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Mediation Effects of Placental Inflammatory Transcriptional Biomarkers on the Sex-Dependent Associations between Maternal Phthalate Exposure and Infant Allergic Rhinitis: A Population-Based Cohort Study

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Biomedical and Environmental Sciences 2022年第8期35卷 711-721页

作者： WANG Jian Qing LI Zhi Juan GAO Hui SHENG Jie LIANG Chun Mei HU Ya Bin xia xun HUANG Kun WANG Su Fang ZHU Peng HAO Jia Hu TAO Fang Biao Department of Maiernal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina MOE Key Laboratory of Popularion Health across Life Cycle Hefei 230032AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Anhui Medical UniversityHefei 230032AnhuiChina The Fourth Affiliated Hospital Anhui Medical UniversiyHefei 230022AnhuiChina Department of Pediatrics First Afiliated Hospital of Anhui Medical UniversityHefei 230022AnhuiChina

Objective Prenatal phthalate exposure has been associated with placental inflammatory factors and infant allergic rhinitis(AR).However,the results are inconclusive.We designed a population-based cohort study to examine the effects of placental inflammatory biomarkers on the sex-dependent associations between maternal phthalate exposure and infant AR.Methods A total of 2,348 pregnant women from Ma’anshan,Anhui Province,China,who were screened before antenatal visits and met the inclusion criteria,were included in the present study.We assessed AR in their offspring aged 36 months with a questionnaire.Quantitative PCR was performed to measure placental inflammatory factor m RNAs.The independent samples t-test and multivariable logistic regression were used to determine the associations between infant AR and maternal phthalates.Results Childhood AR may be related to education and family monthly income(P = 0.01).The phthalate metabolites,mono(2-ethylhexyl) phthalate(MEHP),mono(2-ethyl-5-hydroxyl) phthalate(MEHHP),in pregnant women were associated with a significantly increased risk for infant AR in males[P < 0.05;odds ratio(OR):1.285;95% confidence interval(CI):1.037-1.591,and OR:1.232,95% CI:1.008-1.507,respectively],but not females.Additionally,irritably-increased expression levels of HO-1 and IL-4 were associated with AR in male infants(OR:1.175;95% CI:1.038-1.329 and OR:1.181;95% CI:1.056-1.322,respectively).The association between maternal urinary MEHHP and placental HO-1 was marginally significant according to mediation analysis.Conclusion The associations of maternal MEHHP and MEOHP levels with fetal AR in males were significant.Placental HO-1 was a fractional mediator in the associations between MEHHP and AR.Thus,the placenta should be further investigated as a potential mediator of maternal exposure-induced disease risk in children.

关键词： Phthalate Infants Allergic rhinitis Inflammation Sex difference

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曹植《远游篇》创作年代新探

许昌学院学报 2024年第1期43卷 21-26页

作者：夏洵若上海建桥学院新闻传播学院上海201306

《远游篇》是汉魏著名诗人曹植的五言诗,创作年代不详,且至今未有定论。对《远游篇》具体创作年代,或简而概之认为是曹植人生后期作品,但对诗人在黄初与太和年间的差异状态不予区分,更多的则是避而不谈。联系作者生平,细究作者心理,通... 详细信息

《远游篇》是汉魏著名诗人曹植的五言诗,创作年代不详,且至今未有定论。对《远游篇》具体创作年代,或简而概之认为是曹植人生后期作品,但对诗人在黄初与太和年间的差异状态不予区分,更多的则是避而不谈。联系作者生平,细究作者心理,通过文本互证可知,《远游篇》创作年代可确定于黄初中后期。

关键词：《远游篇》曹植游仙诗作品断代魏王朝

孕早期胎儿结构畸形超声筛查的卫生经济学评价

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健康发展与政策研究 2024年第1期27卷 21-28页

作者：敖超群蒋理添夏珣厉进伍丽群深圳市卫生健康发展研究和数据管理中心广东深圳518028 深圳市南山区妇幼保健院广东深圳518052

目的通过成本-效用分析,评价孕早期行胎儿结构畸形超声筛查相比于孕中期行胎儿结构畸形超声筛查的经济性,为临床路径优化提供循证依据。方法从全社会角度出发,构建决策树模型,模拟孕妇于孕早期行胎儿结构畸形超声筛查(干预组)与于孕中... 详细信息

目的通过成本-效用分析,评价孕早期行胎儿结构畸形超声筛查相比于孕中期行胎儿结构畸形超声筛查的经济性,为临床路径优化提供循证依据。方法从全社会角度出发,构建决策树模型,模拟孕妇于孕早期行胎儿结构畸形超声筛查(干预组)与于孕中期行胎儿结构畸形超声筛查(对照组)2种不同产前筛查方案的临床选择及转归路径,评估2组不同路径下的成本-效用情况。模型模拟时长为18周,临床转移概率和成本参数来源于深圳市南山区妇幼保健院数据,效用数据来源于已公开发表的文献。结果指标包括成本、质量调整生命年(qualityadjusted life years,QALYs)和增量成本-效果比(incremental cost-effectiveness ratio,ICER)。通过敏感性分析评估模型结果的稳健性。结果相比对照组,干预组可减少不必要的妊娠发生,以更少的总成本投入获得更多的QALYs,ICER为−161732.68元/QALY,具有绝对成本效果优势。概率敏感性分析表明基础分析结果具有稳健性,干预组具有成本效果的概率为94.60%。结论在全社会角度下,于孕早期进行胎儿结构畸形筛查相比于孕中期具有绝对的经济学优势。

