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Three-dimensional stability calculation method for high and large composite slopes formed by mining stope and inner dump in adjacent open pits

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International Journal of mining Science and Technology 2024年第4期34卷 507-520页

作者： Zuchao Liang Dong Wang Guanghe Li Guangyu Sun mingyu yu Dong xia Chunjian Ding College of mining Engineering Liaoning Technical UniversityFuxin 123000China Inner Mongolia Pingxi Baiyinhua Coal Industry Co. Ltd.Xilingol League 026000China Guoneng Baorixile Energy Co. Ltd.Hulunbuir 021008China

The 2D limit equilibrium method is widely used for slope stability ***,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical ***,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope *** the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding *** integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is ***,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is *** analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear *** spatial form equation of the sliding mass comprises an ellipsoid and weak plane *** analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite ***,the3D stability coefficient of the composite slope exhibits an exponential co

关键词： Composite slope Destabilization mechanism 3D mechanical effect Three-dimensional stability Coordinated development distance

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Investigation on occupant presence and appliance operation schedules for university campus in south China sub-tropical area

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Building Simulation 2024年第2期17卷 301-318页

作者： Siwei Lou Zhongyuan Lin yukai Zou Dawei xia yu Huang Zhuohong Li Zhaowen Gu School of Civil Engineering Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina School of Architecture and Urban Planning Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina

Building occupant presence during varying periods is crucial to the performance studies of buildings and city ***,the understanding of the building occupancies on the university campus remains *** address this gap,our study employs field measurements,payment records,course arrangements,and building access systems to depict the occupancy patterns of the canteen,dormitory,library,and teaching and lab buildings during weekdays and *** found that the occupancy rates across different buildings are somehow interrelated,given that the total number of occupants on campus is generally ***,dormitory occupancy rates tend to be low during the morning and afternoon course hours,which inversely correlates with the high occupancy rates in the teaching and lab buildings during these ***,canteens experience surges in occupancy during meal times,which coincide with a decrease in library ***,we established appliance operation schedules for dormitories through surveys and on-site *** dispensers and electronic devices were identified as the primary energy consumers for both male and female occupants,with desk-top fans and hairdryers being significant energy users for male and female occupants,*** findings are essential for energy studies within a campus setting,underlining the importance of considering occupant behaviors on a regional scale.

关键词： building occupant behavior university campus occupancy schedule appliance operation schedule

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Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice

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Virologica Sinica 2024年第1期39卷 97-112页

作者： Jiao Hu Zixiong Zeng xia Chen Manyu Zhang Zenglei Hu min Gu xiaoquan Wang Ruyi Gao Shunlin Hu yu Chen xiaowen Liu Daxin Peng Xiufan Liu Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou University225009China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou UniversityYangzhou225009China Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agri-food Safety and Quality Ministry of Agriculture of China(26116120)Yangzhou UniversityYangzhou225009China

Influenza A virus(IAV)continues to pose a pandemic threat to public health,resulting a high mortality rate annually and during pandemic *** modification of viral protein plays a substantial role in regulating IAV ***,based on immunoprecipitation(IP)-based mass spectrometry(MS)and purified virus-coupled MS,a total of 89 phosphorylation sites distributed among 10 encoded viral proteins of IAV were identified,including 60 novel phosphorylation ***,for the first time,we provide evidence that PB2 can also be acetylated at site ***,the PB2 S181 phosphorylation site was consistently identified in both IP-based MS and purified virus-based *** S181 and K187 are exposed on the surface of the PB2 protein and are highly conserved in various IAV strains,suggesting their fundamental importance in the IAV life *** analysis results demonstrated that S181E/A and K187Q/R mimic mutations do not significantly alter the PB2 protein *** continuous phosphorylation mimicked by the PB2 S181E mutation substantially decreases viral fitness in mice,PB2 K187Q mimetic acetylation slightly enhances viral virulence in ***,PB2 S181E substantially impairs viral polymerase activity and viral replication,remarkably dampens protein stability and nuclear accumulation of PB2,and significantly weakens IAV-induced inflammatory ***,our study further enriches the database of phosphorylation and acetylation sites of influenza viral proteins,laying a foundation for subsequent mechanistic ***,the unraveled antiviral effect of PB2 S181E mimetic phosphorylation may provide a new target for the subsequent study of antiviral drugs.

关键词： H5N1 influenza virus PB2 Phosphorylation Acetylation Viral fitness Mice

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Different concentrations of hyaluronic acid eye drops for dry eye syndrome: a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1110-1119页

作者： xiao-Wei Ouyang Sheng Fang yun-min Yi Shi-Peng Zou Qi-yu Hu Zi-Xuan Huang Qing-xia Li Jin-Yan Luo Department of Ophthalmology Nanchang Hongdu Hospital of Traditional Chinese MedicineNanchang 330000Jiangxi ProvinceChina Department of Ophthalmology Jiangxi Hospital of Integrated Traditional Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Cataract Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina Department of Neuro-ophthalmology Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina

AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July *** standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were *** analysis,Egger’s test and Meta-regression analysis were performed for all ***:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 ***-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and ***:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes.

关键词： dry eye hyaluronic acid concentration Meta-analysis

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Grasp Detection with Hierarchical Multi-Scale Feature Fusion and Inverted Shuffle Residual

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Tsinghua Science and Technology 2024年第1期29卷 244-256页

作者： Wenjie Geng Zhiqiang Cao Peiyu Guan Fengshui Jing min Tan Junzhi yu State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Grasp detection plays a critical role for robot *** pixel-wise grasp detection networks with encoder-decoder structure receive much attention due to good accuracy and ***,they usually transmit the high-level feature in the encoder to the decoder,and low-level features are *** is noted that low-level features contain abundant detail information,and how to fully exploit low-level features remains ***,the channel information in high-level feature is also not well ***,the performance of grasp detection is *** solve these problems,we propose a grasp detection network with hierarchical multi-scale feature fusion and inverted shuffle *** low-level and high-level features in the encoder are firstly fused by the designed skip connections with attention module,and the fused information is then propagated to corresponding layers of the decoder for in-depth feature *** a hierarchical fusion guarantees the quality of grasp ***,an inverted shuffle residual module is created,where the high-level feature from encoder is split in channel and the resultant split features are processed in their respective *** such differentiation processing,more high-dimensional channel information is kept,which enhances the representation ability of the ***,an information enhancement module is added before the encoder to reinforce input *** proposed method attains 98.9%and 97.8%in image-wise and object-wise accuracy on the Cornell grasping dataset,respectively,and the experimental results verify the effectiveness of the method.

关键词： grasp detection hierarchical multi-scale feature fusion skip connections with attention inverted shuffle residual

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A study of the effect of local scour on the flow field near the spur dike

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 98-105页

作者： yu-Tian Li Jie-min Zhan Wing-Hong Onyx Wai Department of Industrial Design School of Industrial Design and Ceramic ArtFoshan UniversityFoshan 528000China Department of Applied Mechanics and Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China

The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with *** this study,large eddy simulations with fixed-bed at different scouring stages were conducted to investigate the changes in flow *** results imply that the bed deformation leads to an increase in flow rate per unit area,which represent the capability of sediment transportation by water,in the scour ***,the intensity of turbulent kinetic energy and bimodal motion near the sand bed induced by the HVS were also ***,the peak moments between the two sediment transport mechanisms were ***,understanding the complex feedback mechanism between topography and flow field is essential for the local scour problem.

关键词： Spur dike Local scour Large eddy simulation Down flow Horseshoe vortex system

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Metal-to-insulator transition in platinum group compounds

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Rare Metals 2024年第8期43卷 3460-3474页

作者： yu-Xuan xia Jian-Gang He Nuo-Fu Chen Ji-Kun Chen School of New Energy North China Electric Power UniversityBeijing102206China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for PostMoore Chips(ministry of Education) School of Materials Science and EngineeringJniversity of Science and Technology BeijingBeijing 100083China

The metal-to-insulator transition(MIT) as usually achieved in 3d-orbital transitional metal(TM) compounds opens up a new paradigm in correlated electronics via triggering abrupt variations in their transportation *** to such 3d-orbital TM compounds,the MIT within the platinum group(Pg) element compounds based on the 4d-and 5d-orbital configurations is more complicated,owing to their elevation in the spinorbit coupling and meanwhile weakened intra-atomic Coulomb *** brings in a new freedom to regulate the balance in their metallic or semiconductive orbital configurations,while their MIT properties can be potentially combined with their spintronic properties to enable new electronic ***,we review the electronic transport and MIT behaviors within the existing family of Pg-containing compounds,particularly those showing first-order MIT behaviors that can be useful in correlated *** is also hoped that summarizing the presently reported Pg-containing MIT compounds will lead to the discovery of more new material families and/or new mechanisms associated with the Pg-containing compounds showing MIT properties.

关键词： Metal-to-insulator transition Platinum group compounds Electron correlation Spin-orbital coupling

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A particle-resolved heat-particle-fluid coupling model by DEM-IMB-LBM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： ming xia Jinlong Fu Y.T.Feng Fengqiang Gong Jin yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary(IMB)scheme is used to couple the discrete element method(DEM)and lattice Boltzmann method(LBM),while a recently proposed Dirichlet-type thermal boundary condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IBM-LBM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant physical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKT)simulation with heat transfer,are carried out to validate the accuracy of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice Boltzmann method(LBM) Dirichlet-type thermal boundary Direct numerical simulation

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Metagenomic insights into microorganisms and antibiotic resistance genes of waste antibiotic fermentation residues along production,storage and treatment processes

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Journal of Environmental Sciences 2024年第2期136卷 45-55页

作者： Ziming Han xiao Luan Haodi Feng Yanqin Deng min Yang yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery Beijing 100085China Wuhan Agricultural Inspection Center Wuhan 430016China University of Chinese Academy of Sciences Beijing 100049China

Antibiotic fermentation residue(AFR)is nutrient-rich solid waste generated from fermentative antibiotic production *** is demonstrated that AFR contains high-concentration of remaining antibiotics,and thus may promote antibiotic resistance development in receiving environment or feeding farmed ***,the dominate microorganisms and antibiotic resistance genes(ARGs)in AFRs have not been adequately explored,hampering understanding on the potential antibiotic resistance risk development caused by ***,seven kinds of representative AFRs along their production,storage,and treatment processes were collected,and multiple methods including amplicon sequencing,metagenomic sequencing,and bioinformatic approaches were adopted to explore the biological characteristics of *** expected,antibiotic fermentation producer was found as the predominant species in raw AFRs,which were collected at the outlet of fermentation ***,except for producer species,more environment-derived species persisted in stored AFRs,which were temporarily stored at a semi-open *** genus,classified as Firmicutes phylum and Bacilli class,became predominant bacterial taxa in stored AFRs,which might attribute to its tolerance to high concentration of *** from metagenomic sequencing together with assembly and binning approaches showed that these newly-colonizing species(e.g.,Lactobacillus genus)tended to carry ARGs conferring resistance to the remaining ***,after thermal treatment,remaining antibiotic could be efficiently removed from AFRs,and microorganisms together with DNA could be strongly *** sum,the main risk from the AFRs was the remaining antibiotic,while environment-derived bacteria which tolerate extreme environment,survived in ARFs with high content antibiotics,and may carry ***,hydrothermal or other harmless treatment technologies are recommended to remove antibiotic content and inactivate bacteria befor

关键词： Pharmaceutical manufacturing Antibiotic mycelia residue Antibiotic resistance bacteria Thermal treatment Solid waste

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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO ming-yi FU yu ZHAO Rui-xia WANG Jing-wen FANG yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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