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Oral Arsenic-Containing Qinghuang Powder:A Potential Drug for Myelodysplastic Syndromes

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Chinese Journal of Integrative Medicine 2022年第8期28卷 762-768页

作者： MING Jing LIU Wei-yi xiao Hai-yan XU Yong-gang MA Rou HU xiao-mei Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Qinghuang Powder(QHP),an oral arsenic,has become an effective drug in the treatment of myelodysplastic syndromes(MDS)in Xiyuan Hospital,China Academy of Chinese Medical Sciences for many years,and the action mechanism of the compound or active ingredient AsSof QHP has been *** the relatively safety,chemotherapy-free and convenient oral profile,QHP is widely used in the clinical treatment for MDS patients,especially for elderly *** this review,the authors document the efficacy and safety of oral arsenic-containing compound QHP in the treatment of MDS,with a special focus on the association of efficacy of QHP with the cytogenetics,prognostic risk,DNA methylation,gene mutation,blood arsenic concentration,mechanism of action of AsSand the countermeasures against adverse reactions of gastrointestinal tract.

关键词： arsenic Qinghuang Powder myelodysplastic syndromes review Chinese medicine

N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2313-2328页

作者： yi-xiao He hong Shen Yu-Zhu Ji Hai-Rong Hua Yu Zhu Xiang-Fei Zeng Fang Wang Kai-Xin Wang Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina Department of Pathology and Pathophysiology Faculty of Basic Medical SciencesKunming Medical UniversityKunming 650500Yunnan ProvinceChina Department of Pathology Zhaotong First People’s HospitalZhaotong 657000Yunnan ProvinceChina School of Nursing Henan Vocational College of Applied TechnologyKaifeng 450000Henan ProvinceChina Department of Clinical Pathology West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Department of Pathology Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052Guangdong ProvinceChina

BACKGROUND Invasion and migration are the irreversible stages of colorectal cancer(CRC).The key is to find a sensitive,reliable molecular marker that can predict the migration of CRC at an early stage.N-myc downstream regulated gene 1(NDRG1)is a multifunctional gene that has been tentatively reported to have a strong relationship with tumor invasion and migration,however the current molecular role of NDRG1 in CRC remains *** To explore the role of NDRG1 in the development of *** NDRG1 stably over-expressed Caco2 cell line was established by lentiviral infection and NDRG1 knock-out Caco2 cell line was established by CRISPR/***,the mRNA and protein levels of NDRG1 in Caco2 cells after NDRG1 over-expression and knockout were detected by real-time polymerase chain reaction and western *** cell proliferation rate was measured by the cell counting kit-8 method;cell cycle and apoptosis were detected by flow cytometry;invasion and migration ability were detected by the 24-transwell *** NDRG1 over-expression inhibited Caco2 proliferation and the cell cycle could be arrested at the G1/S phase when NDRG1 was over-expressed,while the number of cells in the G2 phase was significantly increased when NDRG1 was knocked *** suggests that NDRG1 inhibited the proliferation of Caco2 cells by arresting the cell cycle in the G1/S *** data also demonstrated that NDRG1 promotes early cell *** and migration of cells were extensively inhibited when NDRG1 was *** NDRG1 inhibits tumor progression in Caco2 cells which may represent a potential novel therapeutic strategy for the treatment of CRC.

关键词： N-myc downstream regulated gene 1 Caco2 Colorectal cancer Tumor progression CRISPR/Cas9 Lentivirus infection

