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Intelligent risk identification of gas drilling based on nonlinear classification network

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Petroleum Science 2023年第5期20卷 3074-3084页

作者： Wen-He Xia Zong-Xu Zhao cheng-Xiao Li Gao Li Yong-Jie Li Xing Ding xiang-dong chen School of Electrical Engineering and Information Southwest Petroleum UniversityChengdu 610500SichuanChina CCDC Drilling&Production Engineering Technology Research Institute Deyang 618500SichuanChina School of Oil&Natural Gas Engineering Southwest Petroleum UniversityChengdu 610500SichuanChina School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina

During the transient process of gas drilling conditions,the monitoring data often has obvious nonlinear fluctuation features,which leads to large classification errors and time delays in the commonly used intelligent classification *** with the structural features of data samples obtained from monitoring while drilling,this paper uses convolution algorithm to extract the correlation features of multiple monitoring while drilling parameters changing with time,and applies RBF network with nonlinear classification ability to classify the *** the training process,the loss function component based on distance mean square error is used to effectively adjust the best clustering center in *** field applications show that,the recognition accuracy of the above nonlinear classification network model for gas production,water production and drill sticking is 97.32%,95.25%and 93.78%.Compared with the traditional convolutional neural network(CNN)model,the network structure not only improves the classification accuracy of conditions in the transition stage of conditions,but also greatly advances the time points of risk identification,especially for the three common risk identification points of gas production,water production and drill sticking,which are advanced by 56,16 and 8 *** has won valuable time for the site to take correct risk disposal measures in time,and fully demonstrated the applicability of nonlinear classification neural network in oil and gas field exploration and development.

关键词： Gas drilling Intelligent identification of drilling risk Nonlinear classification RBF Neural Network K-means algorithm

Assessing performance of augmented reality-based neurosurgical training

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 45-54页

作者： Wei-Xin Si xiang-Yun Liao Yin-Ling Qian Hai-Tao Sun xiang-dong chen Qiong Wang Pheng Ann Heng Guangdong Provincial Key Laboratory of Computer Vision and Virtual Reality Technology Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences1068 Xueyuan AvenueShenzhen University TownShenzhen 518055China Department of Neurosurgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China E.N.T.department of Shenzhen University General Hospital Shenzhen 518055China Department of Computer Science and Engineering the Chinese University of Hong KongHong KongChina

This paper presents a novel augmented reality(AR)-based neurosurgical training simulator which provides a very natural way for surgeons to learn neurosurgical *** simulation with bimanual haptic interaction is integrated in this work to provide a simulated environment for users to achieve holographic guidance for pre-operative *** achieve the AR guidance,the simulator should precisely overlay the 3D anatomical information of the hidden target organs in the patients in real *** this regard,the patient-specific anatomy structures are reconstructed from segmented brain magnetic resonance *** propose a registration method for precise mapping of the virtual and real *** addition,the simulator provides bimanual haptic interaction in a holographic environment to mimic real brain tumor *** this study,we conduct AR-based guidance validation and a user study on the developed simulator,which demonstrate the high accuracy of our AR-based neurosurgery simulator,as well as the AR guidance mode’s potential to improve neurosurgery by simplifying the operation,reducing the difficulty of the operation,shortening the operation time,and increasing the precision of the operation.

关键词： Augmented reality Personalized virtual operative anatomy Neurosurgical training

Preparation of Tolterodine Metabolite Loaded Biodegradable PLGA Microspheres

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Chemical Research in Chinese Universities 2010年第1期26卷 75-80页

作者： TENG Le-sheng JIANG Chao-jun LIN xiang-you dong Yuan-chen LI Chun-mei MENG Qing-fan LI You-xin College of Life Science Jilin University Changehun 130012 P. R. China

Biodegradable polymer poly（lactic-co-glycolic acid）（PLGA） was used to encapsulate the pharmacological activity metabolite of tolterodine by means of O/W emulsion solvent evaporation method via homogenization in the emulsification process. The influences of preparation parameters were investigated. The results indicate that increa- sing PLGA concentration from 15% to 40% made the encapsulation efficiency of 5-hydroxymethyl derivative of tol- terodine（5-HMT） increased from 55.39% to 76.32%, and the particle size increased from 34.33 μm to 70,78 lain. In addition, when homogenization speed increased from 850 r/min to 2300 r/min, both particle size and encapsulation efficiency of microspheres decreased. An increase in the volume of aqueous phase led to higher encapsulation efficiency and bigger particle size. Increasing temperature made encapsulation efficiency and particle size change significantly. While reaction temperature increased from 20 ℃ to 50 ℃, the encapsulation efficiency decreased from 70.44% to 24.07%, and particle size increased from 38.66 μm to 69.38 μm. High reaction temperature（over 40 ℃） may lead to porous surface of microspheres. Porous surface, encapsulation efficiency and particle size influenced on the in vitro release of 5-HMT together.

