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Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-Tong Cui Hua-Ru Xue Dian-Fang Wei xiao-Yu feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu xiao feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu xiao-feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第01期 39-88页

作者： Feimin Huang Weiqiang Wang Yong Wang feng xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

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Emergy evaluation of aromatics production from methanol and naphtha

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Chinese Journal of Chemical Engineering 2022年第6期35卷 134-141页

作者： Siyue Ren xiao feng School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China

Aromatics are traditionally produced by the catalytic reforming of ***,with the demand of aromatics increasing and the reserves of petroleum resources declining,measures should be made to reduce the dependence of aromatics production on petroleum ***-to-aromatics is proved to be an effective way to replace traditional naphtha-to-aromatics *** order to compare the economic and environmental performance of aromatics production from naphtha and methanol,this paper carries out an emergy evaluation for each system by sorting out the simulation and literature *** on the emergy data collected,the emergy indices of each system are *** results show that the sustainabilities of methanol-to-aromatics systems are higher than that of the naphtha-toaromatics system,indicating the advantages of aromatics production from *** the methanol-to-aromatics systems,the aromatics from biomass-methanol system has the highest sustainability,indicating that the biomass based methanol-to-aromatics system is worth *** sustainability indexes of methanol-to-aromatics systems based on coal and coke oven gas are less than 1,which means ***,the sustainability of natural gas based system is slightly higher than *** economic and environmental benefits of these systems can be optimized by improving resource utilization and reducing investment ***,the combination of different raw materials for methanol production should be considered.

关键词： Aromatics production Naphtha Methanol Emergy Sustainability

Rydberg quantum computation with nuclear spins in two-electron neutral atoms

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Frontiers of physics 2021年第5期16卷 21-38页

作者： xiao-feng Shi School of Physics and Optoelectronic Engineering Xidian UniversityXi’an710071China

Alkaline-earth-like(AEL)atoms with two valence electrons and a nonzero nuclear spin can be excited to Rydberg state for quantum *** AEL ground states possess no hyperfine splitting,but unfortunately a GHz-scale splitting seems necessary for Rydberg *** strong magnetic fields can induce a GHz-scale splitting,weak fields are desirable to avoid noise in ***,we provide two solutions to this outstanding challenge with realistic data of well-studied AEL *** the first theory,the two nuclear spin qubit states∣0〉and∣1〉are excited to Rydberg states∣r〉with detuningΔand 0,respectively,where a MHz-scale detuningΔarises from a weak magnetic field on the order of 1 *** a proper ratio betweenΔandΩ,the qubit state∣1〉can be fully excited to the Rydberg state while∣0〉remains *** the second theory,we show that by choosing appropriate intermediate states a two-photon Rydberg excitation can proceed with only one nuclear spin qubit *** second theory is applicable whatever the magnitude of the magnetic field *** theories bring a versatile means for quantum computation by combining the broad applicability of Rydberg blockade and the incomparable advantages of nuclear-spin quantum memory in two-electron neutral atoms.

关键词： alkaline-earth atom Rydberg state quantum computation neutral atom

Fast nuclear-spin gates and electrons−nuclei entanglement of neutral atoms in weak magnetic fields

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Frontiers of physics 2024年第2期19卷 179-203页

作者： xiao-feng Shi School of Physics Xidian UniversityXi’an 710071China

We present a novel class of Rydberg-mediated nuclear-spin entanglement in divalent atoms with global laser ***,we show a fast nuclear-spin controlled phase gate of an arbitrary phase realizable either with two laser pulses when assisted by Stark shifts,or with three ***,we propose to create an electrons−nuclei-entangled state,which is named a super bell state(SBS)for it mimics a large Bell state incorporating three small Bell ***,we show a protocol to create a three-atom electrons-nuclei entangled state which contains the three-body W and Greenberger−Horne−Zeilinger(GHZ)states *** protocols possess high intrinsic fidelities,do not require single-site Rydberg addressing,and can be executed with large Rydberg Rabi frequencies in a weak,Gauss-scale magnetic *** latter two protocols can enable measurement-based preparation of Bell,hyperentangled,and GHZ states,and,specifically,SBS can enable quantum dense coding where one can share three classical bits of information by sending one particle.

关键词： nuclear-spin qubit electrons−nuclei entanglement super Bell state Greenberger−Horne−Zeilinger state Rydberg-mediated entanglement quantum dense coding

Synthesis of the fluid machinery network in a circulating water system

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Chinese Journal of Chemical Engineering 2019年第3期27卷 587-597页

作者： Wei Gao xiao feng School of Chemical Engineering and Technology Xi'an Jiaotong University

Energy consumption of the fluid machinery network in a circulating water system takes up a large part of energy consumption in the process industry, so optimization on the network will enhance the economic and environmental performance of the industry. In this paper, a synthesis approach is proposed to obtain the optimal network structure. The effective height curves are used as tools to perform energy analysis, so that the potential placement of water turbines and auxiliary pumps can be determined with energy benefit. Then economic optimization is carried out, by the mathematical model with the total cost as the objective function, to identify the branches for water turbines and auxiliary pumps with economic benefit. In this way, the optimal fluid machinery network structure can be obtained. The results of case study indicate that the proposed synthesis approach to optimize the fluid machinery network will obtain more remarkable benefits on economy, compared to optimizing only the water turbine network or pump network. The results under different flowrates of circulating water reveal that using a water turbine to recover power or adding an auxiliary pump to save energy in branches are only suitable to the flowrate in a certain range.

关键词： Fluid machinery network Synthesis approach Flowrate range Network structure

Variational Approach to One-Dimensional Electrons Non- Adiabatically Coupled to Phonons

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Chinese Physics Letters 1999年第2期16卷 129-131页

作者： PANG xiao-feng Department of Physics Southwest Institute for NationalitiesChengdu 610041 International Centre for Material Physics Chinese Academy of SciencesShenyang 110015 Institute of Atomic and Molecular Physics Sichuan Union UniversityChengdu 610065

The effects of the nonadiabatic phonon behaviours on the ground state of the system and the quantum modifications of the polaron characteristics and the modification form of the uncertainty relation between the phonon coordinate and momentum due to fluctuations of the electron density in the coupled electron-phonon systems have been studied by using a new variational ansatz for coherent phonons with correlated displacement and squeezing including internations with *** correlated effect results in the following effect:(1)the energy of the ground state of the system is found to be lower than that for the phonons with uncorrelated displacement and squeezing;(2)the binding energy of the polaron was found to be increased;(3)the nonadiabatic coupling with electrons enhances the quantum uncertainty for the phonon coordinate and momentum when compared with the adiabatic and uncorrelated case.

关键词： phonon momentum coordinate