Design method for hypersonic bump inlet based on transverse pressure gradient

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第6期23卷 479-494页

作者： Shang-cheng XU yi WANG Zhen-guo WANG xiao-qiang FAN Bing XIONG College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Transverse pressure gradient(TPG)is one of the key factors influencing the boundary layer airflow diversion in a bump *** paper proposes a novel TPG-based hypersonic bump inlet design *** method consists of two ***,a parametric optimization approach is employed to design a series of 2D inlets with various compression ***,according to the prescribed TPG,the optimized inlets are placed in different osculating planes to generate a 3D bump *** method provides a means to directly control the aerodynamic parameters of the bump rather than the geometric *** performing this method to a hypersonic chin inlet,a long and wide bump surface is formed in the compression wall,which leads to good integration of the bump/*** show that a part of the near-wall boundary layer flow is diverted by the bump,resulting in a slight decrease in the mass flow but a significant improvement in the total pressure *** addition,the starting ability is significantly improved by adding the bump *** reveals that the bump has a 3D rebuilding effect on the large-scale separation bubble of the unstarted ***,a mass flow correction is performed on the designed bump inlet to increase the mass flow to full airflow *** results show that the mass flow rate of the corrected bump inlet reaches up to 0.9993,demonstrating that the correction method is effective.

关键词： Hypersonic bump inlet Transverse pressure gradient(TPG) Boundary layer flow Total pressure recovery Starting ability Mass flow correction

Unraveling the macroevolution of horseshoe bats(Chiroptera: Rhinolophidae: Rhinolophus)

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Zoological Research 2023年第1期44卷 169-182页

作者： Wei-Jian Guo yi Wu Kai He yi-Bo Hu xiao-Yun Wang Wen-Hua Yu Key Laboratory of Conservation and Application in Biodiversity of South China School of Life SciencesGuangzhou UniversityGuangzhouGuangdong 510000China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Unraveling the diversification mechanisms of organisms is a fundamental and important macroevolutionary question regarding the diversity,ecological niche, and morphological divergence of life. However, many studies have only explored diversification mechanisms via isolated factors. Here,based on comparative phylogenetic analysis, we performed a macroevolutionary examination of horseshoe bats(Chiroptera: Rhinolophidae:Rhinolophus), to reveal the inter-relationships among diversification, intrinsic/extrinsic factors, and climatic ecological niche characteristics. Results showed a general slowing trajectory during diversification, with two dispersal events from Asia into Southeast Asia and Africa playing key roles in shaping regional heterogeneous diversity. Morphospace expansions of the investigated traits(e.g., body size,echolocation, and climate niche) revealed a decoupled pattern between diversification trajectory and trait divergence, suggesting that other factors(e.g., biotic interactions) potentially played a key role in recent diversification. Based on ancestral traits and pathway analyses, most Rhinolophus lineages belonging to the same region overlapped with each other geographically and were positively associated with the diversification rate, implying a competitive prelude to speciation. Overall, our study showed that multiple approaches need to be integrated to address diversification history. Rather than a single factor, the joint effects of multiple factors(biogeography, environmental drivers, and competition) are responsible for the current diversity patterns in horseshoe bats, and a corresponding multifaceted strategy is recommended to study these patterns in the future.

关键词： Diversification Rhinolophus Historical biogeography Abiotic/Biotic factors Climatic niche characteristics Competition

Microscopic origin and relevant grain size effect of discontinuous grain growth in BaTiO_(3)-based ferroelectric ceramics

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Journal of Materials Science & Technology 2023年第33期164卷 119-128页

作者： hong Li Bo Wu Cong Lin xiao Wu Tengfei Lin Min Gao hong Tao Wenjuan Wu Chunlin Zhao College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China Physics Department Southwest Minzu UniversityChengdu 610041China Sichuan Province Key Laboratory of Information Materials and Devices Application Chengdu University of Information TechnologyChengdu 610225China

