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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia yang Qian-Ru He fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

福建省性暴力犯罪特征实证分析——基于404起刑事案件的分析

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福建警察学院学报 2019年第3期33卷 68-74页

作者：闫霞飞福建警察学院侦查系

通过实证分析发现,福建省性暴力犯罪以男性为主,女性较少且多以胁从犯或帮助犯的身份参与犯罪;成年男性犯罪人再犯罪率下降,而未成年人再犯罪率呈上升趋势,其中14~17岁居多,占总量2/3,除了涉及强奸这一传统罪名外,还涉及强制猥亵他人、... 详细信息

通过实证分析发现,福建省性暴力犯罪以男性为主,女性较少且多以胁从犯或帮助犯的身份参与犯罪;成年男性犯罪人再犯罪率下降,而未成年人再犯罪率呈上升趋势,其中14~17岁居多,占总量2/3,除了涉及强奸这一传统罪名外,还涉及强制猥亵他人、儿童罪,强迫卖淫罪等新罪名;中老年人犯罪问题突出,以50~55岁居多,主要涉及强制猥亵妇女、儿童罪,受害人86.6%为不满10岁的儿童。

关键词：性暴力犯罪刑事案件福建省

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基于规则演变的艺术体操成套编排新思路

北京体育大学学报 2006年第8期29卷 1128-1130页

作者：刁在箴尚迎秋夏燕飞华中师范大学体育学院湖北武汉430079 北京体育大学北京100084

艺术体操评分规则的演变导致对成套编排思路的重新认识,在对新规则实施后的两次国际大赛技术分析的基础上,提出新奥运周期成套动作新的编排理念:构架“难、新、险、美”的编排新格局;合理运用“隐形难度”;强调器械交换的多样性和熟练... 详细信息

艺术体操评分规则的演变导致对成套编排思路的重新认识,在对新规则实施后的两次国际大赛技术分析的基础上,提出新奥运周期成套动作新的编排理念:构架“难、新、险、美”的编排新格局;合理运用“隐形难度”;强调器械交换的多样性和熟练性加分;努力提高“CAP”加分中的创新价值。

关键词：艺术体操规则演变成套编排思路创新

鲁东南地区苯丙酮尿症患儿治疗依从性影响因素分析

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山东医学高等专科学校学报 2018年第3期40卷 196-198页

作者：夏飞燕临沂市妇女儿童医院山东临沂276000

目的了解影响PKU患儿治疗依从性的相关因素。方法采用自制调查问卷对103例苯丙酮尿症患儿家长进行调查,以依从性为因变量,其他因素为自变量,进行Logistic回归分析。结果单因素分析结果表明:患儿的主要照顾者、父母学历、家庭月收入等对... 详细信息

目的了解影响PKU患儿治疗依从性的相关因素。方法采用自制调查问卷对103例苯丙酮尿症患儿家长进行调查,以依从性为因变量,其他因素为自变量,进行Logistic回归分析。结果单因素分析结果表明:患儿的主要照顾者、父母学历、家庭月收入等对依从性有影响(χ2=16.00~48.51,P<0.01);多因素分析结果表明:父母学历越高,依从性越好(OR=30.88,P=0.003);家庭月收入越高者,依从性更好(OR=8.33~22.87,P<0.01)。其他因素与依从性关系尚不密切。结论 PKU患儿的主要照顾者、父母学历是影响其治疗依从性的主要因素。

关键词：苯丙酮尿症治疗依从性影响因素

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临沂地区新生儿遗传代谢病串联质谱结果分析

中国优生与遗传杂志 2018年第11期26卷 77-79页

作者：夏飞燕山东省临沂市妇女儿童医院山东临沂276000

目的探讨串联质谱技术在新生儿遗传代谢病筛查和诊断中的作用和意义,统计并了解我市遗传代谢病发病率。方法收集2014年7月～2017年9月临沂市出生的新生儿足跟血干血滤纸片,通过串联质谱技术检测样本中氨基酸及酰基肉碱等指标,以筛查氨... 详细信息

