检索结果-南通市图书馆

Cultural and Religious Studies 2024年第5期12卷 320-323页

作者： xiao yuwei ZHANG Pei Beijing Institute of Graphic Communication BeijingChina

The image of Mulan is well known to the public as an important symbol in the dissemination of Chinese excellent traditional *** paper aims to summarise the mother-title from traditional canonical texts,to explore the content and value of sustainable IP development,and to study a large number of derivatives with the image of Mulan as the mother-title,based on the wide circulation of the prototype of the mother-title“The Poem of Mulan”(木兰辞)and the positive values conveyed by the *** the processing and imagination of scholars and writers on the mother text in the past generations,the image of Mulan has gradually formed a relatively stable cultural communication theme in the process of dissemination in China’s historical period,and many adaptations with international influence based on the mother title of Mulan have emerged in the foreign dissemination,so through the combing and summarisation of the textual works of various periods both at home and abroad,we will dig out the textual transmission of the mother title of Mulan,which is representative of the mother title of China’s excellent traditional culture,and the development of the Chinese spiritual *** Development of the Chinese Spiritual *** paper adopts research methods such as documentary evidence method and discourse analysis to show the textual flow of Mulan’s parent theme in a more diversified form.

关键词： Mulan motifs feminine power textual transmission literature review identity

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面向高密度交通场景的自动驾驶运动规划

计算机工程与应用 2024年第14期60卷 114-122页

作者：肖雨微姚溪子胡学敏罗显志湖北大学计算机与信息工程学院武汉430062

针对现有自动驾驶运动规划方法在提取状态信息时忽略了周边车辆交互、在高密度交通场景下规划效果不理想的问题,提出了一种联合图神经网络和深度强化学习的运动规划模型。基于图神经网络提出了一种自动驾驶车辆的交互式特征提取方法,再... 详细信息

针对现有自动驾驶运动规划方法在提取状态信息时忽略了周边车辆交互、在高密度交通场景下规划效果不理想的问题,提出了一种联合图神经网络和深度强化学习的运动规划模型。基于图神经网络提出了一种自动驾驶车辆的交互式特征提取方法,再基于双延迟深度确定性策略梯度(twin delayed deep deterministic policy gradient,TD3)算法从交互式特征中预测车辆的动作,从而实现运动规划。将所提模型与目前自动驾驶运动规划模型LSTM+TD3、TD3及深度确定性策略梯度(deep deterministic policy gradient,DDPG)模型进行对比,在PGDrive驾驶模拟器中进行训练和测试的实验结果表明,在高密度交通场景中,所提方法的训练奖励值和测试成功率相比于对比方法提升了约36%、43%、23%及13、19、53个百分点。表明所提方法能有效解决自动驾驶周边车辆的交互式信息感知问题,更好地实现自动驾驶运动规划。

关键词：自动驾驶运动规划交互式特征图神经网络强化学习

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治疗阿尔茨海默病创新药物研发进展

中国药理学与毒理学杂志 2024年第4期38卷 286-293页

作者：肖雨薇胡伟强赵梦华连俊荣温金华南昌大学药学院江西南昌330006 南昌大学焕奎书院江西南昌330006 南昌大学第一附属医院临床试验中心GCP 江西南昌330006

阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,临床表现为进行性认知功能下降和行为损害,因其发病机制复杂,目前尚无有效的预防和治疗手段。近年来,依据AD发病机制和病理学特点进行靶向治疗逐渐成为新药开发的重点。靶向药物β淀粉样... 详细信息

阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,临床表现为进行性认知功能下降和行为损害,因其发病机制复杂,目前尚无有效的预防和治疗手段。近年来,依据AD发病机制和病理学特点进行靶向治疗逐渐成为新药开发的重点。靶向药物β淀粉样蛋白(Aβ)单克隆抗体阿度奴单抗和来卡内单抗获美国FDA批准用于AD的治疗,调节肠道菌群药物甘露特纳在中国批准上市,β分泌酶抑制剂、抗Aβ疫苗、tau蛋白聚集抑制剂等创新药物也表现出对AD的治疗潜力并先后进入临床试验。本文梳理近年来治疗AD的创新药物研究进展,分析创新药物研发策略,为治疗AD和开展相关新药研究提供参考和思路。

关键词：阿尔茨海默病靶向药物 β分泌酶 tau蛋白单克隆抗体疫苗

基于STIRPAT模型的广东省碳排放峰值预测分析

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中国资源综合利用 2024年第4期42卷 183-189页

作者：张烜刘国东叶意晶肖羽炜佛山科学技术学院经济管理学院广东佛山528000

为切实减少碳排放,有效应对气候变化,我国计划于2030年前实现碳达峰,2060年前实现碳中和。广东省是我国经济第一大省,预测分析其未来碳排放对实现碳达峰碳中和具有重要意义。本文充分考虑诸多因素对碳排放的影响,构建STIRPAT模型,以1998... 详细信息

为切实减少碳排放,有效应对气候变化,我国计划于2030年前实现碳达峰,2060年前实现碳中和。广东省是我国经济第一大省,预测分析其未来碳排放对实现碳达峰碳中和具有重要意义。本文充分考虑诸多因素对碳排放的影响,构建STIRPAT模型,以1998—2019年数据作为样本进行岭回归,从而得到广东省碳排放预测方程,并通过情景分析法设定3种情景。结果表明,广东省在基准情景下无法于2030年前实现碳达峰目标,在低碳情景和强化低碳情景下则能顺利实现该目标。

关键词：碳排放峰值预测碳达峰碳中和 STIRPAT模型情景分析广东省

OH regulator of highly dispersed Ru sites on host Pd nanocrystals for selective ethanol electro-oxidation

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Nano Research 2024年第5期17卷 3863-3871页

作者： Zhihe xiao Yueguang Chen Renjie Wu yuwei He Chunfeng Shi Leyu Wang State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Research Institute of Petroleum Processing SINOPECBeijing 100083China

The ethanol oxidation reaction(EOR)is crucial in direct alcohol fuel cells and chemical ***,the electro-oxidation of ethanol molecules to produce acetaldehyde and carbon monoxide can poison the active sites of nanocatalysts,resulting in reduced performance and posing challenges in achieving high activity and selectivity for ethanol *** this study,we employed a dynamic seed-mediated method to precisely modify highly dispersed Ru sites onto well-defined Pd *** oxyphilic Ru sites serve as"OH valves",regulating water dissociation,while the surrounding Pd atomic arrangements control electronic states for the oxidation dehydrogenation of carbonaceous ***,Ru0.040@Pd nanocubes(Ru:Pd=0.04 at.%),featuring(100)facets in Ru-Pd4 configurations,demonstrate an outstanding mass activity of 6.53 A·mgPd^(-1) in EOR under alkaline conditions,which is 6.05 times higher than that of the commercial Pd/C catalyst(1.08 A·mgPd-1).Through in-situ experiments and theoretical investigations,we elucidate that the hydrophilic Ru atoms significantly promote the dynamic evolution of H_(2)O dissociation into OHads species,while the electron redistribution from Ru to adjacent Pd concurrently adjusts the selective oxidation of C_(2) *** host-guest interaction accelerates the subsequent oxidation of carbonaceous intermediates(CH_(3)CO_(ads))to acetate,while preventing the formation of toxic*CHx and*CO species,which constitutes the rate-determining step.

关键词： OH regulator atomic sites ethanol electro-oxidation host-guest interaction

In situ Hydrothermal Oxidation of Ternary FeCoNi Alloy Electrode for Overall Water Splitting

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Energy & Environmental Materials 2024年第2期7卷 161-170页

作者： yuwei Chen Lixia Yang Chao Li Yuqiu Wu xiao Lν Hairen Wang Jun'e Qu Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Faculty of Material science and Chemistry China University of GeosciencesWuhan 430074China

Exploring noble metal-free catalyst materials for high efficient electrochemical water splitting to produce hydrogen is strongly desired for renewable energy *** this article,a novel bifunctional catalytic electrode of insitu-grown type for alkaline water splitting based on FeCoNi alloy substrate has been successfully prepared via a facile one-step hydrothermal oxidation route in an alkaline hydrogen peroxide *** shows that the matrix alloy with the atom ratio 4∶3∶3 of Fe∶Co∶Ni can obtain the best catalytic performance when hydrothermally treated at 180℃for 18 h in the solution containing 1.8 M hydrogen peroxide and 3.6 M sodium *** as-prepared Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode exhibits small overpotentials of only 184 and 175 mV at electrolysis current density of 10 mA cm^(-2)for alkaline OER and HER processes,*** overall water splitting at electrolysis current density of 10 mA cm^(-2)can be stably delivered at a low cell voltage of 1.62 *** characteristics including the large specific surface area,the high surface nickel content,the abundant catalyst species,the balanced distribution between bivalent and trivalent metal ions,and the strong binding of in-situ naturally growed catalytic layer to matrix are responsible for the prominent catalytic performance of the Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode,which can act as a possible replacement for expensive noble metal-based materials.

关键词： alkaline water electrolysis bifunctional electrocatalyst FeCoNi alloy hydrothermal oxidation in-situ growing

Ligand effect in surface atomic sites of group VI B transition metals on ultrathin Pt nanowires for enhanced oxygen reduction

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Nano Research 2024年第6期17卷 5298-5304页

作者： yuwei He Yueguang Chen Renjie Wu Zhihe xiao Mengxian Li Chunfeng Shi Leyu Wang State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Petroleum Molecular and Process Engineering SINOPEC Research Institute of Petroleum Processing Co.Beijing 100083China

Increasing the utilization efficiency of platinum is critical for advancing proton exchange-membrane fuel cells(PEMFCs).Despite extensive research on catalysts for the cathodic oxygen reduction reaction(ORR),developing highly active and durable Pt-based catalysts that can suppress surface dealloying in corrosive acid conditions remains ***,we report a facile synthesis of bimetallic ultrathin PtM(M=Mo,W,and Cr)nanowires(NWs)composed of group VI B transition metal atomic sites anchored on the *** NWs possess uniform sizes and well-controlled atomic *** to PtW and PtCr catalysts,the PtMo0.05 NWs exhibit the highest half-wave potential of 0.935 V and a mass activity of 1.43 A·mgPt^(−1).Remarkably,they demonstrate a remarkable 23.8-fold enhancement in mass activity compared to commercial Pt/C for ORR,surpassing previously reported Pt-based ***,the PtMo NWs cathode in membrane electrode assembly tests achieves a remarkable peak power density of 1.443 W·cm^(−2)(H_(2)-O_(2)conditions at 80℃),which is 1.09 times that of commercial Pt/*** ligand effect in the bimetallic surface not only facilitates strong coupling between Mo(4d)and Pt(5d)atomic orbitals to hinder atom leaching but also modulates the d-states of active site,significantly optimizing the adsorption of key oxygen(*O and*OH)species and accelerating the rate-determining step in ORR pathways.

关键词： ligand effect oxygen reduction reaction group VI B transition metal ultrathin nanowires multiple oxygen species

Single-cell transcriptomics reveals neural stem cell trans-differentiation and cell subpopulations in whole heart decellularized extracellular matrix

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Biophysics Reports 2024年第4期10卷 241-253页

作者： xiaoning Yang yuwei Zhao Wei Liu Zhongbao Gao Chunlan Wang Changyong Wang Siwei Li xiao Zhang Beijing Institute of Basic Medical Sciences

The whole heart decellularized extracellular matrix(ECM) has become a promising scaffold material for cardiac tissue engineering. Our previous research has shown that the whole heart acellular matrix possesses the memory function regulating neural stem cells(NSCs) trans-differentiating to cardiac lineage cells. However, the cell subpopulations and phenotypes in the trans-differentiation of NSCs have not been clearly identified. Here, we performed single-cell RNA sequencing and identified 2,765 cells in the recellularized heart with NSCs revealing the cellular diversity of cardiac and neural lineage, confirming NSCs were capable of trans-differentiating into the cardiac lineage while maintaining the original ability to differentiate into the neural lineage. Notably, the trans-differentiated heart-like cells have dual signatures of neuroectoderm and cardiac mesoderm. This study unveils an in-depth mechanism underlying the trans-differentiation of NSCs and provides a new opportunity and theoretical basis for cardiac regeneration.

关键词： Single-cell transcriptomics Neural stem cell Trans-differentiation Decellularized extracellular matrix Cardiac lineage cells

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高校实验室管理体制改革的实践

实验技术与管理 2011年第8期28卷 118-121页

作者：肖玉巍高智琛山西财经大学实验教学中心山西太原030006

从高校实验室管理体制改革的必要性出发,在对不同管理模式进行比较的基础上,确定了山西财经大学实验室管理体制改革的方案,通过制度创新化解了改革过程中出现的显性问题,也使其隐性问题正逐步得以解决。

关键词：实验室管理体制改革管理模式制度创新

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FY-3C微波湿度计-Ⅱ数据的再定标模型

遥感学报 2023年第10期27卷 2283-2294页

作者：王振占肖雨伟王可昕张升伟中国科学院国家空间科学中心、中国科学院微波遥感技术重点实验室北京100190 中国科学院大学北京100049

星载微波湿度计观测的地球表面和大气的亮温是数值天气预报和气候研究的重要基础数据源。由于微波湿度计系统响应特性差异、在轨工作条件的变化,以及星上定标基准的差异,不同卫星微波湿度计、同一微波湿度计数据在长时间范围内都存在一... 详细信息

星载微波湿度计观测的地球表面和大气的亮温是数值天气预报和气候研究的重要基础数据源。由于微波湿度计系统响应特性差异、在轨工作条件的变化,以及星上定标基准的差异,不同卫星微波湿度计、同一微波湿度计数据在长时间范围内都存在一定的偏差。如果这些偏差不进行修正,则会对长时间序列应用(如气候研究等)具有较大的影响,甚至可能导致错误的结果。由于微波辐射目前还不存在绝对基准,无法通过地面绝对基准的传递进行星上数据的绝对定标,因此需要利用其他相对定标方法对湿度计的稳定性及其变化特征进行评价。本文基于OMB (模拟和观测数差)定标的思想,结合微波湿度计的系统响应特性和星上定标基本原理,建立了微波湿度计定标偏差的校正模型—再定标模型,从而实现历史数据的一致性定标。初步研究结果表明:使用再定标模型后,FY-3C微波湿度计-II定标结果的时间序列稳定,原始OMB偏差中的各种异常波动现象得到良好修正。由于该模型是基于微波湿度计的系统响应特性建立的,因此这一方法同样适用于其他FY-3系列卫星微波湿度计数据的定标偏差校正,实现FY-3系列卫星微波湿度计数据的一致性定标。

关键词： FY-3C微波湿度计定标偏差 OMB定标系统响应特性星上定标再定标模型卫星数据的一致性