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Protein profiling identified mitochondrial dysfunction and synaptic abnormalities after dexamethasone intervention in rats with traumatic brain injury

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Neural Regeneration Research 2021年第12期16卷 2438-2445页

作者： Fei Niu Bin zhang {1. Feng Xiang Mao {2.-Jian Xu jin-Qian Dong Bai-Yun Liu Department of Neurotrauma Beijing Key Laboratory of Central Nervous System InjuryBeijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Key Laboratory of Central Nervous System Injury Research Center for Brain TumorBeijing Institute of Brain DisordersBeijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersBeijingChina china National Clinical Research Center for Neurological Diseases BeijingChina

Dexamethasone has been widely used after various neurosurgical procedures due to its anti-inflammatory property and the abilities to restore vascular permeability,inhibit free radicals,and reduce cerebrospinal fluid *** to the latest guidelines for the treatment of traumatic brain injury in the United States,high-dose glucocorticoids cause neurological *** investigate the reason why high-dose glucocorticoids after traumatic brain injury exhibit harmful effect,rat controlled cortical impact models of traumatic brain injury were *** 1.hour and 2.days after surgery,rat models were intraperitoneally administered dexamethasone 1. mg/*** results revealed that 31.proteins were significantly upregulated and 1.0}proteins were significantly downregulated in rat models of traumatic brain injury after dexamethasone *** Ingenuity Pathway Analysis results showed that differentially expressed proteins were enriched in the mitochondrial dysfunction pathway and synaptogenesis signaling *** blot analysis and immunohistochemistry results showed that Ndufv2.Maob and Gria3 expression and positive cell count in the dexamethasone-treated group were significantly greater than those in the model *** findings suggest that dexamethasone may promote a compensatory increase in complex I subunits(Ndufs2.and Ndufv2.,increase the expression of mitochondrial enzyme Maob,and upregulate synaptic-transmission-related protein *** changes may be caused by nerve injury after traumatic brain injury treatment by *** study was approved by Institutional Ethics Committee of Beijing Neurosurgical institute(approval No.2.1.02.01.on June 6,2.1..

关键词： dexamethasone Gria3 Maob mass spectrometry mitochondrial dysfunction Ndufs2 Ndufv2 proteomics synaptic abnormalities traumatic brain injury

Feeding behavior explains the different effects of cabbage on MEAM1.and MED cryptic species of Bemisia tabaci

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Insect Science 2020年第6期27卷 1276-1284页

作者： jie Hu {1.-Jian Yang Bai-Ming Liu Hong-Ying Cui You-Jun {2. xiao-Guo Jiao State Key Laboratory of Biocatalysis and Enzyme Engineering Center for Behavioral Ecology&EvolutionSchool of Life SciencesHubei UniversityWuhanChina institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijingChina Tianjin {1. of Plant Protection TianjinChina Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijingChina

MEAMI(Middle East-Asia Minor 1."B"biotype)anpl MED(Mediterranean,"Q"biotype)are the two most destructive ery pie species of the Bemisia tabaci complex on the *** previous studies have shown that MEAMI outcompets MED on cabbage;the underlying mechanism is *** the Brassicaceae family,the glucosinolate-myrosinase defense system plays a crucial role im deterring feeding,inhibiting growth,and eausing acute toxicity against a wide range of generalist *** the present *** first compared the surv ival of MEAMI and MED exposed to sinigin(a glucosinolate)and myosinase(an enzyme that degrades glucosinolates);we found that survival of both species was high in response 1. sinigrin alone bul was near zer0 in response to sinigrin+*** then used electropenetrography(lectrical penetration graphs,EPG)to assess the feeding bchaviors of MEAMI and MED whiteflies on *** EPG results revealed that the me an dunution of each potential drop(pd,indicating an intreellular puncture)was subsantialy longer for MED than MEAMI on eabbage,indicating that the exposure to the toxic hydrolysates of glucosinolate and myrosinase is greater for MED than for *** therefore conclude that dffreces in penetrating bchaviors may help explain the dfferent fiects of cabbuge on MEAMI and MED whitefly species.

