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Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-xia Xu Jian-Dang Liu Bang-jiao Ye Zi-Wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

我院173例儿童长期发热的抗菌药物使用研究

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中国药房 2014年第46期25卷 4330-4333页

作者：夏小娇浙江温州育英儿童医院浙江温州325027

目的：了解不明原因长期发热疾病的病因分布,探讨长期不明原因发热患儿抗菌药物使用的合理性和有效性。方法：收集我院2012-2013年主诉为发热≥2周且最后诊断明确的完整病例共173例。按照年龄分为4组：〈1岁年龄组（婴儿组）、1~〈3岁... 详细信息

目的：了解不明原因长期发热疾病的病因分布,探讨长期不明原因发热患儿抗菌药物使用的合理性和有效性。方法：收集我院2012-2013年主诉为发热≥2周且最后诊断明确的完整病例共173例。按照年龄分为4组：〈1岁年龄组（婴儿组）、1~〈3岁组年龄组（幼儿组）、3~6岁组年龄组（学龄前组）、〉6岁年龄组（学龄组）,统计所有病例的临床资料以及抗菌药物使用情况。结果：感染性疾病占主要地位,以呼吸道感染为主,感染的病原体中病毒居首位,支原体居第2位。全部病例入院后均使用抗菌药物,抗菌药物使用率为100%;其中使用限制级抗菌药物占51人次（占29.48%）,二联使用抗菌药物22人次（占12.72%）;非细菌感染和非感染性疾病使用限制级别抗菌药物34例,占限制级抗菌药物的66.67%;抗菌药物更改率达到29.41%~62.50%。结论：对不明原因长期发热患儿的治疗上过度依赖抗菌药物,在治疗欠佳的情况下,不应盲目更换或升级抗菌药物。

关键词：儿童长期发热抗菌药物合理用药

田湾核电站冷停堆过程中蒸汽发生器二次侧化学清洗配方研究

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核动力工程 2013年第3期34卷 156-158页

作者：夏小娇温菊花马韦刚谢银燕胡志辉中国核动力研究设计院反应堆工程研究所成都610041

为验证冷停堆过程中蒸汽发生器二次侧化学清洗工艺的有效性和安全性,采用高压釜模拟冷停堆过程中蒸汽发生器二次侧化学清洗工艺条件,分别对俄配方和配方A3B1进行清洗有效性验证试验和安全性评价试验研究。试验结果表明,与俄配方相比,配... 详细信息

为验证冷停堆过程中蒸汽发生器二次侧化学清洗工艺的有效性和安全性,采用高压釜模拟冷停堆过程中蒸汽发生器二次侧化学清洗工艺条件,分别对俄配方和配方A3B1进行清洗有效性验证试验和安全性评价试验研究。试验结果表明,与俄配方相比,配方A3B1的清洗有效性和安全性均优于俄配方,更适合于田湾核电站蒸汽发生器二次侧沉积物化学清洗。

关键词：冷停堆化学清洗蒸汽发生器二次侧

超临界水冷堆水化学控制及其相关技术研究进展

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核动力工程 2012年第6期33卷 132-138页

作者：龚宾黄彦平姜峨刘金华夏小娇邱添霍松岷中国核动力研究设计院反应堆工程研究所成都610041 中国核动力研究设计院中核核反应堆热工水力技术重点实验室成都610041

对国内外超临界水在辐照作用下的分解行为、水化学对材料的腐蚀影响、腐蚀产物行为和水化学监控等领域的研究现状进行回顾,介绍了中国核动力研究设计院在超临界水腐蚀领域的研究进展,以及利用新建的超临界水化学试验装置开展的热态试验... 详细信息

对国内外超临界水在辐照作用下的分解行为、水化学对材料的腐蚀影响、腐蚀产物行为和水化学监控等领域的研究现状进行回顾,介绍了中国核动力研究设计院在超临界水腐蚀领域的研究进展,以及利用新建的超临界水化学试验装置开展的热态试验研究,并提出了研发超临界水冷堆(SCWR)尚需攻克的水化学运行控制相关技术难题,为中国百万千瓦级SCWR(CSR1000)的水化学策略研究提供参考。

