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放牧和舍饲对滩羊肌肉及脂肪组织中脂肪酸组成的影响

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家畜生态学报 2023年第2期44卷 71-79页

作者：朱相德张洁李娅楠徐晓锋张力莉宁夏大学农学院宁夏银川750021

该研究旨在分析放牧和舍饲2种饲养方式对滩羊肌肉及脂肪组织中脂肪酸组成的影响。选择体重接近、健康的4月龄滩羊羯羊24只,随机分为舍饲组和放牧组,每组各12只。饲养至9月龄后每组随机挑选6只屠宰,采集滩羊背最长肌、膈肌、股二头肌、... 详细信息

该研究旨在分析放牧和舍饲2种饲养方式对滩羊肌肉及脂肪组织中脂肪酸组成的影响。选择体重接近、健康的4月龄滩羊羯羊24只,随机分为舍饲组和放牧组,每组各12只。饲养至9月龄后每组随机挑选6只屠宰,采集滩羊背最长肌、膈肌、股二头肌、皮下脂肪、肾周脂肪和尾部脂肪,利用气相色谱法分析其脂肪酸的种类和含量。结果表明:(1)在短链饱和脂肪酸中,放牧组膈肌中C4:0含量显著高于舍饲组(P0.05),肾周脂肪中单不饱和脂肪酸的含量显著低于舍饲组(P<0.05);多不饱和脂肪酸中,放牧组股二头肌、肾周脂肪和尾部脂肪中n-6多不饱和脂肪酸的含量均显著(P<0.05)或极显著(P<0.01)低于舍饲组;而放牧组各体组织中n-3多不饱和脂肪酸的含量均显著(P<0.05)或极显著(P<0.01)高于舍饲组。(3)与舍饲相比,放牧滩羊肉中n-6多不饱和脂肪酸/n-3多不饱和脂肪酸的比值更合理。综上可知,放牧和舍饲2种饲养方式对滩羊不同体组织脂肪酸组成存在明显影响,放牧方式提高了羊肉的营养价值。

关键词：饲养方式滩羊脂肪酸组成

Disaster Loss Evaluation and Characteristics of the Seismic Hazard of the Nilka-Gongliu Earthquake with M_S6. 0

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Earthquake Research in China 2014年第2期28卷 261-273页

作者： Tan Ming Tang lihua Wu Guodong Chang xiangde Zhang Yong Song lijun li Yang li Yigang Wang Wei Shi Guangling li Zhihai Earthquake Administration of Xinjiang Uygur Autonomous Region China Earthquake Administration

The epicenter intensity of Nilka-Gongliu earthquake with MS6. 0 was Ⅶ degrees; no fatalities but many residential buildings and public facilities were moderately damaged during the earthquake. Traffic and water conservation facilities were damaged to a certain extent but after emergency repair,production and life in the disaster area were not influenced. According to a sample survey of the earthquake filed,this earthquake caused direct economic loss of approximately 678. 46 million yuan( RMB),and the reconstruction funds required will be about 1. 20349 billion yuan( RMB).

关键词：地震危险性灾害损失评估直接经济损失尼勒克县震中烈度公共设施住宅建筑水利设施

新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物的设计合成以及生物活性研究

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有机化学 2021年第4期41卷 1722-1727页

作者：谢伟彬李焕功孟祥德李正名周莎南开大学元素有机化学研究所元素有机化学国家重点实验室天津300071

为了开发出高效、低毒性的新型绿色农药,引入七氟异丙基,设计合成了新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物,其结构经过NMR,HRMS分析确认.初步的生物活性测定表明,大部分化合物含有较好的杀虫活性,其中化合物Ic在2.5 m... 详细信息

为了开发出高效、低毒性的新型绿色农药,引入七氟异丙基,设计合成了新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物,其结构经过NMR,HRMS分析确认.初步的生物活性测定表明,大部分化合物含有较好的杀虫活性,其中化合物Ic在2.5 mg/L时抑制率为20%.本研究结果为后期的农药创制工作奠定了一定的基础.

关键词：七氟异丙基邻甲酰氨基苯甲酰胺合成杀虫活性

基于全基因组重测序的藏猪脂质沉积相关基因鉴定

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南方农业学报 2023年第2期54卷 325-335页

作者：张彦熊和丽张斌相德才刘韶娜赵智勇云南省畜牧兽医科学院养猪与动物营养研究所云南昆明650024

【目的】从全基因组水平解析藏猪与大白猪间的遗传差异,并鉴定出与藏猪脂质沉积相关的基因,为藏猪优质肉质特征的利用及新品种培育提供理论参考。【方法】选用5份自测云南迪庆藏猪的全基因组重测序数据,以及NCBI数据库中来自西藏、四川... 详细信息

