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Corrosion Inhibition of SiCp/5A06 Aluminum Metal Matrix Composite by Cerium Conversion Treatment

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Chinese Journal of Aeronautics 2009年第6期22卷 670-676页

作者： Irfan Aziz Zhang Qi xiang min School of Materials Science and Engineering Beo'ing University of Aeronautics and Astronautics Beijing 100191 China

This article studies the effects of the CeCl3 concentrations in conversion solutions with and without addition of NaCl, pH-values of conversion solution, drying temperature, time and temperature of immersion on the Ce-conversion coatings for corrosion protection of the SiCp/5A06 Al-MMC and 5A06 Al-alloy in the 3.5% NaCl aqueous solution at room temperature. Potentiodynamic polarization tests reveal that the Ce-conversion treatment could markedly improve the pitting corrosion resistance of the composite and the matrix alloy in chloride containing environment. The best corrosion resistance effects are obtained for the samples treatment in 1% CeCl3.7H2O/3.5% NaCl solution at 45℃ for 60 min, followed by drying at 100 ℃ for 30 min. Examinations by means of scanning electron microscopy （SEM）, energy dispersion spectroscopy （EDS） and X-ray photoelectron spectroscopy （XPS） indicate that this behavior is due to the precipitation of Ce-oxides/hydroxides on the cathodic intermetallics and the Al-oxide film on the rest of the metal matrix.

关键词： cerium thermal coatings SiCp/5A06 Al matrix composites potentiodynamic polarization alkaline corrosion

Determination of the Flavonoids from Ginkgo Biloba Extract by High Performance Liquid Chromatography

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Chinese Chemical Letters 2002年第10期13卷 968-970页

作者： Li ZHANG Zhi min xiang Department of Food Science Hangzhou Institute of CommerceHangzhou 310035

HPLC method for analysis of the flavonoids from ginkgo biloba extract (GBE) was studied. By suitable selection of columns. symmetrical chromatographic peaks were obtained without using acidic modifier in the mobile phase, which can eliminate the time for cleaning the chromatographic system and simplify the analystic method for GBE Experimental conditions: column: Hypersil BDS C-18, 5mumx4x250 mm: column temperature: 35degreesC; mobile phase: 46% methanol-54% water; flow rate: 0.7 mL/min; detection wavelength: 360nm.

关键词： Ginkgo biloba extract flavone glycoside high performance liquid chromatography.

Subacute toxicity of exogenous manganese on rat hippocampal neurons Examination by MRI and optical microscopy

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Neural Regeneration Research 2008年第5期3卷 550-553页

作者： Xiaoli Xu Yun xiang min Yang School of Medicine ＆ Life Science Jianghan University Wuhan 430056 Hubei Province China

BACKGROUND： Manganism may cause learning and memory impairment by influencing the normal function of the hippocampus, however, this effect requires further examination. OBJECTIVE： To investigate the effects of manganism on the rat hippocampus using immunohistochemistry and MRI examination. DESIGN, TIME AND SETTING： A randomized controlled study, performed in the School of Medicine and Life Science, Jianghan University and the State Key Laboratory of Atomic ＆ Molecular Physics and Spectroscopy, Chinese Academy of Science, from July to September 2005. MATERIALS： Fourteen healthy SD rats aged two months were selected for this study. MnCl2 4H2O （BHD, UK）（batch number： 9791325）; glial fibrillary acidic protein （GFAP） staining kit （Beijing Zhongshan Biotechnology）; Biospec 4.7T/30 animal MRI formatter （Bruker, Germany）. METHODS： Fourteen rats were randomly divided into a control group （n =7） and a manganism group （n = 7）. Rats in the manganism group received intraperitoneal injection of MnCl2 · 4H2O （50 mg/kg）, once a day, for four successive days. Rats in the control group were injected according to the manganism regimen, but using saline instead of manganese solution. MAIN OUTCOME MEASURES： Twenty-four hours after the last injection, rats were examined using MRI. Immunohistochemically stained GFAP and hematoxylin-eosin stained hippocampal sections were observed under optical microscopy. RESULTS： Fourteen rats were included in the final analysis. After manganese treatment, T1 weighted image and inversion recovery MR1 demonstrated that the signal intensity was significantly enhanced in hippocampus, compared to controls. Neuronal necrosis was not observed in the hippocampus after HE staining. As compared to the control group, GFAP expression was markedly enhanced in the hippocampus of the manganism group. CONCLUSION： Within the rat brain, manganese preferentially localizes to the hippocampus and can induce astroctye activation.

