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A mini-review on pharmacological effects of ginsenoside Rb3,a marked saponin from Panax genus

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BIOCELL 2022年第6期46卷 1417-1423页

作者： WEI LI YUEYANG DUAN XIAOTONG YAN xiangxiang liu MEILING FAN ZI WANG College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun130118China National&Local Joint Engineering Research Center for Ginseng Breeding and Development Changchun130118China Maternity Diagnosis&Treatment Center The Affiliated Hospital of Changchun University of Chinese MedicineChangchun130021China

Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain ***,pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins,such as Compound K,F2,etc.A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials,which was achieved by diminishing oxidative stress and ***,more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical *** article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.

关键词： Ginsenoside Rb3 Pharmacological effects Review Signaling pathway

Research on Construction of Bill of Quantities of Prefabricated Buildings Based on BIM

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Journal of Architectural Research and Development 2022年第5期6卷 25-30页

作者： xiangxiang liu Chongqing Institute of Engineering Chongqing 40056China

Building Information Model(BIM)Technology can be widely used in various construction *** construction quality and project cost of the prefabricated construction industry based on BIM can be effectively *** on BIM Technology,the integration of bill of quantities can effectively control the cost of prefabricated construction and improve competitiveness in the bidding *** on this,the characteristics and advantages of bill of quantities pricing based on BIM were expounded in this ***,the structure and content construction of bill of quantities were analyzed,followed by an analysis of pricing control strategy based on BIM were analyzed for assembly building quantities for reference.

关键词： Building Information Modeling(BIM) Prefabricated building Bill of quantities

The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density

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Science China(Life Sciences) 2022年第6期65卷 1171-1180页

作者： xiangxiang liu Mohamed M.Khodeiry Danting Lin Yunxiao Sun Qing Zhang Jiawei Wang Richard K.Lee Ningli Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiami FL 33136USA Research institute of Ophthalmology Giza 12557Egypt Beijing Ophthalmology and Visual Science Key Laboratory Beijing Eye InstituteBeijing 100730China Department of Neurology and Medical Research Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The present study aims to investigate the effect of temporary cerebrospinal fluid pressure(CSFP) reduction on optic nerve head(ONH) and macular vessel density(VD) using optical coherence tomography ***-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were ***-two eyes of 32 healthy volunteers were *** and macular VD images were evaluated differences between baseline and after CSFP *** results showed that the mean CSFP decreased from(11.6±2.1) mm Hg to(8.2±3.4) mm Hg(P0.05).In the study group,decreased VD in the macular parainferior region was associated with CSFP reduction(R^(2)=0.192,P=0.003),the reduction of macular VD in parafoveal(R^(2)=0.098,P=0.018),parainferior(R^(2)=0.104,P=0.021),parasuperior(R^(2)=0.059,P=0.058),paranasal(R^(2)=0.057,P=0.042),paratemporal(R^(2)=0.079,P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP *** vessel density did not differ after CSFP reduction(all P>0.05).In conclusion,macular vessel density decreased in association with CSFP *** vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction.

关键词： cerebrospinal fluid pressure reduction macular vessel density peripapillary vessel density blood pressure

LncRNA SNHG16 promotes colorectal cancer proliferation by regulating ABCB1 expression through sponging miR-214-3p

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The Journal of Biomedical Research 2022年第4期36卷 231-241页

作者： Pei Tan Mu Xu Junjie Nie Jian Qin xiangxiang liu Huiling Sun Shukui Wang Yuqin Pan General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China School of Medicine Southeast UniversityNanjingJiangsu 210009China Jiangsu Collaborative Innovation Center on Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211100China

Mounting evidence indicates that long non-coding RNAs(lncRNAs)have critical roles in colorectal cancer(CRC)progression,providing many potential diagnostic biomarkers,prognostic biomarkers,and treatment ***,we sought to investigate the role and underlying regulatory mechanism of lncRNA small nucleolar RNA host gene 16(SNHG16)in *** expressions of SNHG16 in CRC were identified by RNA-sequencing and quantitative reverse transcription *** functions of SNHG16 were explored by a series of in vitro and in vivo assays(colony formation assay,flow cytometry assay,and xenograft model).Bioinformatics analysis,RNA fluorescence in situ hybridization and luciferase reporter assay were used to investigate the regulatory mechanism of effects of ***16 was found to be significantly elevated in human CRC tissues and cell *** studies suggested that SNHG16 promoted CRC cell growth both in vitro and in ***,we identified that SNHG16 is expressed predominantly in the ***16 could interact with miR-214-3p and up-regulated its target *** study indicated that SNHG16 plays an oncogenic role in CRC,suggesting it could be a novel biomarker and therapeutic target in CRC.

