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基于文字冒险模式的科普游戏设计探索

艺术科技 2024年第4期37卷 137-139,157页

作者：彭立肖小月湖北工业大学艺术设计学院湖北武汉430068

目的:市场上的科普游戏质量参差不齐,难以平衡产品的娱乐性和科普性,为解决当前科普教育类游戏普遍存在的问题,文章基于文字冒险这一游戏模式针对科普类游戏提出设计策略,为科普游戏研究者和开发者提供新思路。方法:研究科普游戏现状,... 详细信息

目的:市场上的科普游戏质量参差不齐,难以平衡产品的娱乐性和科普性,为解决当前科普教育类游戏普遍存在的问题,文章基于文字冒险这一游戏模式针对科普类游戏提出设计策略,为科普游戏研究者和开发者提供新思路。方法:研究科普游戏现状,分析科普游戏发展中存在的问题及解决办法,梳理文字冒险游戏模式在科普教育中的潜在优势,探讨其在科普游戏设计中的应用策略。结果:文字冒险游戏具有开发难度低、玩法丰富、剧情时长可控等优势,作为一种科普类游戏,有潜力实现高效科普,游戏开发者可在此基础上注重内容优化,根据不同用户需求定制游戏细节,提升科普游戏的教育价值。结论:游戏作为一种流行文化形式,其在传播科学知识方面也具有独特优势。相较于传统教学方式,将科普内容融入游戏的剧情、玩法和关卡设计,搭配精良的美术设计,玩家在游戏过程中可以一边享受乐趣一边系统地理解和掌握相关知识。文字冒险游戏注重情感交流,交互形式简单却不枯燥,可塑性强,将这一模式应用于科普游戏中,开发者可以设计出内容丰富、层次分明的游戏与任务,提升科普游戏在教育推广中的效率和吸引力。

关键词：科普游戏文字冒险游戏教育性游戏设计

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DRG高倍率病例特征及住院费用结构分析

中国医院 2024年第4期28卷 10-13页

作者：郑心月周彧沈可一肖晓月陈诗雨康正孟雪晖浙江中医药大学人文与管理学院浙江省杭州市311402 哈尔滨医科大学卫生管理学院黑龙江省哈尔滨市150081

目的:分析DRG高倍率病例特征及住院费用结构,为医院精细化管理和科学控费提供参考依据。方法:选取某三甲医院2021年度高倍率病例1 618例,正常倍率病例37 738例。描述高倍率病例特征,比较高倍率组与正常倍率组的差异,采用灰色关联度分析... 详细信息

目的:分析DRG高倍率病例特征及住院费用结构,为医院精细化管理和科学控费提供参考依据。方法:选取某三甲医院2021年度高倍率病例1 618例,正常倍率病例37 738例。描述高倍率病例特征,比较高倍率组与正常倍率组的差异,采用灰色关联度分析高倍率病例住院费用的关联结构。结果:与正常倍率组相比,高倍率组在住院天数、性别、次诊断数量、出院情况以及除其他类费用外的所有住院费用均存在显著差异(P<0.05)。住院费用结构中,多组诊断费与住院总费用关联最大。总体灰色关联度排序中诊断费关联最高,治疗费次之,西药费对住院总费用的影响高于中药费。结论:应推动特病单议和专家评审制度,鼓励新技术及重点专科建设;科学制定高倍率病例认定标准,落实医保办专人包保联动制;加强高倍率病例审核,创新智能监管手段;优化临床路径管理,促进中西医结合治疗。

关键词：高倍率病例 DRG 费用结构灰色关联度分析

Spatial Distribution and Cultural Features of Traditional Villages in Beijing and Influencing Factors

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Journal of Resources and Ecology 2022年第6期13卷 1074-1086页

作者： xiao xiaoyue TANG Chengcai LIANG Wenqi School of Tourism Sciences Beijing International Studies UniversityBeijing 100024China Research Center of Beijing Tourism Development Beijing 100024China

