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弹性体 2024年第3期34卷 70-80页

作者：焦冰晶肖恒吕小王曹红宝田雨黎明化工研究设计院有限责任公司河南洛阳471000

热分析技术是评价弹性体材料热行为的主要手段之一。通过热分析技术全面深入地研究弹性体的物化特性,对改善和提高弹性体的应用性能具有重要的现实意义和价值。本文介绍了常见的热分析方法,包括:差示扫描量热法(DSC)、热机械分析法(TMA... 详细信息

热分析技术是评价弹性体材料热行为的主要手段之一。通过热分析技术全面深入地研究弹性体的物化特性,对改善和提高弹性体的应用性能具有重要的现实意义和价值。本文介绍了常见的热分析方法,包括:差示扫描量热法(DSC)、热机械分析法(TMA)、动态热机械分析(DMA)、热重分析(TGA)技术及热分析联用技术在弹性体材料中的应用研究进展。综述了热分析技术表征弹性体材料的特点及优势,同时展望了热分析技术的应用前景。

关键词：弹性体热分析差示扫描量热法(DSC) 热机械分析法(TMA) 动态热机械分析(DMA) 热重分析技术(TGA) 热分析联用技术

Advanced primary peritoneal carcinoma:clinicopathological and prognostic factor analyses

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 435-440页

作者： Chao ZHANG xiao-ping LI heng CUI Dan-hua SHEN Li-hui WEI Gynecological Oncology Center Peking University People＇s Hospital Beijing 100044 China

Objective: To investigate the factors favoring a positive prognosis for advanced primary peritoneal carcinoma (PPC). Methods: Twenty-four cases meeting the criteria for PPC were analyzed retrospectively for the clinicopathologic profiles. Im- munohistochemistry was used to determine the expressions of p53, Top2α, Ki-67 and Her-2/neu. Then all these clinicopa- thological factors and molecular markers were correlated with the prognosis. Results: There were 15 cases of primary peritoneal serous papillary carcinoma (PPSPC), 6 cases of mixed epithelial carcinoma (MEC) and 3 cases of malignant mixed Mullerian tumor (MMMT). All patients underwent cytoreductive surgery with optimal debulking achieved in 3 cases. Among those re- ceiving first-line chemotherapy, 13 patients received the TP regimen (paclitaxel-cisplatin or carboplatin) and 7 patients received the PAC regimen (cisplatin-doxorubicin-cyclophosphamide). The median overall survival of all patients was 42 months, while the breakdown for survival time for patients with PPSPC, MMT and MEC was 44, 13 and 19 months, respectively. The expressions of p53, Top2α and Ki-67 were all demonstrated in 11 cases respectively. None showed the expression of Her-2/neu. There were significant differences in the median survival between patients with PPSPC and those with MMMT (44 months vs 13 months, P<0.05), also between patients receiving TP combination and those receiving the PAC regimen (75 months vs 28 months, P<0.05). Another significant difference in the median progression-free survival (PFS) was identified between patients with positive p53 immunostaining and those with negative p53 immunostaining (15 months vs 47 months, P<0.05), whereas age, menopausal status, residual tumor size and the other molecular factors did not significantly impact survival. Conclusion: Patients with PPC should be treated with a comprehensive management plan including appropriate cytoreductive surgery and responsive chemotherapy. Overestimating an opt

关键词： Primary peritoneal carcinoma (PPC) Cytoreductive surgery Chemotherapy Immunohistochemistry Prognosis

Frame Invariance and Scalability of Neural Operators for Partial Differential Equations

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Communications in Computational Physics 2022年第7期32卷 336-363页

作者： Muhammad I.Zafar Jiequn Han Xu-Hui Zhou heng xiao Kevin T.Crofton Department of Aerospace and Ocean Engineering Virginia TechBlacksburgVirginiaUSA Center for ComputationalMathematics Flatiron InstituteNew YorkUSA

Partial differential equations(PDEs)play a dominant role in themathematicalmodeling ofmany complex dynamical *** these PDEs often requires prohibitively high computational costs,especially when multiple evaluations must be made for different parameters or *** training,neural operators can provide PDEs solutions significantly faster than traditional PDE *** this work,invariance properties and computational complexity of two neural operators are examined for transport PDE of a scalar *** operator based on graph kernel network(GKN)operates on graph-structured data to incorporate nonlocal *** we propose a modified formulation of GKN to achieve frame *** cloud neural network(VCNN)is an alternate neural operator with embedded frame invariance which operates on point cloud ***-based neural operator demonstrates slightly better predictive performance compared to ***,GKN requires an excessively high computational cost that increases quadratically with the increasing number of discretized objects as compared to a linear increase for VCNN.

