检索结果-南通市图书馆

运动训练对背根神经节切除模型大鼠运动功能的影响

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2018年第16期22卷 2537-2541页

作者：安普天朱文文李脉超崔晓娟周燕张益萌金利新青岛大学医学部临床医学院山东省青岛市266071 青岛大学医学解剖学教研室山东省青岛市266071

背景:周围神经损伤后可导致中枢神经系统通路发生广泛的变化,运动训练对于中枢神经系统损伤后运动功能恢复有一定的促进作用。目的:观察运动训练后部分感觉缺失模型大鼠的运动功能变化及相应脊髓节段囊泡谷氨酸转运蛋白表达的变化规律,... 详细信息

背景:周围神经损伤后可导致中枢神经系统通路发生广泛的变化,运动训练对于中枢神经系统损伤后运动功能恢复有一定的促进作用。目的:观察运动训练后部分感觉缺失模型大鼠的运动功能变化及相应脊髓节段囊泡谷氨酸转运蛋白表达的变化规律,探究运动训练对背根神经节切除模型大鼠运动功能的影响。方法:10周龄雄性Wistar大鼠39只随机分成实验组(15只)、对照组(15只)和假手术组(9只)。实验组和对照组切除右侧L3、L4.根神经节制备局部感觉缺失的周围神经损伤模型,假手术组只咬除相应关节突,分离至观察到背根神经节。实验组于造模后7 d开始进行15 m/min的跑步机训练,对照组和假手术组自由活动。在术前3 d及术后7,14.2.,2. d进行大鼠步态分析,观察模型大鼠行为学变化。于术后7,14.2. d取大鼠L3脊髓节段制作组织切片,免疫组织化学观察脊髓内囊泡谷氨酸转运蛋白1变化及其特点。结果与结论:(1)步态分析:实验组、对照组造模后各时间点腓神经功能指数值均低于术前(P2.及2. d腓神经功能指数值显著大于对照组(P2.脊髓内囊泡谷氨酸转运蛋白1表达:实验组、对照组造模后各时间点脊髓第IX板层囊泡谷氨酸转运蛋白1均明显低于假手术组(P1);实验组造模后14.2. d脊髓第IX板层囊泡谷氨酸转运蛋白1高于对照组(P1表达呈下降趋势(P<0.05),对照组下降更加明显;(3)结果表明:运动训练可以促进周围神经损伤后运动功能的恢复。

关键词：囊泡谷氨酸转运蛋白类周围神经康复脊神经后根神经节切除术运动训练步态分析囊泡谷氨酸转运蛋白周围神经损伤运动康复 wistar大鼠腓神经功能指数

喀斯特断陷盆地不同植被恢复模式土壤水分动态变化

在线全文

学校读者我要写书评

暂无评论

林业科学研究 2018年第4期31卷 104-112页

作者：孙永磊周金星庞丹波刘玉国肖桂英张清北京林业大学水土保持学院云南建水荒漠生态系统国家定位观测研究站北京100083 北京林业大学水土保持国家林业局重点实验室北京100083 中国林业科学研究院荒漠化研究所北京100091 云南酋建水县林业技术推广所云南建水654300

[目的]以喀斯特断陷盆地小流域中典型植被恢复模式,即桉树(Eucalyptus maideni)林、冲天柏(Cupressus duclouxiana)林、马尾松(Pinus massoniana)林以及天然次生灌丛、高盖度车桑子(Dodonaea viscosa)灌丛和低盖度车桑子灌丛为研究对象... 详细信息

[目的]以喀斯特断陷盆地小流域中典型植被恢复模式,即桉树(Eucalyptus maideni)林、冲天柏(Cupressus duclouxiana)林、马尾松(Pinus massoniana)林以及天然次生灌丛、高盖度车桑子(Dodonaea viscosa)灌丛和低盖度车桑子灌丛为研究对象,探究断陷盆地不同植被恢复模式土壤水分时空变异规律,为该地区植被生态恢复工作提供参考。[方法]利用自动气象观测系统和土壤水分传感器同步监测2.16年5月—2.17年4.期间小流域降雨量与各林地土壤水分,采用变异系数与克里金插值分析方法,对6种植被恢复模式林地的土壤水分时空异质性以及持续干旱条件下土壤水分衰减特征进行研究。[结果]表明:(1)同一植被类型不同土层雨季和旱季土壤体积含水量垂直变化趋势相同,且雨季土壤水分含量显著高于旱季(P12.88%2..66%)。(2.同一乔木林雨季和旱季的土壤活跃层与次活跃层垂直分布不同,但同一灌丛雨季和旱季分布相同。(3)6种植被恢复模式土壤体积含水量均在降雨量较充足的8—9月达到最大值,其变化范围介于2..2.%4..08%之间,在降雨量明显不足的3—4.达到最小值,土壤体积含水量介于9.4.%17.4.%之间。(4.3种乔木林0 30 cm土层、3种灌丛0 10 cm土层充分降雨后约10 d土壤水分恢复为降雨前1 d水平,低盖度和高盖度车桑子灌丛10 30 cm土层土壤水分降雨后15 d恢复为降雨前1 d水平,并且接近植物萎蔫系数。[结论]不同植被恢复模式间雨季、旱季和月均土壤体积含水量均表现为桉树林>天然次生灌丛>冲天柏林>马尾松林>高盖度车桑子灌丛>低盖度车桑子灌丛。喀斯特断陷盆地季节性干旱和临时性干旱问题严峻,乔木林和灌丛经充足降雨,达到田间持水量后,在连续放晴天气下林地土壤水分可供植物10 15 d的消耗。

