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Sporamin suppresses growth of xenografted colorectal carcinoma in athymic BALB/c mice by inhibiting liver β-catenin and vascular endothelial growth factor expression

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World Journal of Gastroenterology 2019年第25期25卷 3196-3206页

作者： Chun Yang Jing-Jie zhang xiao-peng zhang Rong xiao peng-Gao Li School of Public Health Capital Medical UniversityBeijing Key Laboratory of Clinical Epidemiology

BACKGROUND Colorectal cancer(CRC)is the third most common malignancy of the digestive tract and the fifth leading cause of cancer-related mortality in ***,a Kunitz-type trypsin inhibitor isolated from sweet potato,is a potential anti-cancer agent with activities against a number of malignant tumor cells in *** liver secretes a myriad of endocrine factors that may facilitate the growth and transformation of tumors in the development of *** To investigate the effects of sporamin on liver morphology and biomarkers of xenografted CRC in the liver of athymic BALB/c *** Twenty-seven male BALB/c nude mice were randomly divided into control,vehicle,and sporamin *** in the latter two groups were intraperitoneally xenografted with LoVo colorectal carcinoma cells and intragastrically infused with saline or sporamin(0.5 g/kg body weight/d),respectively,for 3 *** and eosin(HE)staining of the sections was performed to observe morphological changes in hepatic tissue and real-time fluorescent quantitative PCR(qPCR)and enzyme-linked immunosorbent assay(ELISA)were used to measure the expression ofβ-catenin and vascular endothelial growth factor(VEGF)in the *** Sporamin significantly reduced the number and weight of tumor nodules formed in the abdominal *** with the vehicle group,the mean tumor weight(±SD)in the sporamin group was significantly reduced(0.44±0.10 g vs 0.26±0.15 g)and the total number of tumors decreased from 93 to *** staining showed that enlargement of the nucleus and synthesis of proteins within hepatocytes,as well as infiltration of inflammatory cells into the liver,were attenuated by *** staining and ELISA showed that the concentrations ofβ-catenin and VEGF in the liver were significantly reduced by *** with the vehicle group,the expression ofβ-catenin measured in integrated optical density units per area was reduced in the sporamin group(47.29±9.10 vs 26

关键词： Sporamin Colorectal cancer Liver Vascular endothelial growth factor β-catenin

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Fast and Error-Bounded Space-Variant Bilateral Filtering

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Journal of Computer Science & Technology 2019年第3期34卷 550-568页

作者： Meng-Ke Yuan Long-Quan Dai Dong-Ming Yan Li-Qiang zhang Jun xiao xiao-peng zhang National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Technology Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Remote Sensing Science School of GeographyBeijing Normal UniversityBeijing 100875China

The traditional space-invariant isotropic kernel utilized by a bilateral filter(BF)frequently leads to blurry edges and gradient reversal artifacts due to tlie existence of a large amount of outliers in the local averaging ***,the efficient and accurate cstiinatioii of space-variant k(4rnels which adapt to image structures,and the fast realization of the corresponding space-variant bilateral filtering are challenging *** address these problems,we present a space-variant BF(SVBF).and its linear time and error-bounded acceleration ***,we accurately estimate spacevariant,anisotropic kernels that vary with image structures in linear time through structure tensor and mininnini spanning ***,we perform SVBF in linear time using two error-bounded approximation methods,namely,low-rank tensor approximation via higher-order singular value decomposition and exponential sum *** proposed SVBF can efficiently achieve good edge-preserving *** validate the advantages of the proposed filter in applications including:image denoising,image enhancement,and image focus *** results(leinonstrate that our fast and error-bounded SVBF is superior to state-of-the-art methods.

关键词： error-bounded acceleration edge-aware smoothing space-variant bilateral filtering

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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu xiao-peng zhang Gang Liu Wen-Dan Tan Xin-Dan zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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Activation cross sections for reactions induced by 14 MeV neutrons on natural copper

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Nuclear Science and Techniques 2018年第10期29卷 254-260页

作者： Jing-Jie Ma Feng-Qun Zhou xiao-Jun Sun xiao-peng zhang Shu-Qing Yuan School of Electrical and Mechanical Engineering Pingdingshan UniversityPingdingshan 467000China Henan Quality Polytechnic Pingdingshan 467000China

The cross sections for the^(63)Cu(n,a)^(60(m+g))Co,^(65)Cu(n,2 n)^(64)Cu, and ^(65)Cu(n,p)^(65)Ni reactions have been studied in the neutron energy range of 13.5–14.8 MeV using the activation technique. The neutron beams were produced via the^3 H(d,n)~4 He reaction. The neutron energies of different directions in the measurements were determined beforehand by the method of cross section ratios for the^(90)Zr(n,2 n)^(89 m+g)Zr and ^(93)Nb(n,2 n)^(92 m)Nb reactions. The results in the present work were discussed and compared with measurement results found in the literatures.

