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The cytochrome P4501A1 (CYP1A1) inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection

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中华创伤杂志(英文版) 2024年第05期

作者： Qiao Ruo-Bai Dai Wei-Hong Li Wei Yang Xue He Dong-Mei Gao Rui Cui Yin-Qin Wang Ri-Xing Ma xiao-Yuan Wang Fang-Jie Liang hua-Ping The College of Emergency and Trauma Hainan Medical University Haikou China The First Research Department State Key Laboratory of Trauma and Chemical Poisoning Army Medical Center (Daping Hospital) Army Medical University Chongqing China Emergency Department The Second Affiliated Hospital Hainan Medical University Haikou China

Purpose:Vibrio vulnificus (V. Vulnificus) infection is characterized by rapid onset, aggressive progression, and challenging treatment. Bacterial resistance poses a significant challenge for clinical anti-infection treatment and is thus the subject of research. Enhancing host infection tolerance represents a novel infection prevention strategy to improve patient survival. Our team initially identified cytochrome P4501A1 (CYP1A1) as an important target owing to its negative modulation of the body''s infection tolerance. This study explored the superior effects of the CYP1A1 inhibitor bergamottin compared to antibiotic combination therapy on the survival of mice infected with multidrug-resistantV. Vulnificus and the protection of their vital ***:An increasing concentration gradient method was used to induce multidrug-resistantV. Vulnificus development. We established a lethal infection model in C57BL/6J male mice and evaluated the effect of bergamottin on mouse survival. A mild infection model was established in C57BL/6J male mice, and the serum levels of creatinine, urea nitrogen, aspartate aminotransferase, and alanine aminotransferase were determined using enzyme-linked immunosorbent assay to evaluate the effect of bergamottin on liver and kidney function. The morphological changes induced in the presence of bergamottin in mouse organs were evaluated by hematoxylin and eosin staining of liver and kidney tissues. The bacterial growth curve and organ load determination were used to evaluate whether bergamottin has a direct antibacterial effect on multidrug-resistantV. Vulnificus. Quantification of inflammatory factors in serum by enzyme-linked immunosorbent assay and the expression levels of inflammatory factors in liver and kidney tissues by real-time quantitative polymerase chain reaction were performed to evaluate the effect of bergamottin on inflammatory factor levels. Western blot analysis of IκBα, phosphorylated IκBα, p65, and phosphorylated p65 prot

关键词： Multidrug-resistantVibrio vulnificus Bergamottin CYP1A1 inhibitors Infection tolerance

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Classifying Genomic Sequences by Sequence Feature Analysis

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Genomics, Proteomics & Bioinformatics 2005年第4期3卷 201-205页

作者： Zhi-hua Liu Dian Jia xiao Sun State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China.

Traditional sequence analysis depends on sequence alignment. In this study, we analyzed various functional regions of the human genome based on sequence features, including word frequency, dinucleotide relative abundance, and base-base correlation. We analyzed the human chromosome 22 and classified the upstream, exon, intron, downstream, and intergenic regions by principal component analysis and discriminant analysis of these features. The results show that we could classify the functional regions of genome based on sequence feature and discriminant analysis.

关键词： genome sequence feature analysis BBC PCA discriminant analysis

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Protection of Two-Qubit Entanglement by the Quantum Erasing Effect

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Chinese Physics Letters 2012年第5期29卷 26-29页

作者： XIANG Shao-hua DENG xiao-Peng SONG Ke-Hui Department of Physics and Information Engineering Huaihua UniversityHuaihua 418008

We present a scheme to save the entanglement of two spatially separated atoms,each located in a leaky cavity,through the quantum erasing *** is shown that no matter whether the two atoms are in the pure or mixed state,one can robustly save their initial entanglement even if the number of erasing events is *** also briefly discuss the challenging aspect of implementing such a scheme.

关键词： method spatially separated

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A simple method for determining water content in organic solvents based on cobalt(Ⅱ) complexes

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Chinese Chemical Letters 2011年第2期22卷 189-192页

作者： Lin Zhou xiao hua Liu Hai Xin Bai Hong Juan Wang College of Plant Protection Henan Agricultural UniversityZhengzhou 450002China College of Sciences Henan Agricultural UniversityZhengzhou 450002China

A method to determine water content in organic solvents was developed based on the color change of cobalt（Ⅱ） nitrate in different *** color-change mechanism and optimal conditions for determining the water content were *** results showed that there was a good linear relationships between the absorbance of cobalt（Ⅱ） complexes in organic solvents and water contents withγin 0.9989～*** method has the advantages of low cost,good reproducibility,good sensitivity,simple in operation,fast in detection,friendly to the environment and no limitation on linear range for determining water *** was used to determine water in samples with a satisfactory recovery in 97.81%～101.24%.

