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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG Guo-xing xia xin-lu GUO Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

The Effect of Accelerated Aging on the Energy Supply of Maize Seed

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The Effect of Accelerated Aging on the Energy Supply of Maiz...

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

第二届国际整合植物生物学学术研讨会

作者： Ze-Lin Wang,Chao Song,Yue Zhao,xia xin and xin-Xiong lu~* Institute of Crop Science,Chinese Academy of Agricultural Sciences,Beijing 100081,China

It is necessary to mobilize storage compounds to provide energy for seed *** starchy seeds,such as maize seeds,the energy for germination is mainly provided by *** proteomic analyses showed that in maize seed,the expression of some proteins responsible for energy supply,such as 3-phosphoglycerate kinase,malate dehydrogenase and ATP synthase, were significantly down-regulated by accelerated *** was presumed that the energy supply system was closely related to seed *** further study the effect of accelerated aging on energy supply system at the level of the catalytic activity of the enzyme and gene expression,we detected the activity of key enzymes of glycolysis and phosphate pentose pathway by spectrophotography,such as hexokinase,glucose-6-phosphate dehydrogenase and pyruvate ***,the expression of their related genes was determined by RT-PCR and the level of ATP was estimated by bioluminescence,so as to explore the effect of accelerating aging on the pathway and the efficiency of energy *** the present study,maize(Zea mays ***. Jiyu 8) seeds,with the initial germination of 96%,were accelerated aged at 50℃,and seeds with germination percentages of 85%,73%,54%,22%,0%were used for further *** results showed that with declining germination,the activities of the three enzymes and gene expression displayed a downward trend,and ATP content decreased in non-imbibing seeds after *** the imbibition process,the activity of hexokinase gradually increased in non-aging seeds,but this trend was inhibited in aging *** the seeds with germination percentage higher than 54%, the activity of phosphate-6-glucose dehydrogenase slightly decreased until 12 h imbibition,and then increased to 1.5-1.8 times that of dry seeds after 24 h of imbibition,whereas no obvious changes in seeds with germination lower than 22%were *** activity of pyruvate kinase in non-aging dry seeds was 1.16 umol NADH mg protein min,but

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei xia Jinxin lu Jiale Liu Lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Analgesic domain of interferon-a

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Acta Pharmacologica Sinica 1999年第5期 88-88页

作者： JIANG Chun-Lei, WANG Yun-xia, SONG Lian-xia, LIU xin-Yuan, lu Chang-Lin( Department of Neurobiology, Second Military Medical University, Shanghai 200433, China Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China)

There is a bidirectional flow of information between immune and central nervous ***-α(IFN-α) is not only an important immunoregulatory factor, but also an important neuroregulatory molecule in the *** analgesic effect of IFN-α may be mediated by μ opiate *** are two distinct domains in IFN-α molecule mediating immunologic and analgesic activity, *** analgesic domain is located

关键词： IFN Analgesic domain of interferon-a

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-xin Yang Bao-xia Dong Tong-Bu lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-lu Chang Yan Gao xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

xiaokeping-containing serum suppresses high-glucose-induced proliferation of mesangial cells involved in the regulation of cell cycle progression and the p38 mitogen-activated protein kinase pathway

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Journal of Traditional Chinese Medicine 2021年第1期41卷 44-50页

作者： xin Chuanwei xia Zhongni YANG Bo lu Lisong Department of Pharmacy Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012China

OBJECTIVE: To investigate the efficacy of xiaokeping(XKP)-containing serum on the proliferation of high-glucose-induced mesangial cells(MCs)and the potential underlying ***: XKP-containing serum was prepared by the intragastric administration of XKP in ***-1 cells were cultured with normal glucose(NC group), high glucose(HG group), and high glucose with different XKP concentrations. Cell proliferation was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,and the cell cycle distribution was detected by flow cytometry. The expression of p38 mitogen-activated protein kinase(p38 MAPK) pathway components in MCs was detected by Western blotting and quantitative real-time polymerase chain ***: The MC proliferation level in the high-glucose group was significantly higher than that in the normal control group, and XKP suppressed the HG-induced proliferation of MCs dose dependently. Moreover, flow cytometry revealed that XKP blocked cell cycle progression by inducing cell cycle arrest in G1 phase and inhibiting S phase entry. XKP down-regulated the protein and m RNA expression of p38 MAPK in MCs(P luSION: The present study demonstrated that XKP-containing serum inhibits high-glucoseinduced proliferation of MCs by causing cell cycle arrest at G1 phase and inhibiting S phase entry. The underlying mechanism involves the down-regulation of the p38 MAPK signaling pathway, providing a theoretical basis for the use of XKP to treat diabetic kidney disease.