关键词：断陷盆地土壤水分时空变异变异系数水分衰减特征

Novel and favorable genomic regions for spike related traits in a wheat germplasm Pubing 3504.with high grain number per spike under varying environments

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第11期16卷 2386-2401页

作者： CHEN Dan WU xiao-yang WU Kuo zhang {2.-peng LIU Wei-hua YANG Xin-ming LI Xiu-quan LU Yu-qing LI Li-hui National Key Facility for Crop Gene Resources and Genetic Improvement/institute of Crop sciences Chinese Academy of Agricultural Sciences Biotechnology and Germplasm Resources institute Yunnan Academy of Agricultural Sciences/Key Laboratory of Southwestern Crop Gene Resources and Germplasm InnovationMinistry of Agriculture/Scientific Observation for Rice Germplasm Resources of YunnanMinistry of Agriculture/Yunnan Provincial Key Laboratory of Agricultural Biotechnology

Grain number per spike （GNPS） is a major factor in wheat yield breeding. A new wheat germplasm Pubing 3504.shows superior features in spike traits. To elucidate the genetic basis of spike and yield related traits in Pubing 3504. 2.2.F2.3 families were generated from the cross Pubing 3504.jing 4.39, and seven spike and yield related traits, including GNPS, spike length （SL）, kernel number per spikelet （KPS）, spikelet number per spike （SNS）, thousand-grain weight （TGW）, spike number per plant （SNP）, and plant height （HT） were investigated. Correlation analysis indicated significant positive correlations between GNPS and spike-related traits, including KPS, SNS, and SL, especially KPS. A genetic map was constructed using 190 polymorphic simple sequence repeat （SSR）, expressed sequence tag （EST）-SSR, and sequence- tagged-site （STS） markers. For the seven traits measured, a total of 37 quantitative trait loci （QTLs） in a single-environment analysis and 2. QTLs in a joint-environment analysis were detected. Additive effects of 70.3% （in a single environment） and 57.6% （in a joint environment） of the QTLs were positively contributed by Pubing 3504.alleles. Five important genomic regions on chromosomes 1A, 4., 4., 2., and 4. could be stably detected in different environments. Among these regions, the marker interval Xmag834.Xbarc83 on the short arm of chromosome 1A was a novel important genomic region that included QTLs controlling GNPS, KPS, SNS, TGW, and SNP with stable environmental repeatability. This genomic region can improve the spike trait and may play a key role in improving wheat yield in the future. We deduced that this genomic region was vital to the high GNPS of Pubing 3504.

关键词： wheat high GNPS germplasm QTL mapping genomic region

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2.variants:a randomized phase 2.trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng zhang Yun Kang Yu Qin jin Jun Wei Hou jing zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue zhang Chang Qu Dan Ying Liu jing zhang Mengjie Yang Islam Eltantawy Peng xiao Fu jie Shen jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang jin Liang Yin xiao Yan Mao jin zhang Liang Qu Yun Tao zhang xiao Ming Yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G4.0}Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2.trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 2. and 30,2.2.,516 adults received booster vaccination with 2.0 in NVSI-06-09 group and 2.6 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14.post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.4.-fold),Omicron BA.1.1(4.0}35 vs 3.78-fold),BA.2.2..09 vs 2.91-fold),BA.4.2..4.0}vs 2.69-fold),and BA.5 variants(2..06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2.variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

Two new phenolic amides from Allium chinense

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Herbal Medicines 2023年第4期15卷 603-606页

作者： xiaoqing Li Shikai Yan Jihong Lu Rui Wang Xianpeng Ma Xue xiao Yan {2. Huizi jin Department of Natural Product Chemistry School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China institute of chinese Medicinal {2. Guangdong Pharmaceutical UniversityGuangzhou 510006China Guizhou jingcheng Pharmaceutical Co. Ltd.Guiyang 550200China

