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Age of Yingfeng rapakivi granite p{1.ton on the north flank of Qaidam and its geological significance

Science china Earth Sciences 2004年第4期47卷 357-365页

作者： xiao qinghui1,2. lu xinxiang1,3,{2., sun yangui5, wei xiangdong3 & xing zuoyun6 1. division of granite geology, china geological survey, yichang 443003, china 2. Information Center of Ministry of Land and Resources, Beijing 100812. china 3. geological survey of Henan Province and Institute of geological Research of Henan Province, Zhengzhou 450053, china 4. geological Institute, china Seismological Bureau, Beijing 10002., china 5. geological survey Institute of Qinghai Province, Xining 810032. china 6. china University of Geosciences, Wuhan 430074, china division of {1. {2. China Geological Survey Yichang China Information Center of Ministry of Land and Resources Beijing China geological {1. of Henan Province and Institute of geological Research of Henan Province Zhengzhou China geological Institute China Seismological Bureau Beijing China geological {1. Institute of Qinghai Province Xining China china University of Geosciences Wuhan China

The Yingfeng rapakivi granite on the north flank of Qaidam is a newly discovered Proterozoic rapakivi p{1.ton in china, which was found after the discovery of Shachang rapakivi in Miyun County, Beijing and Kuandian rapakivi in Jilin Province. Yingfeng rapakivi p{1.ton is ex-posed on the north side of the suture belt between Qinling-Kun{1.n orogenic belt and North china plate. U-Pb zircon isotopic dating and Ar-Ar isotopic dating of both hornblende and K-feldspar from the Yingfeng rapakivi granite have been conducted. The results show that the age of (1.76±33)Ma at the upper intercept in Concorde diagram represents the age of formation of the p{1.-ton, whereas the age of (52. 2.1. Ma at the lower intercept and Ar-Ar mineral dating of horn-blende and K-feldspar correspond to the age of a later event affecting the p{1.ton, suggesting that Yingfeng p{1.ton has ever been affected by strong regional Caledonian-Hercynian tectonic movement after its formation. The discovery of middle Proterozoic Yingfeng rapakivi granite pro-vides a petrologic evidence for the timing of cratonization of both the continental crust basement in western china and the basement of the North china plate and for a rifting event taking place in the mid-Proterozoic, suggesting that an amalgamation of ancient china continents had ever happened during the L liang Movement?between the early Proterozoic and the mid-Proterozoic.

关键词： rapakivi, U-Pb dating, Ar-Ar dating, Kunlun-Qinling orogenic belt.

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Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2.-activated K＋ channel impairment

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Chinese Medical Journal 2012年第14期125卷 2548-2555页

作者： wang Ru-{1. SHI Hai-feng CHAI Qiang WU Ying {2. wei JI Yuan YAO Yong LI Ku-lin ZHANG Chang-ying ZHENG Jie GUO Su-xia LI xiao-rong lu Tong Department of Cardiology Wuxi People's Hospital Affiliated toNanjing Medical University Wuxi Jiangsu 214023 China Department of Cardiology Beijing Hospital of Ministry of HealthBeijing 100730 China Department of Pathology and Physiology Basic Medical InstituteShandong Academy of Medical Sciences Jinan Shandong 250062China division of Cardiovascular Diseases Department of InternalMedicine Mayo Clinic 200 First St SW Rochester MN 55905USA

