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Comprehensive applicability evaluation of four precipitation products at multiple spatiotemporal scales in Northwest China

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Journal of Arid Land 2024年第9期16卷 1232-1254页

作者： wang xiangyu XU Min KANG Shichang LI Xuemei HAN Haidong LI Xingdong School of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China

Precipitation plays a crucial role in the water cycle of Northwest *** accurate precipitation data is crucial for regional water resource management,hydrological forecasting,flood control and drought ***,the applicability of multi-source precipitation products for long time series in Northwest China has not been thoroughly *** this study,precipitation data from 183 meteorological stations in Northwest China from 1979 to 2020 were selected to assess the regional applicability of four precipitation products(the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5),Global Precipitation Climatology Centre(GPCC),Climatic Research Unit gridded Time Series Version 4.07(CRU TS v4.07,hereafter CRU),and Tropical Rainfall Measuring Mission(TRMM))based on the following statistical indicators:correlation coefficient,root mean square error(RMSE),relative bias(RB),mean absolute error(MAE),probability of detection(POD),false alarm ratio(FAR),and equitable threat score(ETS).The results showed that precipitation in Northwest China was generally high in the east and low in the west,and exhibited an increasing trend from 1979 to *** with the station observations,ERA5 showed a larger spatial distribution difference than the other *** overall overestimation of multi-year average precipitation was approximately 200.00 mm and the degree of overestimation increased with increasing precipitation *** multi-year average precipitation of GPCC and CRU was relatively close to that of station *** trend of annual precipitation of TRMM was overestimated in high-altitude regions and the eastern part of Lanzhou with more *** the monthly scale,GPCC performed well but underestimated precipitation in the Tarim Basin(RB=-4.11%),while ERA5 and TRMM exhibited poor accuracy in high-altitude ***5 had a large bias(RB≥120.00%)in winter months

关键词： precipitation products the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5) Global Precipitation Climatology Centre(GPCC) Climatic Research Unit gridded Time Series(CRU TS) Tropical Rainfall Measuring Mission(TRMM) applicability evaluation Northwest China

Experimental demonstration of a quantum downstream access network in continuous variable quantum key distribution with a local local oscillator

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Photonics Research 2024年第6期12卷 1262-1273页

作者： DENGKE QI xiangyu wang ZHENGHUA LI JIAYU MA ZIYANG CHEN YUEMING LU SONG YU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China Key Laboratory of Trustworthy Distributed Computing and Service(MoE) Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronicsand Center for Quantum Information TechnologyPeking UniversityBeijing 100871China

Quantum networks provide opportunities and challenges across a range of intellectual and technical frontiers,including quantum computation,communication,and *** traditional communication networks,quantum networks utilize quantum bits rather than classical bits to store and transmit *** key distribution(QKD)relying on the principles of quantum mechanics is a key component in quantum networks and enables two parties to produce a shared random secret key,thereby ensuring the security of data *** this work,we propose a cost-effective quantum downstream access network structure in which each user can get their corresponding key information through terminal *** on this structure,we demonstrate the first four-end-users quantum downstream access network in continuous variable QKD with a local local *** contrast to point-to-point continuous variable QKD,the network architecture reevaluates the security of each user and accounts for it accordingly,and each user has a lower tolerance for excess noise as the overall network expands with more ***,the feasibility of the experiment is based on the analysis of the theoretical model,noise analysis,and multiple techniques such as the particle filter and adaptive equalization algorithm used to suppress excess *** results show that each user can get a low level of excess noise and can achieve secret key rates of 546 kbps,535 kbps,522.5 kbps,and 512.5 kbps under a transmission distance of 10 km,respectively,with the finite-size block of 1×10~*** not only verifies the good performance but also provides the foundation for the future multi-user quantum downstream access networks.

关键词： quantum oscillator local

Direct Analysis of Whole Blood by a Disposable Monolithic Column Mass Spectrometry Analysis Kit

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Chinese Journal of Chemistry 2024年第10期42卷 1073-1078页

作者： Wenxin wang Jin Han Yutong Zheng Haijie wang Chengbiao Zhu Yongyi Li Yuqi Feng Zhenwei Wei xiangyu wang College of Chemistry and Molecular Science Wuhan UniversityWuhanHubei 430072China School of Public Health Wuhan UniversityWuhanHubei 430072China Schoolof Bioengineering and Health Wuhan Textile UniversityWuhanHubei 430200China

