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Functional monodisperse microspheres fabricated by solvothermal precipitation co-polymerization

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Chinese Journal of Chemical Engineering 2021年第6期34卷 323-331页

作者： Fenghao Guo Yuanyuan Ding Yanyan Wang xiao Gao zhiyong Chen Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

Simultaneous achievement in high solid content and high microsphere yield is deemed a challenge in the fabrication of monodisperse microspheres by precipitation polymerization.We herein demonstrate that micro-sized monodisperse poly(methacrylic monomer-divinylbenzene)microspheres containing epoxy,lauyl,carboxyl and hydroxyl functions can be fabricated by solvothermal precipitation copolymerization at 20%(mass)monomer loading with over 94%microsphere yield.The morphology and porosity of the obtained particles can be readily tuned by cosolvent-acetonitrile binary solvents.Addition of a small amount of cosolvent that has similar solubility parameter to that of the functional monomer can significantly improve the monodispersity of the obtained microspheres.When tetrahydrofuran was used as the co-solvent,the surface area of the highly porous microspheres achieved higher than 400 m^(2)·g^(-1).Solvothermal precipitation co-polymerization can be expected in scale-up fabrication of various monodisperse functional microspheres free of any surfactant and additive.

关键词： Monodisperse microsphere Solvothermal Methacrylic monomer Precipitation polymerization Core-shell structure

Comparison of survival prediction values of different scoring models for patients undergoing transjugular intrahepatic portal shunt:A multicenter retrospective study

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Portal Hypertension & Cirrhosis 2022年第2期1卷 107-115页

作者： Yuyi Liu zhiyong Mu Wei Xiong Hong Hu Aimin Liu Xuan An Yuqiang Xu Haohong Yu Jinneng Wang Jun Wang xiao xiao Dongfeng Chen Liangzhi Wen Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqingChina Department of Gastroenterology The Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Interventional Radiology Nanchong Central HospitalThe Second Clinical Medical CollegeThe North Sichuan Medical College(University)NanchongSichuanChina Department of Gastroenterology Fuling Central Hospital Affiliated to Chongqing UniversityChongqingChina Department of Hepatology Chongqing University Three Gorges HospitalChongqingChina Department of Gastroenterology Leshan People's Hospital of SichuanLeshanSichuanChina Department of Gastroenterology Qianjiang Central Hospital of ChongqingChongqingChina Department of Gastroenterology The Ninth People's Hospital of ChongqingChongqingChina

Aim:The aim of this study is to compare the prognostic values of the Child–Pugh,integrated model for end‐stage liver disease(iMELD),albumin–bilirubin(ALBI),and Freiburg index of postsurvival(FIPS)scores in patients undergoing transjugular intrahepatic portosystemic shunt(TIPS).Methods:We conducted a multicenter retrospective study including patients who underwent TIPS by collecting data from several hospitals in southwest China between January 2014 and February 2021.We compared the performance of different scoring models for survival prediction in these patients.The performance of each scoring model was assessed via area under the receiver‐operating characteristic(AUROC)curve analysis.Results:The study included 378 TIPS patients(268 men,110 women;median age 52[interquartile range,45–60]years).Age;cirrhosis etiology;ascites severity;albumin levels;international normalized ratio;total bilirubin levels;sodium levels;and Child–Pugh,iMELD,ALBI,and FIPS scores were significant prognostic factors in cirrhotic patients who underwent TIPS.The Child–Pugh,iMELD,ALBI,and FIPS scores were all independent predictors of survival in TIPS patients.Survival analysis showed that all scoring models effectively stratified the prognostic risk of these patients.The Child–Pugh score was the best predictor of postoperative survival,followed by the ALBI and FIPS scores.The iMELD score was the worst predictor.The Child–Pugh,iMELD,ALBI,and FIPS scores predicted the 1‐year postoperative survival,with AUROC values of 0.832,0.677,0.761,and 0.745,respectively,and the 3‐year postoperative survival,with AUROC values of 0.710,0.668,0.721,and 0.658,respectively.The calibration curve showed that the Child–Pugh,ALBI,and FIPS models performed well in predicting 1‐and 3‐year survival,whereas the iMELD model was a poor predictor.Conclusions:The four scoring models can predict survival in cirrhotic patients after TIPS and can effectively stratify prognostic risk.The Child–Pugh score may be more suitable for predicting survival after TIPS in patients with