关键词：超临界水冷反应堆(SCWR) CSR1000 水化学控制辐解氧化应力腐蚀腐蚀产物

Precision storage lifetime measurements of highly charged heavy ions in the CSRe storage ring using a Schottky resonator

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Nuclear Science and Techniques 2025年第1期36卷 150-160页

作者： Qian Wang Xin-Liang Yan Guang-Yu Zhu Shahab Sanjari Li-Jun Mao He Zhao Yuri ALitvinov Rui-Jiu Chen Meng Wang Yu-Hu Zhang You-Jin Yuan Jun-xia Wu Hong-Yang jiao Yue Yu Zu-Yi Chen Yin-Fang Luo Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China GSI Helmholtzzentrum für Schwerionenforschung Planckstrasse 164291 DarmstadtGermany FH Aachen University of Applied Sciences Heinrich-Mussmann-Str.152428 JülichGermany

Schottky mass spectrometry utilizing heavy-ion storage rings is a powerful technique for the precise mass and decay half-life measurements of highly charged *** to the nondestructive ion detection features of Schottky noise detectors,the number of stored ions in the ring is determined by the peak area in the measured revolution frequency *** of their intrinsic amplitude-frequency characteristic(AFC),Schottky detector systems exhibit varying sensitivities at different *** low-energy electron-cooled stored ions,a new method is developed to calibrate the AFC curve of the Schottky detector system of the Experimental Cooler Storage Ring(CSRe)storage ring located in Lanzhou,*** the amplitude-calibrated frequency spectrum,a notable refinement was observed in the precision of both the peak position and peak *** a result,the storage lifetimes of the electron-cooled fully ionized^(56)Fe^(26+)ions were determined with high precision at beam energies of 13.7 and 116.4 MeV/u,despite of frequency drifts during the *** electron cooling was turned off,the effective vacuum condition experienced by the 116.4 MeV/u^(56)Fe^(26+)ions was determined using amplitude-calibrated spectra,revealing a value of 2×10^(−10)mbar,which is consistent with vacuum gauge readings along the CSRe *** method reported herein will be adapted for the next-generation storage ring of the HIAF facility under construction in Huizhou,*** can also be adapted to other storage ring facilities worldwide to improve precision and enhance lifetime measurements using many ions in the ring.

关键词： Lifetime measurement Schottky mass spectrometry Sensitivity response Highly charged heavy ion Resonator UH vacuum Nondestructive diagnostics

皮质抑素在人肾组织中及IgA肾病肾组织中的表达情况

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军事医学 2017年第2期41卷 106-110页

作者：宁小元陈霞焦晓静张雪光徐家云河南科技大学临床医学院河南科技大学第一附属医院河南洛阳471003 郑州大学人民医院河南省人民医院郑州450003 解放军总医院肾脏病科解放军肾脏病研究所肾脏疾病国家重点实验室国家慢性肾病临床医学研究中心北京100853

目的探讨皮质抑素(cortistatin,CST)在人肾组织中的表达情况及其在不同分级IgA肾病肾组织中的表达变化。方法收集10例肾癌切除术患者的癌旁正常肾组织,通过逆转录聚合酶链反应(RT-PCR)与Western印迹分别检测人肾组织中CST mRrNA与蛋白... 详细信息

