检索结果-南通市图书馆

Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu Zhao-Li Ding rui Mao Gui-Gang Zhao Yu-Qi He xiao-Lu Li Jiang liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

引用

Advances in Manufacturing 2024年第1期12卷 167-176页

作者： Qiang-Qiang liu Shu-Ting liu Ying-Guang Li Xu liu xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Berry-Esseen bounds and moderate deviations for the norm, entries and spectral radius of products of positive random matrices

引用

Science China Mathematics 2024年第3期67卷 627-646页

作者： Hui xiao Ion Grama Quansheng liu Institut fur Mathematik und Angewandte Informatik Universitat HildesheimHildesheim 31141Germany Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China LMBA Universite Bretagne SudCNRS UMR 6205Vannes F-56000France

Let(g_(n))_(n≥1) be a sequence of independent and identically distributed positive random d×d matrices and consider the matrix product G_(n)=g_(n)…g_*** suitable conditions,we establish the Berry-Esseen bounds on the rate of convergence in the central limit theorem and Cramer-type moderate deviation expansions,for any matrix norm ‖G_(n)‖ of G_(n),its entries G_(n)^(i,j) and its spectral radius ρ(G_(n)).Extended versions of their joint law with the direction of the random walk G_(n)x are also established,where x is a starting point in the unit sphere of R~d.

关键词： Berry-Esseen bound Cramér-type moderate deviation product of random matrices operator norm entry spectral radius

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fatigue properties and damage constitutive model of salt rock based on CT scanning

引用

International Journal of Mining Science and Technology 2024年第2期34卷 245-259页

作者： Junbao Wang xiao liu Qiang Zhang Xinrong liu Zhanping Song Shijin Feng College of Civil Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Shaanxi Key Lab of Geotechnical and Underground Space Engineering Xi’an 710055China School of Civil Engineering Chongqing UniversityChongqing 400045China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

To investigate the macroscopic fatigue properties and the mesoscopic pore evolution characteristics of salt rock under cyclic loading,fatigue tests under different upper-limit stresses were carried out on salt rock,and the mesoscopic pore structures of salt rock before and after fatigue tests and under different cycle numbers were measured using CT scanning *** on the test results,the effects of the cycle number and the upper-limit stress on the evolution of cracks,pore morphology,pore number,pore volume,pore size,plane porosity,and volume porosity of salt rock were *** failure path of salt rock specimens under cyclic loading was analyzed using the distribution law of plane *** damage variable of salt rock under cyclic loading was defined on basis of the variation of volume porosity with cycle *** order to describe the fatigue deformation behavior of salt rock under cyclic loading,the nonlinear Burgers damage constitutive model was further *** results show that the model established can better reflect the whole development process of fatigue deformation of salt rock under cyclic loading.

关键词： Salt rock Cyclic loading CT scanning Mesoscopic pore evolution Constitutive model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Slowly rotating charges from Weyl double copy for Kerr black hole with Chern–Simons correction

引用

Communications in Theoretical Physics 2024年第8期76卷 141-148页

作者： Yi-Ran liu Jing-rui Zhang Yun-Long Zhang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCAS CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences National Astronomy Observatories Chinese Academy of Science International Center for Theoretical Physics Asia-Pacific

The Weyl double copy builds the relation between gauge theory and gravity theory, in particular the correspondence between gauge solutions and gravity solutions. In this paper, we obtain the slowly rotating charge solutions from the Weyl double copy for the Kerr black hole with small Chern–Simons correction. Based on the Weyl double copy relation, for the Petrov type D solution in Chern–Simons modified gravity, we find the additional correction to the electromagnetic field strength tensor of the rotating charge. For the Petrov type I solution, we find that the additional electromagnetic field strength tensors have external sources, while the total sources vanish at the leading order.

关键词： Chern-Simons modified gravity Kerr black hole Weyl double copy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hepatoprotective effects of xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

引用

World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： xiao-Li Mei Shu-Yi Wu Si-Lan Wu xiao-Lin Luo Si-Xing Huang rui liu Zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative understanding of phase segregation behaviors by precisely building discrete oligo-ester-b-oligo-olefin block copolymers