关键词： Determination Water content Cobalt(Ⅱ) nitrate Organic solvent

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Association between adjuvant chemotherapy and survival in stage I gastric cancer patients after curative resection

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Gastroenterology Report 2023年第1期11卷 512-518页

作者： Qiuying Chen hua xiao Lu Zhang Jingjing You Zhe Jin Bin Zhang Department of Radiology The First Affiliated HospitalJinan UniversityGuangzhouGuangdongP.R.China Graduate College Jinan UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary and Intestinal Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China

Background:The efficacy of adjuvant chemotherapy(AC)on survival outcomes of patients with stage I gastric cancer(GC)after curative resection remains *** aimed to determine whether these patients would benefit from ***:This retrospective study included patients with pathologically confirmed stage I GC who underwent curative resection between November 2010 and December *** were divided into AC and non-AC groups,then a 1:1 propensity score matching(PSM)analysis was performed to minimize the selection *** risk factors including age,pN stage,pT stage,lymphovascular invasion,perineural invasion,tumor size,histological type,and carcinoembryonic antigen level were used as matching *** recurrence-free survival(RFS)and disease-specific survival(DSS)were compared between groups using the Kaplan–Meier ***:A total of 902 consecutive patients were enrolled and 174(19.3%)patients were treated with *** created 123 pairs of *** PSM,patients receiving AC had lower 10-year RFS rates(90%vs 94.6%,P=0.035)than those who did not receive AC;the two groups had similar 10-year DSS rates(93.8%vs 95.0%,P=0.240).After PSM,there were no statistical differences in the 10-year RFS(90.9%vs 93.0%,P=0.507)or DSS rates(93.5%vs 93.6%,P=0.811)between the two *** results were found in the stage IA and IB ***,these findings were not affected by AC ***:The addition of AC could not provide survival benefits for patients with stage I GC after surgery and follow-up is thus ***,large-scale randomized clinical trials are required.

关键词： gastric cancer stage I survival adjuvant chemotherapy propensity score matching

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Thermodynamic Calculation and MnS Solubility of Mn-Ti Oxide Formation in Si-Mn-Ti Deoxidized Steel

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Journal of Iron and Steel Research International 2010年第2期17卷 10-16页

作者： ZHUO xiao-jun WANG Yuan-qi WANG Xin-hua Lee Hae-geon Technology Management Section China Minmetals Corporation Beijing 100044 China Department of Scienee and Technology Information China Iron and Steel Research Institute Group Beijing 100081 China Metallurgieal and Ecological Engineering Sehool University of Science and Technology Beijing Beijing100083 China Graduate Institute of Ferrous Teehnology Pohang University of Science and TechnologyPohang 790-784 South Korea

Mn-Ti oxides in Si-Mn-Ti deoxidized steels after cooling in the furnace were investigated. The composition and morphology of inclusions were analyzed by using FE-SEM with EDS. Mn-Ti oxides were found to be effective sites to induce intragranular ferrite formation. The thermodynamic calculation was employed to interpret the critical condition for Mn-Ti oxide formation. Mn-Ti oxide formation was controlled not only by Mn and Ti content, but also by total oxygen content in steel. When the Mn and Ti contents were around 1.5% and 0. 005% --0.01%, respectively, Mn-Ti oxide could form as the total oxygen content was 0. 001%- 0. 002 %. The experimental results were in good agreement with thermodynamic calculation results. Also, MnS solubilit：（ was examined in Mn-Ti oxide inclusion system. With an increase of MnO content in Mn-Ti oxide, MnS solubility in the oxides increased. MnS precipitation benefited from high MnO content in Mn-Ti oxide.

关键词： Si-Mn-Ti deoxided steel Mn-Ti oxide MnS intragranular ferrite thermodynamic calculation

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Development of an XBP1 agonist,HLJ2,as a potential therapeutic agent for ulcerative colitis

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中国药理学与毒理学杂志 2017年第10期31卷 970-971页

作者： xiao-nan TANG Hai-jing ZHANG Guang-ming SONG hua-chen SONG wen-jie WANG Lian-qiu WU State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

OBJECTIVE To identify the valid targets and new drugs of ulcerative colitis(UC),a recurrent and intractable inflammatory bowel *** and RESULTS In an in vivo mouse model of DSS-induced colitis,HLJ2 decreased weight loss,colon contracture,disease activity index(DAI),colon mucosa damage index(CMDI)and histopathological index(HI).HLJ2 also decreased myeloperoxidase(MPO)activity and reduced production of the inflammatory cytokines TNF-α,IL^(-1)β,and ***2 improved intestinal mucosa damage induced by dextran sodium sulfate(DSS)and increased the expression of ZO-1 and *** 16s rRNA high-throughput sequencing demonstrated a significant improvement in UC intestinal dysbacteriosis in mice treated with HLJ2,including increased abundance of probiotics such as Lachnospiraceae,Prevotellaceae,and *** the same time there was a reduction in the abundance of pathogenic or conditional pathogenic microorganisms such as Bacteroidaceae,Porphyromonadaceae,Deferribacteraceae,and Pseudomonadaceae in HLJ2-treated mice compared with untreated *** Our results demonstrated that the XBP1 agonist HLJ2 inhibits inflammation,regulates the intestinal flora,and protects the intestinal *** is thus a potential therapeutic agent for ulcerative colitis.