关键词： Poly(lactic-co-glycolic acid) Microsphere Tolterodine Tolterodine metabolite

A Bright Single-Photon Source from Nitrogen-Vacancy Centers in Diamond Nanowires

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Chinese Physics Letters 2017年第9期34卷 70-73页

作者： Shen Li Cui-Hong Li Bo-Wen Zhao Yang dong Cong-Cong Li xiang-dong chen Ya-Song Ge Fang-Wen Sun Key Lab of Quantum Information Chinese Academy of Sciences University of Science and Technology of China Hefei 230026 Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100049

Single-photon flux is one of the crucial properties of nitrogen vacancy （NV） centers in diamond for its application in quantum information techniques. Here we fabricate diamond conical nanowires to enhance the single-photon count rate. Through the interaction between tightly confined optical mode in nanowires and NV centers, the single-photon lifetime is much shortened and the collection efficiency is enhanced. As a result, the detected single-photon rate can be at 564 kcps, and the total detection coefficient can be 0.8%, which is much higher than that in bulk diamond. Such a nanowire single-photon device with high photon flux can be applied to improve the fidelity of quantum computation and the precision of quantum sensors.

关键词： A Bright Single-Photon Source from Nitrogen-Vacancy Centers in Diamond Nanowires

General anesthesia mediated by effects on ion channels

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World Journal of Critical Care Medicine 2012年第3期1卷 80-93页

作者： cheng Zhou Jin Liu xiang-dong chen Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine Translational Neuroscience Center West China Hospital Sichuan University

Although it has been more than 165 years since the first introduction of modern anesthesia to the clinic, there is surprisingly little understanding about the exact mechanisms by which general anesthetics induce unconsciousness. As a result, we do not know how general anesthetics produce anesthesia at different levels. The main handicap to understanding the mechanisms of general anesthesia is the diversity of chemically unrelated compounds including diethyl ether and halogenated hydrocarbons, gases nitrous oxide, ketamine, propofol, benzodiazepines and etomidate, as well as alcohols and barbiturates. Does this imply that general anesthesia is caused by many different mechanisms? Until now, many receptors, molecular targets and neuronal transmission pathways have been shown to contribute to mechanisms of general anesthesia. Among these molecular targets, ion channels are the most likely candidates for general anesthesia, in particular γ-aminobutyric acid type A, potassium and sodium channels, as well as ion channels mediated by various neuronal transmitters like acetylcholine, amino acids amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid or N-methyl-D-aspartate. In addition, recent studies have demonstrated the involvement in general anesthesia of other ion channels with distinct gating properties suchas hyperpolarization-activated, cyclic- nucleotide-gated channels. The main aim of the present review is to summarize some aspects of current knowledge of the effects of general anesthetics on various ion channels.

关键词： General anesthesia Ion channels γ-aminobutyric acid type A receptors Hyperpolarization activated cyclic nucleotide Potassium channels Glutamatergic ion channels Sodium channels

Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway

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Journal of Integrative Medicine 2023年第5期21卷 496-508页

作者： Yuan-yuan Ding Feng Xu Ya-feng Wang Lin-lin Han Shi-qian Huang Shuai Zhao Lu-lin Ma Tian-hao Zhang Wen-jing Zhao xiang-dong chen Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

Objective This work explores the impact of electroacupuncture(EA)on acute postoperative pain(APP)and the role of stimulator of interferon genes/type-1 interferon(STING/IFN-1)signaling pathway modulation in the analgesic effect of EA in APP *** The APP rat model was initiated through abdominal surgery and the animals received two 30 min sessions of EA at bilateral ST36(Zusanli)and SP6(Sanyinjiao)***,thermal and cold sensitivity tests were performed to measure the pain threshold,and electroencephalograms were recorded in the primary somatosensory cortex to identify the effects of EA treatment on *** blotting and immunofluorescence were used to examine the expression and distribution of proteins in the STING/IFN-1 pathway as well as neuroinflammation.A STING inhibitor(C-176)was administered intrathecally to verify its role in *** APP rats displayed mechanical and thermal hypersensitivities compared to the control group(P<0.05).APP significantly reduced the amplitude ofθ,αandγoscillations compared to their baseline values(P<0.05).Interestingly,expression levels of proteins in the STING/IFN-1 pathway were downregulated after inducing APP(P<0.05).Further,APP increased pro-inflammatory factors,including interleukin-6,tumor necrosis factor-αand inducible nitric oxide synthase,and downregulated anti-inflammatory factors,including interleukin-10 and arginase-1(P<0.05).EA effectively attenuated APP-induced painful hypersensitivities(P<0.05)and restored theθ,αandγpower in APP rats(P<0.05).Meanwhile,EA distinctly activated the STING/IFN-1 pathway and mitigated the neuroinflammatory response(P<0.05).Furthermore,STING/IFN-1 was predominantly expressed in isolectin-B4-or calcitonin-gene-related-peptide-labeled dorsal root ganglion neurons and superficial laminae of the spinal dorsal *** of the STING/IFN-1 pathway by intrathecal injection of C-176 weakened the analgesic and anti-inflammatory effects of EA on APP(P<0.05).Conclusion

