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Multiple factors interact in editing of PPR-E+-targeted sites in maize mitochondria and plastids

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Plant Communications 2024年第5期5卷 225-240页

作者： yong Wang Zi-Qin Huang Kai-Di Tian Hao Li Chunhui Xu Bingyujie xia Bao-Cai Tan Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China

RNA cytidine-to-uridine editing is essential for plant organellar gene *** repeat(PPR)-E+proteins have been proposed to bind to target sites and recruit the cytidine deaminase AtDYW2,facilitated by *** we analyze the function of ZmNUWA,ZmDYW2A,and ZmDYW2B and their re-lationships with other editing factors in *** zmdyw2a and zmdyw2b single mutants are normal,but the zmdyw2a::zmdyw2b and zmnuwa mutants are severely arrested in seed ***,ZmDYW2A,and ZmDYW2B are dual localized in mitochondria and *** of ZmNUWA decreases the editing at 99 mitochondrial sites and 8 plastid ***,loss of ZmDYW2A:ZmDYW2B affects almost the same set of sites targeted by PPR-E+*** interacts with ZmDYW2A and ZmDYW2B,suggesting that ZmNUWA recruits ZmDYW2A/2B in the editing of PPR-E+-targeted sites in *** protein interaction analyses show that ZmNUWA and ZmDYW2A/2B interact with ZmMORF1,ZmMORF8,ZmMORF2,and ZmMORF9 and that ZmOZ1 interacts with ZmORRM1,ZmDYW2A,ZmDYW2B,ZmMORF8,and *** results suggest that the maize mitochondrial PPR-E+editosome contains PPR-E+,ZmDYW2A/2B,ZmNUWA,and ZmMORF1/8,whereas the plastid PPR-E+editosome is composed of PPR-E+,ZmDYW2A/2B,ZmNUWA,ZmMORF2/8/9,ZmORRM1,and ZmOZ1.

关键词： maize plant organelles RNA editing ZmNUWA ZmDYW2A/2B

Two-stage Planning Method for Energy Router Considering Its Optimal Operation in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 605-616页

作者： Meifu Chen Mingchao xia Qifang Chen School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

An energy router can effectively optimize the network loss and power quality of distribution networks. The optimal configuration of the energy router is relatively complex because issues dynamically influence each other, such as the location of the energy router, optimal number and capacity of its ports, and building new distribution lines for the ports. Presently, there has been very few research studies on the practical problems for the energy router. In this paper, a planning model of an energy router combined with the distribution network is established, which fully exploits the active and reactive power control abilities of the energy router to optimize the operation of the grid. The configuration problem is decoupled into two stages. The upper layer determines the location of the energy router and the parameters of the candidate new distribution lines for the ports. The lower layer calculates the optimal configuration of the energy router by minimizing the total annual cost. Because of the same rated bus voltage in the distribution network, the existing structure of the energy router is changed to be more applicable for the distribution network, and then the power flow model of the energy router is also modified. Due to the nonlinearity of the model, the planning model is converted into a mixed-integer second-order cone model to solve efficiently. In addition, some core factors influencing the optimal scheme of the energy router are also analyzed in this paper. Simulation results show that the optimal scheme of the energy router can significantly improve the economic deployment of the energy router, and optimize the network loss and power quality of the distribution network.

关键词： Capacity allocation distribution network energy router optimal operation

Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

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World Journal of Clinical Cases 2024年第4期12卷 835-841页

作者： Yan Song Hua Li xia Zhang Lei Wang Hong-Yan Xu zhi-Chao Lu xiao-Gang Wang Bo Liu Department of Clinical Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Cardiology Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Imaging Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pulmonary and Critical Care Medicine Department of Clinical MicrobiologyZibo City Key Laboratory of Respiratory Infection and Clinical MicrobiologyZibo City Engineering Technology Research Center of Etiology Molecular DiagnosisZibo Municipal HospitalZibo 255400Shandong ProvinceChina

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains *** is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating *** study significantly contributes to the medical *** SUMMARY The blood-thinning treatment of a patient with AMI and LVT was *** blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice *** 15 d,the patient’s LVT did not decrease but instead *** pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug *** drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six *** clinical pharmacist provided the patient with professional and standardized pharmaceutical *** patient’s condition was discharged after meeting the international normalized ratio value(2-3)*** patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical *** Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

关键词： Myocardial infarction Left ventricular thrombus Dabigatran etexilate Warfarin Clinical pharmacist Case report

Light-based 3D printing of stimulus-responsive hydrogels forminiature devices:recent progress and perspective

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Bio-Design and Manufacturing 2024年第5期7卷 721-746页

作者： Chen Xin Neng xia Li Zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China Multi-Scale Medical Robotics Center Hong Kong Science ParkShatin NTHong Kong 999077China Chow Yuk Ho Technology Center for Innovative Medicine The Chinese University of Hong KongHong Kong 999077China Department of Surgery The Chinese University of Hong KongHong Kong 999077China CUHK T Stone Robotics Institute The Chinese University of Hong KongHong Kong 999077China

Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine,precise sensors,and tunable *** and advanced fabricationmethods are critical formaximizing the application capabilities ofminiature ***-based three-dimensional(3D)printing technology offers the advantages of a wide range of applicable materials,high processing accuracy,and strong 3D fabrication capability,which is suitable for the development of miniature devices with various *** paper summarizes and highlights the recent advances in light-based 3D-printed miniaturized devices,with a focus on the latest breakthroughs in lightbased fabrication technologies,smart stimulus-responsive hydrogels,and tunable miniature devices for the fields of miniature cargo manipulation,targeted drug and cell delivery,active scaffolds,environmental sensing,and optical ***,the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are *** opportunities that will promote the development of tunable microdevices are elaborated,contributing to their improved understanding of these miniature devices and further realizing their practical applications in various fields.