关键词： SNHG16 ATP-binding cassette subfamily B member 1 microRNA colorectal cancer ceRNA

Reclassifying Early-Stage Colorectal Cancer into Two Subgroups with Different Overall Survival,Tumor Microenvironment,and Response to Immune Checkpoint Blockade Treatment

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Reclassifying Early-Stage Colorectal Cancer into Two Subgrou...

基于SSA-MPC-SMC的四旋翼无人机轨迹跟踪

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： xiangxiang liu Shukui Wang Nanjing First Hospital Nanjing Medical University

Purpose:The traditional TNM staging system is often insufficient to differentiate the survival discrepancies of colorectal cancer(CRC) patients at early stages(TNM-Ⅰ/Ⅱ).Our study aimed to reclassify early-stage CRC patients into several subgroups with different prognoses and explore their suitable therapeutic *** and methods:Single-cell RNA(scRNA) sequencing data,bulk RNA sequencing data,and clinicopathological information of CRC patients were enrolled from the TCGA and GEO *** tumor microenvironment of CRC tissues was accessed by the ESTIMATE *** prognostic genes were identified by Cox regression *** and KEGG analyses were conducted in the DAVID *** analysis was performed for annotation of the correlated gene ***:We successfully reclassified early-stage CRC patients into two subgroups and discovered that patients in cluster-2 underwent worse overall survival than those in *** analysis showed that immune-associated gene sets were positively enriched in ***,the differentially expressed genes(DEGs) between cluster-1 and cluster-2 patients also participated in immune-related biological processes and signaling ***,we found that more immune cells infiltrated the microenvironment of cluster-2 patients compared to that of cluster-1 patients,such as Tregs and tumor-associated *** sequencing analysis uncovered that most of the enriched immune-associated signaling in cluster-2 patients was mainly attributed to these upregulated immune cells whose infiltration levels were also high in CRC tissues rather than in normal *** addition,we demonstrated that the expression of immune checkpoint genes was significantly higher in cluster-2 patients compared to cluster-1 *** sequencing analysis revealed that the infiltrated CD8+T cells in CRC were na?ve T cells and can be activated into effector T cells after immune checkpoint blockade(ICB) ***

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弹道学报 2024年第3期36卷 49-57页

作者：唐亮刘响响江西工业工程职业技术学院信息工程学院江西萍乡337000 上海海事大学物流工程学院上海201306

为解决六自由度四旋翼无人机(UAV)在轨迹跟踪控制过程中,因为存在复杂的外部未知干扰,而使系统的轨迹跟踪精度产生较大波动的问题,设计了一种新型的级联双闭环控制系统,分别针对速度误差和位置姿态误差。首先,使用模型预测控制(MPC)设... 详细信息

为解决六自由度四旋翼无人机(UAV)在轨迹跟踪控制过程中,因为存在复杂的外部未知干扰,而使系统的轨迹跟踪精度产生较大波动的问题,设计了一种新型的级联双闭环控制系统,分别针对速度误差和位置姿态误差。首先,使用模型预测控制(MPC)设计速度闭环控制器,麻雀搜索算法(SSA)因具有快速收敛性和强鲁棒性,被应用于MPC滚动优化进程求取最优解。为了克服MPC存在的计算量过大的缺点,使用滑模控制(SMC)分别设计位置和姿态动力学控制器。SMC对外界干扰不敏感、鲁棒性强、无需精确建模,从而解决了UAV外部干扰不确定以及难以准确建模的问题。使用饱和函数替代符号函数,使实际系统的输入具有连续性,从而有效地减轻SMC中的高频抖振现象。最后使用李雅普诺夫理论验证所提出的SSA-MPC控制器的稳定性。实验结果表明:在受到复杂的外部未知干扰以及参数不确定的情况下,所提出的方法能够保证六自由度四旋翼UAV实现高精度跟踪,且控制效果明显优于传统单一控制器构成的UAV控制系统。所提出的级联控制器可以有效地实现复杂的外部未知干扰下的四旋翼UAV轨迹跟踪。