Traditional villages are important part of Beijing, an internationally famous historic and cultural city. Exploring the spatial distribution and cultural features of traditional villages, and the factors that have shaped them,will help promote the protection and utilization of traditional villages in Beijing. ArcGIS spatial analysis, literature analysis, fieldwork and in-depth interviews were mainly carried out to analyze the spatial distribution and cultural features of traditional villages in Beijing and their influencing factors. The results show three main features.(1) The overall distribution of traditional villages in Beijing is random, although there are more traditional villages in the southwest and northeast and less in the southeast and northwest. Most of them are distributed along the higher piedmont plains or intermountain basins, and most of them are backed by hills and surrounded by rivers or along the ancient road.(2) There are some cultural commonalities among the traditional villages in Beijing, and nine typical traditional village cultures have been formed, including traditional residential culture, traditional folklore culture,the Great Wall garrison culture, mausoleum guarding culture, etc.(3) The formation of the spatial distribution and cultural features of traditional villages in Beijing is influenced by natural environmental factors like terrain, climate,and rivers, as well as human activities such as royal life, capital construction, ancient military defense, transportation, trade, etc. This study can provide a reference for the scientific protection and effective utilization of traditional villages in Beijing and all over the country.

关键词： traditional villages spatial distribution cultural features rural culture rural vitalization Beijing

Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy

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Bioactive Materials 2021年第10期6卷 3074-3084页

作者： Li Huang Xing Yin Jun Chen Ruojing Liu xiaoyue xiao Zhiai Hu Yan He Shujuan Zou State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China The Medical&Nursing School Chengdu UniversityChengdu610106China Laboratory for Regenerative Medicine Tianyou HospitalWuhan University of Science and TechnologyWuhan430064China Department of Oral and Maxillofacial Surgery Massachusetts General Hospital and Harvard School of Dental MedicineBostonMA02114USA

Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement,bone resorption,and tooth loss during orthodontic *** bone formation and reducing bone resorption are strategies for controlling these *** several decades,the autophagy inducer lithium chloride(LiCl)has been explored for *** this study,we investigated the autophagy-promoting effect of LiCl on bone remodeling under osteoporotic conditions during tooth *** was used to induce osteoporosis status in *** results showed that LiCl rejuvenated autophagy,decreased apoptosis,and promoted bone formation,thus protecting tooth movement in osteoporotic ***,in vitro experiments showed that LiCl reversed the effects of ovariectomy on bone marrow-derived mesenchymal stem cells(BMSCs)extracted from ovariectomized mice,promoting osteogenesis and suppressing apoptosis by positively regulating *** findings suggest that LiCl can significantly decrease adverse effects of osteoporosis on bone remodeling,and that it has great potential significance in the field of bone formation during tooth movement in osteoporosis patients.

关键词： Lithium chloride Autophagy Osteogenesis Orthodontic tooth movement Apoptosis

开玄泄浊方对阳虚型银屑病大鼠外周血Th细胞平衡及相关细胞因子表达的影响

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中医药导报 2024年第2期30卷 32-36,47页

作者：刘朝圣周琦彭丽丽岳扬肖晓月徐翠萍湖南中医药大学第一附属医院湖南长沙410007 湖南中医药大学护理学院湖南长沙410208

目的:探究开玄泄浊方对阳虚型银屑病大鼠外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)平衡及相关细胞因子表达的影响。方法:将72只大鼠随机分为空白对照组(16只)、模型组(56只)。所有大鼠背部脱毛后,空白对照组大鼠外涂凡士林,模型组... 详细信息

目的:探究开玄泄浊方对阳虚型银屑病大鼠外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)平衡及相关细胞因子表达的影响。方法:将72只大鼠随机分为空白对照组(16只)、模型组(56只)。所有大鼠背部脱毛后,空白对照组大鼠外涂凡士林,模型组大鼠予5%咪喹莫特乳膏外用+大黄灌胃建立阳虚型银屑病SD大鼠模型。将50只造模成功大鼠随机分为模型对照组、雷公藤多苷片组和开玄泄浊方低、中、高剂量组,每组10只。各组大鼠予以相应药物灌胃干预,1次/d,连续7 d。观察并记录大鼠背部皮损银屑病面积与严重性指数(PASI)评分,流式细胞仪检测外周血Th17/Treg比例,ELISA法检测白介素-17(IL-17)、转化生长因子β(TGF-β)水平,并取背部皮肤行病理组织切片观察。结果:与模型对照组比较,雷公藤多苷片组和开玄泄浊方低、中、高剂量组PASI评分、Th17/Treg比例、IL-17水平下降(P<0.05),TGF-β水平上升,差异均有统计学意义(P<0.05)。结论:开玄泄浊方治疗阳虚型银屑病的机制可能与调节Th17/Treg比例及相关因子的表达有关。

