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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-mei xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan Liu Wei Yuan Xue mei Jing Li Tao Li Rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

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Identification and Functional Analysis of Differentially Expressed Genes of Ascaris suum Goeze,1782 from Ascaris lumbricoides Linnaeus, 1758

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Agricultural Sciences in China 2010年第6期9卷 903-910页

作者： WU Shao-qiang LIN xiang-mei ZHU Xing-quan Institute of Animal and Plant Quarantine Chinese Academy of Inspection and Quarantine Beijing 100029 P.R.China State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 P.R. China

In order to provide further evidence to prove that Ascaris suum Goeze,1782 and Ascaris lumbricoides Linnaeus,1758 are really different species in taxonomy,and to identity *** larval migrans-related genes for diagnosis and prevention use,*** genes that were differentialy expressed from the same gender of *** were enriched by subtracting the same expressed genes using suppression subtractive hybridization （SSH） *** of the selectively enriched cDNA was verified by Southern blot *** female *** specific cDNA library was then constructed and *** local alignment search tool （BLAST） analysis of female *** specific cDNA identified 6 specific ESTs with tentative functions related to larva *** study provided further evidence for differentiating *** from *** for the detailed information and application of the 6 ESTs are worth being done in the future studies.

关键词： Ascaris suum Ascaris lumbricoides nematode suppression subtractive hybridization EST larva migrans

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Removal of Cr from tannery sludge by bioleaching method

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Journal of Environmental Sciences 2006年第5期18卷 885-890页

作者： ZHOU Shun-gui ZHOU Li-xiang WANG Shi-mei FANG Di College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China

Bioleaching of Cr（Ⅲ） from tannery sludge using the mixture of ingenuous iron- and sulfur-oxidizing bacteria was investigated in batch flasks. Experiments involved the adaptation of indigenous iron-and sulfur-oxidizing bacteria, the pre-acidification the sludge to pH 6.0 and the addition of energy substrates. Results showed the inoculation of mixture of ingenuous iron- and sulfur-oxidizing bacteria and co-addition of Fe^2 and elemental sulfur accelerated acid production and increase of oxidation-reduction potential originating from the bio-oxidation of Fe2^＋ and elemental sulfur. Dissolved Cr concentration increased concomitant with pH decreased in the sludge and reached its maximum removal of 95.6%. The amelioration of the odor of bioleached sludge could be noted. However, 20.4%o of N, 24.5% of P and 14.3% of organic matter were lost in the bioleaching process. The residual Cr content in the leached tannery sludge was acceptable for use in agriculture. This study had shown the feasibility of applying the bioleaching process, developed for sewage sludge, to tannery sludge with high Cr.

关键词： tannery sludge: Cr: removal: bioleaching

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Morphology and features of Cambrian oncoids and responses to palaeogeography of the North China Platform

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Journal of Palaeogeography 2020年第2期9卷 150-167页

作者： En-Zhao Xiao Ming-xiang mei Shu Jiang Tehseen Zafar School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education and Faculty of Earth Resources China University of Geosciences(Wuhan)Wuhan 430074China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081China Institute of Geology University of the PunjabLahore 54590Pakistan

The Cambrian strata in the North China Platform are fully exposed. A wide variety of carbonate oncoids with different shapes occur in the Xuzhuang and Zhangxia formations(Miaolingian Series) from six Cambrian sections in the study area. A comprehensive study involving outcrop description, microscopic observation, scanning electron microscopy(SEM), energy dispersive X-ray spectroscopy(EDX), X-ray diffraction(XRD), and carbon and oxygen isotope analysis is conducted to determine the facies, morphology, internal structure, and geochemical properties of the oncoids. The oncoids are divided into six types based on their morphology and internal *** and ultrastructural observations reveal typical microbial fossils(Girvanella) and microbially-related sediments(framboidal pyrite), indicating the biogenicity of the oncoids. Additionally, the XRD and carbon and oxygen isotope analysis results suggest that the formational environments of these oncoids are different due to terrestrial influences. Statistical data on the oncoids from the six sections show that there are obvious differences in the types of oncoids and the proportions of different varieties in each section. The spatial differences in the oncoid morphologies are associated with different palaeogeographic settings. The rough oncoid growth patterns developed in nearshore environments were influenced by terrigenous debris and steep terrain, whereas the delicate oncoid growth patterns developed in offshore environments were less affected by terrestrial factors and were featured by more stable depositional processes related to microbial mats.