引用

Science China Chemistry 2024年第3期67卷 1008-1016页

作者： Yuxin liu rui Tan Haibing Wu Xue-Hui Dong Zhengbiao Zhang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Block copolymers(BCPs) with high Flory-Huggins parameter(χ) and balanced surface energy have aroused tremendous interest for ultra-small nanopatterns ***,high χ and balanced surface energy are generally *** fine tune of chain structure might be a useful way to achieve high χ and balanced surface *** realize this,the block copolymer with exactly uniform chain structure,i.e.,defined molecular structure,is highly desirable for accurately evaluating the phase ***,two kinds of discrete oligo ester-b-oligo olefin block copolymers with different chemical structures(oligo lactic acid-boligo olefin BCP,oLA_(n)-b-C_(m);oligo phenyl lactic acid-b-oligo olefin BCP,oPL_(n)-b-C_(m)) were modularly synthesized through iterative growth *** effect of chain structure on segregation strength and surface properties was quantitatively investigated using the discrete BCPs as precise *** the one hand,introducing rigid and nonpolar phenyl groups into oligo ester block has a negligible effect on the chemical incompatibility,as confirmed by the identical high χ values of oLA_(n)-b-C_(m) and oPL_(n)-b-C_(m)(χ_(oLA/C)=0.21 and χ_(oPL/C)=0.19).On the other hand,the incorporation of nonpolar phenyl groups creates balanced surface energy,that is,the high χ and balanced surface energy were simultaneously achieved by oPL_(n)-b-C_(m).Therefore,sub-10 nm perpendicular nanopatterns can be easily produced upon brief thermal treatment,demonstrating its potential application in semiconductor manufacturing with ultra-small feature *** discrete BCP can serve as a quantitative and exquisite model to study the critical contribution of chain structures on phase separation behavior,providing insightful understanding to facilitate the potential application in the chip process.

关键词： discrete polymer iterative growth self-assembly highχ balanced surface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Collision-free parking recommendation based on multi-agent reinforcement learning in vehicular crowdsensing

引用

Digital Communications and Networks 2024年第3期10卷 609-619页

作者： Xin Li Xinghua Lei Xiuwen liu Hang xiao College of Computer Science and Technology China University of Petroleum(East China)QingDao266580China

The recent proliferation of Fifth-Generation(5G)networks and Sixth-Generation(6G)networks has given rise to Vehicular Crowd Sensing(VCS)systems which solve parking collisions by effectively incentivizing vehicle ***,instead of being an isolated module,the incentive mechanism usually interacts with other *** on this,we capture this synergy and propose a Collision-free Parking Recommendation(CPR),a novel VCS system framework that integrates an incentive mechanism,a non-cooperative VCS game,and a multi-agent reinforcement learning algorithm,to derive an optimal parking strategy in real ***,we utilize an LSTM method to predict parking areas roughly for recommendations *** incentive mechanism is designed to motivate vehicle participation by considering dynamically priced parking tasks and social network *** order to cope with stochastic parking collisions,its non-cooperative VCS game further analyzes the uncertain interactions between vehicles in parking *** its multi-agent reinforcement learning algorithm models the VCS campaign as a multi-agent Markov decision process that not only derives the optimal collision-free parking strategy for each vehicle independently,but also proves that the optimal parking strategy for each vehicle is ***,numerical results demonstrate that CPR can accomplish parking tasks at a 99.7%accuracy compared with other baselines,efficiently recommending parking spaces.

关键词： Incentive mechanism Non-cooperative VCS game Multi-agent reinforcement learning Collision-free parking strategy Vehicular crowdsensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

引用

Journal of Iron and Steel Research(International) 2024年第3期31卷 688-699页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan Ting-song Yang An-rui He Chao liu rui-chun Guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sliced Average Variance Estimation for Tensor Data

引用

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 630-655页

作者： Chuan-quan LI Pei-wen xiao Chao YING xiao-hui liu School of Statistics Jiangxi University of Finance and EconomicsNanchang 330013China Key Laboratory of Data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang 330013China Biostatistics and Medical Informatics University of Wisconsin MadisonMadison 53726USA

Tensor data have been widely used in many fields,e.g.,modern biomedical imaging,chemometrics,and economics,but often suffer from some common issues as in high dimensional *** to find their low-dimensional latent structure has been of great interest for *** this end,we develop two efficient tensor sufficient dimension reduction methods based on the sliced average variance estimation(SAVE)to estimate the corresponding dimension reduction *** first one,entitled tensor sliced average variance estimation(TSAVE),works well when the response is discrete or takes finite values,but is not■consistent for continuous response;the second one,named bias-correction tensor sliced average variance estimation(CTSAVE),is a de-biased version of the TSAVE *** asymptotic properties of both methods are derived under mild *** and real data examples are also provided to show the superiority of the efficiency of the developed methods.

关键词： tensor data sliced average variance estimation sufficient dimension reduction central subspace

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：