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Some rigid results on doubly twisted product complex Finsler manifolds

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Science China Mathematics 2025年第2期68卷 421-432页

作者： Hongchuan xia Wei xiao Chunping zhong School of Mathematics and Statistics Xinyang Normal UniversityXinyang 464000China School of Mathematical Sciences Xiamen UniversityXiamen 361005China

Let(M1×(λ_(1),λ_(2))M_(2),F)be a doubly twisted product complex Finsler manifold of two strongly pseudoconvex complex Finsler manifolds(M_(1),F_(1))and(M_(2),F_(2)).Denote by M the product manifold of M1and M_(2).In this paper,we first give the characterization for(M,F)to be of constant holomorphic curvature,and prove that(M,F)is of constant holomorphic curvature if and only if(M,F),(M_(1),F_(1)),and(M_(2),F_(2))all have vanishing holomorphic curvature under the condition that lnλ_(1)and lnλ_(2)are both pluriharmonic ***,we obtain the classification for(M,F)to be a complex Landsberg ***,we prove that a strongly convex doubly twisted product complex Finsler manifold(M,F)is projectively flat(*** flat)if and only ifλ_(1)F1andλ_(2)F_(2)are both complex Minkowski metrics.

关键词： doubly twisted product complex Finsler manifold holomorphic curvature complex Landsberg manifold

Extraction of gravel characteristics and spatial inversion for ecological restoration monitoring in the Northern Tibetan Plateau

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Journal of Mountain Science 2025年第2期22卷 556-574页

作者： KONG Bo YU huan QIU xia HU Wenkai HE Bing GUAN Xudong Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China College of Geography and Planning Chengdu University of TechnologyChengdu 610059China Tibet Geological Environment Monitoring Center Lhasa 850000China School of Computer Science Chengdu University of Information TechnologyChengdu 610225China Sichuan Real Estate Registration Center(Sichuan Provincial Land and Cadastral Affairs Center) Chengdu 610072China

Previous studies have often focused on monitoring grassland growth as the primary target of remote sensing investigations on grassland ecological restoration in the northern Tibetan Plateau,overlooking the crucial role played by gravel in the ecological restoration of these *** study utilizes supervised classification and segmentation techniques based on machine learning to extract gravel morphology profiles from field-sampled plot images and calculate their characteristic *** a multivariate linear approach combined with Principal Component Analysis(PCA),a model for inferring gravel characteristic parameters is *** features,particle size characteristics,and spatial distribution patterns of gravel are *** reveal that gravel predominantly exhibit sub-rounded shapes,with 80%classified as fine *** coefficients of determination(R2)between gravel particle size and coverage,perimeter,and area are 0.444,0.724,and 0.557,respectively,indicating linear *** cumulative contribution rate of the top five remote sensing factors is 95.44%,with the first geological factor contributing 77.64%,collectively reflecting the primary information of the 20 factors *** shows that areas with larger gravel particle sizes correspond to increased perimeter and *** in the Nagqu Prefecture of northern Tibet have a particle size range of 4-8 mm,primarily comprising fine gravel which accounts for 94.61%.These findings provide a scientific basis for extracting gravel characteristic parameters and understanding their spatial distribution variations in the northern Tibetan Plateau.

关键词： Gravel characteristics parameters Northern Tibetan Plateau Gravel outline extraction Remote sensing inversion Grassland degradation

Mitochondrial dysfunction in the pathogenesis of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 76-83页

作者： xia Chen Rui zhong Bing Hu Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041China Department of Gastroenterology Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500China

The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as a key event in the pathophysiology of AP. Mitochondrial dysfunction is closely related to calcium (Ca^(2+)) overload, intracellular adenosine triphosphate depletion, mitochondrial permeability transition pore openings, loss of mitochondrial membrane potential, mitophagy damage and inflammatory responses. Mitochondrial dysfunction is an early triggering event in the initiation and development of AP,and this organelle damage may precede the release of inflammatory cytokines, intracellular trypsin activation and vacuole formation of pancreatic acinar cells. This review provides further insight into the role of mitochondria in both physiological and pathophysiological aspects of AP, aiming to improve our understanding of the underlying mechanism which may lead to the development of therapeutic and preventive strategies for AP.

