskite *** a result,a large-area perovskite film possessing larger grains,fewer pinholes,and reduced defects could be *** inverted PSM with an active area of 61.56 cm^(2)(10×10 cm^(2)substrate)achieved a champion power conversion efficiency of 20.56%and significantly improved *** method suggests an innovative approach to resolving the uniformity issue associated with large-area film fabrication.

关键词： Inverted perovskite solar cells Perovskite solar modules Two-step film formation Crystallization Defect passivation