Objective: To isolate the phenolic amides from the dried bulbs of Allium chinense and investigate their myocardium protective ***: The chemical constituents were isolated and purified by combining with silica gel column,Sephadex LH-2. column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells in ***: Two new phenolic amides, namely, alichinemide Ⅰ(1) and alichinemide Ⅱ(2., and six konwn amides were isolated from the dried bulbs of A. chinense. The structures of compounds 3–8 were identified as 3-indolcarbaldehyde(3), 1-(2.aminophenyl)urea(4., 2.3,4.9-tetrahydro-1H-pyrido[3,4.b]indole-3-carboxylic acid(5), N-trans-feruloyltyramine(6), N-trans-p-coumaroyltyramine(7), and N-(3,4.dimethoxyphenethyl) acetamide(8). Compound 3(50 μmol/L) showed significant inhibitory effect on the damage of H9c2.myocardial cells induced by H2.2.n ***: Compounds 1 and 2.were new phenolic amides. Compound 3 could be one of the potential myocardium protective constituents of A. chinense.

关键词： alichinemideⅠ alichinemideⅡ Allium chinense 3-indolcarbaldehyde myocardium protective activities phenolic amides

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第3期6卷 1001-1020页

作者： Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou xiao-Yang Li Xian-Feng zhang Zheng-Wei zhang jie Fu Bao-Ying Wen {4.-Bo Yu Xuetao Cao Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China The First Hospital of Jilin University Changchun 130021China Department of Immunology&Centre for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the *** this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4.)as a ***,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut *** BBR acts in a way similar to *** L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to *** verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)*** bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria ***,2.4.6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain *** demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the ***,a study of 2. patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the ***,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect.

关键词： dopamine berberine vitamin

不同剂量阿加曲班联合丁苯酞对急性脑梗死患者效果及预后的影响因素分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2024年第12期24卷 2279-2283页

作者：张龙吴小燕高金玉李群杨国强葛纪刘赟中国人民解放军陆军第七十一集团军医院神经内科江苏徐州221000

目的:本研究旨在探讨不同剂量阿加曲班联合丁苯酞对急性脑梗死患者效果及预后的影响因素。方法:以自2.19年6月到2.2.年8月在我院收治的90例急诊急性脑梗死为研究对象,采用随机数字表法将其分为高剂量组(给予高剂量阿加曲班联合丁苯酞治... 详细信息

目的:本研究旨在探讨不同剂量阿加曲班联合丁苯酞对急性脑梗死患者效果及预后的影响因素。方法:以自2.19年6月到2.2.年8月在我院收治的90例急诊急性脑梗死为研究对象,采用随机数字表法将其分为高剂量组(给予高剂量阿加曲班联合丁苯酞治疗)和低剂量组(给予低剂量阿加曲班联合丁苯酞治疗)各4.例。对比治疗7 d后两组临床疗效及预后,分析治疗前及治疗7 d后两组神经功能[中国卒中量表(CSS)评分、神经功能(NIHSS)评分],根据不同预后将患者分为预后良好组和预后不良组,采用单/多因素Logisitic回归分析急性脑梗死预后的影响因素。结果:(1)将两组的临床疗效纳入研究并实施组间差异性比较,结果显示,高剂量组总有效率高于低剂量组(P2.将两组的神经功能采用CSS评分、NIHSS评分评估纳入研究并实施组间差异性比较,结果显示治疗前,两组采用CSS评分、NIHSS评分比较(P>0.05);治疗7 d后,高剂量组采用CSS评分、NIHSS评分高于低剂量组(P3)将两组的预后采用m RS评分评估纳入研究并实施组间差异性比较,结果显示,高剂量组预后良好2.2.%(1/4.)高于低剂量组15.56%(7/4.)(P4.预后良好组患者年龄、治疗前CSS评分及治疗前NIHSS评分与预后不良组存在差异(P<0.05)。(5)以急性脑梗死预后为因变量,以单因素中对比有差异的指标为自变量,经多因素Logisitic回归分析急性脑梗死预后的影响因素为治疗前CSS评分及治疗前NIHSS评分。结论:高剂量阿加曲班联合丁苯酞能够有效治疗急性脑梗死患者,而急性脑梗死预后的影响因素为治疗前CSS评分及治疗前NIHSS评分。

关键词：高剂量阿加曲班低剂量阿加曲班丁苯酞急性脑梗死

Mechanically flexible V_(3)S_(4.@carbon composite fiber as a high-capacity and fast-charging anode for sodium-ion capacitors

