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Current Medical Science 2024年第1期44卷 241-243页

作者： Miao YU xiang cheng Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Atherosclerosis(AS)is the main underlyingpathology of atherosclerotic cardiovascular disease(ASCVD),which is the leading cause of mortality inthe worldwide[1,2].Since the 19th century,Virchowhas already stated that AS is a chronic inflammatorystate induced by *** that,it took at leastthree decades’worth of study to establish the multipleinflammatory pathways related to AS.

关键词： Virchow mortality cardiovascular

Skin-inspired interface modification strategy toward a structurefunction integrated hybrid smart fabric system with self-powered sensing property for versatile applications

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Nano Research 2024年第9期17卷 8200-8208页

作者： xiang cheng Teng Chen De Gong Pengcheng Ma Bo Chen Jun Cai Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100190China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Beijing U-Precision Tech Co. Ltd.Beijing 100176China University of Chinese Academy of Sciences Beijing 100049China

Fabric-based composites with superior mechanical properties and excellent perceptive function are highly ***,it remains a huge challenge to attain structure-function integration,especially for hybrid fabric ***,a skin-inspired interface modification strategy is proposed toward this target by constructing a hybrid smart fabric system consisting of two types of smart fabrics:carbon nanotube(CNT)/MXene-modified aramid fabrics and zinc oxide nanorod(ZnO NR)-modified carbon *** on that,flexible piezoelectric pressure sensors with skin-like hierarchical perception interfaces are fabricated,which demonstrate superb sensitivity of 2.39 V·kPa^(-1)and are capable of various wearable monitoring ***,the interface-modified hybrid fabric reinforced plastics can also be fabricated,which are proven to possess 13.6%higher tensile strength,10.1%elastic *** impressively,their average energy absorption can be improved by 111.9%,accompanied with inherent damage alert *** offers a paradigm to fabricate structure-function integrated hybrid smart fabric composites for the smart clothing and intelligent aerial vehicles.

关键词： hybrid fabrics interface modification piezoelectric pressure sensors self-diagnostic composites structure-function integration

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang Li Tian-Shuo Feng Ji Gao Xin-xiang Yang xiang-cheng Li Zhen-Hua Deng Yong-xiang Xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

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LLM4CP:Adapting Large Language Models for Channel Prediction

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Journal of Communications and Information Networks 2024年第2期9卷 113-125页

作者： Boxun Liu Xuanyu Liu Shijian Gao xiang cheng Liuqing Yang State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China Internet of Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Internet of Things Thrust and Intelligent Transportation Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Department of Electronic and Computer Engineering and Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Channel prediction is an effective approach for reducing the feedback or estimation overhead in massive multi-input multi-output (m-MIMO) systems. However, existing channel prediction methods lack precision due to model mismatch errors or network generalization issues. Large language models (LLMs) have demonstrated powerful modeling and generalization abilities, and have been successfully applied to cross-modal tasks, including the time series analysis. Leveraging the expressive power of LLMs, we propose a pre-trained LLM-empowered channel prediction(LLM4CP)method to predict the future downlink channel state information (CSI) sequence based on the historical uplink CSI sequence. We fine-tune the network while freezing most of the parameters of the pre-trained LLM for better cross-modality knowledge transfer. To bridge the gap between the channel data and the feature space of the LLM,preprocessor, embedding, and output modules are specifically tailored by taking into account unique channel characteristics. Simulations validate that the proposed method achieves state-of-the-art (SOTA) prediction performance on full-sample, few-shot, and generalization tests with low training and inference costs.

关键词： channel prediction massive multi-input multi-output(m-MIMO) large language models(LLMs) fine-tuning time-series

Color coded metadevices toward programmed terahertz switching

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Light(Science & Applications) 2024年第7期13卷 1383-1392页

作者： Weibao He xiang’ai cheng Siyang Hu Ziheng Ren Zhongyi Yu Shun Wan Yuze Hu Tian Jiang College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina. Nanhu Laser Laboratory National University of Defense TechnologyChangshaChina. Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangshaChina. Institute for Quantum Science and Technology College of ScienceNational University of Defense TechnologyChangshaChina

Terahertz modulators play a critical role in high-speed wireless communication,non-destructive imaging,and so on,which have attracted a large amount of research ***,all-optical terahertz modulation,an ultrafast dynamical control approach,remains to be limited in terms of encoding and *** we experimentally demonstrated an optical-programmed terahertz switching realized by combining optical metasurfaces with the terahertz metasurface,resulting in 2-bit dual-channel terahertz *** terahertz metasurface,made up of semiconductor islands and artificial microstructures,enables effective all-optical programming by providing multiple frequency channels with ultrafast modulation at the nanosecond ***,optical metasurfaces covered in terahertz metasurface alter the spatial light field distribution to obtain color *** to the time-domain coupled mode theory analysis,the energy dissipation modes in terahertz metasurface can be independently controlled by color excitation,which explains the principle of 2-bit encoding *** work establishes a platform for all-optical programmed terahertz metadevices and may further advance the application of composite metasurface in terahertz manipulation.