关键词： Morphological classification Microbial m at Girvonello Carbon and oxygen isotopes Miaolingian series North China

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Bifurcation of Periodic Orbits and Chaos in Duffing Equation

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Acta Mathematicae Applicatae Sinica 2006年第3期22卷 495-508页

作者： mei-xiang Cai Jian-ping Yang Department of Mathcmatics Hunan Normal University Changsha 410081 China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 Chian and Graduate School of the Chinese Academy of Sciences Beijing 100039

Duffing equation with fifth nonlinear-restoring force, one external forcing and a phase shift is investigated, The conditions of existences for primary resonance, second-order, third-order subharmonics, morder subharmonics and chaos are given by using second-averaging method, Melnikov methods and bifurcation theory. Numerical simulations including bifurcation diagrams, bifurcation surfaces, phase portraits, not only show the consistence with the theoretical analysis, but also exhibit the new dynamical behaviors. We show the onset of chaos, chaos suddenly disappearing to period orbit, one-band and double-band chaos, period-doubling bifurcations from period 1, 2, and 3 orbits, period-windows （period-2, 3 and 5） in chaotic regions.

关键词： Duffing equation Melnikov's method second-order averaging method chaos

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三江源区适宜的小黑麦和饲用豌豆混播比例及施肥方法

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植物营养与肥料学报 2024年第8期30卷 1539-1553页

作者：冯廷旭林伟山向雪梅李菲张琳魏希杰德科加青海大学青海西宁810016 青海省畜牧兽医科学院青海西宁810016

【目的】三江源区地处青藏高原,是中国母亲河的发源地,也是牦牛等典型牲畜的重要草场。探索适宜的施肥方法和牧草作物混播比例,旨在提高牧草产量,减轻生态重要地区天然草场的放牧压力。【方法】于2022年在三江源地区进行了小黑麦和饲用... 详细信息

【目的】三江源区地处青藏高原,是中国母亲河的发源地,也是牦牛等典型牲畜的重要草场。探索适宜的施肥方法和牧草作物混播比例,旨在提高牧草产量,减轻生态重要地区天然草场的放牧压力。【方法】于2022年在三江源地区进行了小黑麦和饲用豌豆的田间试验,试验材料为小黑麦品种‘青饲麦1号’和饲用豌豆品种‘青建1号’。设置3个施肥处理:不施肥(A_(1))、单施氮肥(尿素75 kg/hm^(2),A_(2))、氮磷配合施用(尿素75 kg/hm^(2)和过磷酸钙300 kg/hm^(2),A3);每个施肥处理下,分别设小黑麦和豌豆混合播种比例70∶30(B1)、50∶50(B_(2))和30∶70(B_3)。在豌豆盛花期刈割前,调查小黑麦和饲用豌豆株高、叶片形态指标(面积、周长、长度、宽度),及生物量和营养品质。【结果】与不施肥处理A_(1)相比,施肥处理(A_(2)和A_3)显著提高了牧草的鲜重和干重、蛋白质产量以及两种作物的株高和叶面积。A_(2)和A_3处理在上述指标上没有显著差异,但A_3处理叶宽的增幅显著高于A_(2)。A_(2)和A_3处理对两种牧草粗蛋白、可溶性糖、中性和酸性洗涤纤维含量均无显著影响,但A_(2)处理增加了粗脂肪含量。小黑麦和饲用豌豆的播种比例对两种作物的鲜重、干重、蛋白质产量和株高没有显著影响,但降低小黑麦播种比例增加了饲草粗脂肪和可溶性糖含量,显著降低了中性与酸性洗涤纤维含量。播种比例与施肥有显著的交互作用,A_3B_(1)的牧草鲜重和干重最高,分别比其他处理高36.09%~180.08%和62.27%~281.59%,叶面积和蛋白质、可溶性糖含量也最高。A_3B_(1)处理的小黑麦叶片周长比A_(1)B_(1)、A_(1)B_(2)和A1B3处理分别高15.76%、40.29%和54.51%,饲用豌豆叶面积比A1B1、A1B2和A1B3处理分别提高20.31%、14.06%和64.65%,饲草中性洗涤纤维含量分别比A1B1、A1B2和A1B3处理增加了7.15%、27.14%和17.89%。【结论】氮磷配施可显著提高牧草生产性能、叶片形态和牧草质量。小黑麦和饲用豌豆按70∶30的比例混合播种,牧草生产性能、叶片形态和质量均优于其他处理。因此,在高寒地区,建议推广小黑麦和饲用豌豆按70∶30的比例混合播种,并配施氮、磷肥。

关键词：三江源地区禾豆混播比例氮磷配施叶片形态饲草产量饲草品质

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High efficiency hydrogen purification through P2C3 membrane:A theoretical study

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Chinese Physics B 2019年第12期28卷 389-392页