【目的】从全基因组水平解析藏猪与大白猪间的遗传差异,并鉴定出与藏猪脂质沉积相关的基因,为藏猪优质肉质特征的利用及新品种培育提供理论参考。【方法】选用5份自测云南迪庆藏猪的全基因组重测序数据,以及NCBI数据库中来自西藏、四川、甘肃地区34份藏猪和具有低脂肪沉积特征的14份大白猪全基因组重测序数据,获得全基因组SNP后以VCFtools进行选择信号检测,采用VCFtools分别计算候选SNP在藏猪和大白猪中的等位基因频率,再利用自编Python脚本及所有SNP注释文件进行注释以确定候选基因,最后运用DAVID对候选基因进行GO功能注释和KEGG信号通路富集分析,进一步鉴定与脂质沉积相关的功能基因。【结果】经全基因组重测序及与参考基因组比对、过滤后得到19374832个高质量的SNPs,根据受选择区域条件筛选出370778个候选SNPs,其中符合在藏猪中等位基因频率>0.5而在大白猪中等位基因频率<0.5条件的SNPs有152877个,共注释到1486个候选基因。GO功能注释分析结果显示,1486个候选基因注释到17个GO功能簇(Cluster1~Cluster17),其中Cluster11和Cluster12与脂肪生成相关,涉及与脂滴转运、结合过程相关的基因NME4、C4BPA、AP2M1、CD36、FABP5、PMP2、PDZD8、OSBPL6、APOD和OSBPL1A,与脂肪酸合成、延伸和代谢过程相关的基因TECR、ELOVL7、HACD2,以及与脂肪形成相关的细胞外基质基因(CCN3、EGFL6、KAZALD1、ASPN、ADAMTS18、ECM2、COL18A1、COL3A1和COL4A5);通过文献分析还发现8个基因(APOOL、PLAG1、PLAUR、SUCLG2、CPE、AKR1B1、SLC4A4和CHPT1)在藏猪与大白猪皮下脂肪或肌肉组织呈差异表达,且与脂肪形成相关。【结论】藏猪与大白猪间的脂肪沉积差异涉及脂肪形成的多个过程和多个基因,细胞外基质基因也可能与藏猪脂肪形成相关,且这些基因在藏猪中均具有较高的等位基因频率。

关键词：藏猪脂质沉积选择信号等位基因频率全基因组重测序

The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment

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Journal of Meteorological Research 2019年第3期33卷 375-399页

作者： Ping ZHAO Yueqing li Xueliang GUO xiangde XU Yimin liU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi liU La JIA Yun CHEN Yanju liU Jian li Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG lixin DONG Juyang HU Shuai HAN Xiuji ZHOU State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing 100081 National Climate Center China Meteorological Administration Beijing 100081 Meteorological Observation Center China Meteorological Administration Beijing 100081 Jiangxi Meteorological Observatory Nanchang 330096 Chengdu Institute of Plateau Meteorology of the China Meteorological Administration Chengdu 610072 Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 National Satellite Meteorological Center China Meteorological Administration Beijing 100081 National Meteorological Information Center China Meteorological Administration Beijing 100081 Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 Meteorological Institute of Shaanxi Province Xi'an 710014 Meteorological Observatory of Tibet Autonomous Region Lhasa 850000 National Meteorological Centery China Meteorological Administration Beijing 100081

The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian "atmospheric water tower" and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compar

关键词： Tibetan Plateau field observation data processing weather and climate numerical forecasting

Circular RNA IARS(circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

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Circular RNA IARS(circ-IARS) secreted by pancreatic cancer c...

诊所法律教育:中国法律硕士培养制度改革的基本方向

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Jie li Zhonghu li Peng Jiang Minjie Peng Xi Zhang Kai Chen Hui liu Huaqiang Bi xiangde liu Xiaowu li Hepatobiliary Surgery Institute Southwest Hospital Third Military Medical University (Army Medical University) Dept.Hepatobiliary Surgery Shenzhen University General Hospital

Background: Recent studies show that exosomes are involved in intercellular communication and that abundant circular RNAs(circRNAs) are present within exosomes. However,whether these exosomal circRNAs contribute to tumor invasion and metastasis remains unclear, as do their associated ***: Quantitative reverse transcription-polymerase chain reaction(qRT-PCR) was used to measure the expression levels of circ-IARS in 85 pancreatic ductal adenocarcinoma(PDAC) tissues, plasma exosomes, and Hs 766 T, Hs 766 T-L2 and human microvascular vein endothelial(HUVECs) cells. RhoA, ZO-1 and RhoA-GTP levels were detected by qRT-PCR and western blotting(WB);RhoA activity analysis was also performed. Transwell assays were performed to examine changes in endothelial monolayer permeability, and immunofluorescence and WB were employed to evaluate F-actin expression and focal adhesion. Finally, an animal experiment was performed to detect the contribution of circ-IARS to cancer ***:circ-IARS expression was up-regulated in pancreatic cancer tissues and in plasma exosomes of patients with metastatic disease. circ-IARS was found to enter HUVECs through exosomes and promote tumor invasion and metastasis. circ-IARS expression was positively correlated with liver metastasis, vascular invasion, and tumor-node-metastasis(TNM) stage and negatively correlated with postoperative survival time. Overexpression of circ-IARS significantly down-regulated miR-122 and ZO-1 levels,up-regulated RhoA and RhoA-GTP levels, increased F-actin expression and focal adhesion, enhanced endothelial monolayer permeability, and promoted tumor invasion and metastasis. Conclusions:circ-IRAS accesses HUVECs via exosomes derived from pancreatic cancer cells followed by increased endothelial monolayer permeability. Furthermore, this process promotes tumor invasion and *** results of this study suggest that the presence of circRNAs in exosomes may be important indicator for early diag