Background Diabetes mellitus is associated with coronary dysfunction, contributing to a 2. to 4-fold increase in the risk of coronary heart diseases. The mechanisms by which diabetes induces vasculopathy involve endothelial-dependent and -independent vascular dysfunction in both type 1.and type 2.diabetes mellitus. The purpose of this study is to determine the role of vascular large conductance Ca2.-activated K＋（BK） channel activities in coronary dysfunction in streptozotocin-induced diabetic rats. Methods Using videomicroscopy, immunoblotting, fluorescent assay and patch clamp techniques, we investigated the coronary BK channel activities and BK channel-mediated coronary vasoreactivity in streptozotocin-induced diabetic rats. Results BK currents （defined as the iberiotoxin-sensitive K＋ component） contribute （65＋4）% of the total K＋currents in freshly isolated coronary smooth muscle cells and 〉50% of the contraction of the inner diameter of coronary arteries from normal rats. However, BK current density is remarkably reduced in coronary smooth muscle cells of streptozotocin-induced diabetic rats, leading to an increase in coronary artery tension. BK channel activity in response to free Ca2. iS impaired in diabetic rats. Moreover, cytoplasmic application of DHS-1.（a specific BK channel i~ subunit activator） robustly enhanced the open probability of BK channels in coronary smooth muscle cells of normal rats. In diabetic rats, the DHS-1.effect was diminished in the presence of 2.0 nmol/L Ca2. and was significantly attenuated in the presence of high free calcium concentration, i.e., 1.μmol/L Ca2.. Immunoblotting experiments confirmed that there was a 2.fold decrease in BK-β1.protein expression in diabetic vessels, without alterinq the BK channel a-subunit *** the cytosolic Ca2. concentration of coronary arterial smooth muscle cells was increased from （1.3±2.） nmol/L （n=5） of control rats to （1.3±2.） nmol/L （n=6, P 〈0.05） of STZ-induced diabetic rats, red

关键词： large conductance Ca 2. -activated K+ channel coronary artery, smooth muscle cell, diabetes mellitus β1.subunit patch clamp

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Transarterial chemoembolization with PD-(L)1.inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001.

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-wei Wen Yan-Ming Lei Yu-Sheng Song Chun-wang Yuan wei-Dong wang Ming Huang wei Zhao Jian-Bing Wu Song wang Xu Zhu Jian-Jun Han wei-Xin Ren Zai-Ming lu Wen-Ge xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao xiao-Li Zhu Li-Gong lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1.PD-[L]1.inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1.inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,8{1. HCC patients receiving either TACE plus PD-(L)1.blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January {1.1. to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,{1.8 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-1..0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.00{1..OS and ORR were also significantly higher in combination group(median OS,1..{1.1..1.{1..3]vs.1..7 months[1..0-{1..{1.;adjusted HR,0.63,P=0.001.ORR,60.1.vs.3{1.0%;P1..Grade 3/4 adverse events were observed at a rate of 1..8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1.blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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新型冠状病毒(2.1.-nCoV)感染的肺炎诊疗快速建议指南(标准版)

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解放军医学杂志 2020年第1期45卷 1-20页

作者：靳英辉蔡林程真顺程虹邓通范逸品方程黄笛黄璐琦黄桥韩勇胡波胡芬李柄辉李一荣梁科林丽开罗丽莎马晶马琳璐彭志勇潘运宝潘振宇任学群孙慧敏王莹王云云翁鸿韦超洁吴东方夏剑熊勇徐海波姚晓梅叶太生袁玉峰张笑春张莹雯张银高张华敏赵剡赵明娟訾豪曾宪涛王永炎王行环武汉大学中南医院新型冠状病毒感染的肺炎防治课题组无武汉大学中南医院循证与转化医学中心武汉430071 武汉大学医院管理研究所武汉430071 武汉大学中南医院呼吸与危重症医学科武汉430071 武汉大学中南医院药学部武汉430071 河南大学循证医学与临床转化研究院河南开封475000 中国中医科学院北京100700 中国中医药循证医学中心北京100700 武汉大学中南医院重症医学科武汉430071 武汉大学中南医院医学检验科武汉430071 武汉大学中南医院感染科武汉430071 武汉大学中南医院医务处武汉430071 武汉大学中南医院护理部武汉430071 武汉大学中南医院院内感染办公室武汉430071 武汉大学中南医院急救中心武汉430071 武汉大学中南医院医学影像中心武汉430071 麦克马斯特大学卫生研究方法证据及影响系加拿大安大略省哈密尔顿市L8S4L8 武汉大学中南医院中医科武汉430071 武汉大学全球健康研究中心武汉430072 不详中国医疗保健国际交流促进会循证医学分会