作者： Zhao-Qin Chu Xiao Gu xiang-mei Duan Department of Physics Ningbo UniversityNingbo 315211China Laboratory of Clean Energy Storage and Conversion Ningbo UniversityNingbo 315211China

It is critical to design an effective two-dimensional membrane for hydrogen purification from the mixed gas, due to its wide range of scientific and industrial applications. In this work, we investigate the hydrogen separation performance of P2C3 membranes by density functional theory and molecular dynamics simulations. The results show that the energy barrier of the H2 molecule through the P2C3 film is only 0.18 e V, while the energy barriers of the CO, N2, CO2, and CH4 molecules are 0.77 eV, 0.87 eV, 0.52 eV, and 1.75 eV, respectively. In addition, the P2C3 film has high H2 selectivity toward other gas molecules and high H2 permeability at room temperature. Under 6% tensile strain, 82% hydrogen molecules pass through the film with a H2 permeance of 2.22 × 107 gas permeance unit(GPU), while other molecules cannot across the membrane at all. Therefore, the P2C3 membrane is an excellent material for hydrogen purification.

关键词： two-dimensional membrane hydrogen separation first-principles

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Positive psychological intervention for anxiety, depression and coping in subjects addicted to online games

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World Journal of Clinical Cases 2021年第14期9卷 3287-3293页

作者： Xiu-Jun Gao Ji-Jun Sun mei xiang Department of Psychiatry Hangzhou Seventh People’s HospitalHangzhou 310013Zhejiang ProvinceChina Department of Elderly Psychiatry Hangzhou Seventh People’s HospitalHangzhou 310013Zhejiang ProvinceChina

BACKGROUND Addiction to online games is not *** patients usually refuse to take medications and present with affective symptoms such as anxiety,depression and negative coping *** intervention based on positive psychology is a promising treatment for such *** To evaluate the effect of positive psychological intervention on anxiety,depression and coping in people addicted to online *** This self-controlled study included 89 people addicted to online games,who received treatment at Hangzhou Seventh People’s Hospital,Hangzhou,China in *** Hamilton Anxiety Scale,Hamilton Depression Scale and Trait Coping Style Questionnaire were administered to evaluate the anxiety,depression and coping style among these *** intervention based on positive psychology was provided for 6 wk followed by another *** results were compared against those from the previous *** After 6 wk of psychological intervention,89 people achieved a significant improvement in the Hamilton Anxiety Scale and Hamilton Depression Scale-24 *** score for positive coping style in Trait Coping Style Questionnaire was significantly improved,while that of the negative coping style decreased significantly(P<0.05).CONCLUSION Psychological intervention based on positive psychology alleviated affective symptoms,such as anxiety and depression,in subjects addicted to online *** intervention corrected negative coping style,thereby improving mental health.

关键词： Online game addiction Positive psychology Anxiety Depression Coping style Psychological intervention

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Construction and Functionalization of Highly Strained N-Doped Zigzag Hydrocarbon Belts

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CCS Chemistry 2023年第1期5卷 117-123页

作者： Ming Xie Shuo Tong mei-xiang Wang MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084

Recent years have witnessed breakthroughs in the study of zigzag hydrocarbon ***,the synthesis of heterocycle-containing zigzag molecular belts remains very rare and challenging despite their interesting structures and potential applications in chemistry and materials ***,we report the expeditious construction of a highly strained belt[4]arene[4](1,4-dihydropyridine)structure using the fjords-stitching *** synthesis comprised four-fold abnormal m-bromination of four Npivaloylaniline units and Pd_(2)(dba)_(3)/4-Me_(2)NC_(6)H_(4)Pt Bu_(2)-catalyzed intramolecular C-N bond-forming *** functionalization through Narylations produced a variety of tetraza-embedded octahydrobelt[8]*** oxidation of p-methoxyphenyl-substituted belt[4]arene[4](1,4-dihydropyridine)with Ag[Al(O^(t)Bu^(F))^(4)]yielded a singlet diradical dication N-doped zigzag belt.

关键词： zigzag molecular belt cyclacene octahydrobeltarenepyridine meta-bromination of Nacylaniline palladium-catalyzed C-N bond formation diradical dication salt

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Tea consumption and risk of stroke:a dose-response meta-analysis of prospective studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 652-662页

作者： Li SHEN Liu-guang SONG Hong MA Chun-na JIN Jian-an WANG mei-xiang xiang Department of Cardiology the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Cardiovascular Key Lab of Zhejiang Province the Second A3filiated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

Objective:To determine the association between tea consumption and the risk of stroke. Methods:We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates. Results:Fourteen studies, consisting of 513 804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81-0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69-0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82-1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57-1.16). Conclusions:Tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes.

关键词： Tea Stroke Prospective studies Dose-response meta-analysis

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