在线全文

学校读者我要写书评

暂无评论

稀有金属:英文版 2023年第8期42卷 2633-2642页

作者： Zhi-Fei Mao xiao-Jun Shi Tao-Qiu zhang Peng-Ju Liang Rui Wang Jun {2. Bei-Bei He Yan-Sheng Gong Qiang Wang Xi-Li Tong Huan-Wen Wang Faculty of Material Science and Chemistry China University of GeosciencesWuhan 430074China Engineering Laboratory of Chemical Resources Utilization in South Xinjiang of XPCC Department of Chemistry and Chemical EngineeringCollege of LifeTarim UniversityAlar 843300China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China

Hybrid Na-ion capacitors(NICs)have received considerable interests owing to their low-cost,high-safety,and rapidly charging energy-storage *** NICs are composed of a capacitor-type cathode and a battery-type *** major challenge for NICs is to search for suitable electrode materials to overcome the sluggish diffusion of Na^(+)in the ***,ultrafine vanadium sulfide is encapsulated in carbon fiber(V_(3)S_(4.@CNF)as a self-supported electrode by electrospinning and in situ *** carbon cladding and one-dimensional(ID)nanofiber network-like structure could alleviate the volume expansion of V_(3)S_(4.during Na^(+)de-/intercalation ***,the V_(3)S_(4.@CNF anode exhibited a pseudocapacitive sodium storage in terms of large Na^(+)-storage capacity(4.6 mAh·g^(-1)at 0.1A·g^(-1)),high-rate capability(2.0 mAh·g^(-1)at 2..0 A·g^(-1))and excellent cycling stability(95%capacity retention for1500 cycles at 2.0 A·g^(-1))in Na *** employing V_(3)S_(4.@CNF as the anode and the activated carbon(AC)cathode,the as-assembled NICs could deliver a high energy density of 110 Wh·kg^(-1)at a power density of2.0 W·kg^(-1).Even at a high power of 10,000 W·kg^(-1),the specific energy is still up to 4.0}Wh·kg^(-1).

关键词： Electrospinning Na-ion capacitor(NIC) Nanofibers Vanadium sulfide Fast-charging

Impact of psychosocial stress on airway inflammation and its mechanism in a mUrine model of allergic asthma

在线全文

学校读者我要写书评

暂无评论

chinese Medical Journal 2013年第2期126卷 325-334页

作者： LI Bei DUAN xiao-hong WU jin-feng LIU Bao-jun LUO Qing-li jin Hua-liang DU Yi-jie {4. Hong-ying CAO Yu-xue DONG jing-cheng Department of Integrative Medicine Huashan Hospital FudanUniversity Shanghai 200040 China

Background It has already been recognized that psychosocial stress evokes asthma exacerbation; however, the mechanism of how stress gets inside the body is not clear. This study aimed to observe the impact of psychosocial stress on airway inflammation and its mechanism in the ovalbumin-induced asthmatic mice combined with social disruption stress. Methods Thirty-six male BALB/c mice were randomly divided into： control group, asthma group （ovalbumin-induced）, asthma plus social disruption stress group （SDR）, and SDR group. The open field video tracking system was used to assess animal behaviors. The invasive pulmonary resistance （RL） and dynamic lung compliance （cdyn） test system from Buxco was applied to detect pulmonary function. The enzyme-linked immunosorbent assay （ELISA） was utilized to determine OVA-IgE, T-helper type 2.（Th2. cytokines （IL-4. IL-5, IL-13） and corticosterone in mouse serum, the Th2.cytokines （IL-4. IL-5, IL-13, IL-6, TNF-a） in bronchoalveolar lavage fluid （BALF）, and IL-6 and TNF-a levels in the supernatant of splenocytes cultured in vitro. Hematoxylin-eosin （H＆E） staining was used to assess airway inflammation in lung histology. The cell count kit-8 assay （CCK-8） was applied to evaluate the inhibitory effect of corticosterone on splenocyte proliferation induced by lipopolysacchadde （LPS）. Real time-PCR and Western blotting were utilized to determine glucocorticoid receptor （GR） mRNA and GR protein expression in lungs. Results The open field test showed that combined allergen exposure and repeated stress significantly shortened the time the mice spent in the center of the open field （P 〈0.01）, increased ambulatory activity （P 〈0.01） and the count of fecal boli （P 〈0.01）, but deceased vertical activity （P 〈0.01）. Results from pulmonary function demonstrated that airway hyperresponsiveness （AHR） was enhanced by psychosocial stress compared with allergy exposure alone. The ELISA results showed that cytokines in serum and BALF were significantly in

关键词： psychosocial stress, asthma, glucocorticoid insensitivity glucocorticoid receptor