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Synthesis and Properties Investigation of Thiophene-aromatic Polyesters: Potential Alternatives for the 2.5-Furandicarboxylic Acid-based Ones

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chinese Journal of Polymer Science 2020年第10期38卷 1082-1091,I0005页

作者： jing Gang Wang xiao-Qin {2. Ang Shen jin Zhu Ping An Song Hao Wang xiao Qing Liu Ningbo institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Universty of chinese academy of{2. Bejing 100049China University of Southern Queensland SpringfieldQLD 4300Australia

In order to explore new substitutes for 2.5 furandicarboxylic acid(FDCA)or poly(ethylene 2.5 furandicarboxylate)(PEF)and try to develop more ideal bio based polyesters,several thiophene aromatic polyesters(PETH,PPTH,PBTH,and PHTH)were synthesized from dimethyl thiophene 2.5-dicarboxylate(DMTD)and different diols,including ethylene glycol,1,3-propanediol,1,4.butanediol,and 1,*** chemical structures of obtained polyesters were confirmed by nuclear magnetic resonance spectroscopy(H-NMR and 1'C-NMR).Determined by GPC measurement,their average molecular weight(M.)varied from 5.2. x 10*g/mol to 7.94.x 10*g/mol with the molar-mass dispersity of *** on the DSC and TGA results,the synthesized polyesters PETH,PPTH,and PBTH displayed comparable or even better thermal properties when compared with their FDCA-based *** PETH to PHTH,their Tg varied from 64.6°Cto-1°C while Tsm ranged from 4.9 C to 380°C in nitrogen atmosphere,PETH showed elongation at break as high as 378%,tensile strength of 67 MPa,and tensile modulus of 1800 ***,the CO2.and O2.barrier of PETH was 12.0 and 6.6 folds higher than those of PET,respectively,and similar to those of *** the overall properties,the synthesized thiophene aromatic polyesters,especially PETH,showed great potential to be used as an excellent bio based packaging material in the future.

关键词： 2.5-Thiophenedicarboxlic acid(TDCA) 2.5 Furandicarborxylic acid(FDCA) Bio based polyesters Brrier properties

Enhanced Antileukemia Efficacy but not Cardiotoxicity Exerted by Proteasome Inhibitor/Imatinib Combinations in Chronic Myeloid Leukemia

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Enhanced Antileukemia Efficacy but not Cardiotoxicity Exerte...

Oral everolimus inhibits intimal proliferation in injured carotid artery in rats

第五届全国化学生物学学术会议

作者： Zheng Hu~1 xiao-Fen Pan~1 jing-Lei Liu~(1,5) Da-Peng Liu~1 xiao-Li Liu~2.Fan-Yi Meng~2.Feng-Xiang zhang~1 Fu-Qun Wu~1 Juan Li~4.Zhu Chen~3 Sai-Juan Chen~3 Guang-Biao Zhou~(1*) 1 Laboratory of Molecular Target-Based Therapy for Cancer,Guangzhou institute of Biomedicine and Health,{4. academy of sciences,Guangzhou 510663 2.Department of Hematology,Nanfang Hospital Affiliated to Nanfang Medical University,Guangzhou,510515 3 State Key Laboratory of Medical Genomics and Shanghai institute of Hematology, Rui jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai, 2.002. 4.Department of Hematology,the First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510080 5 University of Science and Technology of China,Hefei,2.002.,China.

＜正＞Resistance developed by leukemic cells,cardiotoxity,and unsatisfactory efficacy on patients with chronic myeloid leukemia（CML）at accelerated and blastic phases,have been limitations for imatinib mesylate（IM）in treating *** IM based combinatory regimens could be one of the strategies to overcome these limitations needs more *** we showed that the

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chinese Medical Journal 2013年第10期126卷 1906-1912页

作者： WANG xiao-fang SHEN De-liang ZHAO xiao-yan N1NG Hong-{2. FENG Ri-sheng zhang {4.-ying Department of Cardiology First Affiliated Hospital College ofMedicine Zhengzhou University Zhengzhou Henan 450052 China