目的探讨串联质谱技术在新生儿遗传代谢病筛查和诊断中的作用和意义,统计并了解我市遗传代谢病发病率。方法收集2014年7月～2017年9月临沂市出生的新生儿足跟血干血滤纸片,通过串联质谱技术检测样本中氨基酸及酰基肉碱等指标,以筛查氨基酸、有机酸和脂肪酸代谢病共48种遗传代谢病,可疑阳性者进一步确诊。结果共筛查83 570例新生儿,可疑阳性2002例,确诊16例,包括氨基酸代谢病1例(高甲硫氨酸血症),有机酸代谢病6例(甲基丙二酸血症5例,戊二酸血症Ⅰ型1例),脂肪酸代谢病9例(原发性肉碱缺乏症7例、短链酰基辅酶a脱氢酶缺乏症2例)。结论应用串联质谱技术在全市范围内筛查并确诊16例病例,实现了新生儿遗传代谢病早发现早治疗的目的,有效保障儿童健康,降低出生缺陷,提高出生人口素质。

关键词：新生儿遗传代谢病串联质谱

不同麻醉方法与老年患者术后下呼吸道感染相关性分析

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中华医院感染学杂志 2012年第12期22卷 2555-2556页

作者：夏燕飞黄浩曹赞浙江医院麻醉科浙江杭州310013

目的研究不同麻醉方法与老年患者术后下呼吸道感染的相关性。方法对227例接受气管插管全身麻醉老年患者与265例接受神经阻滞麻醉老年患者,术后下呼吸道感染发生率进行回顾性调查。结果全身麻醉组227例患者中20例发生下呼吸道感染,感染率... 详细信息

目的研究不同麻醉方法与老年患者术后下呼吸道感染的相关性。方法对227例接受气管插管全身麻醉老年患者与265例接受神经阻滞麻醉老年患者,术后下呼吸道感染发生率进行回顾性调查。结果全身麻醉组227例患者中20例发生下呼吸道感染,感染率为8.8%;神经阻滞麻醉组265例患者中2例发生下呼吸道感染,感染率为0.8%,两组患者的感染率比较,差异有统计学意义(P<0.05)。结论不同麻醉方法与老年患者下呼吸道感染相关。

关键词：麻醉方法老年患者下呼吸道感染

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小球式旋转直驱压力伺服阀卡滞机理研究

浙江大学学报（工学版） 2019年第7期53卷 1265-1273,1339页

作者：陆亮夏飞燕訚耀保原佳阳郭生荣同济大学机械与能源工程学院上海200092 南京机电液压工程研究中心航空机电系统综合航空科技重点实验室江苏南京210061

针对小球式旋转直驱压力伺服阀(BRDDPSV)静态测试卡滞问题,建立阀芯运动全局函数,包括基于缝隙流理论建立倾斜阀芯径向力模型,基于Coulomb摩擦理论建立阀肩触壁静摩擦-滑动摩擦模型.理论解析曲线合理复现了静态测试卡滞问题:偏心驱动下... 详细信息

针对小球式旋转直驱压力伺服阀(BRDDPSV)静态测试卡滞问题,建立阀芯运动全局函数,包括基于缝隙流理论建立倾斜阀芯径向力模型,基于Coulomb摩擦理论建立阀肩触壁静摩擦-滑动摩擦模型.理论解析曲线合理复现了静态测试卡滞问题:偏心驱动下阀芯逆时针旋转倾斜,右侧阀肩触壁,初始静摩擦导致阀芯卡滞,逐渐提升的电流水平克服摩擦形成阀芯运动超调.为了保证电流指令与控制压力的近似比例特性,阀芯回拉复位,形成重复的正向驱动阀芯卡滞.基于阀肩不触壁原则,获得阀芯是否卡滞阈值条件.研究结果表明:增大阀芯与阀套初始半径间隙或减小小球偏离阀芯轴线的初始偏心量,均可以提高阀芯不卡滞的输出压力阈值;对于21MPa系统压力及0~8MPa输出压力的实际需求,在不改变其他参数的情况下,将初始半径间隙和初始偏心距分别调整为5.1μm和0.2mm,可以在维持原有性能的基础上获得阀芯运动全局不卡滞的最优解.

关键词：小球式旋转直驱压力伺服阀阀芯卡滞防卡滞参数优化

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： yan Li Peng Hao Hongmei Duan fei Hao Wen Zhao Yudan Gao Zhaoyang yang Kwok-Fai So xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1