关键词： Bemisia tabaci glucosinolate-myrosinase system potential drop electrical penetration graph

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有机物(水)混合物分离的国外膜工业现状

水处理技术 2005年第1期31卷 1-6,19页

作者：蔡邦肖张金锋浙江工商大学食品生物与环境工程学院膜科学与工程研究所浙江省食品安全重点实验室浙江杭州310035 国家海洋局杭州水处理技术研究开发中心浙江杭州310012

渗透汽化(PV)、蒸汽渗透(VP)膜分离方法,在有机物/水混合物、有机物/有机物混合物的分离中得到了广泛应用。本文基于美国专利和有关文献以及国际交往的有关资料,概要描述了国外特别是欧美等国发展的PV(VP)膜工业现状,重点讨论了PV(VP)... 详细信息

渗透汽化(PV)、蒸汽渗透(VP)膜分离方法,在有机物/水混合物、有机物/有机物混合物的分离中得到了广泛应用。本文基于美国专利和有关文献以及国际交往的有关资料,概要描述了国外特别是欧美等国发展的PV(VP)膜工业现状,重点讨论了PV(VP)膜、膜组器件及其成套膜分离装置和应用工艺的专利申请、生产商、应用领域、典型应用工程,分析了PV(VP)膜技术的先进性、经济性和发展前景。

关键词：膜工业膜分离渗透汽化混合物蒸汽渗透美国专利有机物 PV 外膜用工

将症状群引入中医治疗功能性胃肠病症状重叠疗效评价体系

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中国中西医结合杂志 2024年第4期44卷 492-497页

作者：肖梦丽赵迎盼赵梦杰谭琴冀瑾瑾张慧娥应佳珂唐旭东陆芳中国中医科学院西苑医院中药临床研究与评价重点实验室北京100091 中国中医科学院西苑医院脾胃病研究所北京100091

功能性胃肠病是中医药治疗的优势病种,其临床诊断及治疗均以症状学为主。功能性胃肠病症状重叠的疗效评价不同于单个功能性胃肠病疾病或单个症状的评价,在中医药治疗功能性胃肠病症状重叠的临床研究中仍缺乏高质量的临床疗效评价工具。... 详细信息

功能性胃肠病是中医药治疗的优势病种,其临床诊断及治疗均以症状学为主。功能性胃肠病症状重叠的疗效评价不同于单个功能性胃肠病疾病或单个症状的评价,在中医药治疗功能性胃肠病症状重叠的临床研究中仍缺乏高质量的临床疗效评价工具。症状群指标已在国内外多个临床研究中使用,它既符合中医药治疗功能性胃肠病症状重叠临床实际,又符合现代医学对评价工具的要求。通过阐述症状群的概念、制定方法以及其应用于功能性胃肠病症状重叠的可行性,进而探讨将症状群引入功能性胃肠病症状重叠临床疗效评价体系的可行性,以期为中医药治疗功能性胃肠病症状重叠提供特色的临床疗效评价工具。

关键词：症状群中医药功能性胃肠病症状重叠疗效评价

Quafu-RL:The cloud quantum computers based quantum reinforcement learning

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chinese Physics B 2024年第5期33卷 29-34页

作者：靳羽欣许宏泽王正安庄伟峰黄凯旋时运豪马卫国李天铭陈驰通许凯冯玉龙刘培陈墨李尚书杨智鹏钱辰马运恒肖骁钱鹏顾炎武柴绪丹普亚南张翼鹏魏世杰曾进峰李行龙桂鲁金贻荣于海峰范桁刘东胡孟军 Beijing {1. of Quantum Information {2. Beijing 100193China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China institute of Physics Chinese Academy of SciencesBeijing 100190China Frontier Science Center for Quantum Information Beijing 100184China School of Physical sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China School of Mathematical sciences Nankai UniversityTianjin 300071China

