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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia LIU xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Influence of transcatheter arterial embolization on symptom distress and fatigue in liver cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 810-818页

作者： Xu-min Yang Xu-Yan Yang Xin-yu Wang yue-xia Gu Department of Nursing The First Affiliated Hospital of Naval Medical University(Changhai Hospital)Shanghai 200433China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignancy,and transcatheter arterial embolization(TAE)has emerged as a pivotal therapeutic ***-ever,TAE may induce symptom distress and fatigue,adversely affecting the quality of life of *** To investigate symptom distress,fatigue,and associated factors in HCC patients undergoing *** We used a cross-sectional design and purposive sampling to enroll HCC patients who underwent TAE at our institution from January to December ***-naires were utilized to collect data on symptom distress and fatigue scores from the first to the third day after *** Our study revealed a significant reduction in fatigue and symptom distress among patients after ***,fatigue,insomnia,fever and abdominal dis-tension were the most common symptoms troubling patients during the first 3 d *** status,presence of family support,physical functional status,age,and symptom distress were identified as predictors of fatigue in *** Healthcare professionals should educate HCC patients on symptom distress and INTRODUCTION Hepatocellular carcinoma(HCC)ranks as the fifth most prevalent cancer and the third leading cause of cancer-related mortality *** intervention remains the cornerstone of HCC treatment;however,due to the challenges associated with early diagnosis and the lack of specific diagnostic markers,a considerable proportion of patients are diagnosed at advanced stages,rendering them ineligible for surgical *** arterial embolization(TAE)is an interventional therapeutic approach involving the insertion of a fine catheter via the femoral artery to reach the vasculature near the tumor *** aims to obstruct the arterial supply to the tumor by deploying embolic agents,thereby inducing necrosis in cancer *** procedure is suitable for patients with good liver function and overall health,particularly those with large HCCs that ha

关键词： Transcatheter arterial embolization Fatigue Symptom distress Hepatocellular carcinoma Influencing factors

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Idiopathic mesenteric phlebosclerosis missed by a radiologist at initial diagnosis: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1810-1816页

作者： min Wang yu-xia Wan Jin-Wen Liao Fei Xiong Department of Gastroenterology Changning County People’s HospitalYibin 644300Sichuan ProvinceChina Department of Gastroenterology Qianwei People’s HospitalLeshan 614400Sichuan ProvinceChina Department of Gastroenterology The People’s Hospital of Jianyang CityChengdu 641400Sichuan ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina

BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare type of ischemic colitis characterized by thickening of the wall of the right hemicolon and calcification,sclerosis,and fibrosis of mesenteric *** diagnosis of IMP is based on typical clinical features and imaging *** report a case of IMP that was initially missed by the *** SUMMARY A 77-year-old woman was admitted to the hospital due to chronic diarrhea for over 2 *** had been consuming Chinese patent medicines(CPM)containing fructus gardeniae for more than 15 *** revealed an edematous mucosa,bluish-purple discoloration,erosions,and ulcerations throughout the colorectal *** computed tomography(CT)showed diffuse mural thickening of the entire colorectum,with tortuous thread-like calcifications in the right hemicolon,left hemicolon,and *** of the calcifications were located in the mesenteric *** diagnosis of IMP was established based on medical history,colonoscopy,CT findings,and histopathological *** patient was treated conservatively with papaverine and rifaximin,and CPM was *** diarrhea symptoms improved,indicating the effectiveness of the *** the next several years,she took opium alkaloids for an extended period and did not require hospitalization for the aforementioned gastrointestinal *** IMP is a rare gastrointestinal disease affecting Asian populations,possibly related to long-term herbal medicine *** imaging analysis is crucial for diagnosis,but insufficient understanding of the disease can lead to misdiagnosis or missed *** strategies should be personalized.

关键词： Idiopathic mesenteric phlebosclerosis Computed tomography Colonoscopy Chinese patent medicines Fructus gardeniae Case report

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Sequence-Controlled Synthesis of Alternating Poly(ester amide)s using Water as Control Agent in One-Pot

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Chinese Journal of Polymer Science 2024年第8期42卷 1015-1020页

作者： Tao Liu Fang-Fang Niu Kan Cheng yu-min xia Bo-Mou Ma Xue-Li Wang Jian-Yong yu and Yong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Poly(ester amide)s(PEAs)attract much attention as a new kind of biodegradable ***,the synthesis of PEAs with sequence-regulated chain structures is still complicated due to the multistep polymerization,high monomer purity,as well as the usage of organic solvents,which greatly inhibits its development and ***,a one-pot strategy without solvent was developed to synthesize the alternating PEA fromα,ω-amino alcohol and dicarboxylic acid by sequential polycondensation,where water was used as the controlling agent for amidation and ***,the amidation and esterification were controlled to proceed in turn by adding or removing water,realizing the one-pot preparation of alternating *** resultant PEA is characterized by^1H-and^(13)C-NMR,and its chain structure is confirmed to be highly quasi-alternating similar to alternating PEAs prepared by classical methods The evaluations from DSC and DMA demonstrate that the properties of quasi-alternating PEA(T_(m)=102℃,ΔH_(m)=30J·g^(-1))are far superior to those of random PEA(T_(m)=72℃,ΔH_(m)<1 J·g^(-1)).