关键词：胎儿结构畸形出生缺陷超声筛查孕早期孕中期成本-效用分析决策树模型

虚拟现实康复锻炼在创伤性颅脑损伤术后恢复中的应用研究

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创伤外科杂志 2024年第1期26卷 31-36页

作者：王艳李朝明杨平亮夏勋成都医学院第一附属医院麻醉科成都610500 成都医学院第一附属医院神经外科成都610500

目的研究虚拟现实康复锻炼(VR-RE)在创伤性颅脑损伤(TBI)术后恢复中的应用效果。方法前瞻性选择2020年7月—2022年6月成都医学院第一附属医院行手术治疗的TBI患者86例,男性64例,女性22例;年龄28~60岁,平均46.6岁;道路交通伤62例,高处坠... 详细信息

目的研究虚拟现实康复锻炼(VR-RE)在创伤性颅脑损伤(TBI)术后恢复中的应用效果。方法前瞻性选择2020年7月—2022年6月成都医学院第一附属医院行手术治疗的TBI患者86例,男性64例,女性22例;年龄28~60岁,平均46.6岁;道路交通伤62例,高处坠落伤18例,打击伤4例,其他2例。依据锻炼方法不同将患者分为RE组[43例,行常规康复锻炼(RE)]、VR-RE组(43例,行常规RE+VR-RE)。RE主要行床上锻炼、转移锻炼、床旁站立锻炼、床旁行走锻炼及日常能力锻炼等。VR-RE组主要行RE+搬运物体、驾船、接椰子、乘坐汽车、躲避训练及整理家务等模拟训练。观察两组术后并发症及术后7dGCS。观察两组锻炼前、锻炼8周后神经功能、运动功能,日常生活能力,精神状态,血清胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)、泛素羧基末端水解酶L1(UCH-L1)等神经损伤因子水平。结果两组术后并发症发生率(11.63%vs.9.30%)及术后7d GCS[(11.18±1.22)分vs.(11.02±1.20)分]比较差异均无统计学意义(P>0.05)。锻炼8周后,VR-RE组美国国立卫生研究院卒中量表(NIHSS)评分、Rankin评分均低于RE组[(11.64±1.35)分vs.(15.79±1.90)分、(1.89±0.21)分vs.(2.49±0.27)分,P<0.05]。锻炼8周后,VR-RE组简式Fugel-Meyer(FMA)评分、Berg平衡量表(BBS)评分均高于RE组[(95.38±9.87)分vs.(88.64±9.24)分,(48.94±5.17)分vs.(42.66±4.60)分,P<0.05]。锻炼8周后,VR-RE组Barthel指数(BI)评分、简易智力状态检查量表(MMSE)评分均高于RE组[(9.13±0.94)分vs.(6.74±0.70)分、(26.19±2.93)分vs.(21.91±2.43)分,P<0.05]。锻炼8周后VR-RE组血清GFAP、NSE、UCH-L1水平均低于RE组[(1.83±0.21)pg/mL vs.(2.29±0.25)pg/mL、(15.37±1.85)ng/mL vs.(20.64±2.28)ng/mL、(0.76±0.09)ng/mL vs.(0.95±0.12)ng/mL,P<0.05]。结论VR-RE可促进TBI患者术后损伤脑神经修复,改善其神经功能、运动功能及精神状态,提高患者术后日常生活能力。

关键词：创伤性颅脑损伤虚拟现实康复锻炼术后恢复

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当归补血汤改善肾性贫血的研究进展

微循环学杂志 2024年第2期34卷 109-112页

作者：邹训霞赵娜妹(综述) 何美杉王宝霞(审校) 中国中医科学院广安门医院保定医院肾病风湿科保定071000

肾性贫血是慢性肾脏病的一种常见并发症,其发病机制主要包括内源性促红细胞生成素(EPO)的减少和铁代谢障碍。当归补血汤(DBT)作为一种传统的中医方剂,已被用于治疗由血虚引起的各类疾病,包括肾性贫血。DBT通过其主要成分当归和黄芪的协... 详细信息

肾性贫血是慢性肾脏病的一种常见并发症,其发病机制主要包括内源性促红细胞生成素(EPO)的减少和铁代谢障碍。当归补血汤(DBT)作为一种传统的中医方剂,已被用于治疗由血虚引起的各类疾病,包括肾性贫血。DBT通过其主要成分当归和黄芪的协同作用,可促进铁的吸收和红细胞的生成,提高血红蛋白水平,从而改善贫血状况。此外,DBT还能通过调节免疫功能和改善铁代谢,对抗肾性贫血。