关键词： Neural operators graph neural networks constitutive modeling inverse modeling deep learning

Effect of Zn^(2+)-Cu^(2+)combined heavy metal on mechanical properties and microstructure of clayey soil

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Journal of Mountain Science 2022年第9期19卷 2556-2569页

作者： MA Qiang WU Nian-ze xiao heng-lin LI Wen-tao XIANG Jun-chen School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China Innovation Demonstration Base of Ecological Environment Geotechnical and Ecological Restoration of Rivers and Lakes Hubei University of TechnologyWuhan 430068China School of Resources and Civil Engineering Northeastern UniversityShenyang 10819China Science and Technology Innovation Center for Smart Water Conservancy and Resources and Environment Northeastern UniversityShenyang 10819China

The strength deterioration mechanism of soil polluted by heavy metals plays a crucial role in the research of mine site *** this study,an unconfined compressive strength(UCS)test,a pH test,a scanning electron microscopy(SEM)test,a low filed nuclear magnetic resonance(NMR)test,and an X-ray diffraction(XRD)test were conducted on Zn^(2+),Cu^(2+) and the combination of Zn^(2+) and Cu^(2+) polluted soil to investigate the strength deterioration *** results show that both the UCS and pH value of soil decrease with increasing heavy metal *** UCS of Zn^(2+)-Cu^(2+) combined polluted soil is between Zn^(2+) and Cu^(2+) polluted soil at the same total ***,the deterioration rate of combined heavy metal polluted soil is less than the sum of deterioration rate of the two single polluted soils at the same total *** addition,heavy metal cations in polluted soil cause flocculent gels of cosmids to shrink,the micropores to become smaller and the macropores to become *** porosity increases slightly with the increase of heavy metal concentration due to decreased pH *** results from SEM,low field NMR,and pH could explain the dynamic evolution process of soil structure with different heavy metals and concentrations,which provides an experimental basis for mine-site polluted heavy metal treatment technology and the prediction of clayey soil strength deterioration.

关键词： Combined polluted soil Mechanical properties Pore size distribution Microstructure Heavy metal

CBL、Mini-CEX联合Sim Man3G教学模式在急诊科教学中的应用

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中国继续医学教育 2024年第5期16卷 63-67页

作者：徐波黄敏许宏洲王小玲肖恒蚌埠医科大学第一附属医院急诊内科安徽蚌埠233000 蚌埠医科大学第一附属医院感染科安徽蚌埠233000

目的观察急诊科教学过程中案例式教学法(casebased learning,CBL)、迷你临床演练测评(mini-clinical evaluation exercise,Mini-CEX)联合第三代智慧模拟人(SimMan3G)的教学效果。方法于2021年6月—2022年6月将蚌埠医科大学第一附属医院... 详细信息

目的观察急诊科教学过程中案例式教学法(casebased learning,CBL)、迷你临床演练测评(mini-clinical evaluation exercise,Mini-CEX)联合第三代智慧模拟人(SimMan3G)的教学效果。方法于2021年6月—2022年6月将蚌埠医科大学第一附属医院急诊科58名本科临床医学生作为教学对象,遵循随机分组原则而设为传统组和试验组各29名。传统组采用传统教学模式,试验组采用CBL、Mini-CEX联合Sim Man 3G教学模式,2组教学3个月。统计2组考核成绩、教学质量、MiniCEX量表评估得分,比较2组医学生对教学模式的满意程度。结果试验组笔试成绩(96.57±3.33)分、操作成绩(92.39±1.79)分高于对照组,差异有统计学意义(P<0.001);试验组教学3个月后技能操作、协调配合、医患沟通、应急能力及服务态度评分高于对照组,差异有统计学意义(P<0.001);试验组Mini-CEX中问诊能力、查体能力、诊断能力、沟通技巧、人文素养、总体临床能力及组织能力得分较传统组更高,差异有统计学意义(P<0.001);试验组教学满意度96.55%较传统组72.41%更高,差异有统计学意义(P<0.05)。结论急诊科教学过程中全方位融入CBL、Mini-CEX、Sim Man3G模拟人的应用,能够进一步提高临床医学生综合能力,有助于提升考核成绩,提高教学质量及满意度。

关键词：急诊科临床教学案例式教学法迷你临床演练第三代智慧模拟人笔试成绩操作成绩

Cronkhite-Canada syndrome:Report of six cases and review of literature

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World Journal of Gastroenterology 2014年第23期20卷 7518-7522页

作者： xiao-heng Wen Lan Wang Yu-Xuan Wang Jia-Ming Qian Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences Department of Behavioral Sciences and Health Education Rollins School of Public HealthEmory University

Cronkhite-Canada syndrome(CCS)is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances in the gastrointestinal tract and *** aim of this study was to investigate the clinical features and potential therapies for *** patients with CCS admitted from December 1992 to July 2008 to Peking Union Medical College Hospital were *** patients had clinical manifestation of nonhereditary gastrointestinal polyposis with diarrhea,skin hyperpigmentation,alopecia,and nail *** occult blood was positive in all six *** hemoglobin,potassium,calcium and protein were below the normal range in two ***-Saccharomyces cerevisiae and antinuclear antibodies were present in three *** polyps were found in all patients by gastroscopy and colonoscopy,with only one in the ***,there were hyperplastic polyps in five cases,tubular adenoma in three,and juvenile polyp in one with chronic inflammation and mucosal *** treatment led by corticosteroids can result in partial remission of clinical symptoms,and longterm follow-up is necessary.

