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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Regional features of pollen R-values in China

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Science China Earth Sciences 2024年第1期67卷 295-308页

作者： jie xia Jian NI College of Life Sciences Zhejiang Normal UniversityJinhua 321004China Jinhua Mountain Observation and Research Station for Subtropical Forest Ecosystems Jinhua 321004China

Establishing a quantitative relationship between modern pollen and vegetation remains a pivotal but intricate pursuit within the field of Quaternary *** R-value,a well-established and traditional metric characterized by its simplicity and direct applicability,serves to calibrate the nonlinear disparities between surface pollen and modern *** study entails the construction of a comprehensive pollen R-value dataset for China derived from R-values published between 1987 and *** dataset,compiled after rigorous screening,calibration,and standardization processes,encompasses 898 modern pollen sampling sites and 2115 pollen R-value data entries,encapsulating 152 pollen taxa spanning 65 families and 113 *** the extracted R-values yielded the following insights:(1)A macrospatial analysis validates previously established knowledge at a site-specific ***,pollen R-value variations across China are statistically *** two-thirds of pollen taxa exhibit underrepresentation(e.g.,Taxodiaceae,Corylus,Nitraria,Tamarix,Cyperaceae,Poaceae,and Fabaceae),while the remaining one-third display overrepresentation(e.g.,Pinus,Picea,Betula,Ephedra,Chenopodiaceae,and Artemisia).The degree of underrepresentation surpasses that of overrepresentation,and the representation patterns of Castanea,Quercus,Polygonaceae,and Asteraceae are contingent upon vegetation types.(2)Pollen R-values follow distinct spatial distribution patterns within *** the woody vegetation region of eastern China,R-values progressively decline from north to south,correlating with rising temperatures and ***,in herbaceous vegetation regions of northern and western China,R-values decrease from east to west and from northeast to southwest,corresponding to increased ***,pollen R-values manifest variation contingent on pollen taxa,vegetation types,and climatic regions,even differing for the same taxa across varying

关键词： Pollen R-value Modern pollen-vegetation relationship Regional pattern Variability Paleovegetation reconstruction

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Hot Corrosion Behavior of Ti45Al8.5Nb Alloy: Effect of Anodization and Pre-oxidation

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1531-1546页

作者： Hao-jie Yan Jun-jie xia Lian-Kui Wu Fa-He Cao School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen518107China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou310014China

The hot corrosion behavior of Ti45 A18.5 Nb alloy was studied in the salt of Na_(2)SO_(4)and/or NaCl at 700℃.To improve the hot corrosion resistance,Ti45 A18.5 Nb alloy was anodized in fluorine-containing solution and pre-oxidized in *** showed that the combination of anodization and pre-oxidation can efficiently enhance the hot corrosion resistance of Ti45 A18.5 Nb alloy contaminated with Na_(2)SO_(4)or Na_(2)SO_(4)+NaCl *** is because anodization and pre-oxidation result in the formation of compact AlOlayer which can act as a diffusion barrier to prevent sulfur,chlorine,and oxygen from attacking the alloy,therefore providing good resistance against hot *** exposed to NaCl deposit,however,no obvious improvement was achieved on the hot corrosion behavior no matter the alloy was anodized or further pre-oxidized in air.

关键词： Hot corrosion TiAl alloy Anodization Pre-oxidation Halogen effect

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New method for high performance multiply-accumulator design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 1067-1074页

作者： Bing-jie xia Peng LIU Qing-dong YAO Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

This study presents a new method of 4-pipelined high-performance split multiply-accumulator (MAC) architecture, which is capable of supporting multiple precisions developed for media processors. To speed up the design further, a novel partial product compression circuit based on interleaved adders and a modified hybrid partial product reduction tree (PPRT) scheme are proposed. The MAC can perform 1-way 32-bit, 4-way 16-bit signed/unsigned multiply or multiply-accumulate operations and 2-way parallel multiply add (PMADD) operations at a high frequency of 1.25 GHz under worst-case conditions and 1.67 GHz under typical-case conditions, respectively. Compared with the MAC in 32-bit microprocessor without interlocked piped stages (MIPS), the proposed design shows a great advantage in speed. Moreover, an improvement of up to 32% in throughput is achieved. The MAC design has been fabricated with Taiwan Semiconductor Manufacturing Company (TSMC) 90-nm CMOS standard cell technology and has passed a functional test.

关键词： Multiply-accumulator (MAC) Pipeline Compressor Partial product reduction tree (PPRT) Split structure

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Physical design method of MPSoC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 631-637页

作者： LIU Peng xia Bing-jie TENG Zhao-wei Department of Information Science ＆ Electronic Engineering Zhejiang University Hangzhou 310027 China

Floorplan, clock network and power plan are crucial steps in deep sub-micron system-on-chip design. A novel di- agonal floorplan is integrated to enhance the data sharing between different cores in system-on-chip. Custom clock network con- taining hand-adjusted buffers and variable routing rules is constructed to realize balanced synchronization. Effective power plan considering both IR drop and electromigration achieves high utilization and maintains power integrity in our MediaSoC. Using such methods, deep sub-micron design challenges are managed under a fast prototyping methodology, which greatly shortens the design cycle.