关键词： albumin bilirubin end‐stage liver disease liver cirrhosis portosystemic shunt transjugular intrahepatic

北羌塘盆地东部上三叠统矿物成分特征分析及其地质意义

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矿产勘查 2024年第1期15卷 13-23页

作者：刘中戎张启燕刘晓何志勇范志伟吴浩葛天助中国石油化工股份有限公司勘探分公司四川成都610041 自然资源实物地质资料中心北京100083

本文以羌塘盆地雀莫错地区上三叠统地层为研究对象,利用红外光谱扫描获取岩心的矿物类型、含量、组合特征等信息,分析各主要矿物的空间变化规律,结合微观空间结构特征,研究该地层的沉积、储层及地质作用。结果表明:上三叠统矿物以碳酸... 详细信息

本文以羌塘盆地雀莫错地区上三叠统地层为研究对象,利用红外光谱扫描获取岩心的矿物类型、含量、组合特征等信息,分析各主要矿物的空间变化规律,结合微观空间结构特征,研究该地层的沉积、储层及地质作用。结果表明:上三叠统矿物以碳酸盐和碎屑矿物为主,垂向上呈现规律性变化,其中碳酸盐矿物含量随深度增加逐渐增加,反之,石英、长石及黏土矿物等逐渐降低。黏土矿物以伊利石-蒙脱石为主,高岭石少见;绿泥石主要分布于上部巴贡组碎屑岩中;整体未见明显的白云石化现象。巴贡组以细颗粒沉积物为主,岩性致密,粒间孔、溶蚀孔少量发育,零星可见黏土矿物孔和微裂缝。波里拉组储集空间以微米级别孔隙为主,孔隙类型主要为晶间孔和黏土矿物孔。基于矿物和微观空间特征分析,研究区晚三叠世沉积环境由早期的深水沉积逐渐转换到浅水三角洲沉积,矿物成分从碳酸盐沉积转变为碎屑岩沉积,认为巴贡组地层早期为烃源岩主要发育期,黄铁矿等矿物存在指示还原环境,有利于烃类的生成和保存。

关键词：矿物组成光谱特征定量分析沉积环境北羌塘盆地

Fisson-track constrains on superposed folding in the Beishan orogenic belt, southernmost Altaids

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Geoscience Frontiers 2016年第2期7卷 181-196页

作者： Zhonghua Tian Wenjiao xiao zhiyong Zhang Xu Lin Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China CAS Center for Excellence in Tibetan Plateau Earth Sciences China

The Hongyanjing inter-arc basin, is located at the central part of Beishan Orogenic College （BOC）, Gansu Province, northwest China. Thick sequences of Permian sediments were strongly folded, forming extremely spectacular superposed folds. To better understand the thermal history of Hongyanjing interarc basin and to potentially constrain the timing of deformation, apatite fission track thermochronology method was applied on two superposed folds in the Hongyanjing Basin. Samples from the basin, yield central AFT ages ranging from - 206 to 118 Ma. AFT peak ages were largely consistent between samples and can divided into three groups： 245, 204-170 and 112-131 Ma. Subsequent thermal history modeling of the samples from the Hongyanjing Basin can be summarized as follows：（1） thermal reheating by sedimentary burial at - 260 to -220 Ma; （2） major cooling from -220 to -180 Ma; （3） an episode of very slow subsequent cooling from -180 to 65 Ma （-80 ℃） to present-day outcrop temperatures. Sediments in the Hongyanjing Basin were folded forming F1 fold during the early to late Triassic （-240--220 Ma）, by regional stress, and at the time that the adjacent Xingxingxia shear zone started to become active. It is further suggested that the F2 folding occurred at -225-219 Ma. The deformation age of F2 should he extended to 180 Ma based on our thermal history modeling for the Hongyanjing Basin, which show a rapid exhumation and cooling at the late Triassic to early Jurassic （-220-- 180 Ma）. In our interpretations, the F1 folding is therefore thought to he related to the final closure of the Paleo-Asian Ocean, while the F2 folding occurred at - 225-180 Ma associated with a major pulse of orogenesis in the BOC.

