检索结果-南通市图书馆

New clinical trial design in precision medicine:discovery,development and direction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： xiao-Peng Duan Bao-Dong Qin xiao-Dong jiao Ke Liu Zhan Wang Yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive

Bibliometric study of sepsis-associated liver injury from 2000 to 2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第30期30卷 3609-3624页

作者： Zheng Zhang xiao-jiao Tan Hai-Qing Shi Huan Zhang Jian-Bo Li Xue-Lian Liao Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Critical Care Medicine West China Tianfu Hospital of Sichuan UniversityChengdu 610200Sichuan ProvinceChina

BACKGROUND Sepsis-associated liver injury(SLI)is a severe and prevalent complication of *** To explore the literature on SLI via a bibliometric *** Reviews and articles correlated with SLI published from January 1,2000 to October 28,2023 were searched from the Web of Science Core ***,the searched data were analyzed using VOSviewer,CiteSpace,and R *** There were 787 publications involved in this paper,comprising 745 articles and 42 ***,the United States,and Germany are the primary publication sources in this *** related to SLI primarily focused on mechanisms of pathogenesis,as evidenced by analyzing keywords,references,and the counting of original *** studies mainly involved tumor necrosis factor alpha,inflammation,oxidative stress,and nuclear factor-kappa *** There is significant growth in the research on *** investigations primarily involve basic experiments that aimed at uncovering pathogenic *** to the analyzed literature,the identified pathogenic mechanisms and potential therapeutic targets serve as the foundation for translating findings from basic research to clinical applications.

关键词： Sepsis Liver injury Bibliometric analysis Cite space VOS viewer

Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2024年第1期16卷 151-161页

作者： Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren jiao xiao Dongmei Wang xiaoqiu Liu Yingni Pan School of Chinese Materia Medica Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic ***: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular ***: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory ***: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin.

关键词： anti-hyperglycemic activity anti-oxidant flowers of Xanthoceras sorbifolia Bunge NADPH oxidase off-line UPLC-QTOF-MS/MS-free radical scavenging

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang Jin Zheng Lei xiao-jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-Yuan Shi Ding-Yuan Wan Xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

阿尔茨海默病102例睡眠障碍特点分析及中西医结合干预效果研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国基层医药 2024年第1期31卷 8-13页

作者：潘权肖娇周琴浙江中医药大学附属湖州中医院脑病科湖州313000

目的探讨阿尔茨海默病患者睡眠障碍特点及中西医结合干预效果。方法选择2019年7月至2022年12月浙江中医药大学附属湖州中医院收治的阿尔茨海默病睡眠障碍患者102例为研究对象(观察组),另选取同期在该院健康体检老年人102例为对照组,进... 详细信息

目的探讨阿尔茨海默病患者睡眠障碍特点及中西医结合干预效果。方法选择2019年7月至2022年12月浙江中医药大学附属湖州中医院收治的阿尔茨海默病睡眠障碍患者102例为研究对象(观察组),另选取同期在该院健康体检老年人102例为对照组,进行随机对照研究。采用临床问诊法,对阿尔茨海默病患者的睡眠障碍类型进行统计,分析其睡眠障碍特点。根据随机数字表法将阿尔茨海默病睡眠障碍患者分为甲组和乙组,每组51例,甲组予以常规西医干预,乙组在甲组基础上增加中医干预。观察阿尔茨海默病睡眠障碍患者与健康体检老年人睡眠障碍类型;观察甲组及乙组患者干预前后中医证候评分及睡眠质量变化。结果观察组尖叫、入眠困难、日间过度嗜睡、夜间躁动、阻塞性睡眠呼吸暂停综合征(OSAS)及片段睡眠发生率依次为13.73%(14/102)、58.82%(60/102)、49.02%(50/102)、49.02%(50/102)、24.51%(25/102)和98.04%(100/102),均高于对照组的1.96%(2/102)、23.53%(24/102)、17.65%(18/102)、4.90%(5/102)、5.88%(6/102)和50.98%(52/102),差异均有统计学意义(χ^(2)=9.76、26.22、22.58、50.40、13.73、59.46,均P<0.05);乙组干预后失眠、头晕耳鸣、精神恍惚及健忘积分依次为1.00(0.00,1.00)、0.00(0.00,1.00)、0.00(0.00,1.00)和1.00(1.00,1.00)分,均低于甲组的1.00(1.00,2.00)、1.00(1.00,2.00)、1.00(0.00,1.00)和1.00(1.00,2.00)分,差异均有统计学意义(Z=-1.86、-2.13、-2.36、-2.00,均P<0.0.5);乙组干预后匹兹堡睡眠质量指数(PSQI)评分、改良爱泼沃斯嗜睡量表(mESS)评分分别为(7.56±1.93)分、(13.02±2.06分),均低于甲组的(10.87±2.21)分、(16.44±2.87)分,差异均有统计学意义(t=8.05、6.91,均P<0.001)。结论阿尔茨海默病患者睡眠障碍主要特点包括尖叫、入眠困难、日间过度嗜睡、夜间躁动、OSAS及片段睡眠,中西医结合干预可缓解阿尔茨海默病睡眠障碍患者临床症状,并改善其睡眠质量。