关键词：银屑病阳虚开玄泄浊方辅助性T细胞17/调节性T细胞平衡白介素-17 转化生长因子-β 大鼠

Evaluation and Promotion Model of Tourist Satisfaction in Ice and Snow Tourism Destinations

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Journal of Resources and Ecology 2022年第4期13卷 635-645页

作者： CHEN Xiangyu XU Shiyi TANG Chengcai FAN Zhijia xiao xiaoyue School of Tourism Sciences Beijing International Studies UniversityBeijing 100024China Research Center of Beijing Tourism Development Beijing 100024China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

The successful bid for the Beijing Winter Olympics has brought historic opportunities for the development of ice and snow tourism in *** index system for the evaluation of tourist satisfaction in ice and snow tourism destinations was constructed from the target layer-factor layer-index layer approach in this *** tourists with ice and snow tourism experience as the research object,and integrating a questionnaire survey and the Importance-Performance Analysis(IPA)method,a total of 840 valid questionnaires were collected to assess the satisfaction of tourists in snow and ice tourism destinations,and the promotion model of tourist satisfaction in ice and snow tourism destinations was put *** process led to three main results.(1)Ice and snow tourists in China are characterized as young and better-educated,with college students aged 19 to 25 as the main consumer *** than 70%of ice and snow tourists are pretty satisfied with the current development of ice and snow destinations in China,and are willing to participate again.(2)Other than“ice and snow souvenirs”,tourists’perceptions of importance are all higher than the level of perceived satisfaction,and the importance values of the 13 indicators including“Scenic spot security”and“Diversity of ice and snow entertainment and sports”are especially high,showing that tourists have high expectations and demands of the ***,the perceived satisfaction level of tourists for all indexes is generally low,mostly at the general satisfaction level,indicating that ice and snow tourism destinations have only partially met the demands of ice and snow tourists,and there is still much room for improvement.(3)After IPA analysis,five suggestions for improving the satisfaction of tourists in ice and snow tourism destinations were put forward,including diversification of the tourism business model,construction of tourism facilities,a market diversified cultivation model,a humanized mode of tourism ser

关键词： ice and snow tourism tourist satisfaction ice and snow sports tourism destinations Beijing Winter Olympic Games high-quality development

Promotion effect of FOXCUT as a microRNA sponge for miR-24-3p on progression in triple-negative breast cancer through the p38 MAPK signaling pathway

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Chinese Medical Journal 2024年第1期137卷 105-114页

作者： Xiafei Yu Fangze Qian xiaoqiang Zhang Yanhui Zhu Gao He Junzhe Yang Xian Wu Yi Zhou Li Shen xiaoyue Shi Hongfei Zhang xiao’an Liu Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Triple-negative breast cancer(TNBC)is a type of highly invasive breast cancer with a poor *** to new research,long noncoding RNAs(lncRNAs)play a significant role in the progression of *** the role of lncRNAs in breast cancer has been well reported,few studies have focused on *** study aimed to explore the biological function and clinical significance of forkhead box C1 promoter upstream transcript(FOXCUT)in triple-negative breast ***:Based on a bioinformatic analysis of the cancer genome atlas(TCGA)database,we detected that the lncRNA FOXCUT was overexpressed in TNBC tissues,which was further validated in an external cohort of tissues from the General Surgery Department of the First Affiliated Hospital of Nanjing Medical *** functions of FOXCUT in proliferation,migration,and invasion were detected in vitro or in *** assays and RNA immunoprecipitation(RIP)were performed to reveal that FOXCUT acted as a competitive endogenous RNA(ceRNA)for the microRNA miR-24-3p and consequently inhibited the degradation of ***:lncRNA FOXCUT was markedly highly expressed in breast cancer,which was associated with poor prognosis in some *** of FOXCUT significantly inhibited cancer growth and metastasis in vitro or in ***,FOXCUT competitively bounded to miR-24-3p to prevent the degradation of p38,which might act as an oncogene in breast ***:Collectively,this research revealed a novel FOXCUT/miR-24-3p/p38 axis that affected breast cancer progression and suggested that the lncRNA FOXCUT could be a diagnostic marker and therapeutic target for breast cancer.