Background Everolimus, a derivative of sirolimus, is a potent immunosuppressant that has important anti-proliferative properties. In the present study, we demonstrated the inhibiting neointimal hyperplasia in injured carotid arteries in rats by using two different doses of everolimus administrated via the oral route for a long time. Methods A rat model of carotid artery injury was established by balloon inflation. Eighty rats were randomly divided into the sham-operated group （n=2.）, injury group （n=2.）, low dosage of everolimus group （n=2.）, and high dosage of everolimus group （n=2.）. The low close of everolimus （1.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 0.75 mg/kg per day for 2. days via intragastric gavage. High dose everolimus （2.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 1 mg/kg per day for 2. days. Expression of eukaryotic translation initiation factor 4. （elF-4.） and phosphorylation of ribosomal proteinS6 kinase 1 （P70S6K） were determined by reverse transcription-polymerase chain reaction and Western blotting analysis. Results In the injured carotid artery, neointimal hyperplasia was normally observed four weeks after injury. Everolimus inhibited neointimal hyperplasia after balloon injury in a dose dependent manner. At the same time, the study demonstrated that everolimus reduced the expression of P-P70S6K, elF-4., transforming growth factor （TGF）-131 and of proliferating cell nuclear antigen （PCNA）. Conclusions Everolimus significantly inhibited neointimal hyperplasia of the injured carotid artery. The effect depended on dosaqe and was associated with the reduction of phosphorylation of P70S6K and the elF-4. expression level.

关键词： everolimus ribosomal protein S6 kinase 1, eukaryotic translation initiation factor 4.

脉幅有序变化OTDM信号的支路及群路全光时钟提取

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中国激光 2001年第11期28卷 1010-1012页

作者：宋立军李世忱葛春风余震虹张劲冶贾东方黄超于晋龙马晓红戴居丰杨恩泽天津大学精密仪器与光电子工程学院教育部光电信息技术科学重点实验室天津大学电子工程学院天津300072

将含暗帧脉冲的 4. 2..5GHz的光时分复用 (OTDM)信号注入一含半导体光放大器 (SOA)的锁模光纤激光器 ,利用SOA的交叉增益调制效应 ,提取出 2..5GHz的支路时钟信号和 5GHz,10GHz的群路时钟信号 ;群路时钟的提取机制是有理数谐波锁模机... 详细信息

将含暗帧脉冲的 4. 2..5GHz的光时分复用 (OTDM)信号注入一含半导体光放大器 (SOA)的锁模光纤激光器 ,利用SOA的交叉增益调制效应 ,提取出 2..5GHz的支路时钟信号和 5GHz,10GHz的群路时钟信号 ;群路时钟的提取机制是有理数谐波锁模机制。光时分复用信号采用暗帧脉冲不但可以用来识别支路信号。

关键词：全光时钟提取注入锁模光时分复用光纤通信

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干细胞移植患者白消安暴露量的估算模型研究

中国药理学通报 2024年第6期40卷 1193-1198页

作者：李晋文徐燕王晓丹廖应熙何帅徐姗章萍苗文娟中国医学科学院血液病医院(中国医学科学院血液学研究所) 天津300020

目的采用有限采样法建立接受自体造血干细胞移植(autologous stem cell transplantation,ASCT)的淋巴瘤患者体内白消安暴露量-药时曲线下面积(area under the concentration-time curve,AUC)的估算模型。方法选取12.适合接受ASCT的淋... 详细信息

目的采用有限采样法建立接受自体造血干细胞移植(autologous stem cell transplantation,ASCT)的淋巴瘤患者体内白消安暴露量-药时曲线下面积(area under the concentration-time curve,AUC)的估算模型。方法选取12.适合接受ASCT的淋巴瘤患者,采用含白消安105 mg·m^(-2.,静脉滴注3 h的预处理方案,分别于白消安第1剂输注开始后1 h,输注结束后5 min,1、2.4.6、18 h采集血样,采用液质联用法进行白消安血药浓度测定。采用传统药动学方法计算白消安的临床药动学参数后,采用多元线性逐步回归分析法,建立有限采样法的白消安的AUC 0-t估算模型。以Jackknife法和Bootstrap法进行模型内部验证,采用Bland-Altman图评价经典药动学方法与有限采样法的一致性。结果采取有限采样法得出以AUC对C 60min、C 180min、C 300min进行多元线性回归的方程分析,方程的线性关系和预测效果最好,为AUC 0-t=2.5.003C 60min+2.3.050C 180min+2.3.163C 300min-12.2.713,其中r 2.0.995,平均预测误差为-0.87%,均方根误差为2.4.%。结论采用三点法估算的有限采样法模型,可以用于接受ASCT的淋巴瘤患者体内白消安AUC 0-t的估算,为临床合理应用白消安提供参考。

