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Age of Yingfeng rapakivi granite p{1.ton on the north flank of Qaidam and its geological significance

Science china Earth Sciences 2004年第4期47卷 357-365页

作者： xiao qinghui1,{1.,{2.,{3., wei xiangdong3.& xing zuoyun6 1. division of granite geology, china Geological survey, yichang 443.03. china 2. Information Center of Ministry of Land and Resources, Beijing 1.081.2} china 3. Geological survey of Henan Province and Institute of Geological Research of Henan Province, Zhengzhou 450053. china 4. Geological Institute, china Seismological Bureau, Beijing 1.002., china 5. Geological survey Institute of Qinghai Province, Xining 81.03.2} china 6. china University of Geosciences, Wuhan 43.074, china division of {1. {2. China Geological Survey Yichang 443003 China Information Center of Ministry of Land and Resources Beijing 100812 China Geological survey of Henan Province and Institute of Geological Research of Henan Province Zhengzhou 450053 China Geological Institute China Seismological Bureau Beijing 100029 China Geological survey Institute of Qinghai Province Xining 810032 China china University of Geosciences Wuhan 430074 China

The Yingfeng rapakivi granite on the north flank of Qaidam is a newly discovered Proterozoic rapakivi p{1.ton in china, which was found after the discovery of Shachang rapakivi in Miyun County, Beijing and Kuandian rapakivi in Jilin Province. Yingfeng rapakivi p{1.ton is ex-posed on the north side of the suture belt between Qinling-Kun{1.n orogenic belt and North china plate. U-Pb zircon isotopic dating and Ar-Ar isotopic dating of both hornblende and K-feldspar from the Yingfeng rapakivi granite have been conducted. The results show that the age of (1.76±3.)Ma at the upper intercept in Concorde diagram represents the age of formation of the p{1.-ton, whereas the age of (52. 2.1. Ma at the lower intercept and Ar-Ar mineral dating of horn-blende and K-feldspar correspond to the age of a later event affecting the p{1.ton, suggesting that Yingfeng p{1.ton has ever been affected by strong regional Caledonian-Hercynian tectonic movement after its formation. The discovery of middle Proterozoic Yingfeng rapakivi granite pro-vides a petrologic evidence for the timing of cratonization of both the continental crust basement in western china and the basement of the North china plate and for a rifting event taking place in the mid-Proterozoic, suggesting that an amalgamation of ancient china continents had ever happened during the L liang Movement?between the early Proterozoic and the mid-Proterozoic.

关键词： rapakivi, U-Pb dating, Ar-Ar dating, Kunlun-Qinling orogenic belt.

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Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

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Chinese Physics C 2024年第9期48卷 1-7,300页

作者： xiaoying {1. Abdusalam Abdukerim Zihao Bo wei Chen Xun Chen Yunhua Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou Yu Hou {{3. Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong {1. Lingyin {1.o Yunyang {1.o Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen Lin Si Wenliang sun Yi Tao Anqing wang Meng wang Qiuhong wang Shaobo wang Siguang wang wei wang Xiuli wang Xu wang Zhou wang Yuehuan wei Mengmeng Wu weihao Wu Yuan Wu Mengjiao xiao Xiang xiao Kaizhi Xiong Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang Li Zhao Jifang Zhou Ning Zhou xiaopeng Zhou Yubo Zhou Zhizhen Zhou Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(1.%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from {1. to 1.4 keV using the PandaX-4T commissioning data with 0.63.tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±1..0(syst))×1.1. s^(-1.cm^(-{1.,which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of {1..3.1.^(1.)s^(-1.cm^(-{1.at 90%C.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves {1.ming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang {1. Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen {1. Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng {1.-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a {1. GeV Linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of {1. MW per beam,it can achieve a luminosity of 5×1.^({1.)cm^(-2.s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1.1.ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.{1.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.{1.s.