关键词： 3D printing Stimulus-responsive hydrogels Miniature devices Shape-morphing

Effects of baffle position in serpentine flow channel on the performance of proton exchange membrane fuel cells

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Chinese Journal of Chemical Engineering 2024年第5期69卷 250-262页

作者： Guodong xia xiaoya Zhang Dandan Ma MOE Key Laboratory of Enhanced Heat Transfer and Energy Conservation Beijing Key Laboratory of Heat Transfer and Energy ConversionBeijing University of TechnologyBeijing 100124China

This study used a three-dimensional numerical model of a proton exchange membrane fuel cell with five types of channels:a smooth channel(Case 1);eight rectangular baffles were arranged in the upstream(Case 2),midstream(Case 3),downstream(Case 4),and the entire cathode flow channel(Case 5)to study the effects of baffle position on mass transport,power density,net power,***,the effects of back pressure and humidity on the voltage were *** showed that compared to smooth channels,the oxygen and water transport facilitation at the diffusion layer-channel interface were added 11.53%-20.60%and 7.81%-9.80%at 1.68 A·cm^(-2)by adding *** closer the baffles were to upstream,the higher the total oxygen flux,but the lower the flux uniformity the worse the water *** oxygen flux of upstream baffles was 8.14%higher than that of downstream baffles,but oxygen flux uniformity decreased by 18.96%at 1.68 A·cm^(-2).The order of water removal and voltage improvement was Case 4>Case 5>Case 3>Case 2>Case *** power of Case 4 was 9.87%higher than that of the smooth *** the Case 4,when the cell worked under low back pressure or high humidity,the voltage increments were *** potential increment for the back pressure of 0 atm was 0.9%higher than that of 2 atm(1 atm=101.325 kPa).The potential increment for the humidity of 100%was 7.89%higher than that of 50%.

关键词： Proton exchange membrane fuel cell Baffle position Mass transfer Net power Uniformity Voltage increment

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关于加强高校学生思想政治工作的若干思考

三明高等专科学校学报 2004年第1期21卷 139-142页

作者：夏志勇共青团三明高等专科学校委员会福建三明365004

进入新世纪,高校思想政治工作面临的客观环境、工作对象、工作内容等方面都发生了深刻的变化,因此必须清醒地认识当前高校思想政治工作所面临的挑战,解放思想,与时俱进,不断探索更加有效的工作方法,采取切实有效的措施,加强和改进高校... 详细信息

进入新世纪,高校思想政治工作面临的客观环境、工作对象、工作内容等方面都发生了深刻的变化,因此必须清醒地认识当前高校思想政治工作所面临的挑战,解放思想,与时俱进,不断探索更加有效的工作方法,采取切实有效的措施,加强和改进高校学生思想政治工作。

关键词：高校思想政治工作价值观念创新人才服务意识教学改革以人为本干部队伍建设

Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits

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Chinese Journal of Integrative Medicine 2024年第9期30卷 809-817页

作者： LU Man MENG De-hong SHE Ze-yu WU xian xia Shuai YANG Kai-ning LIU Cun-bin LI Tao YANG yong-hui The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei230031China The Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei230038China Department of Acupotomy Rehabilitation Anhui Provincial Hospital of Integrated Traditional Chinese and Western MedicineHefei230031China

Objective:To explore the effect of acupotomy intervention on autophagy of chondrocytes in rabbits with knee osteoarthritis(KOA),and to determine the possible mechanisms of acupotomy to alleviate cartilage ***:The modified Videman method was used to construct a KOA rabbit *** modeling,40 rabbits were randomly divided into 4 groups by a random number table:control;KOA(model);KOA+acupotomy(acupotomy),and KOA+sham acupotomy(sham),10 in each *** a 3-week treatment course,the knee joint activity was determined by the modified Lequesne MG ***-eosin staining staining was used to examine the morphological changes of *** of chondrocytes was observed by transmission electron *** surface morphology of cartilage tissue was observed by scanning electron *** mRNA and protein levels of AMP kinase/mammalian target of rapamycin/Unc-51(AMPK/mTOR/ULK1)signal pathway key proteins,autophagy-related factor Beclin-1 and microtubule-associated protein 1A/1B light chain 3(LC3)in rabbit knee cartilage were assessed by real-time fluorescence quantitative polymerase chain reaction and Western blot,***:The modified Lequesne MG score of acupotomy group was significantly lower than that of model group(P<0.05).Pathological results showed that chondrocyte autophagy decreased and cartilage surface was rough in the model group,which recovered after acupotomy *** mRNA expressions of AMPK,ULK1,Beclin-1 and the protein levels of p-AMPK,p-ULK1,Beclin-1,and LC3Ⅱ/LC3Ⅰwere decreased in the model group,while the mRNA and protein expressions of mTOR were increased(P<0.01).However,acupotomy treatment reversed these abnormal changes(P<0.05).Conclusions:Acupotomy could effectively up-regulate the expressions of AMPK,ULK1 and Beclin1,reduce the expression of mTOR,promote autophagy,and alleviate joint *** is a promising complementary and alternative therapy for KOA.

关键词： acupotomy knee asteoarthritis autophagy AMPK/mTOR/ULK1 signaling pathway rabbit