关键词： Cronkhite-Canada syndrome Clinical feature Etiology Therapeutics

晚期非小细胞肺癌患者EGFR-TKI治疗效果及预后分析

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山西医科大学学报 2024年第1期55卷 24-28页

作者：周淑杰肖恒王海东陈丁莉邯郸市中心医院检验科邯郸056201 邯郸市中心医院精准医学中心

目的总结冀南地区晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者驱动基因突变情况,探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)突变患者采用一代酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)吉非替尼一线治疗的疗效,寻找影响预后的预测因子。方法收集2021年1月至2021年6月邯郸市中心医院收治的201例晚期NSCLC患者的临床资料,采用二代测序技术(next generation sequencing,NGS)总结驱动基因突变情况;对入组的91例接受吉非替尼靶向治疗的EGFR突变患者进行随访研究,定期收集患者的生存资料,使用Kaplan-Meier方法绘制吉非替尼治疗后不同影响因素下患者的中位无进展生存期(median progression-free survival,mPFS)曲线;Log-rank检验评估生存差异;采用Cox回归建立风险评估模型,分析不同危险因素对吉非替尼靶向治疗疗效及预后的影响。结果201例晚期NSCLC患者中138例(68.66%)至少发生1种基因突变;EGFR突变频率最高[91例(52.6%)],其中EGFR 21号外显子L858R点突变(42.7%)和EGFR 19号外显子缺失(33.6%)占比排名前两位;40例(43.96%)患者为复杂突变。Kaplan-Meier生存分析及Log-rank检验显示EGFR突变中EX19 del、EX21 L858R、少见突变与复杂突变患者mPFS依次为17.0月、13.0月和8.0月,其中EX19 del组mPFS最优,三组差异有统计学意义(P<0.05);无胸腔积液患者mPFS优于恶性胸腔积液患者(17.0月vs 10.0月,P=0.005);Cox回归分析提示EGFR突变类型是影响NSCLC患者mPFS的独立因素(P<0.05)。结论EGFR为冀南地区晚期NSCLC患者突变频率较高的基因,驱动基因突变类型可作为独立预测因子判断吉非替尼靶向治疗后患者的生存情况,少见突变和复杂突变患者疗效和预后均较差。

关键词：表皮生长因子受体吉非替尼基因突变二代测序非小细胞肺癌

REEs recovery from molten salt electrolytic slag:Challenges and opportunities for environmentally friendly techniques

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Journal of Rare Earths 2024年第6期42卷 1009-1019,I0001页

作者： Ziyan Yang Faxin xiao Shuchen Sun heng Zhong Ganfeng Tu School of Metallurgy Northeastern UniversityShenyang110819China Key Laboratory for Recycling of Nonferrous Metal Resources(Shenyang) Shenyang110819China

Due to the unique physical and chemical properties,rare earth elements(REEs)play a significant role in the high-tech *** the past few decades,the rare earth reserve in China has been gradually decreasing and more pressure has been exerted on the global rare earth supply for the increasing demand of REEs,which indicates that it is essential to recycle secondary resources to meet the rare earth *** for rare earth molten salt electrolytic slag(REMES),although its high rare earth content has potential huge economic value,its high fluorine content of approximately 10 wt%-20 wt%can pollute the *** methods are used to treat *** metallurgical and pyro-hydrometallurgical methods have gotten a big success for solving most of the hydrometallurgical problems,while some problems,like long route and waste water,need to be *** distillation is a new and promising method with a short process due to its harmlessness and high efficiency,but has shortcomings such as high energy consumption and material *** review presents these above three treatment methods,and the challenges and chances of using the recovery technique of REMES in an environmentally friendly way.

关键词： Rare earths Molten salt electrolytic slag Hydrometallurgy Pyro-hydrometallurgy Vacuum distillation Recovery

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具有圆弧曲面特征的模具镶件组合制造工艺

模具工业 2024年第9期50卷 62-66页

作者：林静财刘健肖恒严一钊陈代玉成都宏明双新科技股份有限公司四川成都610091

针对高精度圆弧曲面成形凹模单件加工效率低、加工难度大、报废率高等问题,根据圆弧曲面成形凹模结构特点,采用组合加工制造工艺进行加工,新制造工艺缩短了校对基准时间,降低了镶件的制造成本和圆弧曲面成形镶件的加工难度。

关键词：高精度成型凹模组合加工制造工艺

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