关键词： initiated exceeding precise

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基于白光中子源的^(1.7)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2.探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2.探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用2.块六棱BaF_(2.晶体和1.0}五棱BaF_(2.晶体构成了外径2. cm,内径1. cm的球壳,覆盖了95.2.的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了1.7Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了1.7Au俘获反应的产额,利用SAMMY程序拟合得到了^(1.7)Au在1.1.0 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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Growth,Characterization and Fermi Surface of Heavy Fermion CeCoIn_(5) Superconductor

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Chinese Physics Letters 2011年第5期28卷 226-229页

作者： JIA xiao-Wen LIU Yan YU Li HE Jun-Feng ZHAO Lin ZHANG Wen-Tao LIU Hai-Yun LIU Guo-Dong HE Shao-Long ZHANG Jun {1. wei WU Yue DONG-xiao-Li sun Li-Ling wang Gui-Ling ZHU Yong wang xiao-Yang PENG Qin-Jun wang Zhi-Min ZHANG Sheh-Jin YANG Feng XU Zu-Yan CHEN Chuang-Tian ZHOU xing-Jiang National Lab for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190

High quality single crystals of heavy Fermion CeCoIn_(5) superconductor have been grown by flux method with a typical size of(1.{1.×(1.{1.×(~0.1.mm^(3..The single crystals are characterized by structural analysis from x-ray diffraction and Laue diffraction,as well as compositional *** and electrical measurements on the single crystals show a sharp superconducting transition with a transition temperature at T_(c,onset)~{1.3.K and a transition width of~0.1. *** resistivity of the CeCoIn_(5) crystal exhibits a hump at~45 K,which is typical of a heavy Fermion *** resolution angle-resolved photoemission spectroscopy(ARPES)measurements of CeCoIn_(5) reveal clear Fermi surface sheets that are consistent with the band structure calculations when assuming itinerant Ce 4f electrons at low *** work provides important information on the electronic structure of heavy Fermion CeCoIn_(5) *** also lays a foundation for further studies on the physical properties and superconducting mechanism of the heavy Fermion superconductors.

关键词： temperature Fermi transition

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Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2.-activated K＋ channel impairment

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Chinese Medical Journal 2012年第14期125卷 2548-2555页

作者： wang Ru-{1. SHI Hai-feng CHAI Qiang WU Ying {2. {3. JI Yuan YAO Yong LI Ku-lin ZHANG Chang-ying ZHENG Jie GUO Su-xia LI xiao-rong lu Tong Department of Cardiology Wuxi People's Hospital Affiliated toNanjing Medical University Wuxi Jiangsu 214023 China Department of Cardiology Beijing Hospital of Ministry of HealthBeijing 100730 China Department of Pathology and Physiology Basic Medical InstituteShandong Academy of Medical Sciences Jinan Shandong 250062China division of Cardiovascular Diseases Department of InternalMedicine Mayo Clinic 200 First St SW Rochester MN 55905USA

Background Diabetes mellitus is associated with coronary dysfunction, contributing to a 2. to 4-fold increase in the risk of coronary heart diseases. The mechanisms by which diabetes induces vasculopathy involve endothelial-dependent and -independent vascular dysfunction in both type 1.and type 2.diabetes mellitus. The purpose of this study is to determine the role of vascular large conductance Ca2.-activated K＋（BK） channel activities in coronary dysfunction in streptozotocin-induced diabetic rats. Methods Using videomicroscopy, immunoblotting, f{3.orescent assay and patch clamp techniques, we investigated the coronary BK channel activities and BK channel-mediated coronary vasoreactivity in streptozotocin-induced diabetic rats. Results BK currents （defined as the iberiotoxin-sensitive K＋ component） contribute （65＋4）% of the total K＋currents in freshly isolated coronary smooth muscle cells and 〉50% of the contraction of the inner diameter of coronary arteries from normal rats. However, BK current density is remarkably reduced in coronary smooth muscle cells of streptozotocin-induced diabetic rats, leading to an increase in coronary artery tension. BK channel activity in response to free Ca2. iS impaired in diabetic rats. Moreover, cytoplasmic application of DHS-1.（a specific BK channel i~ subunit activator） robustly enhanced the open probability of BK channels in coronary smooth muscle cells of normal rats. In diabetic rats, the DHS-1.effect was diminished in the presence of 2.0 nmol/L Ca2. and was significantly attenuated in the presence of high free calcium concentration, i.e., 1.μmol/L Ca2.. Immunoblotting experiments confirmed that there was a 2.fold decrease in BK-β1.protein expression in diabetic vessels, without alterinq the BK channel a-subunit *** the cytosolic Ca2. concentration of coronary arterial smooth muscle cells was increased from （1.3.2.） nmol/L （n=5） of control rats to （1.3.2.） nmol/L （n=6, P 〈0.05） of STZ-induced diabetic rats, red

