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Illuminating spin-crossover octanuclear metal-organic cages

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Science China Chemistry 2024年第4期67卷 1208-1215页

作者： Zhi-Kun Liu Alyona A.Starikova Yu-xia Li ke Sun Meng Yu Zi-Shuo Yao Jun Tao key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical EngineeringLiangxiang CampusBeijing Institute of TechnologyBeijing 102488China Institute of Physical and Organic Chemistry Southern Federal UniversityRostov-on-Don 344090Russia

Spin-crossover(SCO)materials that reversibly switch between high-and low-spin states have potential for the storage of spin state-relative information,and have gained much attention incorporating secondary physical properties,such as fluorescence and magneto-optical *** this study,we synthesized three octanuclear metal-organic cages(MOCs)using tetraphenylethylene-based luminophores,aldehydes,and Fe^(Ⅱ)salts,by subcomponent self-assembly approach,namely[Fe1]-[Fe3].By controlling the ligand-field strength and guest encapsulation,we finely tuned their SCO *** them,MOC[Fe2]displayed nearly complete SCO behavior in the solid state,which is rare for high-nuclearity *** also demonstrated the coupling of SCO with fluorescence emission in these MOCs by using isostructural Zn^(Ⅱ)complexes([Zn1]-[Zn3])as control experiments,for the first *** calculations revealed the energy-transfer mechanism between fluorophores and SCOactive centers,which emphasizes the significant contribution of d-d transitions in the interplay between the occurrence of SCO and fluorescence emission.

关键词： metal-organic cages spin crossover fluorescence switching materials DFT calculation

Study on the Promotion of Wound Healing in Mice with Burn Injuries by Bioactive Glass 1393

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 9-16,26页

作者： xia Wei-dong XU ke ZHENG Chao-yu CHEN Xue-nan National Clinical key Specialty(Wound Repair Department) Wenzhou Medical University Affiliated First HospitalWenzhou Zhejiang 325000China Institute of Life Sciences Wenzhou UniversityWenzhou Zhejiang 325000China Wuhan University of Science and Technology School of Medicine Wuhan Hubei 430000China

Objective:To investigate the effect and mechanism of bioactive glass1393 on wound healing in mice with burn ***:A benchtop temperature-controlled scald instrument was used to establish a mouse burn wound model,which was divided into an injury group(simple scald group)and a bioactive glass 1393treatment *** wound healing of burn injuries in mice was observed at different times after the operation,and the formation of granulation tissue,collagen deposition and tissue proliferation in the wounds were observed by HE staining,Masson staining and Ki67 staining,and the levels of apoptosis-related proteins and the expression of wnt3a/β-catenin signaling pathway were detected in the wounds by Western ***:Compared with the injury group,the bioactive glass 1393 group accelerated burn wound healing and promoted granulation tissue formation,collagen deposition,and cell *** addition,compared with the injury group,the bioactive glass 1393 group promoted the expression of Bcl-2 protein,inhibited the expression of Bax protein and up-regulated the expression of Wnt3a andβ-catenin ***:Bioactive glass 1393 promotes burn wound healing in mice by inhibiting apoptosis through modulation of wnt3a/β-catenin signaling pathway.

关键词： bioactive glass 1393 wound healing apoptosis

Statistical Channel Modeling for Indoor VLC Communications Based on Channel Measurements

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China Communications 2024年第1期21卷 131-147页

作者： Shuo Liu Pan Tang Jianhua Zhang Yue yin Yu Tong Baobao Liu Guangyi Liu Liang xia State key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China State key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China China Mobile Research Institute Beijing 100053China

Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)***,channel modeling is the foundation for designing efficient and robust VLC *** this paper,we present extensive VLC channel measurement campaigns in indoor environments,i.e.,an office and a *** on the measured data,the large-scale fading characteristics and multipath-related characteristics,including omnidirectional optical path loss(OPL),K-factor,power angular spectrum(PAS),angle spread(AS),and clustering characteristics,are analyzed and modeled through a statistical *** on the extracted statistics of the above-mentioned channel characteristics,we propose a statistical spatial channel model(SSCM)capable of modeling multipath in the spatial ***,the simulated statistics of the proposed model are compared with the measured *** instance,in the office,the simulated path loss exponent(PLE)and the measured PLE are 1.96and 1.97,***,the simulated medians of AS and measured medians of AS are 25.94°and 24.84°,***,the fact that the simulated results fit well with measured results has demonstrated the accuracy of our SSCM.