A monolithic column-based mass spectrometry(MS)analysis kit was prepared for whole blood analysis with *** kit is disposable and can be used for purification,storage,transportation and direct analysis of whole *** kit mainly consists of a capillary for quantitative microsampling,a cation exchange monolithic column for purification and storage,and a syringe for loading *** kit is very friendly to various users that one can easily siphon the blood in the kit followed by rapid *** established a quantitative method using the kit with a limit detection as low as 0.33 nmol/L,and achieved more than five orders of magnitude enhancement in sensitivity compared to direct nanoelectrospray ionization MS *** column can avoid analyte exposure to environment,which helps the storage of the sample for laboratory *** relative standard deviation of immediate blood analysis and storage blood analysis within 10 d was less than 10%.This method has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2μL rat *** results indicate that this disposable kit does have the potential to achieve highly sensitive quantitative MS analysis in biological samples,which is expected to become a cost-effective and powerful tool for in vitro diagnostics.

关键词： Clinical Ms Whole blood analysis Porous polymers Matrix isolation Trace analysis

Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy

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Chinese Chemical Letters 2024年第6期35卷 385-391页

作者： An Lu Yuhao Guo Yi Yan Lin Zhai xiangyu wang Weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun Zhu Xiaoyan Liu Huining He Zhiyu wang Jian-Cheng wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Immuno-oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Pharmacy Clinical Trial Research CenterChina-Japan Friendship HospitalBeijing 100029China Laboratory of innovative formulations and pharmaceutical excipients Ningbo Institute of Marine MedicinePeking UniversityNingbo 315832China

Immunosuppressive microenvironments present critical problems in clinical *** regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)with chemotherapeutics has been applied *** this study,miriplatin(MiPt),the lipidic derivative of 5-fluorouracil(Fu-OA),as well as the programmed death ligand 1(PD-L1)target si RNA(siPD-L1)were integrated into Lip-Pt/Fu@siPD-L1 nanoparticles(NPs)for *** vitro results showed that Lip-Pt/Fu@siPD-L1 NPs could exhibit effective siRNA gene silencing and promote the phagocytosis of tumor cells by ***,in vivo results revealed that LipPt/Fu@siPD-L1 NPs showed significantly higher anti-tumor efficiency than that of the physical mixing of Mi Pt,5-fluorouracil,and Lip@siPD-L1 NPs(delivery of siPD-L1 by liposomes).The best anti-tumor efficiency of Lip-Pt/Fu@siPD-L1 NPs resulted from the synergistic immunotherapeutic effects of Mi Pt and siPD-L1 based on the inhibition of CD47 expression and the downregulation of PD-L1 in tumor cells,which elicited a robust anti-tumor immune response through the activation of macrophage phagocytosis and immune checkpoint *** Lip-Pt/Fu@siPD-L1 NPs provide a potential strategy for tumor chemo-immunotherapy.

关键词： Chemo-immunotherapy Immune checkpoint inhibition Gene silencing Miriplatin Macrophage phagocytosis Nanotechnology

System reliability-based robust design of deep foundation pit considering multiple failure modes

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Geoscience Frontiers 2024年第2期15卷 169-182页

作者： Li Hong xiangyu wang Wengang Zhang Yongqin Li Runhong Zhang Chunxia Chen School of Civil Engineering Chongqing UniversityChongqing 400045China School of Design and the Built Environment Curtin UniversityBentley 6102Western AustraliaAustralia Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing 400045China Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu 610097China China Southwest Geotechnical Investigation&Design Institute Co. LtdChengdu 610052SichuanChina

Recently,reliability-based design is a universal method to quantify negative influence of uncertainty in geotechnical ***,for deep foundation pit,evaluating the system safety of retaining structures and finding cost-effective design points are main *** address this,this study proposes a novel system reliability-based robust design method for retaining system of deep foundation pit and illustrated this method via a simplified case history in Suzhou,*** proposed method included two parts:system reliability model and robust design *** Propagation Neural Network(BPNN)is used to fit limit state functions and conduct efficient reliability *** common source random variable(CSRV)model are used to evaluate correlation between failure modes and determine the system ***,based on the system reliability model,a robust design method is *** method aims to find cost-effective design *** solve this problem,the third generation non-dominated genetic algorithm(NSGA-III)is *** efficiency and accuracy of whole computations are improved by involving BPNN models and NSGA-III *** proposed method has a good performance in locating the balanced design point between safety and construction ***,the proposed method can provide design points with reasonable stiffness distribution.