With the rapid advancement of quantum computing,hybrid quantum–classical machine learning has shown numerous potential applications at the current stage,with expectations of being achievable in the noisy intermediate-scale quantum(NISQ)*** reinforcement learning,as an indispensable study,has recently demonstrated its ability to solve standard benchmark environments with formally provable theoretical advantages over classical ***,despite the progress of quantum processors and the emergence of quantum computing clouds,implementing quantum reinforcement learning algorithms utilizing parameterized quantum circuits(PQCs)on NISQ devices remains *** this work,we take the first step towards executing benchmark quantum reinforcement problems on real devices equipped with at most 1.6 qubits on the BAQIS Quafu quantum computing *** experimental results demonstrate that the policy agents can successfully accomplish objectives under modified conditions in both the training and inference ***,we design hardware-efficient PQC architectures in the quantum model using a multi-objective evolutionary algorithm and develop a learning algorithm that is adaptable to quantum *** hope that the Quafu-RL can be a guiding example to show how to realize machine learning tasks by taking advantage of quantum computers on the quantum cloud platform.

关键词： quantum cloud platform quantum reinforcement learning evolutionary quantum architecture search

Effect of Ag Addition on Microstructure,Mechanical and Corrosion Properties of Mg-Nd-Zn-Zr Alloy for Orthopedic Application

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 295-309页

作者： Yu-jin Nie Jian-Wei Dai {1.-Bo {2. School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167China

The as-extruded Mg-3Nd-0.2.n-0.4Zr-xAg(x=0,0.2.0.5,1.wt%)alloys were prepared for biomedical *** electron microscope,electron backscattered diffraction,X-ray diffraction,tensile test machine,electrochemical workstation,and immersion experiments were used to study microstructures,mechanical properties,and corrosion behavior of the as-extruded *** results indicate that the microstructures of all the as-extruded alloys are composed of coarse undynamic recrystallized grains,fine equiaxed recrystallized grains,and precipitated *** element plays a positive role in promoting dynamic recrystallization and grain *** during the extrusion,all the four alloys generate a 1.1.>//ED fiber *** the increase of Ag element,the volume fraction of Mg_(1.0}Nd phase increases and then decreases *** increasing Ag addition,both yield strength and ultimate tensile strength of the as-extruded alloys reduce first and then improve,and the elongation improves gradually from 9.4 to 1.0}7%.More importantly,the addition of Ag accelerates corrosion of the as-extruded alloys in simulated body fluid,and all the as-extruded alloys show uniform corrosion mode.

关键词： Magnesium alloy Hot extrusion Mechanical properties Corrosion resistance

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水下重力匹配导航适配性评价方法比较研究

大地测量与地球动力学 2024年第7期44卷 737-743页

作者：陈垲宁肖云张锦柏曹杰王宇康洪晓东长安大学地质工程与测绘学院西安市710054 地理信息工程国家重点实验室西安市710054 西安测绘研究所西安市710054

重力匹配导航精度受重力适配区选取的影响。针对如何有效筛选最优适配区,采用信息熵的单特征准则与多属性决策的多特征准则评价重力底图的适配性。选择重力标准差、相关系数、粗糙度、坡度、重力特征丰度与累加梯度均值6种参数,利用单/... 详细信息

重力匹配导航精度受重力适配区选取的影响。针对如何有效筛选最优适配区,采用信息熵的单特征准则与多属性决策的多特征准则评价重力底图的适配性。选择重力标准差、相关系数、粗糙度、坡度、重力特征丰度与累加梯度均值6种参数,利用单/多特征两种准则筛选同一海域适配/非适配区,通过地形轮廓匹配(terrain contour matching, TERCOM)算法在所筛选区域进行重力匹配导航验证,对比分析两者的匹配导航精度。结果表明,单特征准则在适配/非适配区的导航误匹配率分别为30%和2.%;多特征准则在适配区无明显误匹配,误差在百米级,在非适配区出现多次误匹配。分析表明,多特征分析准则与单特征分析准则相比,可更准确有效地评价重力匹配区的适配性。

关键词：重力匹配导航适配性评价重力特征参数坡度信息熵多属性决策

Refertilization of ancient lithospheric mantle beneath the central North china Craton:Evidence from petrology and geochemistry of peridotite xenoliths

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Refertilization of ancient lithospheric mantle beneath the c...