关键词：白消安有限采样法 Jackknife法 Bootstrap法自体造血干细胞移植药时曲线下面积治疗药物监测

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Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress

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chinese Journal of Integrative Medicine 2023年第1期29卷 19-27页

作者： LI Yan-rong FAN Hui-jie SUN Rui-rui JIA Lu YANG Li-yang zhang Hai-fei {2. xiao-ming xiao Bao-guo MA Cun-gen CHAI Zhi The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional chinese Medicine Shanxi University of Chinese MedicineJinzhongShanxi Province030619China institute of Brain Science Department Neurology of First Affiliated HospitalShanxi Datong UniversityDatongShanxi Province037009China Department of Anatomy and Cell Biology Department of Neurological SurgerySpinal Cord and Brain Injury Research GroupStark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN46202USA institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200025China

Objective:To investigate the protective effects and its possible mechanism of Wuzi Yanzong Pill(WYP) on Parkinson’s disease(PD) model ***:Thirty-six C57BL/6 male mice were randomly assigned to 3 groups including normal,PD,and PD+WYP groups,12.mice in each *** week of intraperitoneal injection of 1-methyl-4.phenyl-1,2.3,6-tetrahydropyridine(MPTP) was used to establish the classical PD model in ***,mice in the PD+WYP group were administrated with 16 g/kg WYP,twice daily by *** 14.days of administration,gait test,open field test and pole test were measured to evaluate the movement *** hydroxylase(TH) neurons in substantia nigra of midbrain and binding immunoglobulin heavy chain protein(GRP78) in striatum and cortex were observed by *** levels of TH,GRP78,p-PERK,p-elF2.,ATF4.p-IRE1α,XBP1,ATF6,CHOP,ASK1,p-JNK,Caspase-12.-9 and-3 in brain were detected by Western ***:Compared with the PD group,WYP treatment ameliorated gait balance ability in PD mice(P2.,ATF4.p-IRE1α,XBP1,CHOP,Caspase-12.and Caspase-9(P<0.05or P<0.01).Conclusions:WYP ameliorated motor symptoms and pathological lesion of PD mice,which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway.

关键词： Wuzi Yanzong Pill Parkinson’s disease dopaminergic neurons endoplasmic reticulum stress apoptosis

基于树轮-气候资料的160多年来秦岭太白山降水变化特征重建

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生态学杂志 2018年第5期37卷 1467-1475页

作者：苏凯白红英张扬黄晓月秦进西北大学西安710127 陕西省地表系统与环境承载力重点实验室西安710127

秦岭作为中国南北地理分界线的重要组成部分,一直是全球气候变化研究的热点地区之一。依据秦岭主峰太白山北坡太白红杉(Larix chinensis)树轮宽度指数以及周边宝鸡和眉县多年的气象站数据,通过多元回归模型重建了该地区160年来上年11月... 详细信息

秦岭作为中国南北地理分界线的重要组成部分,一直是全球气候变化研究的热点地区之一。依据秦岭主峰太白山北坡太白红杉(Larix chinensis)树轮宽度指数以及周边宝鸡和眉县多年的气象站数据,通过多元回归模型重建了该地区160年来上年11月至当年6月的累计降水量序列,揭示了1852.2.12.秦岭主峰太白山降水变化特征。结果表明:重建方程方差解释量为39.6%(R2.dj=0.370,F=15.11,P1),重建序列的可靠性得到了气象灾害历史记录以及周边重建结果的支持与验证;重建降水序列表现出明显的干湿变化和周期性波动特征,在过去160年中较湿润的时段主要有1875—1885、1908—192.和1983—2.02.;持续干旱的时段包括1857—1867、1886—1907、192.—1935年以及1954.1965年;周期分析结果显示,研究区160年来降水变化存在4.~54.17~2.、准13和3~7 a的4.震荡周期,并且表现出小周期弱化、大周期增强的趋势。研究区气候变化还受到更大尺度水文气候变化的影响。