关键词： manganism hippocampus rats MRI glial fibrillary acidic protein

Formation Characteristic of CO_2 Corrosion Product Layer of P110 Steel Investigated by SEM and Electrochemical Techniques

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Journal of Iron and Steel Research International 2009年第4期16卷 89-94页

作者： ZHAO Guo-xian LU xiang-hong xiang Jian-min HAN Yong Department of Materials Science and Engineering Xi'an Shiyou University Xi'an 710065 Shaanxi China Tarim Oil Field Kuerle 841000 Xinjiang China Xi'an Maurer Petroleum Engineering Laboratory Xi'an 710065 Shaanxi China

Formation characteristic of CO2 corrosion product layer on the surface of P110 steel was investigated in simulated oilfield environment using massqoss experiment, potentiodynamic polarization curve, impedance spectroscopy, and SEM micrograph analysis. Samples of different times up to 240 h were tested during exposure. Corrosion product was primarily composed of Fe（Ca, Mg）（CO3 ）2, which was distinguished by two layers. With an increase in the exposure time, the charge transfer resistance and polarization resistance increased progressively, the uniform cor- rosion rate decreased, and the corrosion reaction was controlled by the diffusion process instead of the activation process. All phenomena were attributed to the formation of the protective corrosion product layer. More compact and lower porosity of the layer made it more difficult to transfer and diffuse through the corrosion product layer for the charges and ions. Similar results were obtained bv electrochemical test and mass-loss experiment.

关键词： CO2 corrosion P110 steel electrochemistry impedance spectra

The connection between meridians and physiological functions:A quantum principle

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Nano Research 2023年第11期16卷 12817-12820页

作者： xiang-Yu Kong min xiang Jiancheng Fang Dong Han Bo Song Lei Jiang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Science and Technology Center for Quantum Biology National Institute of Extremely-Weak Magnetic Field InfrastructureHangzhou 310051China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Optical-Electrical Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human *** are regarded to be the channels connecting the internal organs with the body surface and various parts of the *** there are many studies and doctrines trying to reveal the nature of meridians for their validation in TCM,the mechanism underlying the meridians remains ***,based on our macroscopic quantum state concept of ion channels(i.e.,sub-nanometer scale channels),we propose a quantum principle of *** acupoints and organ symptom are in a macroscopic coherence state of the ion channels in *** applying TCM treatments(e.g.,TCM massage,acupuncture,moxibustion,and electroacupuncture)on the acupoint,the corresponding organ symptom could be well regulated with help of quantum meridian state.

关键词： traditional Chinese medicine meridians macroscopic quantum state external stimulation

Sedimentary environment of vermicular red clay in South China

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Journal of Mountain Science 2017年第3期14卷 513-526页

作者： YANG Li-hui ZHENG xiang-min YE Wei School of Geographic Science East China Normal UniversityShanghai 200214China Anhui Key Laboratory of Natural Disaster Process and Protection Research Anhui Normal UniversityWuhu 241003China College ofC eography and Environmental ScienceZhejiang Normal UniversityJinhua 321004China