关键词： Physical design Fast prototyping Floorplan Clock tree synthesis (CTS) Power plan Multiprocessor system-onchip (MPSoC)

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Predictive control for mechanical system with backlash based on hybrid model

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Journal of Systems Engineering and Electronics 2009年第6期20卷 1301-1308页

作者： Dou Lihua Dong Lingxun Chen jie xia Yuanqing Dept. of Information Science and Technology Beijing Inst. of Technology Beijing 100081 P. R. China

The mechanical system with backlash is distinguished between a＂backlash mode＂and a＂contact mode＂.The inherent switching between the two operating modes makes the system a prime example of hybrid *** eliminating the bad effect of backlash, a piecewise affine（PWA） model of the mechanical servo system with backlash is *** optimal control of constrained PWA system is obtained by taking advantage of model predictive control（MPC） method, and the explicit solution of MPC in a look-up table form is figured out by combining the dynamic programming and multi-parametric quadratic programming, thereby establishing an explicit hybrid model predictive ***, a piecewise quadratic（PWQ） function for guaranteeing the stability of closed-loop control is found by formulating the search of PWQ function as a semi-definite programming *** the tracking experiments, it is demonstrated that the explicit hybrid model predictive controller has a good traction control effect on the mechanical system with *** error meets the demands of real ***, compared to the direct on-line computation, the computation burden is reduced by the explicit solution, thereby being suitable for real-time control of system with short sampling time.

关键词： predictive controller hybrid model hybrid control backlash mode.

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Coherent-driving-assisted quantum speedup in Markovian channels

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Chinese Physics B 2021年第2期30卷 176-184页

作者： xiang Lu Ying-jie Zhang Yun-jie xia Shandong Provincial Key Laboratory of Laser Polarization and Information Technology Department of PhysicsQufu Normal UniversityQufu 273165China

As is well known,the quantum evolution speed of quantum state can never be accelerated in the Markovian regime without any operators on the *** Hamiltonian corrections induced by the action of coherent driving forces are often used to fight dissipative and decoherence mechanisms in *** this reason,considering three noisy channels(the phase-flip channel,the amplitude damping channel and the depolarizing channel),we propose a scheme of speedup evolution of an open system by controlling an external unitary coherent driving operator on the *** is shown that,in the presence of the coherent driving,no-speedup evolution can be transformed into quantum speedup evolution in the Markovian dynamics ***,under the fixed coherent driving strength in the above three noisy channels,the best way to achieve the most degree of quantum speedup for the system has been acquired by rotating the system with appropriate driving direction angles,***,we conclude that the reason for this acceleration is not the nonMarkovian dynamical behavior of the system but due to the oscillation of geometric distance between the initial state and the target final state.

关键词： quantum dynamics control quantum speed limit Markovian dynamics

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Quantifying coherence with dynamical discord

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Chinese Physics B 2021年第12期30卷 222-228页

作者： Lian-Wu Yang Yun-jie xia School of Physical Science and Intelligent Engineering Jining UniversityQufu 273155China Shandong Provincial Key Laboratory of Laser Polarization and Information Technology Department of PhysicsQufu Normal UniversityQufu 273165China

Quantum coherence and discord are two kinds of manifestations of *** calculating the coherence and discord in the specific bipartite quantum systems,we show quantitative connections between the coherence and the discord in the bipartite quantum systems created from local systems with the help of incoherent *** show that the coherence bounds the dynamical discord,and under particular conditions of the initial quantum states,the coherence of single systems is equal to the dynamical *** extend these results to the multipartite quantum systems.

关键词： quantum coherence dynamical discord relative entropy

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Calculation of Loudspeaker Cabinet Diffraction and Correction

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Chinese Physics Letters 2011年第10期28卷 142-145页

作者： LE Yi SHEN Yong xia jie Laboratory of Modern Acoustics and Institute of Acoustics Nanjing UniversityNanjing 210093

A method of calculating the cabinet edge diffractions for loudspeaker driver when mounted in an enclosure is proposed,based on the extended Biot–Tolstoy–Medwin *** to the third order,cabinet diffractions are discussed in detail and the diffractive effects on the radiated sound field of the loudspeaker system are quantitatively described,with a correction function built to compensate for the diffractive *** method is applied to a practical loudspeaker enclosure that has rectangular *** diffractive effects of the cabinet on the forward sound radiation are investigated and predictions of the calculations show quite good agreements with experimental measurements.

关键词： mounted correction calculating

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An overview of prostate diseases and their characteristics specific to Asian men

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Asian Journal of Andrology 2012年第3期14卷 458-464,I0008页

作者： Shu-jie xia Di Cui Qi Jiang Department of Urology The First People's Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200080China

In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia （BPH）, prostate cancer （PCa） and chronic prostatitis （CP） that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of these diseases, we find that Asians have a lower incidence of PCa than whites, but the incidences of BPH and CP are similar. Asian men with CP often suffer from fewer disease sites, but have a higher frequency of pain during urination rather than after sexual climax. Prostate-specific antigen （PSA） is a widely used marker for the diagnosis of PCa in both Asian and Western countries. Although the PSA level may be lower in Asians, the threshold used is based on whites. After reviewing the treatments available for these diseases, we did not find a fundamental difference between Asians and whites. Furthermore, the selection for the most appropriate treatment based on the individual needs of patients remains a challenge to urologists in Asia. After considering the traits of prostate diseases that are specific to Asian men, we hope to pave the way for the development of specific diagnostic and therapeutic strategies targeted specifically to Asian men.

关键词： Asians benign prostatic hyperplasia chronic prostatitis prostate cancer

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