关键词： terahertz surface excitation

Perioperative and long-term results of ultrasonography-guided single-and multiple-tract percutaneous nephrolithotomy for staghorn calculi

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World Journal of Clinical Cases 2024年第7期12卷 1243-1250页

作者： Rui-xiang cheng Ni Dai Yan-Min Wang Pei Qi Fen Chen Department of Urology Wuhan Ninth HospitalWuhan 430081Hubei ProvinceChina Department of Urinary Pain Wuhan Hankou HospitalWuhan 430000Hubei ProvinceChina Pre-hospital Emergency Department Wuhan Puren HospitalWuhan 430081Hubei ProvinceChina Department of Orthopedic Trauma Surgery Wuhan Hankou HospitalWuhan 430000Hubei ProvinceChina Department of Ultrasound Hubei Provincial Hospital of Integrated Traditional Chinese and Western MedicineWuhan 430015Hubei ProvinceChina

BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical *** recent clinical studies have shown that multi-tract percutaneous nephrolithotomy(MPCNL)has a similar stone free rate(SFR)as standard percutaneous nephrolithotomy(S-PCNL).As a result,M-PCNL was also recommended as a treatment option for staghorn *** To examine the perioperative and long-term results of ultrasonography-guided single-and *** This was a retrospective cohort *** March 2021 and January 2022,the urology department of our hospital selected patients for the treatment of staghorn calculi using percutaneous *** primary outcomes were com plication rate and SFR,and the characteristics of patients,operative parameters,laboratory measurements were also *** In total,345 patients were enrolled in the study(186 in the S-PCNL group and 159 in the M-PCNL group).The SFR in the M-PCNL group was significantly higher than that in the S-PCNL group(P=0.033).Moreover,the incidence rates of hydrothorax(P=0.03)and postoperative infection(P=0.012)were higher in the M-PCNL group than in the S-PCNL *** regression analysis demonstrated that post-operative white blood cell count(OR=2.57,95%CI:1.90-3.47,P<0.001)and stone size(OR=1.59,95%CI:1.27-2.00,P<0.001)were associated with a higher overall complication rate in the S-PCNL *** mass index(OR=1.22,95%CI:1.06-1.40,P=0.004)and stone size(OR=1.70,95%CI:1.35-2.15,P<0.001)were associated with increased overall complications in the M-PCNL *** Multiple access tracts can facilitate higher SFR while slightly increasing the incidence of acceptable complications.

关键词： Single-tract percutaneous nephrolithotomy Multiple-tract percutaneous nephrolithotomy Staghorn calculi Ultrasonography

Astrometric Observations of NEA 1998 HH49 Using the Daocheng 50 cm Telescope

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Research in Astronomy and Astrophysics 2024年第7期24卷 74-81页

作者： Huan Xu xiang-Ming cheng Yi-Gong Zhang Teng-Fei Song Zhen-Jun Zhang Qing-Yu Peng Yunnan Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Engineering Laboratory on Applied Astronomical Technology of Yunnan School of Information Engineering Kunming University School of Computer Science and Information Engineering Anyang Institute of Technology Department of Computer Science Jinan University Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan University

This study details an astrometric observation campaign of the Near-Earth Asteroid 1998 HH49, conducted with the aim of refining our understanding of its physical characteristics. Utilizing the 50 cm telescope located at the Wumingshan Mountain in Daocheng, Sichuan, images were obtained over four nights, from 2023 October 19 to October 22. These observations were processed using Astrometrica software, facilitating the precise determination of the asteroid's position. The observational results were compared with the ephemerides from three distinct sources to verify accuracy: the Jet Propulsion Laboratory(JPL) Horizons System, the Institut de Mécanique Céleste et de Calcul des éphémérides(IMCCE) Miriade, and the Near-Earth Objects Dynamic Site(NEODyS-2).When compared with the JPL ephemeris, a mean observed-minus-calculated(O-C) result of 0.''07 in the *** and-0.''35 in the decl. direction was yielded. Furthermore, the comparison with the IMCCE ephemeris yielded mean O-C results of 0.''08 in the R.A. direction and-0.''06 in the decl. direction. The comparison with the NEODyS-2 ephemeris yielded the mean O-C results of 0.''06 in R.A. and-0.''49 in decl. direction. The study's findings demonstrate a general consistency between the observed data and the ephemeris predictions, with minor discrepancies observed across the data sets. Notably, both the JPL and NEODyS-2 ephemerides show that the residuals in the decl. direction exceed those in the R.A. direction. The disparities may result from atmospheric differential color refraction, ephemeris discrepancies, observational errors, and other factors. Additionally, it is worth noting that further investigation is required due to the potential influence of additional factors. Overall, the Daocheng 50 cm Telescope exhibits the ability to conduct high-precision positional measurements.