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法学杂志 2011年第2期23卷 59-62页

作者：冀祥德李庆明中国社会科学院法学研究所北京100720 中国社会科学院国际法研究所北京100720

中国法律硕士教育的宗旨是培养高级型复合型、实践性法律人才,然而其传统的注重课堂教授而忽视实践教育的教育方法和模式并不能完成这个目标。为了更好地培养法律硕士,有必要将诊所法律教育引入法律硕士教育。将诊所法律教育作为法律硕... 详细信息

中国法律硕士教育的宗旨是培养高级型复合型、实践性法律人才,然而其传统的注重课堂教授而忽视实践教育的教育方法和模式并不能完成这个目标。为了更好地培养法律硕士,有必要将诊所法律教育引入法律硕士教育。将诊所法律教育作为法律硕士教育的必修课有助于对法律硕士学生职业技能、职业道德的培养,也是诊所法律教育本土化和可持续发展的必然要求。诊所法律教育是中国法律硕士培养制度改革的基本方向。

关键词：法学教育法律硕士教育诊所法律教育

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圆柱尾流中眼镜蛇探针与热线的性能对比

实验流体力学 2014年第5期28卷 104-110页

作者：王汉封李卓峰林祥德中南大学土木工程学院长沙410075 中南大学高速铁路建造技术国家工程实验室长沙410075

在雷诺数为7200的圆柱尾流中对眼镜蛇探针与热线的测量结果进行了详细对比,主要包括:时均速度、雷诺应力、概率密度函数、自相关函数和能谱等。从对比结果可以发现眼镜蛇探针数据的拒绝率随湍流度增大而增大,但在本实验中其对时均测量... 详细信息

在雷诺数为7200的圆柱尾流中对眼镜蛇探针与热线的测量结果进行了详细对比,主要包括:时均速度、雷诺应力、概率密度函数、自相关函数和能谱等。从对比结果可以发现眼镜蛇探针数据的拒绝率随湍流度增大而增大,但在本实验中其对时均测量结果无明显影响。尽管眼镜蛇探针数据有效率在95%以上,但相对于热线其明显高估了雷诺应力。尤其是主雷诺剪切应力u*v*,眼镜蛇探针与热线测量结果的差异要显著大于两者在雷诺正应力上的测量差异。由于无法反映高频随机脉动的影响,眼镜蛇探针所测信号自相关系数的周期性明显强于热线。眼镜蛇探针对速度u和v的响应存在区别,使得两者能谱在惯性子区内有显著差异,不能像热线一样反映出惯性子区内小尺度湍流的各向同性。

关键词：眼镜蛇探针热线性能对比湍流统计量能谱

基于LC-MS/MS技术研究稻草替代部分玉米青贮对奶牛血浆代谢产物的影响

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浙江农业学报 2023年第2期35卷 266-274页

作者：李娅楠冶文兴朱相德陈林徐晓锋张力莉宁夏大学农学院宁夏银川750021

为探讨稻草替代部分玉米青贮后对奶牛的血浆代谢物的影响,本文利用LC-MS/MS物质分离鉴定技术,结合多元统计方法对稻草替代部分玉米青贮前后的代谢产物进行分析。结果表明:稻草替代部分玉米青贮后,两组奶牛血浆中共检测到41种差异代谢物... 详细信息

为探讨稻草替代部分玉米青贮后对奶牛的血浆代谢物的影响,本文利用LC-MS/MS物质分离鉴定技术,结合多元统计方法对稻草替代部分玉米青贮前后的代谢产物进行分析。结果表明:稻草替代部分玉米青贮后,两组奶牛血浆中共检测到41种差异代谢物。与对照组相比,试验组奶牛血浆中肾上腺素、β-羟丁酸、烟酰胺、胆酸等22个代谢物上调,谷胱甘肽、皮质醇、皮质酮等19个代谢物下调。由此可见:稻草替代部分玉米青贮后,奶牛脂肪动员增强,抗应激能力下降。研究结果为稻草替代玉米青贮在奶牛日粮中的应用提供参考,为稻草资源的开发利用提供新思路。

关键词：稻草玉米青贮奶牛血浆代谢物

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