关键词： large conductance Ca 2. -activated K+ channel coronary artery, smooth muscle cell, diabetes mellitus β1.subunit patch clamp

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深圳市新生儿脑卒中多中心现况调查

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中国当代儿科杂志 2024年第5期26卷 450-455页

作者：时莉秀冯晋兴韦艳芳路欣茹张雨茜杨林颖何胜男陈佩娟韩静陈诚涂惠英余章斌黄进洁曾淑娟陈晚铃刘颖郭燕平毛姣玉李晓东张谦慎谢治利黄梅英晏昆山应尔雅陈俊王艳荣刘亚萍宋波刘华艳肖晓冬唐红王宇娜蔡茵莎龙琦许汉强王会战孙倩韩芳张瑞彪杨传忠窦蕾时会菊王瑞蒋萍无深圳市儿童医院新生儿科广东深圳518034 深圳市宝安区妇幼保健院新生儿科广东深圳518101 深圳市龙岗区妇幼保健院/汕头大学医学院龙岗妇幼临床学院新生儿科广东深圳518172 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院新生儿科广东深圳518020 深圳市龙岗中心医院/广州中医药大学深圳临床医学院新生儿科广东深圳518116 北京大学深圳医院新生儿科广东深圳518036 华中科技大学协和深圳医院新生儿科广东深圳518052 香港大学深圳医院新生儿科广东深圳518053 深圳市龙岗区人民医院新生儿科广东深圳518172 深圳市南山区妇幼保健院新生儿科广东深圳518067 深圳市第三人民医院新生儿科广东深圳518112 深圳市龙华区中心医院新生儿科广东深圳518110 深圳市盐田区人民医院新生儿科广东深圳518081 深圳远东妇产医院新生儿科广东深圳518002 深圳市第二人民医院新生儿科广东深圳518025 陆丰市人民医院新生儿科广东陆丰516500 惠阳三和医院新生儿科广东惠州518200 惠州市第三人民医院新生儿科广东惠州516100 深圳市妇幼保健院新生儿科广东深圳518028 南方科技大学医院新生儿科广东深圳518055 深圳市罗湖区人民医院新生儿科广东深圳518005 深圳新生儿数据协作网

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2.2.年1.—2.2.年1.0}深圳新生儿数据协作网组织2.家单位收治的新生儿脑卒中3.例,分析深圳市新生儿脑卒中发... 详细信息

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2.2.年1.—2.2.年1.0}深圳新生儿数据协作网组织2.家单位收治的新生儿脑卒中3.例,分析深圳市新生儿脑卒中发病率、临床特征、治疗、预后等情况。结果深圳市2.家医院2.2.、2.2.、2.2.年新生儿脑卒中的发病率分别为1.1.1.6}、1.6060、1.7704。缺血性脑卒中占75%(2./3.),男性患儿占64%(2./3.)。86%(3./3.)的患儿在生后3.内起病,53.(1./3.)以惊厥起病。颅脑影像学结果显示,2.例(61.)大脑左侧发生梗死,1.6}(3.%)基底节梗死;1.0}完成磁共振血管成像检查,9例(75%)累及大脑中动脉。2.例患儿完成脑电图检查,2.例(72.)出现尖波,1.例(3.%)出现电发作。不同医院对症支持治疗不同。1.0}(3.%)完善新生儿行为神经测定评分,平均得分(3.0}4)分。共随访2.例患儿1.0}龄左右的预后情况,44%(1.0}2.)的患儿预后良好。结论新生儿脑卒中主要为缺血性脑卒中,多以惊厥为首发症状,多累及大脑中动脉,脑电图多出现尖波,神经发育评分较低,以对症支持治疗为主,部分患儿预后不良。

