检索结果-南通市图书馆

Chemical Research in Chinese Universities 2012年第4期28卷 652-655页

作者： WU Ping xia er-yan SUN Jing yan Chao-guo Department of Biochemical Engineering Yangzhou Polytechnic UniversityYangzhou 225000P.R.China College of Chemistry&Chemical Engineering Yangzhou UniversityYangzhou 225002P..R.China

An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl *** reaction mechanism invol... 详细信息

关键词： 1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

芳香胺,丁炔二酸二甲酯和环状二羰基化合物的三组分反应

在线全文

学校读者我要写书评

暂无评论

扬州职业大学学报 2013年第3期17卷 42-45页

作者：刘正铭夏二艳孙晶扬州大学江苏扬州225002

芳香胺,丁炔二酸二甲酯和环状二羰基化合物如丙二酸亚异丙酯以及巴比妥酸于室温下在乙醇中顺利反应,高产率的生成2-丁烯酸甲酯取代的丙二酸亚异丙酯以及巴比妥酸芳香铵盐。所有产物结构通过红外,1H NMR,13C NMR,HPLC/MS的表证,并且得到... 详细信息

芳香胺,丁炔二酸二甲酯和环状二羰基化合物如丙二酸亚异丙酯以及巴比妥酸于室温下在乙醇中顺利反应,高产率的生成2-丁烯酸甲酯取代的丙二酸亚异丙酯以及巴比妥酸芳香铵盐。所有产物结构通过红外,1H NMR,13C NMR,HPLC/MS的表证,并且得到了X-衍射单晶结构分析的确定。

关键词：多组分反应缺电子炔烃芳香胺二羰基化合物

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang yan Gao xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu Wei Wu Ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

有机肥替代化肥氮对谷子氮素累积、产量及品质的影响

在线全文

学校读者我要写书评

暂无评论

作物学报 2025年第1期51卷 149-160页

作者：王媛许佳茵董二伟王劲松刘秋霞黄晓磊焦晓燕山西农业大学资源环境学院山西太原030031

有机肥部分替代化肥是一种实现化肥减量的可持续农业生产措施。本研究于2020和2021连续2年以“沁黄2号”为供试材料,设不施氮(CK)、常量化肥氮(NPK)、有机肥替代25%化肥氮(25%M)、有机肥替代50%化肥氮(50%M)、有机肥替代75%化肥氮(75%M... 详细信息

有机肥部分替代化肥是一种实现化肥减量的可持续农业生产措施。本研究于2020和2021连续2年以“沁黄2号”为供试材料,设不施氮(CK)、常量化肥氮(NPK)、有机肥替代25%化肥氮(25%M)、有机肥替代50%化肥氮(50%M)、有机肥替代75%化肥氮(75%M)和有机肥替代100%化肥氮(100%M) 6个处理,研究不同替代率对谷子产量构成和氮素吸收的影响,并分析氮素吸收调控小米米色、糊化特性和类胡萝卜素组分的效应,明确谷子生产中有机肥最佳替代率。结果表明,2年中较低的有机肥替代化肥氮率显著提高了谷子植株氮素累积,但随着替代率的持续增加,植株氮素累积量呈降低趋势,最终影响谷子产量和小米品质。2020年, 25%M处理显著提高了谷子地上部氮素累积量,较NPK处理提高9.6%;2021年,25%M处理谷子地上部氮素累积量、生物量、穗粒数和产量达到最高,较NPK处理分别提高6.1%、12.0%、15.4%和12.0%。50%M处理显著影响了小米的米色、糊化特征和类胡萝卜素含量,与NPK相比,小米籽粒红绿值、橘色值、支链淀粉含量、总淀粉含量、小米糊化最终黏度、叶黄素含量、玉米黄质含量和黄色素含量的增幅分别可达6.0%、6.0%、7.4%、4.3%、7.8%、20.7%、17.4%和2.8%。但有机肥完全替代化肥降低了谷子地上部氮素吸收、地上部生物量、穗粒数及谷子产量,也抑制了小米叶黄素和玉米黄质含量的提升。2年均表现出谷子地上部氮吸收量与小米单粒重、直链淀粉含量和小米糊化回升值呈显著的负相关。且2021年谷子地上部氮吸收量还与小米总淀粉含量、蛋白质含量、小米粉糊化峰值黏度和小米黄色素含量呈显著的负相关,与小米糊化峰谷黏度呈显著的正相关。综上,施氮总量120 kg hm^(–2)下,有机肥替代25%~50%化肥氮能通过促进植株氮素的吸收,实现产量、米色、蒸煮特性及类胡萝卜素的协同提升,为谷子化肥减量和提质增效生产提供技术支撑。