Barium titanate[BaTiO_(3)(BT)]-based ceramics are typical ferroelectric ***,the discontinuous grain growth(DGG)and relevant grain size effect are deeply *** obvious DGG phenomenon is observed in a paradigmatic Zr^(4+)-doped BT-based ceramic,with grains growing from∼2.2–6.6 to∼121.8–198.4μm discontinuously near 1320℃.It is found that fine grains can get together and grow into large ones with liquid phase surrounding them above eutectic *** the grain boundary density(D g)is quantitatively studied and shows a first-order reciprocal relationship with grain size,and the grain size effect is dependent on D *** grains lead to high D g,and then cause fine domains and pseudocubic-like phase structure because of the interrupted long-range ferroelectric orders by grain *** D g also causes the diffusion phase transition and low Curie dielectric peak due to the distribution of phase transition temperature induced by internal *** domain switching experiments reveal that the polarization orientation is more difficult near the grain boundary,implying that the grain boundary inhibition dominates the process of polarization orientation in fine-grain ceramics,which leads to low polarization but a high coercive ***,large-grain ceramics exhibit easy domain switching and high&similar *** work reveals that the grain boundary effect dominates the grain size effect in fine-grain ceramics,and expands current knowledge on DGG and grain size effect in polycrystalline materials.

关键词： BT-based ferroelectric ceramics Discontinuous grain growth Grain boundary density Grain size effect on structure/property Microscopic origin

Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： Li He Wan-Sheng Ji Hai-Long Jin Wen-Jing Lu Yuan-Yuan Zhang Hua-Guang Wang Yu-Yu Liu Shuang Qiu Meng Xu Zi-Peng Lei Qian Zheng xiao-Li Yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(P<0.001).The DCA shows that the model has better clinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma Liver transplantation Liver cancer Nomogram Prognosis

MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma

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Neural Regeneration Research 2022年第7期17卷 1617-1622页

作者： Xin-yi Gu Bo Jin Zhi-Dan Qi xiao-Feng yin Department of Orthopedics and Traumatology Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) BeijingChina Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu ProvinceChina

MicroRNAs can regulate the function of ion channels in many *** on our previous study we propose that miR-142a-39,which is highly expressed in denervated skeletal muscle,might affect cell excitability through similar *** this study,we overexpressed or knocked down miR-142a-3p in C2C12 cells using a lentivirus *** 7 days of differentiation culture,whole-cell currents were *** results showed that overexpression of miR-142a-3p reduced the cell membrane capacitance,increased potassium current density and decreased calcium current *** of miR-142a-3p reduced sodium ion channel current *** results showed that change in miR-142a-3p expression affected the ion channel currents in C2C12 cells,suggesting its possible roles in muscle cell *** study was approved by the Animal Ethics Committee of Peking University in July 2020(approval ***2017128).

关键词： C2C12 denervation ion channels microRNA miR-142a-3p muscle patch clamp potassium sodium whole-cell currents

光致驱动聚醚的主/侧链结构设计及光致形变性能调控

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高分子学报 2024年第4期55卷 438-451页

作者：胥娥黄宇熊璐璐况涵钊郑海王燚夏小超王锋崔旭东黄炎昊重庆交通大学材料科学与工程学院重庆400074 中国工程物理研究院化学材料研究所绵阳621900 Division of Plastic and Reconstructive Surgery Washington University School of MedicineSt.LouisMo 63110

报道了一种通过开环聚合与点击化学侧基修饰制备的后功能化光敏性聚醚材料.以烯丙基缩水甘油醚(AGE)为前驱体,通过新戊酸铯催化可控阴离子开环聚合(ROP)获得聚烯丙基缩水甘油醚(PAGE),并通过巯基-烯(Thiol-ene)点击化学和酯化两步反应... 详细信息