关键词： Apatite fission track The Hongyanjing inter-arc basin Beishan orogenic belt Central Asia orogenic belt

Mg-Gd-Y合金及其构件的组织与性能研究

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精密成形工程 2024年第2期16卷 38-45页

作者：顾皞蒋清常志勇殷凤杰肖旅顾宝龙颜哲韩红金鑫付一峰宿常旭张建兵鲁若鹏首都航天机械有限公司北京100076 上海航天精密机械研究所上海201600 中北大学材料科学与工程学院太原030051

目的针对VW103(Mg-10Gd-3Y)和VW63(Mg-6Gd-3Y)2种铸造镁合金,从材料微观结构入手,探讨分析2种合金力学性能差异性,获取了2种镁合金在工程应用中的铸造性能及其力学特性。方法采用热分析法和改进的裂纹环试样等方法,开展2种合金的凝固温... 详细信息

目的针对VW103(Mg-10Gd-3Y)和VW63(Mg-6Gd-3Y)2种铸造镁合金,从材料微观结构入手,探讨分析2种合金力学性能差异性,获取了2种镁合金在工程应用中的铸造性能及其力学特性。方法采用热分析法和改进的裂纹环试样等方法,开展2种合金的凝固温度范围和铸造裂纹倾向研究。测量和分析其凝固温度范围、液态流动性、热态和冷态下的材料抗裂性能,获得Mg-Gd-Y稀土铸造镁合金的铸造特性;基于构件本体不同区域取样,获得Mg-Gd-Y合金在室温和150℃下的力学性能,并对整体铸件结构的承载能力和稳定性进行评估。结果在铸造性能方面,热态下脱模,VW103和VW632种合金均未出现开裂现象;冷态下脱模,VW103合金试样出现开裂。在力学性能方面,与VW103合金相比,VW63合金具有更好的综合力学性能,VW63合金铸件本体试样在高温(150℃)条件下拉伸性能均值为320 MPa,表现出优异的力学性能。结论VW63合金具有更好的力学性能和铸造性能,采用VW63合金、树脂砂反重力方法制备的整体铸件满足了结构承载能力需求,并且在测试过程中铸件位移(变形)与载荷和加载时间呈现出良好的线性关系,证实了VW63铸件的安全性与可靠性,可为VW63合金的后续应用提供参考。

关键词： Mg-Gd-Y合金铸造性能力学性能微观结构热分析法

Clinical evaluation of 4D dynamic dose for thoracic tumor stereotactic body radiation therapy with variable parameters

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Radiation Medicine and Protection 2023年第3期4卷 150-158页

作者： Yiling Zeng Yu Chang Sheng Zhang Jun Han Hongyuan Liu Feng xiao Bo Pang Bin Hu Junping Cheng Hong Quan zhiyong Yang Department of Medical Physics School of Physics and TechnologyWuhan UniversityWuhan 430072China Cancer Center Union HospitalTongji Medical CollegeUniversity of Science and TechnologyWuhan 430022China

Objective:To evaluate the dose uncertainty in stereotactic body radiation therapy induced by respiratory motion using a 4D dynamic dose(4DDD)reconstruction method.Methods:A retrospective analysis was conducted on five lung cancer patients who received static intensitymodulated radiation therapy.The 4DDD was constructed using beam delivery log files,four-dimensional computed tomography(4DCT)scans,and treatment plans.To evaluate the impact of respiratory motion,4DDD calculations were performed with 10 starting phases for each field.A total of 270 field doses were simulated and calculated.The differences between the cumulative volume histogram in whole-course treatment and the field doses'gamma passing rate(GPR)were compared.The correlations between plan complexity metrics and the dose deviation caused by respiratory motion were evaluated independently.The phase distributions of 398 subfields were calculated and evaluated for the influence of dose rate and breathing frequency.Results:The GPRs of all fields were different among various starting phases,with the highest range from 62.20% to 76.87% for 2 mm/3%GPR.The deviation of mean point dose was(5.42±5.21)%,and the deviation in the mean dose and D98% within the internal gross tumor volume were(0.97±0.71)% and(0.77±0.53)%,respectively.There was a significant correlation between the beam aperture-to-volume(BA2V)ratio and the average 2 mm/2%GPR(R?0.601,P<0.01).Lower dose rates led to a more homogeneous distribution of phases among subfields(t?44.100,P<0.001).Conclusions:Different beam starting phases had a limited impact on the overall treatment evaluation.However,the respiratory motion could be observed to induce dose deviations using the 4DDD reconstruction model,particularly for fields with small BA2V.

