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Embolic Effects of Bletilla striata Microspheres in Renal Artery and Transplanted VX2 Liver Tumor Model in Rabbits

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Chinese Journal of Integrative Medicine 2019年第6期25卷 431-438页

作者： LUO Shi-hua SONG Song-lin ZHENG Chuan-sheng LI Wei-yong WANG Yong xia xiang-wen FENG Gan-sheng Department of Radiology Union Hospital Tongji Medical College Huazh ong University of Science and Tech no logy Wuhan (430022) China Department of Pharmacy Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan (430022) China

Objective: To evaluate the characteristics of Bletilla striata microspheres(BSMs) and its effects as an embolic agent in a rabbit model. Methods: BSMs were prepared with an emulsi?cation-cool condensation-chemical cross-linking method. The characteristics of BSMs in vitro were observed. Embolization experiments were performed in renal artery of rabbit and in a rabbit liver VX2 carcinoma model. Seventy-two New Zealand rabbits were divided into 2 groups, and the right renal artery was embolized with BSMs(200 μm in diameter) in the experimental group and with polyvinyl alcohol(PVA) of the same size in the control group. The pathological findings were examined with hematoxylin-eosin and Masson stainings. Liver and renal functions were tested before and after ***2 tumor was transplanted in 15 New Zealand rabbits, which were randomly divided into 3 groups(n=5). Group A were treated with saline, group B with a mixture of doxorubicin and lipiodol, and group C with hepatic arterial infusion of BSMs(200 μm in diameter). Tumor growth rate was evaluated by magnetic resonance imaging ***-related factors(bax, bcl-2) and tumor vascular endothelial cell growth factor(VEGF) were evaluated through immunohistochemical staining. Results: The characteristics of BSMs in vitro were in full compliance with the requirements for use in interventional procedures. In the renal artery embolization experiment, after BSMs intervention, it was more dif?cult to form collateral circulation than that with PVAs, and the kidney manifested atrophy and calci?cation. There were no signi?cant difference of liver and renal functions in rabbits between groups. In the liver VX2 carcinoma embolization experiment, compared with group A, the growth rate of VX2 liver tumor and Bcl-2 levels was reduced, while apoptosis index, Bax, and VEGF were increased in group B(P0.05). Conclusions: The characteristics of BSMs in vitro a

关键词： Bletilla striata Chinese medicine microsphere characteristic embolization

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中国近岸区域微塑料污染的研究进展

中国环境科学 2024年第3期44卷 1657-1670页

作者：宋天文陈曲段杉杉金家锋常伟夏文香青岛理工大学环境与市政工程学院山东青岛266520 青岛滨海学院医学院山东青岛266555 中国海洋大学化学化工学院山东青岛266100 中国石油大学(华东)石油工程学院山东青岛266580

为全面评估我国近岸微塑料的污染现状,本文综述了我国近岸大气、陆地和海洋不同区域微塑料的采集分离、分析方法、污染分布特征及生态危害等的研究进展,并展望了我国近岸微塑料未来研究方向.研究表明,近岸大气、沉积物和海水均有微塑料... 详细信息

为全面评估我国近岸微塑料的污染现状,本文综述了我国近岸大气、陆地和海洋不同区域微塑料的采集分离、分析方法、污染分布特征及生态危害等的研究进展,并展望了我国近岸微塑料未来研究方向.研究表明,近岸大气、沉积物和海水均有微塑料的存在,相较于全球其他近岸海域,我国近岸微塑料丰度范围整体上处于中低水平.此外,微塑料及其复合污染物对我国近海生态造成一定危害.我国近岸微塑料在时空分布、源汇格局及生态风险机制方面尚不明确,建议未来在微塑料研究方法标准化的基础上,对微塑料污染进行大范围的长期监测,关注微塑料在大气-陆地-海洋之间的迁移输运,并对微塑料复合暴露的毒理机制及其对人类潜在健康风险等方面进行探索和研究,为我国海洋微塑料污染评估和治理提供参考.

关键词：微塑料近岸区域采集分离分析方法污染现状

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang xia Ning Xu wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Cross-subcarrier precoder design for massive MIMO-OFDM downlink with symplectic optimization

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Science China(Information Sciences) 2025年

作者： Yu-Xuan ZHANG An-An LU xiang-Gen xia Xi-Qi GAO National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Department of Electrical and Computer Engineering University of Delaware

We propose a cross-subcarrier precoder design(CSPD) for massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) downlink. This work aims to significantly improve the channel estimation and signal detection performance by enhancing the smoothness of the frequency domain effective channel. This is accomplished by designing a few vectors known as the transform domain precoding vectors(TDPVs), which are then transformed into the frequency domain to generate the precoders for a set of subcarriers. To combat the effect of channel aging, the TDPVs are optimized under imperfect channel state information(CSI). The optimal precoder structure is derived by maximizing an upper bound of the ergodic weighted sum-rate(WSR) and utilizing the a posteriori beam-based statistical channel model(BSCM). To avoid the large-dimensional matrix inversion, we propose an algorithm with symplectic optimization. Simulation results indicate that the proposed cross-subcarrier precoder design significantly outperforms conventional methods.