报道了一种通过开环聚合与点击化学侧基修饰制备的后功能化光敏性聚醚材料.以烯丙基缩水甘油醚(AGE)为前驱体,通过新戊酸铯催化可控阴离子开环聚合(ROP)获得聚烯丙基缩水甘油醚(PAGE),并通过巯基-烯(Thiol-ene)点击化学和酯化两步反应将光敏基团肉桂酰氯引入到PAGE侧链上,合成了具有光敏特性的聚醚.PAGE的主链长度与肉桂酰氯侧基接枝率可分别通过调控单体/引发剂比例与反应时间灵活调控.将所得侧链修饰后的PAGE预聚物进行光固化成型,获得的光敏性聚酯薄膜具有较低的玻璃化转变温度(T_(g)),同时可在365和254 nm波长紫外光照下发生可逆[2+2]环加成反应,展现出快速可逆的变形特征.本工作通过开环聚合与点击化学反应设计优化了聚醚主侧链结构,为拓宽光功能性聚醚的使用温度窗口、提升其光致变形灵敏度提供了思路,有望使所得材料进一步在药物可控释放、柔性智能机器人等领域得到更加广泛的应用.

关键词：烯丙基缩水甘油醚聚醚肉桂酰氯光响应光致形变

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深度学习重建算法对肾上腺肿瘤的检出及鉴别效能的影响

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放射学实践 2024年第8期39卷 1081-1088页

作者：王诗耕刘义军童小雨范勇李贝贝王旭崔景景陈安良大连医科大学附属第一医院放射科辽宁大连116011 联影智能医疗科技(北京)有限公司北京100094

目的:探讨不同等级深度学习图像重建(DLIR)算法对肾上腺肿瘤的检出、组学特征可重复性和组学模型鉴别肿瘤类型效能的影响。方法:回顾性收集41例肾上腺功能性腺瘤(FAA)和46例肾上腺转移瘤(AM)患者的临床和影像资料。CT增强扫描完成后,对... 详细信息

目的:探讨不同等级深度学习图像重建(DLIR)算法对肾上腺肿瘤的检出、组学特征可重复性和组学模型鉴别肿瘤类型效能的影响。方法:回顾性收集41例肾上腺功能性腺瘤(FAA)和46例肾上腺转移瘤(AM)患者的临床和影像资料。CT增强扫描完成后,对静脉期的原始数据采用4种强度等级(DL1、DL2、DL3、DL4)的DLIR算法进行重建。首先采用主、客观指标比较4种等级间图像质量的差异;然后使用Research Portal V1.1科研平台对各组重建图像上肾上腺肿瘤进行分割并提取450个影像组学特征,包括原始图像特征90个和拉普拉斯(LoG)滤波后的高阶特征(高斯核:0.5、1.0、1.5、2.0)360个。采用一致性相关系数(CCC)评估采用不同图像重建等级测量的FAA和AM组学特征的可重复性。最后,在各组重建图像中采用逐步特征选择策略,筛选出最优特征集并构建鉴别FAA和AM的组学模型。利用五折交叉验证法验证4个组学模型的鉴别效能,利用分层交叉验证法测评4个模型的泛化能力。结果:DL2和DL3在肾显示上腺肿瘤的清晰度方面最优,得分为4(4,5),优于DL1相应得分4(3,5)和DL4相应得分4(3,4),且差异具有统计学意义(F=139.045,P0.85的个数逐渐减少,DL4中FAA和AM特征可重复的比例仅占39.3%(21/90)和50.9%(29/90)。组学特征经过LoG滤波(高斯核2.0)处理后,CCC值>0.85的个数增加,DL4中FAA和AM特征可重复的比例占91.1%(82/90)和93.3%(84/90)。4个组学模型在测试集中的曲线下面积(AUC)和符合率均>0.75,DeLong检验显示AUC的差异无统计学意义(Z=0.177~1.284,P=0.199~0.859)。但分层交叉验证显示,DL4重建图像的泛化能力最弱,AUC和符合率均<0.75。结论:高降噪等级的DLIR算法会降低对肾上腺肿瘤显示的清晰度以及组学模型的泛化性。虽然LoG滤波器(高斯核:2.0)有助于提升组学特征测量的可重复性,但仍建议在肾上腺影像诊断和组学模型训练时,使用中低降噪等级的DLIR图像。

关键词：体层摄影术,X线计算机影像组学深度学习重建算法肾上腺肿瘤可重复性