关键词： Mesangial cells cell proliferation cell cycle p38 mitogen-activated protein kinase xiaokeping mixture

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单核细胞增生李斯特菌测试片检测性能研究

中国卫生检验杂志 2016年第23期26卷 3373-3376页

作者：范俊陈娟丽谢俊平孙霞卢新广东达元绿洲食品安全科技股份有限公司广东广州510627

目的评价单核细胞增生李斯特菌测试片的检测性能。方法将本实验室研制的单核细胞增生李斯特菌测试片与李斯特菌培养基和国家标准方法进行对比。通过接种单核细胞增生李斯特菌和10种其他标准菌株,评价了测试片敏感性和特异性。使用测试... 详细信息

目的评价单核细胞增生李斯特菌测试片的检测性能。方法将本实验室研制的单核细胞增生李斯特菌测试片与李斯特菌培养基和国家标准方法进行对比。通过接种单核细胞增生李斯特菌和10种其他标准菌株,评价了测试片敏感性和特异性。使用测试片定量检测单核细胞增生李斯特菌标准菌悬液和15个人工染菌样品,并与李斯特菌培养基进行对比,对结果进行统计分析。定性试验测试了150个自然样品,并与国家标准方法进行对比。结果测试片特异性良好;灵敏度可以达到2 cfu/ml;标准菌悬液和15个人工染菌样品定量检测结果显示,测试片与李斯特菌培养基比较差异有统计学意义(P<0.05)。对150个自然样品测试结果与国家标准方法总符合率为96.00%,无假阴性。结论单核细胞增生李斯特菌测试片定量检测标准菌与李斯特菌培养基效果有差异,可用于自然样品中单核细胞增生李斯特菌的快速初筛。

关键词：单核细胞增生李斯特菌测试片国家标准方法

Role of MetallothioneinlH in Cisplatin Resistance of Non-Small Cell lung Cancer Cells

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Chinese Journal of Cancer Research 2009年第4期21卷 247-254页

作者： xin-fang Hou Qing-xia Fan Liu-xing Wang Shi-xin lu Department of Medicine Henan Tumor Hospital Zhengzhou 450002 China Cancer center of Zhengzhou University Department of Oncology The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 China Department of Etiology and Carcinogenesis Cancer Institute（Hospital） Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China

Objective： Despite platinum-based adjuvant chemotherapy has improved greatly patients＇ outcomes, drug resistance poses a major impediment to the successful use of such an effective agent. Metallothioneins（MTs） are known to play putative roles in cancer cell proliferation, apoptosis, differentiation, drug resistance and prognosis. The present studiy was to investigte the role of metallethioeinlH（MTIH） in cisplatin resistance of human non-small cell lung cancer（NSCLC） cell lines in vitro or its possible molecular mechanisms. Methods： MTIH mRNA expression in A549 and A549/DDP cells was detected by RT-PCR. A recombinant eukaryotic expression plasmid pcDNA3.1（-）-MT1H was constructed and transfected into A549 cells which express no MTIH. MT1H siRNA was transfected into A549/DDP cells which express MTIH highly. MTIH expression was detected by RT-PCR and Immunoblot. The chemosensitivity to cisplatin was assessed by MTT assay. Apoptosis rate was determined by Tunel and FCM. Bcl-2 and Bax were determined by immunohistochemistry. Results： MT1H mRNA was expressed in A549/DDP but not in A549. After transfection of MT1H, MT1H expression was enhanced and the chemosensitivity to cisplatin was decreased in A549 cells. Inversely, after transfection of MT1H siRNA, MT1H expression was decreased and the chemosensitivity to cisplatin was increased in A549/DDP. The apoptosis rate induced by cisplatin was increased and Bcl-2 was down-regulated but Bax showed little change in A549/DDP cells interferred with MT1H siRNA. Conclusion： MT1H overexpression can promote drug resistance in A549 cells . Down-regulation of MTIH interfered with siRNA can effectively reverses the drug resistance in A549/DDP cells by down-regulating the expression of Bcl-2 and increasing cisplatin induced apoptosis. SiRNA targeting MT1H combined with chemotherapy may be a very promising strategy for treatment of lung cancer.

关键词： Metallothionein MT1H Non-small-cell lung cancer Drug resistance Apoptosis