关键词： System reliability Machine learning method Non-dominated sorting genetic algorithm Robust design Multiple objective optimization models

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

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Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin Xiang Shu He Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long Ma Ying Sun Yongpeng Qin Yi Chen Wen Li xiangyu wang Gong Chen Wenliang Lei Guangdong-Hong Kong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory for Neuroimmunology in Health and Diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIB-KU Leuven Center for Brain&Disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous *** r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing *** this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse ***-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local *** addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable ***,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural *** conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocyte-to-neuron conversion Ca2+imaging direct lineage conversion glia astrocyte in vivo reprogramming lineage-tracing mice NeuroD1 neuron two-photon imaging

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核电站仪控系统故障风险分析方法

核动力工程 2024年第2期45卷 218-224页

作者：罗慧李建伟王翔宇山东核电有限公司山东烟台265116

为满足核电站仪控系统故障定位快速准确、风险分析可靠全面的需求,提出了一种基于风险自动分析模型的仪控系统故障风险分析方法。首先,将传统的系统内嵌式自诊断分析、基于故障模式与影响分析(FMEA)、逻辑信号自动化分析技术相融合构建... 详细信息

为满足核电站仪控系统故障定位快速准确、风险分析可靠全面的需求,提出了一种基于风险自动分析模型的仪控系统故障风险分析方法。首先,将传统的系统内嵌式自诊断分析、基于故障模式与影响分析(FMEA)、逻辑信号自动化分析技术相融合构建了风险自动分析模型;然后基于风险自动分析模型开发了故障风险自动化分析融合平台;最后通过实例分析验证所提方法的有效性。实践表明该方法可有效提高故障精准定位效率,减少故障风险分析时间,降低人因失误风险。

关键词：故障定位自诊断分析 FMEA 逻辑信号自动化分析

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自适应光学在超分辨荧光显微镜中的应用

中国激光 2024年第3期51卷 37-51页

作者：王翔宇陈曦曹暾马冬晗大连理工大学光电工程与仪器科学学院辽宁大连116024

超分辨荧光显微镜突破了传统荧光显微镜的分辨率限制,使得人们能够在纳米量级分辨率下观察细胞和组织样品,极大地推动了生命科学的发展。在这一技术中,仪器和样品引入的像差均会导致空间分辨率降低,进而导致成像质量恶化。为此,人们引... 详细信息

超分辨荧光显微镜突破了传统荧光显微镜的分辨率限制,使得人们能够在纳米量级分辨率下观察细胞和组织样品,极大地推动了生命科学的发展。在这一技术中,仪器和样品引入的像差均会导致空间分辨率降低,进而导致成像质量恶化。为此,人们引入了自适应光学技术,通过直接或间接的手段探测像差,再通过波前校正元件来校正像差,从而获得高质量的超分辨图像。本文介绍了自适应光学的起源与工作原理,总结了其在超分辨荧光显微镜中的应用,并展望了其未来的发展前景。

关键词：显微荧光显微镜超分辨自动与自适应光学像差补偿波前传感

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转移性肝癌的治疗现状与展望

临床肝胆病杂志 2024年第7期40卷 1289-1294页

作者：王祥宇陈进宏复旦大学附属华山医院普外科肝胆外科中心上海200040

肝脏是恶性肿瘤最常见的转移部位之一,肝转移也是转移性肿瘤的主要致死原因。转移性肝癌具有高度异质性,长期以来临床治疗进展缓慢。近年来,随着外科技术的提高、系统治疗的进步及多学科团队诊疗模式的开展,转移性肝癌的临床治疗发生了... 详细信息

肝脏是恶性肿瘤最常见的转移部位之一,肝转移也是转移性肿瘤的主要致死原因。转移性肝癌具有高度异质性,长期以来临床治疗进展缓慢。近年来,随着外科技术的提高、系统治疗的进步及多学科团队诊疗模式的开展,转移性肝癌的临床治疗发生了革命性的变化。本文从外科治疗、系统治疗及局部区域治疗三个方面回顾了近年来转移性肝癌临床治疗进展。以化疗、靶向与免疫治疗为基础的联合疗法仍是转移性肝癌综合治疗的基础,而外科治疗的价值也在部分寡转移患者中得到证实。另外,局部区域治疗的发展为转移性肝癌患者带来新的治疗选择。基于高级别循证医学证据及相关指南的规范化诊疗,及多学科团队指导下的个体化精准治疗,将是未来转移性肝癌临床治疗的发展方向。

关键词：肿瘤转移肝治疗学