关键词： channel characteristics channel measurement channel modeling 6G spatial lobe VLC

Precipitation Evolution from Plain to Mountains during the July 2023 Extreme Heavy Rainfall Event in North China

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Journal of Meteorological Research 2024年第4期38卷 635-651页

作者： Mingxin LI Jisong SUN Feng LI Chong WU Rudi xia Xinghua BAO Jinfang yin Xudong LIANG State key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

North China experienced devastating rainfall from 29 July to 1 August 2023,which caused substantial flooding and *** study analyzed observations from surface rain gauges and S-band dual-polarization radars to reveal the following unique features of the precipitation evolution from the plain to the mountains during this event.(1) The total rainfall was found concentrated along the Taihang Mountains at elevations generally > 200 m,and its spatiotemporal evolution was closely associated with northward-moving low-level jets.(2) Storms propagated northwestward with southeasterly steering winds,producing continuous rainfall along the eastern slopes of the Taihang Mountains owing to mountain blocking,which resulted in the formation of local centers of precipitation ***,most rainfall episodes with an extreme hourly rainfall rate(HRR),corresponding to large horizontal wind shear at low levels,actively occurred in the plain area to the east of the Taihang Mountains.(3) The western portion of the extreme heavy rain belt in the north was mainly caused by long-lasting cumulus–stratus mixed precipitation with HRR 20 mm h~(-1).The contributions of convective precipitation and cumulus–stratus mixed precipitation to the total rainfall of the southern and middle rain belts were broadly equivalent.(4) The local HRR maxima located at the transition zone from the plain to the mountains were induced by moderate storm-scale convective cells with active warm-rain processes and large number of small-sized rain droplets.(5) During the devastating rainfall event,it was observed that the rainfall peaked at around 1800 local time(LT) every day over the upstream plain area(no diurnal cycle of rainfall was observed in relation to the accumulated rainfall centers over mountain areas).This was attributable to convective activities along the storm propagation path,which was a resu

关键词： extreme rainfall from plain to mountains convective precipitation stratiform precipitation hourly rainfall rate low-level jet diurnal variation

The Role of Corticotropin-Releasing Factor Receptor 1 in the Stress-Induced Alteration of Visual Properties in Primary Visual Cortex:Insights from the Single Prolonged Stress Model

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Neuroscience Bulletin 2024年第7期40卷 1012-1016页

作者： Qianhui xia Xi Kuang Wei Meng Fei yin Chenchen Ma Yupeng Yang Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China

Dear Editor,Stress initiates a cascade of hormonal and behavioral responses that enable an organism to adapt to new environmental *** unbalanced stress response can lead to dysregulation of the hypothalamic-pituitary-... 详细信息

关键词： Corti Receptor Cortex

Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： yin-Xi He Ting Wang Wen-xian Li Yan-xia Chen Department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

Self-powered stimuli responsive material for dual stimulation of heat and guest molecules

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Chinese Chemical Letters 2024年第2期35卷 590-593页

作者： Jintao Men ke Xu Taiting Sha Lei He Yan Xu Jie Mu Tijian yin Qiong Ye Jiangsu key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Stimuli-responsive smart materials exhibit reverse chemical/physical changes in response to external stimuli and research on stimuli-responsive smart materials with self-powered properties is still uncultivated ***,we report perovskite crystalline self-powered multiple stimuli-responsive materials triggered by chemical and thermal stimuli.[HMEP]PbI_(3)·(H_(2)O)(1;HMEP is a hydroxytris(1-methylethyl)phosphorus cation)crystallizes in a chiral space group P 21 at 293 K and has the piezoelectric reaction(d_(33)=10 pC/N and output voltage=1 V)of self-powered modes,this value is larger than the value of 3 pC/N for the classical piezoelectric material *** materials can generate energy due to mechanical deformation,and using thermal heating to lose water,[HMEP]PbI_(3)(2)can be obtained.2 crystallizes in the non-centrosymmetric space group,undergoes two reversible phase transitions at 243/255 K and 315/348 K,and shows second harmonic generation ***,2 can return to the hydrated form 1 after absorbing *** work will lay the foundation for self-powered stimuli-responsive compounds and contribute to the construction of novel organic-inorganic hybrid materials with second harmonic generation switching.

关键词： Self-powered Dual stimulation reactive Phase transition SHG switch Organic-inorganic hybrid perovskite

Tofacitinib combined with local low-dose ixekizumab injection benefits those with peripheral psoriatic arthritis

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The Journal of Biomedical Research 2024年第1期38卷 92-94页

作者： Yours Sincerely Ruiyuan xia Weixin Zhang Jing Hang Zhiqiang yin Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Ultrasound the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

Dear Editor,Treating psoriatic arthritis(PsA)is always *** treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability *** injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of *** limited treatment options for PsA present a challenge.

关键词： injection drugs cavity treatment

Unveiling protein corona composition:predicting with resampling embedding and machine learning

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Regenerative Biomaterials 2024年第1期3卷 27-33页

作者： Rong Liao Yan Zhuang xiangfeng Li ke Chen Xingming Wang Cong Feng Guangfu yin xiangdong Zhu Jiangli Lin Xingdong Zhang College of Biomedical Engineering National Engineering Research Centre for BiomaterialsSichuan UniversityChengdu610065China

Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue *** nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of ***,achieving accurate predictions remains a significant *** several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data *** this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC *** ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were *** ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random ***,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification.

关键词： nanoparticles protein corona machine learming resampling technique feature analysis