关键词： astrometry ephemerides time

Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can Hu Yan-Qiang Zhang Peng-cheng Yu Yi Wang Zhi-Yuan Xu Huan-Ying Fu xiang-Dong cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade

Calcitonin gene-related peptide inhibits neuronal apoptosis in heatstroke rats via PKA/p-CREB pathway

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Chinese Journal of Traumatology 2024年第1期27卷 18-26页

作者： Jie Zhu Ya-Hong Chen Jing-Jing Ji cheng-xiang Lu Zhi-Feng Liu Department of Pediatric General Hospital of Southern Theater Command of PLAGuangzhou510010China Department of Medical Intensive Care Unit General Hospital of Southern Theater Command of PLAGuangzhou510010China Department of Intensive Care Unit Zhongshan Hospital Xiamen UniversityXiamenFujian province361004China

Purpose:The incidence of heatstroke(HS)is not particularly high;however,once it occurs,the consequences are *** is reported that calcitonin gene-related peptide(CGRP)is protective against brain injury in HS rats,but detailed molecular mechanisms need to be further *** this study,we further explored whether CGRP inhibited neuronal apoptosis in HS rats via protein kinase A(PKA)/p-cAMP response element-binding protein(p-CREB)***:We established a HS rat model in a pre-warmed artificial climate chamber with a temperature of(35.5±0.5)℃and a relative humidity of 60%±5%.Heatstress was stopped once core body temperature reaches above 41℃.A total of 25 rats were randomly divided into 5 groups with 5 animals each:control group,HS group,HS+CGRP group,HS+CGRP antagonist(CGRP8-37)group,and HS+CGRP+PKA/p-CREB pathway blocker(H89)group.A bolus injection of CGRP was administered to each rat in HS+CGRP group,CGRP8-37(antagonist of CGRP)in HS+CGRP8-37 group,and CGRP with H89 in HS+CGRP+H89 *** were recorded and the serum concentration of S100B,neuron-specific enolase(NSE),neuron apoptosis,activated caspase-3 and CGRP expression,as well as pathological morphology of brain tissue were detected at 2 h,6 h,and 24 h after HSin *** expression of PKA,p-CREB,and Bcl-2 in rat neurons were also detected at 2 h after HSin *** CGRP,CGRP8-37,or H89 were used to determine whether CGRP plays a protective role in brain injury via PKA/p-CREB *** unpairedt-test was used between the 2 samples,and the mean±SD was used for multiple ***-tailedp<0.05 was considered statistically ***:Electroencephalogram showed significant alteration ofθ(54.50±11.51vs.31.30±8.71,F=6.790,p=0.005)andαwave(16.60±3.21vs.35.40±11.28,F=4.549,p=0.020)in HS group compared to the control group 2 h after *** results of triphosphate gap terminal labeling(TUNEL)showed that the neuronal apoptosis of HS rats was increased in the c

关键词： Heatstroke Calcitonin gene-related peptide Brain injury Apoptosis

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Clonal hematopoiesis:a shared risk factor for cardiovascular diseases and tumors

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Oncology and Translational Medicine 2024年第1期10卷 35-41页

作者： Ling-Feng Zha xiang cheng Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Clonal hematopoiesis(CH)is a clonally expanded population of hematopoietic stem cells carrying somatic mutations that differentiate through multilineage hematopoiesis to form terminally differentiated mature hematopoietic cells carrying markers of the clonal *** integral to critical cellular processes such as epigenetic regulation,DNA damage response,and inflammation frequently carry these *** hematopoiesis becomes increasingly prevalent with age and is associated with an increased risk of hematological tumors and some nonhematological *** insights have revealed that the mutations driving CH are not only implicated in hematologic neoplasms but also possess the potential to influence cardiovascular ***,we reviewed up-to-date findings about the roles of CH in cardiovascular diseases and tumors and explored the clinical significance of CH,as well as look forward to future related studies,so as to provide valuable references for future research and clinical practice.

关键词： Cardiovascular diseases Clonal hematopoiesis Tumors

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