检索结果-南通市图书馆

3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma

引用

Acta Pharmaceutica Sinica B 2020年第2期10卷 301-312页

作者： Wan Li Liwen Ren xiangjin zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Glioblastoma is the most common and aggressive primary tumor in the central nervous system,accounting for 12%-15%of all brain tumors.3-O-Acetyl-11-keto-β-boswellic acid(AKBA),one of the most active ingredients of gum resin from Boswellia carteri Birdw.,was reported to inhibit the growth of glioblastoma cells and subcutaneous ***,whether AKBA has antitumor effects on orthotopic glioblastoma and the underlying mechanisms are still *** orthotopic mouse model was used to evaluate the anti-glioblastoma effects of *** effects of AKBA on tumor growth were evaluated using *** effects on the alteration of metabolic landscape were detected by *** underlying mechanisms of autophagy reducing by AKBA treatment were determined by immunoblotting and immunofluorescence,*** electron microscope was used to check morphology of cells treated by *** results showed that AKBA(100 mg/kg)significantly inhibited the growth of orthotopic U87-MG *** from MALDI-MSI showed that AKBA improved the metabolic profile of mice with glioblastoma,while immunoblot assays revealed that AKBA suppressed the expression of ATG5,p62,LC3 B,p-ERK/ERK,and P53,and increased the ratio of p-mTOR/*** together,these results suggested that the antitumor effects of AKBA were related to the normalization of aberrant metabolism in the glioblastoma and the inhibition of *** could be a promising chemotherapy drug for glioblastoma.

关键词： Glioblastoma AKBA MALDI-MSI Phospholipids Autophagy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MELK is an oncogenic kinase essential for metastasis,mitotic progression,and programmed death in lung carcinoma

引用

Signal Transduction and Targeted Therapy 2021年第1期6卷 83-94页

作者： Qin Tang Wan Li xiangjin zheng Liwen Ren Jinyi Liu Sha Li Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines BeijingChina Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical College100050 BeijingChina

Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade,and remains difficult to ***,the molecular mechanisms underlying its development are still *** this study,bioinformatics analysis showed that MELK was highly expressed in lung cancer and negatively correlated to the survival of lung adenocarcinoma(LUAD).Immunohistochemistry analysis of LUAD patient tissues revealed there were a high level of MELK expression in *** of MELK expression inhibits the migration and invasion of LUAD cells,which may be mediated by Twist1,Slug,MMP7,and *** of MELK promoted the growth of LUAD cells in medium,3D Matrigel,and nude *** of MELK by OTSSP167 arrested cycle of LUAD cells at G2/M phase via PLK1-CDC25C-CDK1 pathway,and triggered apoptosis-mediated ***,these data indicate that MELK is critical for metastasis,mitotic progression,and programmed death of LUAD and may be a promising therapeutic target for LUAD.

关键词： metastasis PLK1 lung

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ganglioside GD3 synthase(GD3S),a novel cancer drug target

引用

Acta Pharmaceutica Sinica B 2018年第5期8卷 713-720页

作者： Jinyi Liu xiangjin zheng Xiaocong Pang Li Li Jinhua Wang Cui Yang Guanhua Du Ethnic Drug Screening & Pharmacology Center Key Laboratory of Chemistry in Ethnic Medicinal Resources State Ethnic Affairs Commission & Ministry of Education Yunnan Minzu University Key Laboratory of Drug Target Research and Drug Screen Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College

Gangliosides are a class of important glycosphingolipids containing sialic acid that are widely distributed on the outer surface of cells and are abundantly distributed in brain tissue. Disialoganglioside with three glycosyl groups(GD3) and disialoganglioside with two glycosyl groups(GD2) are markedly increased in pathological conditions such as cancers and neurodegenerative diseases. GD3 and GD2 were found to play important roles in cancers by mediating cell proliferation, migration, invasion, adhesion,angiogenesis and in preventing immunosuppression of tumors. GD3 synthase(GD3S) is the regulatory enzyme of GD3 and GD2 synthesis, and is important in tumorigenesis and the development of *** study of GD3S as a drug target may be of great significance for the discovery of new drugs for cancer treatment. This review will describe the gangliosides and their roles in physiological and pathological conditions; the roles of GD3 and GD2 in cancers; the expression, functions and mechanisms of GD3S,and its potential as a drug target in cancers.

关键词： Ganglioside GD3 GD2 GD3S Drug target Cancer treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tumorigenic bacteria in colorectal cancer:mechanisms and treatments

引用

Cancer Biology & Medicine 2022年第2期19卷 147-162页

作者： Sha Li Jinyi Liu xiangjin zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Colorectal cancer(CRC)is the third most common and the second most fatal *** recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of *** bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella *** been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal *** bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,*** toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from *** bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 ***,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy *** with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different *** this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial *** bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced *** bacteria may be useful as biomarkers or therapeutic targets for CRC.