Increasing interest in recent years has focused on vermicular red clay(VRC) in southern China due to its controversial sedimentary environment and provenance. Grain size is a useful way to determine sedimentary environment and provenance. Fisher Linear Discriminant Analysis(LDA) is a common and widely used method for multivariate statistical analysis. Based on a proper training sample set, the LDA can be used to discuss the sediment provenance. In this study, grain size data for 77 Malan loess samples and 41 floodplain deposit samples were used as a training sample set to deduce a Fisher linear discriminant function. Then, 299 VRC samples from 6 Quaternary red clay profiles were analyzed using the discriminant function. Grain size parameters and microscopic images of quartz grains separated from the VRC were evaluated in detail to determine the VRC sedimentary environment in south China. The results show that VRC profiles can be classified into two regions: the Chiang-nan Hilly Region and Wuyi Mountains Region. The VRC samples in the Chiang-nan Hilly Region originated from eolian dust deposits. This VRC is characterized by a higher content of fine particles(<20 μm) and lower average transport kinetic energy than loess in a C-M plot. The quartz grain sizes and microscope images of this VRC suggest that it could be a polyphyletic mixture of far-sourced and nearsourced eolian deposits. The far-sourced eolian deposits share similar provenance with Xiashu loess and were transported by the East Asian winter monsoon. The near-sourced eolian deposits were dust emitted from the adjacent floodplain. In the Wuyi Mountains Region, the rugged topography weakened the dustfall and strengthened the reconstructive effect of hydrodynamic forces during the Quaternary glacial periods. The VRC in this region was reworked strongly by water and retained typical hydraulic characteristics no matter the source.

关键词： Vermicular red clay Grain size Linear discriminant analysis Eolian deposits Quaternary

Sintilimab-induced autoimmune diabetes:A case report and review of the literature

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World Journal of Clinical Cases 2022年第4期10卷 1263-1277页

作者： Jing Yang Ying Wang xiang-min Tong Clinical Laboratory Center Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Clinical Research Institute Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Department of Hematology Clinical Trial InstituteZhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND With the widespread application of immune checkpoint inhibitor(ICI)therapy,the number of immune-related adverse effects(irAEs)has increased over the *** diabetes mellitus(DM)is a rare irAEs of ICIs and can be troublesome and life *** SUMMARY We report a 78-year-old woman with no history of diabetes who presented with hyperglycemia up to 23.4 mmol/L(random blood glucose level)after 14 courses of *** A1c was 8.2%,fasting insulin was 0.29 mIU/mL,and fasting C-peptide was decreased to a level with negative *** her medical history and laboratory examination,she was diagnosed with programmed cell death(PD)-1-inhibitor-induced,new-onset autoimmune *** controlling her blood glucose,she was treated with daily insulin by subcutaneous *** was allowed to continue anti-PD-1 therapy and she still obtained some therapeutic *** also reviewed some published cases(n=36)of PD-1/PD-ligand 1(PD-L1)inhibitor-induced *** also discuss potential pathogenic mechanisms,clinical features,prognostic markers(βcell antibodies,human leukocyte antigen type,PD-L1 Level)of this rare adverse *** It is important for all clinicians to be aware of DM as an irAEs of ICIs.

关键词： Sintilimab Immune related adverse effects Small cell lung cancer Autoimmune diabetes Case report

Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： Wen-Jing Wang xiang-min Dong Guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

Modified Therapeutic Antibodies: Improving Efficacy

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Engineering 2021年第11期7卷 1529-1540页

作者： Ji-min Dai Xue-Qin Zhang Jing-Yao Dai xiang-min Yang Zhi-Nan Chen Department of Cell Biology National Translational Science Center for Molecular MedicineState Key Laboratory of Cancer BiologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hepatobiliary Surgery Chinese PLA General HospitalBeijing 100853China Department of Hepatobiliary Surgery Air Force Medical CenterBeijing 100142China

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers,inflammatory disorders,and refractory *** drawbacks emerge in clinical trials and practice,such as impeded binding,reduced effector functions,and frequent adverse reactions,modifications of therapeutic antibodies are unprecedently burgeoning in research and development(R&D).These modifications include:①modified glycosylation;②fragment of crystallizable domain(Fc)amino acid alterations;③cross-isotype or cross-subclass exchanges;④antibody–drug conjugates(ADCs);⑤single chain of variable region fragment(scFv)for chimeric antigen receptor T(CAR-T)cells;and⑥bispecific antibodies(bsAbs)in order to promote binding affinity,half-life in circulation,effectiveness toward target cells and,ultimately,to achieve overall improved *** many achievements have been made around the world in the past decades,China has been playing an active role in this realm,with its great demand for biotherapeutics with R&D *** review recapitulates the international progress that has been achieved with modified therapeutic antibodies,and then focuses on that of China in an independent section.

关键词： Therapeutic antibody Modification Efficacy Antigen Antibody-drug conjugate Bispecific antibody