关键词： Copper Activation Neutron Cross section Nuclear reaction

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Systematic review of digital twin technology and applications

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 119-138页

作者： Jun-Feng Yao Yong Yang Xue-Cheng Wang xiao-peng zhang Center for Digital Media Computing School of FilmXiamen UniversityXiamen 361005China School of Informatics Xiamen UniversityXiamen 361005China Key Laboratory of Digital Protection and Intelligent Processing of Intangible Cultural Heritage of Fujian and Taiwan Ministry of Culture and TourismXiamen 361005China State Key Laboratory of Multimodal Artificial Intelligence Systems the Institute of AutomationChinese Academy of SciencesBeijing 101408China

As one of the most important applications of digitalization,intelligence,and service,the digital twin(DT)breaks through the constraints of time,space,cost,and security on physical entities,expands and optimizes the relevant functions of physical entities,and enhances their application *** phenomenon has been widely studied in academia and *** this study,the concept and definition of DT,as utilized by scholars and researchers in various fields of industry,are *** internal association between DT and related technologies is *** four stages of DT development history are *** fundamentals of the technology,evaluation indexes,and model frameworks are ***,a conceptual ternary model of DT based on time,space,and logic is *** technology and application status of typical DT systems are ***,the current technical challenges of DT technology are analyzed,and directions for future development are discussed.

关键词： Digital twin Digitalization Virtual modeling Information technology Simulation

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Detoxification of insecticides, allechemicals and heavy metals by glutathione S-transferase SIGSTE1 in the gut of Spodoptera litura

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Insect Science 2015年第4期22卷 503-511页

作者： Zhi-Bin Xu xiao-peng Zou Ni zhang Qi-Li Feng Si-Chun Zheng Laboratory of Molecular and Developmental Entomology Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life Sciences South China Normal University Guangzhou 510631 China

Insect glutathione S-transferases （GSTs） play important roles in detoxifying toxic compounds and eliminating oxidative stress caused by these compounds. In this study, detoxification activity of the epsilon GST S1GSTE1 in Spodoptera litura was analyzed for several insecticides and heavy metals. S1GSTE1 was significantly up-regulated by chlor- pyrifos and xanthotoxin in the midgut of S. litura. The recombinant S1GSTE1 had Vmax （reaction rate of the enzyme saturated with the substrate） and Km （michaelis constant and equals to the substrate concentration at half of the maximum reaction rate of the enzyme） values of 27.95 ± 0.88μmol/min/mg and 0.87 ± 0.028 mmol/L for glutathione, respec- tively, and Vmax and Km values of 22.96 ± 0,78μmol/min/mg and 0.83 ± 0.106 mmol/L for 1-chloro-2,4-dinitrobenzene, respectively. In vitro enzyme indirect activity assay showed that the recombinant S1GSTE 1 possessed high binding activities to the insecticides chlor- pyrifos, deltamethrin, malathion, phoxim and dichloro-diphenyl-trichloroethane （DDT）. S1GSTE1 showed higher binding activity to toxic heavy metals cadmium, chromium and lead than copper and zinc that are required for insect normal growth. Western blot analysis showed that S1GSTE1 was induced in the gut of larvae fed with chlorpyrifos or cadmium. S1GSTE1 also showed high peroxidase activity. All the results together indicate that S1G- STE1 may play an important role in the gut orS. litura to protect the insect from the toxic effects of these compounds and heavy metals.

关键词： glutathioneS-transferase heavy metal insecticide midgut Spodoptera litura

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Three dimensional phase-field simulation for non-isothermal binary alloy solidification: Comparison with LKT theory

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China Foundry 2023年第6期20卷 545-552页

作者： Jun Wu Ting-yi Liu Gui-chao Hu Rong Ma xiao-peng zhang Yu-fei Li Chao Luo Institute of Materials China Academy of Engineering PhysicsJiangyou 621907SichuanChina

Using the advanced algorithm combining parallel computing,adaptive mesh re-griding and multigrid methods,quantitative 3D phase-field simulations of non-isothermal solidification of binary alloy were carried *** 3D phase-field simulation results were compared with the analytical LKT(Lipton,Kurz and Trivedi)*** comparison,the simulation and analytical results for 2D cases were also *** 3D phase-field simulation results support the transport portion of the LKT ***,the tip radius and tip velocity predicted by the simulations are not in good agreement with the LKT theory over the whole range of *** stability parameter calculated from phase-field simulations varies significantly with the Peclet number,indicating that the stability criterion,which assumes that the stability parameter is constant,is invalid.