关键词：当归补血汤肾性贫血中医药

Corrosion behavior of pure metals(Ni and Ti)and alloys(316H SS and GH3535)in liquid GaInSn

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Nuclear Science and Techniques 2024年第3期35卷 70-83页

作者： Jian-Hui Yu Hong-xia Xu xiang-Xi Ye Bin Leng Han-xun Qiu Xing-Tai Zhou School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

In this study,the interactions between a Ga-based liquid metal,GaInSn,and several metal materials,including pure metals(Ni and Ti)and alloys(316H stainless steel(SS)and GH3535),at 650℃were investigated.The aim was to evaluate the corrosion performance and select a suitable candidate material for use as a molten salt manometer diaphragm in thermal energy storage systems.The results indicated that the alloys(316H SS and GH3535)exhibited less corrosion than pure metals(Ni and Ti)in liquid GaInSn.Ga-rich binary intermetallic compounds were found to form on the surfaces of all the tested metal materials exposed to liquid GaInSn,as a result of the decomposition of liquid GaInSn and its reaction with the constituent elements of the metal materials.The corrosion mechanism for all the tested materials exposed to liquid GaInSn was also investigated and proposed,which may aid in selecting the optimal candidate material when liquid GaInSn is used as the pressure-sensing medium.

关键词： Metal materials Liquid GaInSn Corrosion Intermetallic compounds Thermal energy storage systems

Structure of the brachial plexus root and adjacent regions displayed by ultrasound imaging

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Neural Regeneration Research 2012年第26期7卷 2044-2050页

作者： Zhengyi Li xun xia xiaoming Rong Yamei Tang Dachuan Xu Institute of Clinical Anatomy Southern Medical University Guangzhou 510515 Guangdong Province China Department of Ultrasound Shenzhen Second People's Hospital Shenzhen 518035 Guangdong Province China Department of Neurology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

Brachial plexuses of 110 healthy volunteers were examined using high resolution color Doppler ultrasound. Ultrasonic characteristics and anatomic variation in the intervertebral foramen, interscalene, supraclavicular and infraclavicular, as well as the axillary brachial plexus were investigated. Results confirmed that the normal brachial plexus on cross section exhibited round or elliptic hypoechoic texture. Longitudinal section imaging showed many parallel linear hypo-moderate echoes, with hypo-echo. The transverse processes of the seventh cervical vertebra, the scalene space, the subclavian artery and the deep cervical artery are important markers in an examination. The display rates for the interscalene, and supraclavicular and axillary brachial plexuses were 100% each, while that for the infraclavicular brachial plexus was 97%. The region where the normal brachial plexus root traversed the intervertebral foramen exhibited a regular hypo-echo. The display rate for the C5-7 nerve roots was 100%, while those for C8 and T1 were 83% and 68%, respectively. A total of 20 of the 110 subjects underwent cervical CT scan. High-frequency ultrasound can clearly display the outline of the transverse processes of the vertebrae, which were consistent with CT results. These results indicate that high-frequency ultrasound provides a new method for observing the morphology of the brachial plexus. The C~ vertebra is a marker for identifying the position of brachial plexus nerve roots.

关键词： brachial plexus ultrasound anatomical characteristics CT nerve root brachial plexus block neuralregeneration

Jet Vectoring Control Using a Novel Synthetic Jet Actuator

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Chinese Journal of Aeronautics 2007年第3期20卷 193-201页

作者： LUO Zhen-bing xia Zhi-xun XIE Yong-gao College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China

A primary air jet vectoring control system with a novel synthetic jet actuator （SJA） is presented and simulated numerically. The results show that, in comparison with an existing traditional synthetic jet actuator, which is able to perform the duty of either ＂push＂ or ＂pull＂, one novel synthetic jet actuator can fulfill both ＂push＂ and ＂pull＂ functions to vector the primary jet by shifting a slide block inside it. Therefore, because the new actuator possesses greater efficiency, it has potentiality to replace the existing one in various appli- cations, such as thrust vectoring and the reduction of thermal signature. Moreover, as the novel actuator can fulfill those functions that the existing one can not, it may well be expected to popularize it into more flow control systems.

关键词： jet vectoring control synthetic jet actuator slide block flow control

Potential mosquito-associated melioidosis and analysis of sample processing results in Hainan, China, 2023

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 235-236页

作者： xun Kang Shaowen Cheng Rui Zheng Hengjie Zhu Qianfeng xia NHC Key Laboratory of Tropical Disease Control School of Tropical MedicineHainan Medical UniversityHainanHaikou 571199China Department of Wound Repair the First Affiliated Hospital of Hainan Medical UniversityHainanHaikou 571199China

Burkholderia(B.)pseudomallei is a Gram-negative bacterium causing melioidosis,a tropical infection that is being recognized as a growing public health problem[1].Melioidosis,with mortality rates ranging from under 10%to 40%,is a significant concern in Southeast Asia,Australia,and beyond[2].The underdiagnosis,particularly in rural areas,emphasizes the need for improved awareness,surveillance,and management,potentially classifying melioidosis as a neglected tropical disease[3].

关键词： tropical Hainan neglected