检索结果-南通市图书馆

Research on blade tip clearance cavitation and turbulent kinetic energy characteristics of axial flow pump based on the partially-averaged Navier-Stokes model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第1期36卷 184-201页

作者： xiao-qi Jia Shuai-kang Zhang Zu-chao Zhu Key Laboratory of Fluid Transmission Technology of Zhejiang Province Zhejiang Sci-Tech UniversityHangzhou310018China

To reveal the cavitation forms of tip leakage vortex(TLV)of the axial flow pump and the flow mechanism of the flow field,this research adopts the partially-averaged Navier-Stokes(PANS)model to simulate the cavitation values of an axial flow pump,followed by experimental validation.The experimental result shows that compared with the shear stress transport(SST)k-ωmodel,the PANS model significantly reduces the eddy viscosity of the flow field to make the vortex structure clearer and allow the turbulence scale to be more robustly analyzed.The cavitation area within the axial flow pump mainly comprises of TLV cavitation,clearance cavitation and tip leakage flows combined effect of triangular cloud cavitation formed.The formation and development of cavitation are accompanied by the formation and evolution of vortex,and variations in vortex structure also generate and promote the development of cavitation.In addition,an in-depth analysis of the relationship between the turbulent kinetic energy(TKE)transport equation and cavitation patterns was also conducted,finding that the regions with relatively high TKE are mainly distributed around gas/liquid boundaries with serious cavitation and evident gas-liquid change.This phenomenon is mainly attributed to the combined effect of the pressure action term,stress diffusion term and TKE production term.

关键词： Cavitation axial flow pump tip leakage vortex(TLV) partially-averaged Navier-Stokes(PANS)model turbulent kinetic energy(TKE)

Systematic investigation of Radix Salviae for treating diabetic peripheral neuropathy disease based on network Pharmacology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第5期15卷 945-957页

作者： Tao kang xiao Qin Yan Chen Qian Yang Department of Neurology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment options.Radix Salviae,a traditional Chinese herb,has shown promise in treating DPN,but its therapeutic mech-anisms have not been systematically investigated.AIM Radix Salviae(Danshen in pinin),a traditional Chinese medicine(TCM),is widely used to treat DPN in China.However,the mechanism through which Radix Salviae treats DPN remains unclear.Therefore,we aimed to explore the mechanism of action of Radix Salviae against DPN using network pharmacology.METHODS The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis platform.The genes associated with DPN were obtained from the Gene Cards and OMIM databases,a drug-com-position-target-disease network was constructed,and a protein–protein inter-action network was subsequently constructed to screen the main targets.Gene Ontology(GO)functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes(KEGG)using Bioconductor.RESULTS A total of 56 effective components,108 targets and 4581 DPN-related target genes of Radix Salviae were screened.Intervention with Radix Salviae for DPN mainly involved 81 target genes.The top 30 major targets were selected for enrichment analysis of GO and KEGG pathways.CONCLUSION These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling pathway.Therefore,Danshen may affect DPN by regulating inflammation and apoptosis.

关键词： Diabetic peripheral neuropathy Radix Salviae Network pharmacology Systematic investigation

Characteristics and genesis of tuffaceous shale oil lithofacies:A case study of Lucaogou Formation in Santanghu Basin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Research 2024年第1期9卷 37-47页

作者： Dongsheng xiao Xiong fei Xu Jilun kang Yiting Zhang PetroChina Tuha Oilfield Company Exploration and Development Research Institute China

Lucaogou Formation in the Santanghu Basin is a special lacustrine fine-grained sedimentary deposits rich in volcanic debris and carbonate,with abundant shale oil resources.However,understanding of shale oil characteristics and genesis remains unclear.Lithofacies,sedimentary environment,and formation mechanisms of tuffaceous shale oil are investigated based on core and thin section observations,X-ray diffraction,field emission SEM and geochemical analysis.Results show that three mixed lithofacies types are developed in Lucaogou Formation:blocky tuff,laminated tuffaceous dolomite,and laminated dolomitic tuff.These lithofacies types are characterized by high content of felsic and dolostone,widespread organic matter,and low clay content.Formation of tuffaceous shale oil sweet spots is primarily influenced by four factors:inputting of volcanic ash as a high-quality source rocks and reservoirs provides good material basis;devitrification of volcanic glass,calcitization,and dissolution are crucial for formation of reservoirs;expulsion of source rocks with high-abundance organic matter expulsion facilitates migration and accumulation of hydrocarbon in adjacent reservoirs;fracture development improves reservoir permeability to form highly productive sweet spots.By analyzing characteristics and genesis of tuffaceous shale oil,the main controlling factors of reservoir physical property and oil saturation are clarified,which is of great significance for selection of shale oil exploration zones.

关键词： shale oil Tuffaceous Formation mechanism Lucaogou formation Santanghu basin

Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第1期16卷 248-256页

作者： Gang Huang kang-kang Wu xiao-Na Li Jing-Hua Kuai Ai-Jun Zhang Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and cecum.Small bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more challenging.CASE SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal bleeding.All patients underwent blood tests and imaging examinations.Small bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal ulcers.One patient ultimately underwent surgical treatment.Following a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their condition.CONCLUSION Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal bleeding.Accurate diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications.