关键词： Acute pancreatitis Autophagy Calcium Cell death Inflammation Mitochondria Mitophagy

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO_(2) photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang zhong School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Dinuclear metal synergistic catalysis(DMSC)has been proved powerful in boosting CO_(2)reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework(MOF),obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center(M-In),three MOFs with dinuclear homometallic catalytic centers(MM-In),and three MOFs with dinuclear heterometallic catalytic centers(MM’-In,M/M’=Co(II),Ni(II),Zn(II)).It was found that all these MOFs can serve as catalysts for photochemical CO_(2)reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g^(-1)h^(-1),which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO_(2)reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO_(2)reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO_(2)reduction photocatalysis

IL-17A mediates inflammation-related retinal pigment epithelial cells injury via ERK signaling pathway

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 15-27页

作者： Hui-Min zhong Bing-Qiao Shen Yu-Hong Chen xiao-huan Zhao xiao-Xu huang Min-Wen Zhou xiao-Dong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China National Clinical Research Center for Ophthalmic Diseases Shanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China

AIM:To investigate whether interleukin-17A(IL-17A)gets involved in the mechanisms of inflammation-related retinal pigment epithelium(RPE)cells injury and its significance in age-related macular degeneration(AMD).MRTHODS:A sodium iodate(NaIO3)mouse model as well as IL-17A-/-mice were *** effects of inflammatory cytokines in RPE cells and retinal microglia before and after NaIO3 modeling in vivo and in vitro,were investigated using immunofluorescence,immunoprotein blotting,and quantitative real-time fluorescence polymerase chain reaction(qRT-PCR),*** using recombinant IL-17A protein(rIL-17A)or IL-17A neutralizing antibody(IL-17A NAb)were used to observe the subsequent differences in fundus,fundus photography and optical coherence tomography(OCT),cell viability,and expression of oxidative stress-related markers before and after modeling,and to screen for key signaling ***:In the scenario of NaIO3 stimulation,RPE cells obviously tended to *** proliferation and activation of retinal microglia was confirmed in NaIO3-stimulated mice,whereas such effects induced by NaIO3 were significantly ameliorated with IL-17A NAb intervention or in IL-17A-/-*** addition,IL-17A promoted the proliferation and activation of microglia as well as oxidative damage and the secretion of inflammatory cytokines alongside NaIO3-induced damage in RPE cells in vivo and ex ***,the extracellular signalregulated kinase(ERK)signaling pathway was shown to be participated in the regulation of NaIO3-induced RPE cells injury mediated by IL-17A in vivo and ex vivo,as IL-17A induced inflammatory cytokines release in the NaIO3 model was alleviated after blocking the ERK ***:IL-17A probably promotes the NaIO3-induced RPE cells injury through exacerbating inflammation in terms of retinal microglia activation and inflammatory cytokines release via ERK signaling *** of IL-17A may be a new potential ta

关键词： age-related macular degeneration retinal pigment epithelium NaIO3 microglia IL-17A

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： zhong-xia Yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

Advances and global trends of precancerous lesions of gastric cancer:A bibliometric analysis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 371-384页

