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Electrical control of excitonic oscillator strength and spatial distribution in a monolayer semiconductor

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Nano Research 2024年第9期17卷 8424-8430页

作者： Yanming Wang Junrong Zhang Tianhua Ren meng xia Long Fang xiangyi Wang Xingwang Zhang Kai Zhang Junyong Wang School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Nanophotonic Materials and Devices&Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China Institute of Applied Physics and Materials Engineering University of MacaoTaipaMacao 999078China College of New Energy Inner Mongolia University of TechnologyHohhot 010051China

Electrical modulation of luminescence is significant to modern light-emitting *** transition metal dichalcogenides are emerging direct-bandgap luminescent materials with unique excitonic properties,and the multiple exciton complexes provide new opportunities to modulate the property of luminescence in atomically thin ***,we report an electrical control of exciton emission in the oscillator strength and spatial distribution of excitons in a monolayer *** modulation of excitonic emission intensity with a degree of modulation of~92%has been demonstrated by an electric field at room *** spatial carrier redistribution tuned by a lateral electric field results in distinct excitonic emission patterns by *** modulation approach to exciton oscillator strength and distribution provides an efficient way to investigate the exciton diffusion dynamics and to construct electrically tunable optoelectronic devices.

关键词： monolayer semiconductor exciton electrical modulation spatial distribution

In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes

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Stroke & Vascular Neurology 2024年第1期9卷 8-17,I0001-I0033页

作者： Yu Tian mengxing Wang Yuesong Pan xia meng Xingquan Zhao Liping Liu Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Introduction It remains unclear whether enlarged perivascular spaces(EPVS)predict poor clinical outcomes in patients with acute ischaemic stroke(AIS)or transient ischaemic attack(TIA).Method Data were obtained from the Third China National Stroke Registry *** estimated EPVS in basal ganglia(BG)and centrum semiovale(CSO)using a semiquantified scale(Grade from 0 to 4).Using Cox and logistic regression analyses,the associations of EPVS with 3-month and 1-year adverse outcomes(including recurrent stroke,ischaemic stroke,haemorrhagic stroke,combined vascular event,disability and mortality)were *** analyses of any association of cerebral small vessel disease at baseline and development of a small arterial occlusion(SAO)were *** Among 12603 patients with AIS/TIA,median age was 61.7±11.6 years,and 68.2%were *** adjusting for all potential confounders,frequent-to-severe BG-EPVS was associated with a decreased risk of recurrent ischaemic stroke(HR 0.71,95%CI 0.55 to 0.92,p=0.01)but an increased risk of haemorrhagic stroke(HR 1.99,95%CI 1.11 to 3.58,p=0.02)at 1 year after AIS/TIA,compared with none-to-mild *** with frequent-to-severe CSO-EPVS had a decreased risk of disability(OR 0.76,95%CI 0.62 to 0.92,p=0.004)and all-cause death(HR 0.55,95%CI 0.31 to 0.98,p=0.04)within 3-month but not 1-year follow-ups,compared with those with none-to-mild *** analyses showed that both BG-EPVS(HR 0.43,95%CI 0.21 to 0.87,p=0.02)and CSO-EPVS(HR 0.58,95%CI 0.35 to 0.95,p=0.03)were associated with a decreased risk of subsequent ischaemic stroke in patients with SAO during 1-year *** BG-EPVS increased the risk of haemorrhagic stroke in patients already with AIS/TIA within 1 ***,caution is recommended when selecting antithrombotic agents for secondary stroke prevention in patients with AIS/TIA and more severe BG-EPVS.

关键词： patients haemorrhagic prevention

Mechanism and control of nonuniform phase transformation of microalloyed dual-phase steel during cooling process after hot rolling

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Journal of Iron and Steel Research International 2024年第2期31卷 428-441页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan Chao Liu San-bao Zhou Rui-chun Guo meng-xia Tang National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Strip Production Plant Xichang Steel and Vanadium Corporation of Pangang GroupXichang615000SichuanChina

After cooling in the hot rolling process,the metallographic structure of microalloyed dual-phase steel is nonuniform along the rolling direction,while the thickness fluctuation of microalloyed dual-phase steel with a nonuniform metallographic structure will occur during cold *** mechanism of nonuniform phase transformation of microalloyed dual-phase steels was studied during the cooling process after hot rolling,and the nonuniform phase transformation of microalloyed dual-phase steel was regulated during the cooling process after hot rolling through process ***,the empirical equation of phase transformation temperature was measured by a dilatometer considering thermal ***,the phase field and temperature field of laminar cooling process were calculated to provide initial boundary conditions for the finite element *** that,the coupling finite element model of the temperature phase transformation of the strip steel in coiling transportation process was *** simulation results show that the different thermal contact conditions of the microalloyed dual-phase steel during coil transportation lead to uneven cooling of the coil,which leads to nonuniform transformation of the coil along the rolling *** addition,by prolonging the time interval from coiling to unloading,the phenomenon of nonuniform phase transformation of microalloyed dual-phase steel can be effectively *** simulation results are applied to industrial *** application results show that prolonging the time interval from coiling to unloading can effectively improve the nonuniform phase transformation of microalloyed dual-phase steel in the cooling process after hot rolling.