Cs/O沉积Na_(2.KSb光电阴极表面的第一性原理研究

中国科学院地质与地球物理研究所2.08学术年会

作者： Yan-jie Tang~(a,*),Hong-Fu zhang~a,Ji-Feng Ying~a,{2. zhang~a,{2.-Ming Liu~b a State Key Laboratory of Lithospheric Evolution,institute of Geology and geophysics,chinese academy of sciences, P.O.Box 982.,Bei{2.g 10002.,china b State Key Laboratory of Continental Dynamics,Northwest University,Xi’an 710069,china

The petrology and geochemistry of peridotite xenoliths in the Cenozoic basalts from Fanshi,the central North china Craton (NCC),provide constraints on the evolution of sub-continental lithospheric *** peridotite xenoliths are mainly spinel-facies lherzolites with minor *** lherzolites are characterized by low forsterite contents in olivines(Fo1. and light rare earth element(LREE) enrichments in *** contrast,the harzburgites are typified by high-Fo olivines(>91., high-Cr# spinels and clinopyroxenes with low abundances of heavy REE(HREE).These features are similar to those from old refractory lithospheric mantle around the world,and thus interpreted to be relics of old lithospheric *** old lithospheric mantle has been chemically modified by the influx of melts,as evidenced by the Sr-Nd isotopic compositions of clinopyroxenes and relatively lower Fo contents than typical Archean Hthospheric mantle(Fo>9{1.5).The Sr-Nd isotopic compositions of harzburgites are close to EM1.type mantle,and of the lherzolites are similar to bulk silicate *** latter could be the result of recent modification of old harzburgites by asthenospheric melt,which is strengthened by fertile compositions of minerals in the ***,the isotopic and chemical heterogeneities of the Fanshi peridotite xenoliths reflect the refertilization of ancient refractory lithospheric mantle by massive addition of asthenospheric *** may be an important mechanism for the lithospheric evolution beneath the Central NCC.

关键词： Peridotite xenolitlis Mantle refertilization Lithospheric mantle North china Craton

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物理学报 2024年第8期73卷 341-349页

作者：王麒铭张益军王兴超王亮金睦淳任玲刘晓荣钱芸生南京理工大学电子工程与光电技术学院南京210094 北方夜视科技(南京)研究院有限公司南京211106

Na_(2.KSb光电阴极在光电倍增管、图像增强器、真空电子源等领域具有重要应用.为指导高灵敏度Na_(2.KSb光电阴极的制备,采用第一性原理计算方法,研究不同表面取向和原子终止面的Na_(2.KSb表面模型,获得稳定且最有利于电子发射的表面结构... 详细信息

Na_(2.KSb光电阴极在光电倍增管、图像增强器、真空电子源等领域具有重要应用.为指导高灵敏度Na_(2.KSb光电阴极的制备,采用第一性原理计算方法,研究不同表面取向和原子终止面的Na_(2.KSb表面模型,获得稳定且最有利于电子发射的表面结构.基于该表面进一步研究了不同覆盖度下的Cs原子沉积和Cs/O原子共沉积对Na_(2.KSb表面电子结构和光学性质的影响.对比表面能、吸附能和吸附前后的功函数结果表明,Na_(2.KSb(1.1.K表面具有优越的电子发射能力以及良好的稳定性.当Na_(2.KSb(1.1.K表面吸附2.4单层的Cs原子和1.4单层O原子时,获得最大功函数下降量0.1. eV.表面吸附Cs/O原子有利于电荷往表面上方转移,并产生电荷累积,能形成有效表面偶极矩.通过分析能带结构和态密度,发现吸附Cs原子对导带底存在额外的能带贡献,且引入O原子吸附后价带发生上移.此外,吸附Cs/O原子有利于增强表面近红外光吸收,但是会导致表面紫外和可见光吸收变差.

关键词： Na_(2.KSb 光电阴极 Cs/O沉积功函数偶极矩