关键词： 4D dynamic dose Interplay effect Stereotactic body radiation therapy Beam starting phase Plan complexity

A dual-mode image sensor using an all-inorganic perovskite nanowire array for standard and neuromorphic imaging

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半导体学报:英文版 2023年第9期44卷 75-82页

作者： Zhenghao Long Yucheng Ding xiao Qiu Yu Zhou Shivam Kumar zhiyong Fan Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina State Key Laboratory of Advanced Displays and Optoelectronics Technologies HKUSTClear Water BayKowloonHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Shanghai Artificial Intelligence Laboratory Shanghai 200232China

The high-density,vertically aligned retinal neuron array provides effective vision,a feature we aim to replicate with electronic devices.However,the conventional complementary metal-oxide-semiconductor(CMOS)image sensor,based on separate designs for sensing,memory,and processing units,limits its integration density.Moreover,redundant signal communication significantly increases energy consumption.Current neuromorphic devices integrating sensing and signal processing show promise in various computer vision applications,but there is still a need for frame-based imaging with good compatibility.In this study,we developed a dual-mode image sensor based on a high-density all-inorganic perovskite nanowire array.The device can switch between frame-based standard imaging mode and neuromorphic imaging mode by applying different biases.This unique bias-dependent photo response is based on a well-designed energy band diagram.The biomimetic alignment of nanowires ensures the potential for high-resolution imaging.To further demonstrate the imaging ability,we conducted pattern reconstruction in both modes with a 10×10 crossbar device.This study introduces a novel image sensor with high compatibility and efficiency,suitable for various applications including computer vision,surveillance,and robotics.

关键词： mode image inorganic

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致用书院治学趋向之变化及其原因

海峡人文学刊 2024年第1期4卷 96-103,159页

作者：肖振家《三明学院学报》编辑部福建三明365004

致用书院在清末福建教育界明确高揭“致用”的办学宗旨,其生徒在研读经史之余,始终关注国家局势的风云变幻。第二任山长郑世恭与第三任山长谢章铤主持书院时期,恰好贯穿了整个光绪朝,民族危机的不断加深和郑谢二人的不同人生经历,促使... 详细信息

致用书院在清末福建教育界明确高揭“致用”的办学宗旨,其生徒在研读经史之余,始终关注国家局势的风云变幻。第二任山长郑世恭与第三任山长谢章铤主持书院时期,恰好贯穿了整个光绪朝,民族危机的不断加深和郑谢二人的不同人生经历,促使致用书院在治学风格和趋向上发生显著变化。以致用书院课艺为考察对象,可见其视角从全国转向福建,更加精细、更加务实;更多关注海疆和海权,视野从领土危机扩展到商贸、科技、文化等方面;传统考据也更加侧重民族关系、古代战争、舆地变迁等论题。

关键词：致用书院课艺经世致用

Circular RNAs in Cardiovascular Diseases:Regulation and Therapeutic Applications

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Research 2023年第3期6卷 389-407页

作者： Lijun Wang Gui-e Xu Michail Spanos Guoping Li zhiyong Lei Joost P.G.Sluijter Junjie xiao Cardiac Regeneration and Ageing Lab Institute of Geriatrics(Shanghai University)Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Department of Cardiology Laboratory of Experimental CardiologyUniversity Medical Center UtrechtUtrecht 3508GAThe Netherlands CDL Research University Medical Center UtrechtUtrecht 3584CXThe Netherlands Regenerative Medicine Center Circulatory Health LaboratoryUniversity Medical Center UtrechtUniversity UtrechtUtrecht 3508GAThe Netherlands

Cardiovascular disease is one of the leading causes of mortality worldwide.Recent studies have shown that circular RNAs(circRNAs)have emerged as important players in the prevention and treatment of cardiovascular diseases.circRNAs are a class of endogenous noncoding RNAs that are generated by back-splicing and are involved in many pathophysiological processes.In this review,we outline the current research progress on the regulatory roles of circRNAs in cardiovascular diseases.Further,new technologies and methods available for identifying,validating,synthesizing,and analyzing circRNAs,as well as their applications in therapeutics,are highlighted here.Moreover,we summarize the increasing insights into the potential use of circRNAs as circulating diagnostic and prognostic biomarkers.Finally,we discuss the prospects and challenges of circRNA therapeutic applications for cardiovascular disease therapy,with a particular focus on developing circRNA synthesis and engineering delivery systems.

关键词： cardiovascular prevention Cardiovascular