目的探讨皮质抑素(cortistatin,CST)在人肾组织中的表达情况及其在不同分级IgA肾病肾组织中的表达变化。方法收集10例肾癌切除术患者的癌旁正常肾组织,通过逆转录聚合酶链反应(RT-PCR)与Western印迹分别检测人肾组织中CST mRrNA与蛋白的表达情况,采用免疫组织化学(IHC)技术对CST于肾组织中的表达进行定位。根据Lee分级标准将IgA肾病分为3组:Ⅰ~Ⅱ级为A组、Ⅲ~Ⅳ级为B组、Ⅴ级为C组,每组分别收集10例IgA肾病患者的肾穿组织样本。采用IHC技术,检测正常肾组织及不同分级IgA肾病肾组织中CST的表达变化。对临床指标进行多重线性回归分析,评估其对IgA肾病肾组织内CST表达量的影响。结果 RT-PCR与Western印迹结果均表明肾组织内表达CST,IHC结果显示CST表达于肾小管上皮细胞。IgA肾病中,病理分级越高,肾小管中CST表达越多。多重线性回归分析显示,病理分级与肾组织中CST表达量相关(r=0.875,尸<0.01)。结论 CST可能参与IgA肾病病理损伤的炎症反应,发挥抗炎保护作用。

关键词：皮质抑素肾组织 IgA肾病

Challenges for pediatric liver transplantation in the mainland of China:Where we are and where to *** from worldwide largest pediatric liver transplantation program

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 35-38页

作者： Qiang xia Ming-Xuan Feng Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China

In China pediatric liver transplantation(PLT)has become a safe and standardized *** and measures to further improve long-term survival and quality of life for children should be the next *** particular better strategies related to the surgical treatment of high-risk recipients as well as the long-term follow-up of pediatric liver recipients have to be addressed.A particular attention should be given to children presenting significant co-morbidities and those needing retransplantation.A tight mul-tidisciplinary follow-up system addressing both short-and long-term issues of pediatric liver recipients is still a challenge for the Chinese pediatric transplant community.

关键词： Pediatric liver transplantation Retransplantation Comorbidity

Genome-wide investigation of defensin genes in apple(Malus×domestica Borkh.) and in vivo analyses show that MdDEF25 confers resistance to Fusarium solani

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Journal of Integrative Agriculture 2025年第1期24卷 161-175页

作者： Mengli Yang Jian jiao Yiqi Liu Ming Li Yan xia Feifan Hou Chuanmi Huang Hengtao Zhang Miaomiao Wang Jiangli Shi Ran Wan Kunxi Zhang Pengbo Hao Tuanhui Bai Chunhui Song Jiancan Feng xianbo Zheng College of Horticulture Henan Agricultural UniversityZhengzhou 450046China Zhengzhou Fruit Research Institute Chinese Academy of Agricultural SciencesZhengzhou 450009China

Apple replant disease is a complex soil syndrome that occurs when the same fields are repeatedly utilized for apple orchard *** can be caused by various pathogens,and Fusarium solani is the main *** solani disrupts the structure and function of the orchard soil ecosystem and inhibits the growth and development of apple trees,significantly impacting the quality and yield of *** this study,we conducted a transcriptome comparison between uninoculated apple saplings and those inoculated with F:*** differentially expressed genes were mainly enriched in processes such as response to symbiotic *** defensins are antimicrobial peptides,but their roles during *** infection remain *** performed a genome-wide identification of apple defensin genes and identified 25 genes with the conserved motif of eight cysteine *** wildtype apple rootstock inoculated with ***,the root surface cells experienced severe damage,and showed significant differences in the total root length,total root projection area,root tips,root forks,and total root surface area compared to the control ***-PCR analysis revealed that MdDEF3 and MdDEF25 were triggered in response to *** infection in *** localization showed specific expression of the MdDEF3-YFP and MdDEF25-YFP proteins on the cell *** theMdDEF25-YFP fusiongene enhanced resistance against *** in apple,providing a new strategy for the future prevention and biological control of apple replantdisease.

关键词： apple Fusarium solani defensin resistance replant disease

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang xia Zhi Sun Yong-Chao Chen Lu jiao Wen-Hua Wan Hong-Wei Zhang xiao Guo Hua Guo Shou-Feng Jia xiao-Xin Li Shi-xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology