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Total Reaction Cross Section Measurements at Intermediate Energy for the Proton Halo Candidate ^(23)Al and Its Neighbours

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Chinese Physics Letters 2001年第9期18卷 1189-1191页

作者： CAI Xiang-Zhou SHEN Wen-Qing FENG Jun FANG De-Qing ZHU Zhi-Yuan JIANG Wei-Zhou MA Yu-Gang ZHANG Hu-Yong ZHONG Chen YU Li-Ping ZHAN Wen-Long guO Zhong-Yan xiao gu-qhig WANG Jian-Song ZHU Yong-Tai WANG Jin-Chuan LI Jia-Xing WANG Meng WANG Jian-Feng NING Zhen-Jiang WANG Quan-Jin CHEN Zhi-Qiang Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 CCAST World Laboratory P.O.Box 8730 Beijing 100080 Institute of Modern Physics Chinese Academy of SciencesLanzhuo 730000 Department of Physics Ningbo UniversityNingbo 315211

Total reaction cross sections σR for some proton-rich isotones (N = 10) near ^(23)Al on a carbon target have been measured at intermediate energies in the experiment performed at the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou. The Z-dependence of σR shows a remarkable enhancement for ^(23)Al relative to its neighbours. The difference factor d has been deduced from the measured σR by using the Glauber or Boltzmann-Uehling-Uhlenbeck models. From the above analysis, a possible one-proton halo structure is suggested for ^(23)Al.

关键词： deduced Total Boltzmann

Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology research 2025年第1期33卷 225-234页

作者： Wei Zhang Weicheng Wang Rui Wang xiao Han Lijun Zhu Wenjie guo Yanhong gu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China. Department of Oncology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou 225300 China. State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China.

Background:As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC.Methods and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax's efficacy against tumors. Then we employed various techniques to evaluate different aspects of the experimental outcomes. Immunohistochemistry was used to detect cell proliferation and angiogenesis in tumor tissues. Western blot analysis was utilized to examine the occurrence of cell apoptosis, and flow cytometry to quantitate immune cells within the tumor tissues. Moreover, immunofluorescence was employed to measure cytokine levels.Results:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax, as opposed to individual drug use. Venetoclax was found to amplify the impact of fruquintinib, leading to decreased cancer cell proliferation, increased cancer cell apoptosis, lowered angiogenesis, better vascular structure normalization, and improved immune cell infiltration.Conclusion:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune microenvironment. Our study presents the justification for utilizing the fruquintinib and venetoclax combination in treating CRC. Venetoclax holds promise in being assimilated into anticancer medications for CRC.

关键词： Anti-angiogenesis B-cell lymphoma protein 2 (BCL2) Colorectal cancer (CRC) Fruquintinib Immunotherapy Vascular endothelial growth factor receptor (VEGFR) Venetoclax

Development of a general circumferentially nonuniform heat transfer fuel rod model for subchannel analysis and application to helical fuel rods

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Science China Technological Sciences 2025年

作者： Junsen FU Junlong LI xiaowen WANG Qi ZHANG Yao xiao Hanyang gu School of Mechanical Engineering Shanghai Jiao Tong University Key Laboratory of Nuclear Power Systems and Equipment of the Ministry of Education Shanghai Jiao Tong University National Key Laboratory of Nuclear Reactor Technology Nuclear Power Institute of China State Key Laboratory of Nuclear Power Safety Technology and Equipment Shanghai Jiao Tong University

The subchannel analysis method is one of the most crucial transient safety analysis methods in the thermal design of nuclear reactors. The nonuniformity of circumferential heat transfer is slight in conventional pressurized water reactor (PWR)cores, but it is significant in advanced reactors with wire-wrapped or helical fuel rods. Predicting circumferentially nonuniform heat transfer behavior can be challenging owing to the complex geometry of helical fuel rods. In this study, a general circumferentially nonuniform heat transfer fuel rod (GCNF) model is developed to predict the fuel central temperature and circumferential heat flux and wall temperature. This model incorporates a refined two-dimensional fuel conduction model and circumferential nonuniform shape factor, addressing the dual factors contributing to the circumferential nonuniformity of helical fuel rods. An empirical correlation for the nonuniform shape factor is developed based on the computational fluid dynamics (CFD) results, and it is implemented to the subchannel code. The newly developed model is applied to a helical fuel annulus and validated by comparing the prediction results with CFD data. The maximum wall temperature predicted by the code is 1.15°C lower than the value calculated through CFD. In terms of the heat flux, the maximum value at the inner corner is22 kW lower than that obtained from the CFD prediction. The accurate prediction of circumferentially nonuniform heat transfer in helical fuel, concerning the surface heat flux and cladding temperature, addresses existing shortcomings in helical fuel subchannel analysis methods. Additionally, the capability to predict the fuel central temperature is essential for the safety analysis to determine whether fuel rods are melting. The generality of the model framework allows it to be used for the prediction of circumferential nonuniform heat transfer behavior in other types of fuel assemblies.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Hydrolysis mechanism of Li-argyrodite Li_(6)PS_(5)Cl in air

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Rare Metals 2023年第1期42卷 47-55页

作者： Jin Zhang xiao gu School of Physical Science and Technology Ningbo UniversityNingbo315211China

All-solid-state lithium-ion batteries(ASSLBs) with solid state electrolytes(SSE),regarded as next-generation battery system,have attracted most of the research and industrial interest in the electrochemical storage field due to their higher energy density,wider voltage window,safety and other superior *** promising solid-sate electrolytes with high ionic conductivity and excellent electrochemical stability plays the key role in practicing ***-argyrodites show high ionic conductivity and stable electrochemical properties,which are advantageous to ASSLIBs.