关键词： 3D phase-field non-isothermal solidification free dendritic growth

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Fast Multi-Operator Image Resizing and Evaluation

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Journal of Computer Science & Technology 2012年第1期27卷 121-134页

作者： Wei-Ming Dong Guan-Bo Bao xiao-peng zhang Jean-Claude Paul Sino-French Laboratory for Computer Science Automation and Applied Mathematics/National Laboratory of Pattern RecognitionInstitute of AutomationChinese Academy of SciencesBeijing 100190China National Institute for Research in Computer Science and Control Domaine de Voluceau Rocquencourt Le Chesnay 78153France

Current multi-operator image resizing methods succeed in generating impressive results by using image similarity measure to guide the resizing process. An optimal operation path is found in the resizing space. However, their slow resizing speed caused by inefficient computation strategy of the bidirectional patch matching becomes a drawback in practical use. In this paper, we present a novel method to address this problem. By combining seam carving with scaling and cropping, our method can realize content-aware image resizing very fast. We define cost functions combing image energy and dominant color descriptor for all the operators to evaluate the damage to both local image content and global visual effect. Therefore our algorithm can automatically find an optimal sequence of operations to resize the image by using dynamic programming or greedy algorithm. We also extend our algorithm to indirect image resizing which can protect the aspect ratio of the dominant object in an image.

关键词： image resizing multi-operator operator cost indirect resizing

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Balloon-assisted endoscopic submucosal dissection for treating small intestinal lipomas:Report of two cases

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World Journal of Clinical Cases 2021年第7期9卷 1631-1638页

作者： Hong-Yu Chen Shou-Bin Ning Xin Yin Bai-Rong Li Jing zhang xiao-Wei Jin Tao Sun Zhi-Bo Xia xiao-peng zhang Department of Gastroenterology Air Force Medical CenterPLA of ChinaBeijing 100142China

BACKGROUND Most small intestinal lipomas are treated surgically,and some require repeated surgeries for multiple ***,application of endoscopic submucosal dissection(ESD)technology in the deep small intestine is rarely reported owing to the special anatomical structure of the small intestine,medical equipment limitations,and the lack of relevant experience among *** SUMMARY Two patients with small intestinal lipomas treated at the Air Force Medical Center from November 2015 to September 2019 were selected to undergo balloonassisted ESD to treat the lipomas and explore the technical feasibility and safety of ESD for treating small intestinal *** two patients successfully underwent balloon-assisted ESD to treat four small intestinal lipomas,with a complete resection rate of 100%(4/4),without intraoperative or postoperative bleeding,perforation,or other *** 3-6 mo of postoperative follow-up,the clinical symptoms caused by the lipomas were significantly relieved or disappeared after *** Balloon-assisted ESD is a safe and reliable new method for treating deep intestinal lipomas and shows good clinical feasibility.

关键词： Endoscopic submucosal dissection Balloon-assisted endoscopy Small intestinal lipoma Gastrointestinal tumor Case report

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Correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke

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Journal of Hainan Medical University 2017年第21期23卷 135-138页

作者： xiao-peng zhang Neurology Department Zhouzhi County People's Hospital in Xi'an Shaanxi ProvinceXi'an CityShaanxi Province710400

Objective: To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke. Methods: The patients who were diagnosed with ischemic stroke in Zhouzhi County People's Hospital between February 2015 and March 2017 were selected as the stroke group of the study, and healthy subjects who received physical examination during the same period were selected as the control group of the study. Serum was collected to determine the contents of HMGB1, sTLT-1, oxidative stress reaction molecules and endothelial injury molecules. Results: Serum HMGB1, sTLT-1, vWF, vWF-cp, sTM, ET-1, D-D, 8-OHdG, LPO and NOS contents of stroke group were significantly higher than those of control group while T-SOD and GSH-Px contents were significantly lower than those of control group;serum T-SOD and GSH-Px contents of stroke patients with high HMBG-1 content were significantly lower than those of stroke patients with low HMBG-1 content while 8-OHdG, LPO and NOS contents were significantly higher than those of stroke patients with low HMBG-1 content;serum vWF, vWF-cp, sTM, ET-1 and D-D contents of stroke patients with high sTLT-1 content were significantly higher than those of stroke patients with low sTLT-1 content. Conclusion: The abnormally elevated HMGB1 and sTLT-1 in serum of patients with ischemic stroke can induce oxidative stress response and aggravate endothelial injury.

关键词： Ischemic stroke High mobility group box 1 Triggering receptor expressed on myeloid cells-like transcript-1 Oxidative stress response Endothelial injury

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