关键词：树木年轮秦岭降水重建

Crystal Structure and the Third-order Nonlinear Optical Property of a Cadmium(Ⅱ) Complex Based on a D-π-A Structural Organic Ligand

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chinese Journal of Structural Chemistry 2019年第7期38卷 1099-1106页

作者： jin Feng MAMing-Yue LV jing-{2. GUO xiao-{2. ZHA Quan-Jun SUN Lin zhang Lin LIAO Rong-Bao Department of Chemistry and Chemical Engineering Fuyang Normal University

A triphenylamine-containing Schiff base ligand(L), namely, N-(4.(1 H-imidazol-1-yl)benzylidene)-N,N-diphenylbenzene-1,4.diamine, was synthesized and characterized. By coordination of the ligand with CdI2. a complex CdI2.L2.was obtained. The structure of the complex was analyzed through single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P2./c with a = 2..2.7(5), b = 11.176(5), c = 17.912.5) ?, β = 106.056(5)°, V = 4.63(3) ?3, Z = 4. Dc =1.633 Mg/m3, F(000) = 2.60, Μr = 1195.19, μ = 1.766 mm-1, the final R = 0.032. and wR = 0.0758 for 334.4.observed reflections with I > 2.(I). The linear absorption spectra of the complex were experimentally and theoretically studied. And the third-order nonlinear optical(NLO) property of the complex was also measured through Z-scan technique.

关键词： crystal structure z-scan nonlinear optical property

血清cMyBP-C、ICAM-1、ADAMTS-1水平与急性心肌梗死患者预后的相关性

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中国疗养医学 2024年第3期33卷 68-72页

作者：邱小慧陈防晋张正勋张磊郑州市惠济区人民医院心血管内科河南郑州450000 河南省胸科医院心血管内科河南郑州450000

目的探讨血清心脏肌球蛋白结合蛋白C(cMyBP-C)、细胞间黏附分子-1(ICAM-1)、Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶(ADAMTS-1)水平与急性心肌梗死(AMI)患者预后的相关性。方法选取2.2.年4.至2.2.年4.于郑州市惠济区人民医院... 详细信息

目的探讨血清心脏肌球蛋白结合蛋白C(cMyBP-C)、细胞间黏附分子-1(ICAM-1)、Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶(ADAMTS-1)水平与急性心肌梗死(AMI)患者预后的相关性。方法选取2.2.年4.至2.2.年4.于郑州市惠济区人民医院行经皮冠状动脉介入(PCI)术治疗的14.0}AMI患者作为研究对象,根据入院时Gensini积分将患者分为轻度狭窄组(4.例)、中度狭窄组(55例)、重度狭窄组(38例)。比较三组术前血清cMyBP-C、ICAM-1、ADAMTS-1水平,比较不同预后患者(术前、术后7 d、术后14.d)血清cMyBP-C、ICAM-1、ADAMTS-1水平,采用Pearson分析相关性,采用绘制受试者工作特征(ROC)曲线评估预测价值,分析各指标不同水平患者预后不良的危险度。结果三组术前血清cMyBP-C、ICAM-1、ADAMTS-1水平比较:重度狭窄组>中度狭窄组>轻度狭窄组(P14.d预后不良患者血清cMyBP-C、ICAM-1、ADAMTS-1水平高于预后良好患者(P1、ADAMTS-1水平呈下降趋势(P1、ADAMTS-1水平与Gensini积分均呈正相关(P14.d联合预测AMI患者PCI术后预后不良AUC为0.813;术后14.d血清cMyBP-C、ICAM-1、ADAMTS-1高水平患者PCI术后预后不良的危险度是低水平的4.4.0、5.2.7、3.638倍(P1、ADAMTS-1水平与AMI患者PCI术后转归情况密切相关,临床可根据各指标水平变化给予针对性干预,进而改善患者预后。

关键词：急性心肌梗死经皮冠状动脉介入术心脏肌球蛋白结合蛋白C 细胞间黏附分子-1