关键词： battery electrochemical conductivity

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GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期 145-158页

作者： Wei JU Yiyang gu Zhengyang MAO Ziyue QIAO Yifang QIN xiao LUO Hui XIONG Ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

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Enhanced Thermal Conductivities of Liquid Crystal Polyesters from Controlled Structure of Molecular Chains by Introducing Different Dicarboxylic Acid Monomers

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Research 2022年第4期2022卷 507-517页

作者： xiao Zhong Kunpeng Ruan Junwei gu Research Development Institute of Northwestern Polytechnical University ShenzhenGuangdong 518057China Shanxi Key Laboratory of Macromolecular SCcience and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'anShaanxi 710072China

Enhancing thermal conductivity coefficient (λ) of liquid crystal polyesters would further widen their application in electronics and electricals. In this work, a kind of biphenyl-based dihydroxy monomer is synthesized using 4, 4’-biphenyl (BP) and triethylene glycol (TEG) as raw material, which further reacts with three different dicarboxylic acids (succinic acid, p-phenylenediacetic acid, and terephthalic acid, respectively) by melt polycondensation to prepare intrinsically highly thermally conductive poly 4’, 4”’-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) succinate (PEOS), poly 4’, 4”’-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) p-phenyldiacetate (PEOP) and poly 4’, 4”’-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) terephthalate (PEOT), collectively called biphenyl-based liquid crystal polyesters (B-LCPE). The results show that B-LCPE possess the desired molecular structure, exhibit smectic phase in liquid crystal range and semicrystalline polymers at room temperature, and possess excellent intrinsic thermal conductivities, thermal stabilities, and mechanical properties. λ of PEOT is 0.51 W/(m·K), significantly exceeds that of polyethylene terephthalate (0.15 W/(m·K)) which has similar molecular structure with PEOT, and also higher than that of PEOS (0.32 W/(m·K)) and PEOP (0.38 W/(m·K)). The corresponding heat resistance index (THRI), elasticity modulus, and hardness of PEOT are 174.6℃, 3.6 GPa, and 154.5 MPa, respectively, and also higher than those of PEOS (162.2℃, 1.8 GPa, and 83.4 MPa) and PEOP (171.8℃, 2.3 GPa, and 149.6 MPa).

关键词： properties ethane polyester

guanxinⅤRelieves Ventricular Remodeling by Inhibiting Inflammation:Implication from Virtual Screening,Systematic Pharmacology,Molecular Docking,and Experimental Validation

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1077-1086页

作者： LIANG Bo ZHANG xiao-xiao gu Ning Department of Cardiology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing(210022)China Department of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of ChongqingChongqing Clinical Research Center of Kidney and Urology DiseasesXinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing(400037)China School of Chinese Medicine School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210046)China

Objective:To reveal the anti-inflammatory mechanism of guanxinⅤ,which is prescribed for ventricular remodeling in clinical ***:guanxinⅤ-,ventricular remodeling-,and inflammationrelated targets were obtained through an integrated strategy of virtual screening and systematic pharmacology,and then the shared targets were visualised with a Venn ***Ⅴnetwork and the protein-protein interaction network were drawn,and enrichment analysis was ***,the main results obtained from the integrated strategy were validated by molecular docking and in vivo ***:A total of 251,11,425,and 15,246 guanxinⅤ-,ventricular remodeling-,and inflammation-related targets were acquired,***,211 shared targets were considered to contribute to the mechanism of ventricular remodeling treated by guanxinⅤ.guanxin network and the protein-protein interaction network were drawn,and enrichment analysis showed some cardiovascular-related biological processes and signaling *** docking revealed that the guanxinⅤ-derived compounds could align with key *** in vivo experiments proved that guanxinⅤreverses ventricular remodeling by inhibiting ***:guanxinⅤrelieves ventricular remodeling by regulating inflammation,which provides new ideas for the anti-ventricular remodeling mechanism of guanxinⅤ.

关键词： guanxinⅤ Chinese medicine ventricular remodeling inflammation

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Impacts of household living consumption on energy use and carbon emissions in China based on the input–output model

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Advances in Climate Change Research 2020年第2期11卷 118-130页

作者： ZHOU xiao-Yu gu A-Lun Institute of Energy Environment and EconomyTsinghua UniversityBeijing100084China

China must urgently accelerate its decrease of energy use,optimize its energy structure,reduce CO2 emissions,and promote the early realization of an ecological ***,meeting the growing consumer demand is one of the reasons for the increase in energy *** study investigates the impacts of household consumption on energy use and CO2 emissions from the perspective of the lifestyle of Chinese *** the basis of the input–output model of 30 provinces,we analyze the current situation of energy use and CO2 emissions in different regions(spatial scale)with economic development and income improvement(time scale),investigate the pulling effect of household consumption in different provinces on industrial sectors,examine the influencing factors of indirect CO2 emissions from food,clothing,housing,and transportation in key regions,and explore the policy implications of the transition to a low-carbon lifestyle in different *** show that the fuel structure of Chinese residents should be optimized *** household energy consumption and total CO2 emissions considerably *** 2012,total household energy consumption accounted for nearly 30%of total energy consumption,while indirect CO2 emissions accounted for 66.3%of total household *** regard to the structures of indirect household energy consumption,the housing sector accounted for the largest proportion,reaching 23.4%in indirect energy consumption in *** pulling effect of the housing sector on industrial sectors was also *** decomposition analysis showed that the rapid increase in indirect household CO2 emissions was primarily due to the increase in per capita living *** consumption structures in different provinces produced various impacts,and the energy intensity effect was identified as an important factor for reducing indirect household CO2 emissions.

关键词： Household living consumption CO2 emissions Input–output model Logarithmic mean divisia index(LMDI)decomposition Regional differences