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei xia Jinxin Lu Jiale Liu Lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

环境工程微生物学课程教学中存在的问题与对策

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微生物学通报 2019年第3期46卷 660-665页

作者：宋志文徐爱玲李捷夏文香青岛理工大学环境与市政工程学院山东青岛266033

环境工程微生物学是我国高等学校环境工程专业的基础核心课程,具有知识更新速度快、知识点繁多、内容分散的特点。在其教学过程如何兼顾传统微生物学内容与现代微生物学研究新进展,合理选择教学内容、实验项目和安排实验时间,引导学生... 详细信息

环境工程微生物学是我国高等学校环境工程专业的基础核心课程,具有知识更新速度快、知识点繁多、内容分散的特点。在其教学过程如何兼顾传统微生物学内容与现代微生物学研究新进展,合理选择教学内容、实验项目和安排实验时间,引导学生准确掌握基本概念和知识点,培养学生动手能力、创新意识和创新能力,是摆在每位教师面前的难题。围绕上述问题,我们教学团队在课堂与实验教学内容、教学方法和课外大学生实践活动等方面采取了一系列措施,取得了较好的教学效果。

关键词：环境工程微生物学教学内容教学方法教学手段

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中药白芨提取物作为基因载体的制备与表征

中国药学杂志 2008年第18期43卷 1369-1373页

作者：夏向文李欣冯敢生赵彦兵郑传胜华中科技大学附属协和医院放射科武汉430022 华中科技大学生命科学与技术学院药物研究所武汉430074

目的分离纯化并制备阳离子型白芨多糖,研究其表征,探讨其作为基因载体的可能性。方法经热水抽提,乙醇沉淀,Sevag法脱蛋白,阴离子交换纤维素柱(DE-52)和凝胶柱(Sephadex G-100)色谱,分离纯化得白芨多糖,通过高碘酸钾氧化得到含醛基的还... 详细信息

目的分离纯化并制备阳离子型白芨多糖,研究其表征,探讨其作为基因载体的可能性。方法经热水抽提,乙醇沉淀,Sevag法脱蛋白,阴离子交换纤维素柱(DE-52)和凝胶柱(Sephadex G-100)色谱,分离纯化得白芨多糖,通过高碘酸钾氧化得到含醛基的还原性多糖,该还原性多糖与精胺在碱性条件下形成希夫碱式共轭物,经硼氢化钠还原得含伯胺基的阳离子型多糖,分别通过盐酸羟胺法和三硝基苯磺酸法测醛基与伯胺基的产量,并考察了氧化反应时间对反应产物的影响。进一步通过琼脂糖凝胶电泳检测该阳离子型多糖对基因的结合与保护作用。结果所提纯的白芨多糖为一种不含阳离子基团的非还原性多糖,通过胺化还原反应的方法可成功制备出含伯胺基的阳离子型多糖,红外光谱证实了多糖上伯胺基的存在,进一步的研究表明,该阳离子型多糖可以结合并保护质粒DNA。结论通过胺化还原反应方法制备的阳离子型白芨多糖,有望作为一种多糖基的多聚阳离子型基因载体在真核细胞基因转染中发挥作用。

关键词：白芨多糖基因载体胺化还原反应

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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“环境工程微生物学”实验教学改革初探

微生物学通报 2018年第3期45卷 691-696页

作者：徐爱玲宋志文夏文香孙好芬李捷谢经良青岛理工大学环境与市政工程学院山东青岛266033

"环境工程微生物学"是我国高校环境工程和环境科学专业的一门专业基础必修课,环境工程微生物学实验是本课程的重要组成部分。但目前环境工程微生物学实验教学中存在实验内容滞后、单调,学生的预习甚至实验过程往往流于形式,缺乏有效的... 详细信息

"环境工程微生物学"是我国高校环境工程和环境科学专业的一门专业基础必修课,环境工程微生物学实验是本课程的重要组成部分。但目前环境工程微生物学实验教学中存在实验内容滞后、单调,学生的预习甚至实验过程往往流于形式,缺乏有效的考核方法等一系列问题。针对以上问题,作者采取将移动互联网引入环境工程微生物学实验,鼓励学生参与实验的前期准备等措施来改革传统教学模式,通过编写实验教材、精心安排实验内容、将科研带入到实际教学中等途径来优化教学内容,采用将平时成绩纳入最终实验成绩的方法来改革传统考核方式,取得了较好的教学效果,本文对以上教改内容进行详细阐述。

关键词：环境工程微生物学实验教学模式教学内容考核体系教学改革