关键词： Triple negative breast neoplasms RNA,long noncoding FOXCUT miR-24-3p p38 MAPK signaling pathway Disease progression

中国冰雪旅游研究:内涵辨析、脉络梳理与体系构建

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地理研究 2023年第2期42卷 332-351页

作者：唐承财肖小月秦珊北京第二外国语学院旅游科学学院北京100024 北京旅游发展研究基地北京100024

推动冰雪旅游高质量发展践行了“冰天雪地也是金山银山”发展理念,助推着体育强国、健康中国建设,满足了人民日益增长的美好生活需要。中国冰雪旅游历经三十多年的发展,已形成规模化、整体化发展格局;北京冬奥会的筹办更是给冰雪旅游带... 详细信息

推动冰雪旅游高质量发展践行了“冰天雪地也是金山银山”发展理念,助推着体育强国、健康中国建设,满足了人民日益增长的美好生活需要。中国冰雪旅游历经三十多年的发展,已形成规模化、整体化发展格局;北京冬奥会的筹办更是给冰雪旅游带来重大发展契机,利好政策陆续出台,消费热情不断高涨。与此同时,冰雪旅游相关研究也持续涌现,取得了丰厚研究成果。文章以“内涵辨析-脉络梳理-体系构建”为逻辑主线,从冰雪旅游基础概念、发展脉络演进、研究内容、研究方法及区域等方面对中国冰雪旅游展开分析和评述。研究表明:冰雪旅游内涵丰富,学者们从资源、动机以及季候等视角展开了概念界定;冰雪旅游研究历经4个阶段,研究与实践联系日益紧密,产业发展受资源、政策、市场等因素驱动;研究内容已形成一定体系,与国家、产业发展战略的结合有待加强;以定性研究为主,缺乏定量、纵深研究;研究区域高度集中在东北、华北地区,且视角较为宏观。最后提出从理论构建及研究视角、研究内容、研究方法、区域等方面进行未来研究的创新。以期推动中国冰雪旅游研究的理论化和体系构建,引领和指导未来冰雪旅游领域研究,推进中国后冬奥时代冰雪旅游高质量发展。

关键词：冰雪旅游冰雪产业高质量发展冰雪运动北京冬奥会

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我国反垄断法中经营者集中审查制度探析

学术研究 2010年第4期 69-76页

作者：慕亚平肖小月中山大学法学院中山大学WTO与CEPA法律研究中心

经营者集中审查是我国反垄断法中反垄断审查的重要制度。通过对2009年我国商务部否决可口可乐并购汇源案以及所涉及的经营者集中审查制度的实体和程序方面的合法性分析,反映出我国反垄断审查制度在相关市场的界定、经营者集中申报资格... 详细信息

经营者集中审查是我国反垄断法中反垄断审查的重要制度。通过对2009年我国商务部否决可口可乐并购汇源案以及所涉及的经营者集中审查制度的实体和程序方面的合法性分析,反映出我国反垄断审查制度在相关市场的界定、经营者集中申报资格、程序的细化、调查等方面仍存在问题,建议完善的方面包括:以不同行业来定明经营者集中不同申报标准;强化基本控制标准的指引性,在实施条例或指南中细化我国反垄断执法机构在判断是否会严重妨碍有效竞争时应考虑的影响市场竞争因素;以20%-35%作为我国界定市场份额的安全港标准来考虑市场份额及对市场的控制力;以市场份额标准为主,辅以HHI标准并结合其他因素来计算市场集中度;还应从是否对其他经营者造成人为壁垒,是否增加其他经营者的沉没成本,集中后的技术优势是否成为妨碍其他经营者进入市场等重要因素来考量。

关键词：企业并购经营者集中反垄断法反垄断审查