关键词： Intestinal tuberculosis Gastrointestinal hemorrhage Small bowel endoscopy Case report

Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 159-183页

作者： Yuxi Chen xiao Luo Rui kang Kaixin Cui Jianping Ou Xiya Zhang Puping Liang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center for Reproductive Medicine The Third Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhouGuangdong 510630China

Osteoarthritis(OA)is one of the most common degenerative joint diseases worldwide,causing pain,disability,and decreased quality of life.The balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of OA.Currently,there is a lack of effective therapeutic strategies for OA treatment.With the development of CRISPR-based genome,epigenome,and RNA editing tools,OA treatment has been improved by targeting genetic risk factors,activating chondrogenic elements,and modulating inflammatory regulators.Supported by cell therapy and in vivo delivery vectors,genome,epigenome,and RNA editing tools may provide a promising approach for personalized OA therapy.This review summarizes CRISPR-based genome,epigenome,and RNA editing tools that can be applied to the treatment of OA and provides insights into the development of CRISPR-based therapeutics for OA treatment.Moreover,in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

关键词： Osteoarthritis Genome editing Epigenone editing RNA editing

Present situation of minimally invasive surgical treatment for early gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1154-1165页

作者： Chun-Yan Li Yi-Feng Wang Li-kang Luo xiao-Jun Yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina Gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical wounds.In addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer patients.Surgical minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so on.These new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

Cellulose sub-nanometric ribbons:A new generation of nanocellulose and platform for biomaterials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bioresources and Bioproducts 2024年第1期9卷 1-2页

作者： Shaomin kang Yang Zhao Junlong Song Huining xiao Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Department of Chemical Engineering University of New BrunswickFredericton NB E3B 5A3Canada

With the tremendous progress of research in nanoscience,much attention has been paid to the bottom of the“nano world”:scales around one nanometer or even smaller.In order to describe materials at this scale,a new co... 详细信息

关键词： biomaterials scales emerged

First-principles study on the heterogeneous formation of environmentally persistent free radicals(EPFRs)overα-Fe2O3(0001)surface:Effect of oxygen vacancy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第8期142卷 279-289页

作者： Wenxiao Pan Shuming He Qiao Xue Xian Liu Jianjie Fu kang xiao Aiqian Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310012China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China

Metal oxides with oxygen vacancies have a significant impact on catalytic activity for the transformation of organic pollutants in waste-to-energy(WtE)incineration processes.This study aims to investigate the influence of hematite surface oxygen point defects on the formation of environmentally persistent free radicals(EPFRs)from phenolic compounds based on the first-principles calculations.Two oxygen-deficient conditions were considered:oxygen vacancies at the top surface and on the subsurface.Our simulations indicate that the adsorption strength of phenol on theα-Fe_(2)O_(3)(0001)surface is enhanced by the presence of oxygen vacancies.However,the presence of oxygen vacancies has a negative impact on the dissociation of the phenol molecule,particularly for the surface with a defective point at the top layer.Thermo-kinetic parameters were established over a temperature range of300-1000 K,and lower reaction rate constants were observed for the scission of phenolic O-H bonds over the oxygen-deficient surfaces compared to the pristine surface.The negative effects caused by the oxygen-deficient conditions could be attributed to the local reduction of FeⅢto FeⅡ,which lower the oxidizing ability of surface reaction sites.The findings of this study provide us a promising approach to regulate the formation of EPFRs.

关键词： EPFR formation Phenol dissociation Oxygen-vacancy impact Hematite surface First-principles calculation

Spatial heterogeneity and compositional profiles of dissolved organic matter in farmland soils across China' Mainland

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 593-603页

作者： Bingjun Han Liyuan Chen kang xiao Yang Liu Dong Cao Lu Yu Yujun Li Shu Tao Wenxin Liu Key Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Beijing Yanshan Earth Critical Zone National Research Station College of Resources and EnvironmentUniversity of Chinese Academy of SciencesBeijing 101408China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental ScienceChinese Academy of SciencesBeijing 100085China

Dissolved organic matter(DOM) plays an essential role in many geochemical processes,however its complexity, chemical diversity, and molecular composition are poorly understood. Soil samples were collected from 500 vegetable fields in administrative regions of China' Mainland, of which 122 were selected for further investigation. DOM properties were characterized by three-dimensional excitation-emission matrix(3D-EEM) fuorescence spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry(FTICRMS)(field intensity is 15 Tesla). Our results indicated that the main constituents were UVA humic-like substances, humic-like substances, fulvic acid-like substances, and tyrosine-like substances. A total of 10,989 molecular formulae with a mass range of 100.04 to 799.59 Da were detected, covering the mass spectrometric information of the soil samples from 27 different regions. CHO and CHON molecules were dominant in DOM, whereas lignin, tannins,and aromatic substances served as the main components. The results of cluster analysis revealed that the soil properties in Jiangxi Province were considerably different from those in other regions. The key backgrounds of the DOM molecular characteristics in the vegetablefield soil samples across China' Mainland were provided at the molecular level, with large abundance and great variability.

关键词： Dissolved organic matter(DOM) Fourier transform ion cyclotron resonance mass(FTICR-MS) Excitation-emission matrix(EEM) Vegetable-field soils China' Mainland