关键词： Colorectal cancer microbiota tumorigenic mechanism genotoxicity cancer pathways tumor immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Author correction to‘3-O-Acetyl-11-keto-bboswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma’[Acta Pharm Sin B 10(2020)301-312]

引用

Acta Pharmaceutica Sinica B 2024年第8期14卷 3783-3784页

作者： Wan Li Liwen Ren xiangjin zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

The authors apologize for two inadvertent mistakes in Fig.5:the image of immunofluorescence of LC3B in the Vehicle group(Fig.5c)and the image of transmission electron microscope in the AKBA 10 mmol/L group(Fig.5f)were provided *** corrected Fig.5 is shown *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： correction Office image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The biology,function,and applications of exosomes in cancer

引用

Acta Pharmaceutica Sinica B 2021年第9期11卷 2783-2797页

作者： Jinyi Liu Liwen Ren Sha Li Wan Li xiangjin zheng Yihui Yang Weiqi Fu Jie Yi Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Clinical Laboratory Peking Union Medical College HospitalBeijing 100730China

Exosomes are cell-derived nano vesicles with diameters from 30 to 150 nm,released upon fusion of multi vesicular bodies with the cell *** can transport nucleic acids,proteins,and lipids for intercellular communication and activate signaling pathways in target *** cancers,exosomes may participate in growth and metastasis of tumors by regulating the immune response,blocking the epithelial-mesenchymal transition,and promoting *** are also involved in the development of resistance to chemotherapeutic *** in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of *** of their amphipathic structure,exosomes are natural drug delivery vehicles for cancer therapy.

关键词： Exosomes Tumor immunity Tumor metastasis Drug resistance Biomarkers Drug delivery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

引用

Acta Pharmaceutica Sinica B 2021年第11期11卷 3465-3480页

作者： xiangjin zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Pharmacology Capital Medical UniversityBeijing 100069China

Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for *** of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of ***,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying ***33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 *** also arrested the cell cycle at G2/M phase and induced mitochondria-dependent *** gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the ***33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR ***,SW33 appears to be a promising drug for treating GBM effectively and safely.

关键词： SW33 GBM G2/M phase Apoptosis Autophagy mTOR Anti-inflammation Safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB/IL-6/STAT3 and JNK/PTX3 pathways

引用

Acta Pharmaceutica Sinica B 2022年第12期12卷 4390-4406页

作者： Wan Li Hongqing Cai Liwen Ren Yihui Yang Hong Yang Jinyi Liu Sha Li Yizhi Zhang xiangjin zheng Wei Tan Guanhua Du Jinhua Wang The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Pharmacy Xinjiang Medical UniversityUrumqi 830011China Xinjiang Institute of Materia Medica Urumqi 830004China

Glioblastoma(GBM)is the most challenging malignant tumor of the central nervous system because of its high morbidity,mortality,and recurrence ***,mechanisms of GBM are still unclear and there is no effective drug for GBM in the ***,it is urgent to identify new drug targets and corresponding drugs for *** this study,in silico analyses and experimental data show that sphingosine kinase 1(SPHK1)is up-regulated in GBM patients,and is strongly correlated with poor prognosis and reduced overall *** of SPHK1 promoted the proliferation,invasion,metastasis,and clonogenicity of GBM cells,while silencing SPHK1 had the opposite ***1 promoted inflammation through the NF-κB/IL-6/STAT3 signaling pathway and led to the phosphorylation of JNK,activating the JNK-JUN and JNK-ATF3 pathways and promoting inflammation and proliferation of GBM cells by transcriptional activation of ***1 interacted with PTX3 and formed a positive feedback loop to reciprocally increase expression,promote inflammation and GBM *** of SPHK1 by the inhibitor,PF543,also decreased tumorigenesis in the U87-MG and U251-MG SPHK1 orthotopic mouse *** summary,we have characterized the role and molecular mechanisms by which SPHK1 promotes GBM,which may provide opportunities for SPHK1-targeted therapy.

关键词： Glioblastoma Drug target SPHK1 Inflammation NF-κB/IL-6/STAT3 signal pathway ATF3 PXT3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress on diagnostic and prognostic markers of pancreatic cancer

引用

Oncology Research 2023年第2期31卷 83-99页

作者： HONG YANG WAN LI LIWEN REN YIHUI YANG YIZHI ZHANG BINBIN GE SHA LI xiangjin zheng JINYI LIU SEN ZHANG GUANHUA DU BO TANG HONGQUAN WANG JINHUA WANG The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100050China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate,whose patients are mostly at the stage of locally advanced or metastatic disease when first *** diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment *** far,CA19-9 is the only biomarker for pancreatic cancer approved by the FDA,but its effectiveness is limited by low sensitivity and *** recent advances in genomics,proteomics,metabolomics,and other analytical and sequencing technologies,the rapid acquisition and screening of biomarkers is now *** biopsy also occupies a significant place due to its unique *** this review,we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer.

关键词： Pancreatic cancer Biomarkers Liquid biopsy Systematic review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

引用

Signal Transduction and Targeted Therapy 2024年第8期9卷 3533-3536页

作者： Qin Tang Wan Li xiangjin zheng Liwen Ren Jinyi Liu Sha Li Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College 100050 Beijing China

After online publication of the article[1]the authors noticed inadvertent errors in the panel of 95-D cells(+MELK and-siSlug)invasion in Fig.2J which is partly overlapped with the panel of the 95-D cells(+MELK and+siS... 详细信息

关键词： MMP7 metastasis death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：