关键词：四旋翼无人机轨迹跟踪控制模型预测控制麻雀搜索算法滑模控制

不同工作模式下的IGBT模块瞬态热特性退化分析

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电工技术学报 2019年第S2期34卷 509-517页

作者：刘向向李志刚姚芳河北工业大学省部共建电工装备可靠性与智能化国家重点实验室

对于不同工作模式下的绝缘栅双极晶体管(IGBT)的热退化特性进行研究。首先设计模块动态测试实验,实时监测退化数据,同时应用瞬态双界面法间隔性地测量热阻的退化情况。根据实验结果,从失效机理方面分析退化条件和各层材料的退化情况之... 详细信息

对于不同工作模式下的绝缘栅双极晶体管(IGBT)的热退化特性进行研究。首先设计模块动态测试实验,实时监测退化数据,同时应用瞬态双界面法间隔性地测量热阻的退化情况。根据实验结果,从失效机理方面分析退化条件和各层材料的退化情况之间的关系。同时以有限元分析方法作为辅助手段,验证了实验测量的有效性,且更加直观地得到在不同边界条件下IGBT的热模型。研究结果表明,温度波动对于模块退化特性的影响要远高于温度和开关频率对模块造成的影响。较高的频率对于模块的影响主要在芯片内部,而温度波动对于模块的影响主要在包装级别。

关键词：瞬态双界面法结构函数时间常数谱退化

Prognostic role of long non-coding RNA TUG1 in various cancers: a meta-analysis

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Prognostic role of long non-coding RNA TUG1 in various cance...

Discrete Time Fast Terminal Sliding-Mode for Steer-by-Wire Systems with Nonlinear Disturbance Observer

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： xiangxiang liu Yuqin Pan Tao Xu Xiuxiu Hu Xiaoxiang Chen Shukui Wang Nanjing First Hospital Nanjing Medical University

Background: Long non-coding RNA(lncRNA) plays a crucial role in the development and progression of cancers. A large amount of studies have revealed that the lncRNA taurine upregulated gene1(TUG1) was aberrantly expressed in cancers and related to prognosis of patients with cancer. However, the conclusion was always elusive due to the inconsistent results of published studies. To clearly understand the prognostic role of TUG1 for patients with cancer, this meta-analysis was performed. Methods: We conducted a comprehensive search in PubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure and Wanfang, and the pooled results were drawn from the eligible papers enrolled by the standards of defined inclusion and exclusion criteria. In order to explore the relationship between TUG1 expression and overall survival(OS), hazard ratio(HR) and 95% confidence interval(CI) were calculated. Besedes, risk ratios(RRs)were calculated to assess the association between TUG1 expression and pathologicalparameters. Results: A total of 11 eligible studies containing 1252 patients were enrolled in the meta-analysis. The results revealed that there was a significant association between high expression level of TUG1 and overall survival(OS) of patients with cancer(HR=1.30;95% CI: 1.02-1.65). Subgroup analysis based on cancer type showed that urinary system cancer patients with high TUG1 expression experienced a poor OS(HR=2.76;95% CI: 1.74-4.39). In contrast, in the non-small cell lung cancer(NSCLC) subgroup, patients with high TUG1 expression have a longer OS(HR=0.78;95% CI: 0.69-0.87). The pooled result of clinicopathological parameters demonstrated that enhancive expression of TUG1 was positively correlated with elevated risk of distant metastasis in digestive system malignancies(RR=3.72;95% CI: 1.84-7.51). Conclusion: Aberrant expression of TUG1 is intimately related to an unfavorable prognosis of patients with urinary system cancer or NSCLC, suggesting

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Discrete Time Fast Terminal Sliding-Mode for Steer-by-Wire S...