关键词： Biodegradable macromolecules Polymer architectures Sequence-controlled synthesis One-pot polymerization

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A regularization algorithm of dynamic light scattering for estimating the particle size distribution of dual-substance mixture in water

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Particuology 2024年第6期89卷 246-257页

作者： Yanghong Wang Ziqiang Meng Zipei Zhang min xia Li xia Wei Li School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Dynamic light scattering(DLS)is a nondestructive,well-established technique for the size characterization of proteins,nanoparticles,polymers,and colloidal ***,current DLS techniques are only applied to particle groups of single composition due to the limitation of their inversion *** this study,we propose a particle size distribution inversion algorithm based on the Tikhnonov regularization method that can be applied to the dual-substance particle *** algorithm retrieves the particle size distributions of two substances,respectively,by taking advantage of their refractive index *** simulation results reveal that the algorithm has excellent accuracy and stability when the scattering angle is 30°.Instead of the original identity matrix,the first-order difference matrix and second-order difference matrix are used as the regular matrix when utilizing the Tikhnonov algorithm,which obviously improves the anti-interference,accuracy,and stability of the ***,the inversion of particle size distribution is carried out at a 0.01%–1%noise level,which shows that the algorithm has an available antinoise ***,experimental particle size measurements for a mixture of polystyrene beads and toner particles demonstrate that the proposed algorithm is superior to the traditional Tikhnonov algorithm in applicability and accuracy.

关键词： Dynamic light scattering Dual-substance mixture Particle sized istribution Tikhnonov regularization

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On Stability Discrimination of Limit Cycles for Piecewise Smooth Systems

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1785-1803页

作者： Mao An HAN xia yu ZHOU School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004P.R.China

This paper is concerned with the problem of stability discrimination of limit cycles for piecewise smooth *** first establish the Poincaré map near a periodic orbit,and deduce the first order derivative of the map for general piecewise smooth systems on the ***,we obtain a sufficient condition for determining the stability of limit cycles for these systems.

关键词： Piecewise smooth system limit cycle stability

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Towards imbalanced motion:part-decoupling network for video portrait segmentation

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Science China(Information Sciences) 2024年第7期67卷 197-210页

作者： Tianshu yu Changqun xia Jia LI State Key Laboratory of Virtual Reality Technology and Systems School of Computer Science and EngineeringBeihang University Peng Cheng Laboratory

Video portrait segmentation(VPS), aiming at segmenting prominent foreground portraits from video frames, has received much attention in recent years. However, the simplicity of existing VPS datasets leads to a limitation on extensive research of the task. In this work, we propose a new intricate large-scale multi-scene video portrait segmentation dataset MVPS consisting of 101 video clips in 7 scenario categories,in which 10843 sampled frames are finely annotated at the pixel level. The dataset has diverse scenes and complicated background environments, which is the most complex dataset in VPS to our best *** the observation of a large number of videos with portraits during dataset construction, we find that due to the joint structure of the human body, the motion of portraits is part-associated, which leads to the different parts being relatively independent in motion. That is, the motion of different parts of the portraits is imbalanced. Towards this imbalance, an intuitive and reasonable idea is that different motion states in portraits can be better exploited by decoupling the portraits into parts. To achieve this, we propose a part-decoupling network(PDNet) for VPS. Specifically, an inter-frame part-discriminated attention(IPDA)module is proposed which unsupervisedly segments portrait into parts and utilizes different attentiveness on discriminative features specified to each different part. In this way, appropriate attention can be imposed on portrait parts with imbalanced motion to extract part-discriminated correlations, so that the portraits can be segmented more accurately. Experimental results demonstrate that our method achieves leading performance with the comparison to state-of-the-art methods.

关键词： video portrait segmentation imbalanced motion unsupervised part decoupling motion correlation inter-frame attention

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Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： yu-Zhao Yang Cheng Xu Li-xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

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Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

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World Journal of Clinical Cases 2024年第2期12卷 249-255页

作者： Li-min Wen Ran Li Yan-Ling Wang Qing-xia Kong min xia Clinical Medicine College Jining Medical UniversityJining 272067Shandong ProvinceChina School of Basic Medical Sciences Shandong UniversityJinan 250012Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Jining Medical UniversityJining 272007Shandong ProvinceChina

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular ***-term seizures can seriously affect the prognosis and quality of life of ***(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding *** To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform *** From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were *** clinical,imaging,and EEG characteristics were *** stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively *** In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the *** In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

关键词： Post-stroke epilepsy Electroencephalogram Seizure Stroke Slow wave

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Probing the Kinematic Signatures of Planet Formation in the Gas Disk of MWC 480

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Research in Astronomy and Astrophysics 2024年第6期24卷 110-118页

作者： min Zhao Haochuan yu Zhengxiang Li Department of Astronomy Beijing Normal UniversityBeijing 100875China Sub-department of Astrophysics Department of PhysicsUniversity of OxfordOxfordOX13RHUK

The disk around MWC 480 has shown multiple substructures in both dust and gas observations,possibly suggesting ongoing planet formation in *** this paper,we explore the gas kinematics of the MWC 480 disk by analyzing the archival Atacama Large Millimeter/submillimeter Array observations of^(12)CO(J=2-1),^(13)CO(J=2-1),and C^(18)O(J=2-1).By modeling the line-of-sight velocities,inferred from the Doppler shifts of the emission lines,we are able to decompose the three-dimensional(3D)velocity field of the disk into rotational,radial,and vertical *** analysis reveals the presence of large-scale gas flows in the(r,z)***,we identify potential meridional flows across various heights as traced by all three CO isotopologues in the 80–120 au region,possibly associated with ongoing planet formation activities in this ***,we find upward flows near 200 au for all three CO isotopologues,which may point to the presence of disk winds.

关键词： protoplanetary disks planet-disk interactions planet-star interactions

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