作者： Yuan-Ping Jia Dian-Chun Liu Ting-Lan Cao Hui-zhong Jiang Tao Li Yuan Li xia Ding Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Precancerous lesions of gastric cancer(PLGC)represent a critical pathological stage in the development of intestinal gastric *** detection and diagnosis are key to reducing the incidence of gastric *** advancements have been made in PLGC research in recent years,making it necessary to provide updated reviews using bibliometric *** hypothesize that this review will identify emerging trends,key research areas,and gaps in PLGC research,providing insights that could guide future studies and enhance prevention *** To comprehensively review the current state of research on PLGC,examining development trends and research *** We conducted a bibliometric analysis of PLGC-related studies published between 2004 and 2023 using the Web of Science Core Collection *** employed Software,including VOSviewer,CiteSpace,R software,and SCImago Graphica,to map scientific networks and visualize knowledge trends in terms of publication volume,countries/regions,institutions,journals,authors,and *** A total of 4097 articles were included,and overall publication volume showed an increasing *** the past two decades,China published the most articles,followed by the United States,Japan,South Korea,and *** the top 10 contributors,the United States ranked highest in institutions,authors,and citations and demonstrated the strongest international *** keywords in this field were clustered into three main categories:Risk factors,pathogenesis,and diagnosis and *** and molecular biomarkers remain key areas of *** research should explore the mechanisms of gut microbiota,immune microenvironment,metabolic reprogramming,and *** technologies,including single-cell sequencing,spatially resolved analysis,multi-omics approaches,artificial intelligence,and machine learning,will likely accelerate in-depth investigations of *** PLGC research

关键词： Precancerous lesions of gastric cancer Gastric precancerous lesion Dysplasia Bibliometric Visualization

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典型南方水强化混凝有机物分级处理研究

环境科学 2006年第5期27卷 909-912页

作者：刘海龙夏忠欢王东升汤鸿霄张金松中国科学院生态环境研究中心环境水质学国家重点实验室深圳自来水集团有限公司深圳518031

采用强化常规工艺,对有效去除水体有机物,降低DBP前驱物进行了系统研究.通过烧杯试验和现场试验(中试和生产性试验)对强化混凝和使用PAM作助凝剂进行了对比;着重利用吸附树脂DAX-8的选择性吸附作用,测定了原水、沉后水的有机物分离分级... 详细信息

采用强化常规工艺,对有效去除水体有机物,降低DBP前驱物进行了系统研究.通过烧杯试验和现场试验(中试和生产性试验)对强化混凝和使用PAM作助凝剂进行了对比;着重利用吸附树脂DAX-8的选择性吸附作用,测定了原水、沉后水的有机物分离分级组成状况.发现强化混凝和助凝强化对亲水性致UV254物质有较好地处理效果,去除率可达90%以上;现场条件下强化混凝对疏水碱性物和疏水酸性物有较好的处理能力,相应去除率分别为66%和35%;助凝强化对亲水性有机物效果较好,相应去除率为45%左右;但二者总体去除TOC效果相当.

关键词：强化混凝 PACl PAM 有机物分级

Research on the X-ray polarization deconstruction method based on hexagonal convolutional neural network

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Nuclear Science and Techniques 2025年第2期36卷 49-61页

作者： Ya-Nan Li Jia-huan Zhu Huai-zhong Gao Hong Li Ji-Rong Cang Zhi Zeng Hua Feng Ming Zeng Key Laboratory of Particle&Radiation Imaging Tsinghua UniversityMinistry of EducationBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Tsinghua UniversityBeijing 100084China StarDetect Co. LtdBeijing 100084China

Track reconstruction algorithms are critical for polarization *** neural networks(CNNs)are a promising alternative to traditional moment-based track reconstruction ***,the hexagonal grid track images obtained using gas pixel detectors(GPDs)for better anisotropy do not match the classical rectangle-based CNN,and converting the track images from hexagonal to square results in a loss of *** developed a new hexagonal CNN algorithm for track reconstruction and polarization estimation in X-ray polarimeters,which was used to extract the emission angles and absorption points from photoelectron track images and predict the uncer-tainty of the predicted emission *** simulated data from the PolarLight test were used to train and test the hexagonal CNN *** individual energies,the hexagonal CNN algorithm produced 15%-30%improvements in the modulation factor compared to the moment analysis method for 100%polarized data,and its performance was comparable to that of the rectangle-based CNN algorithm that was recently developed by the Imaging X-ray Polarimetry Explorer team,but at a lower computational and storage cost for preprocessing.

关键词： X-ray polarization Track reconstruction Deep learning Hexagonal conventional neural network