关键词：阿尔茨海默病睡眠障碍,昼夜节律性综合疗法医学,中国传统灸法耳穴疗法嗜睡睡眠呼吸暂停,阻塞性

自由电子激光制备高强度亚稳态氦原子和类氦离子

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第15期73卷 22-29页

作者：杜小娇魏龙孙羽胡水明深圳综合粒子设施研究院深圳518107 中国科学技术大学化学物理系合肥230026

在少电子原子精密光谱测量中,产生高强度、单一量子态的氦原子和类氦离子是实验研究的关键,也是改善实验测量信噪比的决定性因素.本文提出利用自由电子激光获得高强度亚稳态氦原子和类氦离子的实验方案.激光的制备效率可以通过求解光和... 详细信息

在少电子原子精密光谱测量中,产生高强度、单一量子态的氦原子和类氦离子是实验研究的关键,也是改善实验测量信噪比的决定性因素.本文提出利用自由电子激光获得高强度亚稳态氦原子和类氦离子的实验方案.激光的制备效率可以通过求解光和原子相互作用的主方程获得,根据拟建设的深圳自由电子激光装置的设计参数和实验条件,计算得到亚稳态He,Li^(+)和Be^(2+)的制备效率分别可达3%,6%和2%以上.与常见的气体放电和电子轰击等制备方法相比,激光激发产生亚稳态原子/离子不仅可以提高制备产率,也可以降低放电时产生的电子、离子以及光子等高能杂散粒子的影响.利用自由电子激光激发制备亚稳态氦原子和类氦离子有望应用于多个研究领域.

关键词：亚稳态氦原子和类氦离子精密光谱自由电子激光测量信噪比制备效率

在线全文

学校读者我要写书评

暂无评论

基于岩移观测技术的矿山安全监测研究与应用

世界有色金属 2024年第4期 45-47页

作者：焦晓林晟洲信息科技有限公司晋中分公司山西榆次030600

为降低矿产资源开采过程中采空区塌陷风险,提出基于岩移观测技术的矿山安全监测研究与应用方法。该方法利用RTK技术采集矿山塌陷区监测点载波相位安全监测数据后,以该监测数据为基础,对载波相位数据进行空间直角坐标系和大地坐标系转换... 详细信息

为降低矿产资源开采过程中采空区塌陷风险,提出基于岩移观测技术的矿山安全监测研究与应用方法。该方法利用RTK技术采集矿山塌陷区监测点载波相位安全监测数据后,以该监测数据为基础,对载波相位数据进行空间直角坐标系和大地坐标系转换,再将转换后的载波相位数据输入到矿山岩移监测模型内,利用该模型获得矿山塌陷区监测点欧拉移动角和移动矢量,继而获得矿山塌陷区监测点岩移数值,将该数值与基准点进行对比分析,即可实现矿山安全监测。实验结果表明:该方法采集矿山塌陷区监测点载波相位能力较好,可有效获得矿山塌陷区监测点岩移平均值,且结果较为准确。

关键词：岩移观测技术 RTK 矿山安全监测数学模型

维普期刊数据库博看期刊

老年胃癌根治术后并发耐药菌感染的影响因素及耐药菌分布特点研究

在线全文

学校读者我要写书评

暂无评论

世界华人消化杂志 2024年第6期32卷 430-437页

作者：金晓姣徐磊王玉莹金华市中心医院药学部浙江省金华市321000 金华市中医医院药学部浙江省金华市321017 永康市第二人民医院药剂科浙江省金华市321300

背景老年患者身体机能、抵抗能力较差,术后极易发生感染,且随着药细菌不断增多,耐药菌感染发生率较高,经验性用药已不能适应耐药菌的变化.基于此,本研究全面系统分析老年胃癌根治术后并发耐药菌感染情况.目的分析老年胃癌根治术后并发... 详细信息

背景老年患者身体机能、抵抗能力较差,术后极易发生感染,且随着药细菌不断增多,耐药菌感染发生率较高,经验性用药已不能适应耐药菌的变化.基于此,本研究全面系统分析老年胃癌根治术后并发耐药菌感染情况.目的分析老年胃癌根治术后并发耐药菌感染的影响因素及耐药菌分布特点,为胃癌根治术后有效防治感染提供参考依据.方法选取2019-04/2022-09我院收治的359例老年胃癌根治术患者,其中46例术后发生感染,包含耐药菌感染21例(耐药菌组)、非耐药菌感染25例(非耐药菌组)及未感染患者313例(对照组),对老年胃癌根治术后并发耐药菌感染进行单因素与多因素Logistic回归分析,采用R语言绘制预测并发耐药菌感染的列线图,采用受试者工作特征曲线(receiver operating characteristic,ROC)评价列线图模型的预测效能,采用决策分析曲线评价列线图的临床效用.结果感染部位以肺部(42.86%)为主,病原菌类型以革兰阴性菌为主,常见病原菌类型有鲍曼不动杆菌(28.57%)、铜绿假单胞菌(23.81%)等;耐药菌组年龄、糖尿病、术后机械通气、术后留置尿管>3 d、重症加强护理病房(intensive care unit,ICU)住院时间高于非耐药组、对照组,白蛋白、辅助性T淋巴细胞CD4^(+)/记忆性T细胞CD8^(+)低于非耐药组、对照组(P3 d、ICU住院时间是发生耐药菌感染的相关独立危险因素,白蛋白、CD4^(+)/CD8^(+)是发生耐药菌感染的相关保护因素(P<0.05);ROC分析发现,所构建的列线图预测模型ROC曲线下面积为0.980(95%CI:0.857-0.994),校正曲线与理想曲线拟合良好.结论老年胃癌根治术后并发耐药菌感染部位以肺部为主,病原菌类型以革兰阴性菌为主,年龄、糖尿病、术后机械通气、术后留置尿管、白蛋白、ICU住院时间、CD4^(+)/CD8^(+)是耐药菌感染的影响因素,临床可据此制定针对性防护措施,以进一步改善预后.

关键词：胃癌根治术耐药菌感染影响因素预测效能

中国式职业教育“双师型”教师队伍现代化建设:时代意蕴、逻辑遵循与行动方略

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

职业教育研究 2024年第4期 12-18页

作者：焦笑丛辽宁师范大学辽宁大连116029

“双师型”教师队伍是深化职业教育教学改革的关键支柱。“双师型”教师队伍建设以培养现代化建设人才为价值基点,以打造高质量教师教育体系为价值本质,以推进中国式职业教育现代化为价值向度,积极嵌入社会主义现代化建设场域。着眼中... 详细信息

“双师型”教师队伍是深化职业教育教学改革的关键支柱。“双师型”教师队伍建设以培养现代化建设人才为价值基点,以打造高质量教师教育体系为价值本质,以推进中国式职业教育现代化为价值向度,积极嵌入社会主义现代化建设场域。着眼中国式“双师型”教师队伍现代化建设的价值取向,职业院校须明确和牢牢把握理念引领、系统支撑与组织保障的推行逻辑。在此基础上,以“整体+部分”为核心,完善规章制度链;以“三横+三纵”为导向,建设教学资源库;以“中心+外围”为保障,打造治理共同体,探索中国式职业教育“双师型”教师队伍现代化建设行动方略。

关键词：中国式职业教育现代化教师队伍现代化现代化建设人才教育强国