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A new phenanthraquinone from the roots of Peucedanum praeruptorum

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Chinese Chemical Letters 2010年第7期21卷 816-817页

作者： Cun Zhang Li Li Yong Qing xiao Wen Li xiao Jie yin guo Fang Tian Dong Dong Chen Yun Wang Institute of Chinese Materia Madica China Academy of Traditional Chinese MedicineBeijing 100700China

A new compound,9,10-dihydrophenanthrinic acid,9,10-dione-3,4-methylenedioxy-8-methoxy（1） was isolated from the roots of Peucedanum praeruptorum Dunn on the basis of spectral evidences.

关键词： Peucedanum praeruptorum 9 10-Phenanthraquinone 9 10-Dihydrophenanthrinic acid 9 10-Dione-3 4-methylenedioxy-8-methoxy

转型期企业内部物流体系的重构与优化——基于H公司内部物流系统化管理实践

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物流技术 2012年第8期31卷 400-401,419页

作者：尹效国河南经贸职业学院河南郑州450001

介绍了H公司在转型期通过调整与优化企业整体布局、构建企业内部物流系统化管理、成立跨职能的企业运营中心等措施,形成了独具特色的企业内部物流系统化体系,使企业内部物流效率得到极大提高,并总结了H公司实施物流系统化管理的几点启示。

关键词：企业内部物流重构与优化系统化管理

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting guo Yiran Zhang Tingting Xing Peng yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua guo Guanglei Wu Pengfei yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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河南省科技型中小微企业发展体制机制研究

中小企业管理与科技 2021年第7期5卷 128-129页

作者：尹效国河南经贸职业学院管理学院郑州450000

科技型中小微企业是科技创新活动的主力军和生力军。在认清科技型中小微企业的特点、发展特征、运行机制及河南省科技型中小微企业的发展情况及存在问题的基础上,为促进科技型中小微企业的发展,需要有更切合实际的政策措施。

关键词：科技型企业中小微企业发展体制机制

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting Li Zhiying Tian Qichao Li Chenhui Jiang Enfu Liang Yiping guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei xiao Zhiyong Kan Jing guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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南四湖流域产水量空间格局与驱动因素分析

自然资源学报 2017年第4期32卷 669-679页

作者：孙小银郭洪伟廉丽姝刘飞李宝富曲阜师范大学地理与旅游学院/南四湖湿地生态与环境保护山东省高校重点实验室山东日照276826

流域生态系统产水服务功能的空间化和定量化评估,对流域水资源管理、优化配置以及提高流域水生态保护效率具有重要意义。以山东省南四湖流域为研究对象,基于1990—2013年土地利用、降水、蒸散以及土壤属性等基础地理数据,以InVEST模型... 详细信息

流域生态系统产水服务功能的空间化和定量化评估,对流域水资源管理、优化配置以及提高流域水生态保护效率具有重要意义。以山东省南四湖流域为研究对象,基于1990—2013年土地利用、降水、蒸散以及土壤属性等基础地理数据,以InVEST模型为基础,评估和模拟南四湖流域近25 a的产水量,并采用ArcGIS分析产水量的空间分布格局以及变化趋势,探讨了降水、地形等自然地理要素以及人口、土地利用和国内生产总值(GDP)等社会经济因素与产水量空间格局动态变化之间的关系,并在此基础上划分出南四湖流域生态系统产水功能区。研究结果表明:流域产水量在空间格局上呈现出由东向西递减的趋势,东部、东北部等山区、丘陵地区产水量高,西部平原地区产水相对较低;受自然地理要素影响,流域产水量空间分布与社会经济发展水平即GDP、人口密度的空间分布格局有较大差异。近25 a来,流域产水量呈现减少趋势,且产水量峰值区域由东北部向偏南地区转移,最低值区由西部向中部地区转移。降水、海拔和坡度等地理环境与产水量的空间变化呈显著正相关,其中降水量的相关程度最强;人口、GDP等社会经济数据与产水量变化也呈显著正相关,主要原因在于城市化的发展,城市建设用地等不透水层增加,促进了流域产水量。研究结果可以为流域水资源政策制定以及社会经济发展规划等宏观决策提供科学支撑。

关键词：生态系统服务产水功能 InVEST模型南四湖流域