关键词： ulcerative colitis XBP1 intestinal flora intestinal mucosa cytokines

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Period investigation of Algol systems TZ Eri and TU Her

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Research in Astronomy and Astrophysics 2019年第8期19卷 11-18页

作者： Zhi-hua Wang Li-Ying Zhu Lin-Jia Li xiao-Man Tian Yunnan Observatories Chinese Academy of SciencesKunming650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming650216China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China

TZ Eri and TU Her are both classic Algol-type systems(Algols). By observing and collecting times of minimum light, we constructed the O-C curves for the two systems. The long-time upward and downward parabolas shown in these diagrams are considered to be the result of the combination of mass transfer and angular momentum loss. The secular orbital period change rates are d P/dt = 4.74(±0.12) ×10-7 d yr-1 and d P/dt =-2.33(±0.01) × 10-6 d yr-1, respectively. There are also cyclic variations in their O-C curves which might be caused by the light-travel time effect(LTTE). A circumbinary star may exist in the TZ Eri system with a mass of at least 1.34 M⊙, while there are possibly two celestial bodies that almost follow a 2 : 1 resonance orbit around the TU Her binary pair. Their masses are at least 2.43 M⊙and 1.27 M⊙.

关键词： stars:binaries:close stars:binaries:eclipsing stars:individual (TZ Eri, TU Her)

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有限场地内立井施工地面布置与设备选型方案研究

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建井技术 2024年第2期45卷 6-9页

作者：陈弦王箫张书胤温永亮陕西煤业化工建设(集团)有限公司陕西西安710021

针对陕煤建庄煤矿回风立井井筒施工时场地狭小、距离既有建筑物近等现场条件,通过计算与分析制定了双绞车单侧布置、单侧排矸的地面布置方案;根据井筒工程特征确定了井筒施工的相关配套设备,并验算了整体井架在工作时的稳定性;同时对爆... 详细信息

针对陕煤建庄煤矿回风立井井筒施工时场地狭小、距离既有建筑物近等现场条件,通过计算与分析制定了双绞车单侧布置、单侧排矸的地面布置方案;根据井筒工程特征确定了井筒施工的相关配套设备,并验算了整体井架在工作时的稳定性;同时对爆破作业对既有建筑物的振动影响进行了验算,确定了不同井筒深度施工时的一次起爆最大药量,并制定了相应的减震措施。通过实践表明,在有限场地内采取双提升单侧布置的施工方案是可行的,能够保证安全生产,为类似条件的井筒施工提供了借鉴经验。

关键词：矿井建设有限场地井筒施工爆破绞车

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Rosai-Dorfman病7例并文献复习

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诊断病理学杂志 2024年第1期31卷 5-7,11页

作者：肖华静徐嘉忆沈国菊攀枝花市中心医院病理科四川攀枝花617000

目的探讨Rosai-Dorfman病的临床病理学特征、诊断及鉴别诊断,并复习相关文献。方法回顾性研究攀枝花市中心医院2014—2023年诊断为Rosai-Dorfman病的病例,所有病例均由3位高年资病理审核医师复阅。结果7例患者,年龄7~54岁,男性3例,女性4... 详细信息

目的探讨Rosai-Dorfman病的临床病理学特征、诊断及鉴别诊断,并复习相关文献。方法回顾性研究攀枝花市中心医院2014—2023年诊断为Rosai-Dorfman病的病例,所有病例均由3位高年资病理审核医师复阅。结果7例患者,年龄7~54岁,男性3例,女性4例,男女比例3∶4。发生部位:鼻腔、臀部、右上肢上臂外侧、左侧顶部颅内、颈6椎管内、右乳各1例,左大腿、下腹部均发生1例。临床表现因发生部位不同而表现不一。镜下形态大致相同,可见显著增生的组织细胞,周边见大量淋巴细胞、浆细胞浸润,成片的组织细胞与成片的淋巴浆细胞呈交替排列的暗区和亮区分布,高倍镜下可见“伸入现象”,即组织细胞内含有大量完整的淋巴细胞。免疫组化染色显示S-100、CD68、Cyclin-D1阳性,Langerin、AE1/AE3阴性。结论Rosai-Dorfman病发病率低,发病年龄广,女性患者较多见,临床及影像学表现不典型,诊断主要依靠显微镜下特征及免疫组化染色结果。

关键词： Rosai-Dorfman病病理特征诊断鉴别诊断

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