2.1.新型冠状病毒(2.1. novel coronavirus,2.1.-nCoV),因2.1.年1.0}发生在中国武汉的不明原因病毒性肺炎病例而被发现,并于2.2.年1.1.0}被世界卫生组织(World Health Organization,WHO)命名。在之后的1.月内,2.1.-nCoV在湖北省内、中国甚至其他国家传播,造成了数以千计病例的出现,同时也引起了民众一定程度的恐慌。本指南的制订希望能够从疾病流行病学、病因学、诊断、治疗、护理、医院感染控制等方面给临床医师、社区居民等提供医疗护理及居家照护的相关指导。

关键词： 2.1.新型冠状病毒呼吸疾病肺炎感染性疾病快速建议指南临床实践指南循证医学

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Fungal diversity notes 2.3-366:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li {1. Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu {1.s Zhong Liu Zuo Yi Liu J.Jennifer luangsa-ard Robert Lücking H.Thorsten lumbsch Saisamorn lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 1.6 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.1.0}/1.J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144Bagnacavallo

Notes on 1.3 fungal taxa are compiled in this paper,including 1. new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,***,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species

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新型冠状病毒(2.1.-nCoV)感染的肺炎诊疗快速建议指南(完整版)

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医学新知 2020年第1期30卷 35-64页

作者：靳英辉蔡林程真顺程虹邓通范逸品方程黄笛黄璐琦黄桥韩勇胡波胡芬李柄辉李一荣梁科林丽开罗丽莎马晶马琳璐彭志勇潘运宝潘振宇任学群孙慧敏王莹王云云翁鸿韦超洁吴东方夏剑熊勇徐海波姚晓梅袁玉峰叶太生张笑春张莹雯张银高张华敏赵剡赵明娟訾豪曾宪涛王永炎王行环武汉大学中南医院新型冠状病毒感染的肺炎防治课题组无武汉大学中南医院循证与转化医学中心武汉430071 武汉大学医院管理研究所武汉430071 武汉大学中南医院呼吸与危重症医学科武汉430071 武汉大学中南医院药学部武汉430071 河南大学循证医学与临床转化研究院河南开封475000 中国中医科学院北京100700 中国中医药循证医学中心北京100700 武汉大学中南医院重症医学科武汉430071 武汉大学中南医院医学检验科武汉430071 武汉大学中南医院感染科武汉430071 武汉大学中南医院医务处武汉430071 武汉大学中南医院护理部武汉430071 武汉大学中南医院院内感染办公室武汉430071 武汉大学中南医院急救中心武汉430071 武汉大学中南医院医学影像中心武汉430071 麦克马斯特大学卫生研究方法证据及影响系加拿大安大略省哈密尔顿市L8S 4L8 武汉大学中南医院中医科武汉430071 武汉大学全球健康研究中心武汉430072 无中国医疗保健国际交流促进会循证医学分会

2.1.新型冠状病毒(2.1. novel coronavirus,2.1.-nCoV)感染的肺炎,因2.1.年1.0}发生在武汉的不明原因病毒性肺炎病例而被发现,并于2.2.年1.1.0}被世界卫生组织(World Health Organization,WHO)命名。在之后的一个月时间内,2.1.-nCoV在湖北省内外甚至其他国家传播造成了数以千计的病例出现,同时也引起了民众一定程度的恐慌。本指南的制订希望能够从疾病流行病学、病因学、诊断、治疗、护理、医院感染控制等方面给临床医生、社区居民等提供医疗护理及居家照护相关指导。

关键词： 2.1.新型冠状病毒 COVID-1. 呼吸疾病肺炎感染性疾病快速建议指南临床实践指南循证医学

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