关键词： Electroacupuncture Inflammation Pain Primary sensory neurons Stimulator of interferongenes Type-1 interferon

High-sensitivity and wide-bandwidth fiber-coupled diamond magnetometer with surface coating

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Photonics Research 2022年第9期10卷 2191-2201页

作者： SHAO-CHUN ZHANG HAO-BIN LIN YANG dong BO DU XUE-dong GAO CUI YU ZHI-HONG FENG xiang-dong chen GUANG-CAN GUO FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center For Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China National Key Laboratory of ASIC Hebei Semiconductor Research InstituteShijiazhuang 050051China

Mapping magnetic fields from different materials and structures can provide a powerful means for broad applications of activity probe and feature ***,we present a high-sensitivity and wide-bandwidth fiber-based quantum magnetometer at the scale of a few hundred *** propose a fiber-coupled diamond *** a pulsed optically detected magnetic resonance spectrum allows a magnetic field sensitivity of 103 pT∕■and a bandwidth of 2.6 k ***,with an approach of coating the diamond surface with silver reflective film,both the fluorescence collection and excitation efficiency are significantly enhanced,and the sensitivity and bandwidth are expected to be further improved to 50 pT∕■and 4.1 k Hz,***,this fiber-based quantum magnetometer is applied as a probe to successfully map the magnetic field induced by the current-carrying copper-wire *** a stable and compact magnetometer can provide a powerful tool in many areas of physical,chemical,and biological researches.

关键词： coating magnetometer fiber

Picotesla fiberized diamond-based AC magnetometer

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Photonics Research 2024年第6期12卷 1250-1261页

作者： SHAO-CHUN ZHANG YONG LIU LONG-KUN SHAN XUE-dong GAO JIA-QI GENG CUI YU YANG dong xiang-dong chen GUANG-CAN GUO FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China National Key Laboratory of ASIC Hebei Semiconductor Research InstituteShijiazhuang 050051China Electric Power Quantum Sensing Joint Laboratory of Anhui Province State Grid Anhui Electric Power Research InstituteHefei 230601China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Portable quantum sensors are crucial for developing practical quantum sensing and metrology *** nitrogen-vacancy(NV)centers in diamonds have emerged as one of the most promising candidates for compact quantum ***,due to the difficulty of coherently controlling the ensemble spin and noise suppression in a large volume,it often faces problems such as reduced sensitivity and narrowed bandwidth in integrated lensless ***,we propose a fluorescence signal treatment method for NV spin ensemble manipulation by the exponential fitting of spin polarization processes,instead of integrating the photon *** enables spin state readout with a high signal-to-noise ratio and applies to the pulse sensing protocols for large-volume NV *** on this,we further developed a fiberized diamond-based AC *** an XY8-N dynamical decoupling pulse sequence,we demonstrated a T_(2)-limited sensitivity of 8pT/√Hz and T_(1)-limited frequency resolution of 90 Hz over a wide frequency band from 100 kHz to 3 *** integrated diamond sensor leverages quantum coherence to achieve enhanced sensitivity in detecting AC magnetic fields,making it suitable for implementation in a compact and portable endoscopic sensor.

关键词： magnetometer quantum ensemble

Bipolar charged aerosol agglomeration and collection by a two-zone agglomerator

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Journal of Environmental Sciences 2001年第3期13卷 276-279页

作者： xiang Xiao dong 1, chen Bao zhi 1, COLBECK I 2 (1. School of Resource and Civil Engineering, Northeastern University, Shenyang 110006, China. 2. Institute for Environmental Research, Department of Biological and Chemical Sciences, University of Es School of Resource and Civil Engineering Northeastern University Shenyang 110006 China.

In older to collect fine particles more efficiently, a new-type electrostatic agglomerator with two zones was developed. The distinguishing feature of this electrostatic agglomerator is that the particles are bipolarly charged and coagulated in the same alternating electric field simultaneously. The silica flour with 2 fun mass median diameter and the smoke from burning wood powder were used as test aerosol. The comparison experimental results have shown that when the mean electric field is 4 kV/cm the collection efficiency of the new electrostatic agglomerator was 98.2% for silica flour and 67.4% for wood powder smoke, Under the same experimental condition. the collection efficiency of the electrostatic agglomerator with three zones was 97.4% for collecting silica flour and the collection efficiency of the electrostatic precipitator was 56.3% for wood powder smoke.

关键词： charged particle agglomeration alternating electric field electrostatic agglomerator (EA) electrostatic precipitator (ESP) collection efficiency