关键词： Microalloyed dual-phase steel Thickness fluctuation Cooling Heat conduction Nonuniform phase transition Finite element method

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang meng-xia Zhang xiao-xiang meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

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Health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan Wang meng Wang Yanying Wang Dan Tong xia meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Institute of Reproductive and Child Health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University Department of Earth System Science Tsinghua University School of Public Health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 750-760页

作者： Ying-Jie Zhang meng-xia Yuan Wu Wen Fan Li Yi Jian Chuan-Ming Zhang Ye Yang Feng-Lin Chen Department of Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal *** colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent ***-positive colorectal polyps are associated with various diseases;however,their prognosis varies *** snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal *** imaging is required to diagnose and treat CSM-positive colorectal *** This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using *** patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record *** on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal *** The diameters of NHGN and SM polyps were much smaller than those of neoplastic *** NHGN polyps had a deeper red mucosal *** logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic *** 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic *** regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal *** in the CSM mucosa surrounding neoplastic

关键词： Chicken skin mucosa Colorectal cancer Colorectal polyps Endoscopic resection Malignant transformation White light endoscopy

Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fisher Lee H Schwamm Mark Parsons Hao Li Yuesong Pan xia meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volume6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

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双元驱动的中小企业数字化转型协同机制探析

软科学 2024年第3期38卷 99-106页

作者：夏轶群孟夏上海应用技术大学经济与管理学院上海201418

通过解析中小企业数字化转型三重困局,探究政府与数字化服务商双元驱动的系统协同原理,并构建中小企业、政府和数字化服务商三方主体协同参与的演化博弈模型,进而借助仿真和参数敏感性分析探讨系统演化策略稳定性以及关键变量对策略演... 详细信息

通过解析中小企业数字化转型三重困局,探究政府与数字化服务商双元驱动的系统协同原理,并构建中小企业、政府和数字化服务商三方主体协同参与的演化博弈模型,进而借助仿真和参数敏感性分析探讨系统演化策略稳定性以及关键变量对策略演化和稳定结果的影响,结果表明:政府补贴与服务商技术保证策略均能够有效驱动中小企业数字化转型,且主体策略互相呈正反馈关系;中小企业、服务商和政府的初始参与意愿提高有利于主体更快决策参与;政府制定适当小的补贴比例依然能够调动中小企业参与转型的积极性;相对来说,政府补贴前期涨幅对服务商技术保证策略的影响较大;仅补贴单方时政府对服务商的补贴效用更显著。

关键词：数字化转型中小企业数字化服务商协同机制

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Enhanced photothermal dehydration of methanol over W_(18)O_(49)/Au/SAPO-34 catalysts with broadened light absorption

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Rare Metals 2024年第3期43卷 1139-1152页

作者： Ya-Qin Tang meng-xia Yan Chang-Qian Lu Shao-Yuan Li Kui-xian Wei Tao Qu Wen-HuiMa Yong-Nian Dai Kong-Zhai Li Da-Jun Luo Xue-Liang Zhang Yi-Ke Liu Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China School of Materials and Energy Engineering Guizhou Institute of TechnologyGuiyang550003China

Methanol-to-olefins(MTO)process is one of the most critical pathways to produce low carbon ***,the reaction is driven by thermal catalysis,which inevitably needs to consume large amounts of fossil *** a new technique to substitute for the fuel burning is urgent for MTO process to improve the industry prospects and ***,we report a novel W_(18)O_(49)/Au/SAPO-34(W/Au/S),a multifunctional photothermal catalyst for the MTO reaction.A high methanol conversion was achieved under xenonum(Xe)lamp irradiation,yielding methyl ether(ME)and ethylene as the main *** optimized W/Au/S catalysts showed ethylene yield as high as 250μmol in 60 min,which was 2.5 times higher than that of Au/*** physiochemical characterization revealed that the SAPO-34 molecular sieves were surrounded by Au and W_(18)O_(49)nanoparticles,which exhibited a strong localized surface plasmon resonance excitation around 540 nm and light absorption beyond 500 *** multifunctional catalysts showed a strong photothermal effect,arising from the broadened light absorption of Au and W_(18)O_(49)nanoparticles,leading to a temperature as high as 250℃on the surface of the *** study showed that the superior ethylene selectivity of W/Au/S catalysts was attributed to the moderating acidic sites of W_(18)O_(49)for methanol dehydration to *** research may provide new insight for designing heterostructures to improve photo-to-chemical conversion performance and is expected to accelerate progress toward the excellent multifunctional photothermal catalysts with broad light absorption for methanol activation and C-C bond formation.

关键词： Methanol conversion Ethylene Photothermal catalysis W_(18)O_(49) BrΦnsted-acid

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