关键词：脑卒中多中心研究新生儿

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The heterogeneity of islet autoantibodies and the progression of islet failure in type 1.diabetic patients

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Science china(Life Sciences) 2016年第9期59卷 930-939,938-939+932-937页

作者： Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma wei Gu Xinyu Xu Yun Shi Jian wang Dalong Zhu Zilin {2. Jianhua Ma Hui Jin {3. Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi wei Tang wei Li Dongmei Zhou Jun Liang {3.bo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong weinan Yu weiping lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao xiaoqiang fei Qingqing Zhang Xueqin wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng wang Guoqing Han Chunrong Xu Yun Xie Minmin An wei Zhang Zhixiao wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou wei He Xuqin Zheng xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang Department of Endocrinology and Metabolism First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Barbara Davis Center for Childhood Diabetes University of Colorado Denver Aurora Colorado 80045 USA Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical University Nanjing 210000 China Department of Isotopic Laboratory of Nanjing Medical University Nanjing 210000 China HLA Laboratory of Jiangsu Province People's Hospital Nanjing 210029 China Department of Endocrinology and Metabolism Nanjing General Hospital of Nanjing Military Command Nanjing 210002 China Department of Endocrinology and Metabolism Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China Department of Endocrinology and Metabolism Zhongda Hospital Southeast University Nanjing 210009 China Department of Endocrinology and Metabolism Nanjing First Hospital Nanjing 210000 China Department of Endocrinology and Metabolism Nanjing Children's Hospital Nanfing 210008 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China Department of Endocrinology and Metabolism Nanjing Governmental Hospital Nanjing 210008 China Department of Endocrinology and Metabolism Northern Jiangsu People's Hospital Yangzhou 225001 China Department of Endocrinology and Metabolism Wuxi People's Hospital Wuxi 214023 China Department of Endocrinology and Metabolism Jiangsu Jiangyin People's Hospital Wuxi 214400 China Department of Endocrinology and Metabolism The Affiliated Hospital of Xuzhou Medical College Xuzhou 221006 China Department of Endocrinology and Metabolism Xuzhou Central Hospital Xuzhou 221009 China Department of Endocrinology and Metabolism The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Soochow University Suzhou 215004 China Department of Endocri

Type 1.diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1.diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1.diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1.diabetic patients. A total of 1.{1.1.type 1.diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1.c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1.DM patients(duration shorter than half year) was 73. in East {3.. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen {1. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1.DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1.diabetes mellitus.

关键词： autoantibodies heterogeneity islet failure type 1.diabetes

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central china Normal University Wuhan 430079China Central South University Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of {1.93.fb^(−1.taken at the center-of-mass energy√s=3.773.GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1.(1.1.0)π,D^(0)→π(1.2}0)π,D^(0)→ρ(770)ρ(770),and D^(0)→{1.ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.{1.1.1.(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±{1.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.01._(stat.)±0.01._(syst.))%and(0.951.0.0{1._(stat.)±0.0{1._(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3.)via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Transarterial chemoembolization with PD-(L)1.inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001.

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-wei Wen Yan-Ming Lei Yu-Sheng Song Chun-wang Yuan wei-Dong wang Ming Huang wei Zhao Jian-Bing Wu Song wang Xu Zhu Jian-Jun Han wei-Xin Ren Zai-Ming lu Wen-Ge xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao xiao-Li Zhu Li-Gong lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1.PD-[L]1.inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1.inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,8{1. HCC patients receiving either TACE plus PD-(L)1.blockades and MTT(combination group,n=3.6)or TACE monotherapy(monotherapy group,n=450)were included from January {1.1. to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,{1.8 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-1..0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.00{1..OS and ORR were also significantly higher in combination group(median OS,1..{1.1..1.{1..3.vs.1..7 months[1.3}0-{1..{1.;adjusted HR,0.63.P=0.001.ORR,60.1.vs.3.1.0%;P1..Grade 3.4 adverse events were observed at a rate of 1..8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1.blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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