关键词：谷子有机肥替代化肥氮率氮素累积产量米色糊化特性类胡萝卜素

同方期刊数据库博看期刊

Input-Occupancy-Output Analysis of Industrial Wastewater Discharge Coeffcients and Backward and Forward Linkages: Multi-Regional Occupancy

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2015年第6期28卷 1344-1362页

作者： TANG Zhipeng xia yan Key Laboratory of Regional Sustainable Development Modeling Institute of Geography Sciences and Natural Resources Research Chinese Academy of Sciences Center for Energy and Environmental Policy Research Institute of Policy and Management Chinese Academy of Sciences

This paper provides an extended input-occupancy-output analysis of wastewater discharge coeffcients, as well as backward and forward linkages of Chinese multi-regional industrial sectors in2007. The results show that the direct and total industrial wastewater discharge coeffcients of most of the provincial industrial sectors in China＇s Eastern region are lower than those of the whole *** backward and forward linkages of fixed-asset occupancy in industrial sectors in China＇s Central and Western regions are strong. The dissimilarity of cross-sectional data of the relevant industrial wastewater discharge coeffcients and linkages in multi-regional input-output analysis becomes bigger as regions are divided more extensively.

关键词： Backward linkage forward linkage industrial wastewater discharge input-occupancyoutput analysis

“Buckets effect”in the kinetics of electrocatalytic reactions

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 388-396,I0010页

作者： Haowen Cui yan-xia Chen Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic *** results demonstrate a rectangular hyperbolic relationship,i.e.,the ORR current excluding the effect of other variables increases with proton concentration and then tends to a constant *** consider that this is caused by the limitation of ORR kinetics by the trace oxygen concentration in the solution,which determines the upper limit of ORR kinetics.A model of effective concentration is further proposed for rectangular hyperbolic relationships:when the reactant concentration is high enough to reach a critical saturation concentration,the effective reactant concentration will become a constant *** could be due to the limited concentration of a certain reactant for reactions involving more than one reactant or the limited number of active sites available on the *** study provides new insights into the kinetics of electrocatalytic reactions,and it is important for the proper evaluation of catalyst activity and the study of structureperformance relationships.

关键词： Oxygen reduction reaction Kinetics Zero order Rectangular hyperbolic relationship pH effect

β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 505-510页

作者： xiao-jing ZHAO Zhuo PEN Ping LI er-xiu CHEN Jian LIU yan-xia GAO Yun-xia REN Li-jun LI Department of Emergency Medicine the Second Affiliated Hospital of Medical CollegeXi'an Jiaotong University Mechanical Energy and Experimental Center of Medical CollegeXi'an Jiaotong University

Objective:We investigated the influence of β-receptor blocker metoprolol on return of spontaneous circulation(ROSC) during cardiopulmonary resuscitation(CPR) in rats with induced myocardial infarction(MI).Methods:Male Sprague-Dawley rats were randomly divided into three groups:the sham-operated group,the MI group without metoprolol,which was fed the vehicle,and the MI+metoprolol group receiving intragastric *** group was further divided randomly into three subgroups,depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac ***:The ROSC rate was significantly decreased in the low dose subgroup of MI group,unchanged in the medium dose subgroup of MI group,and significantly decreased in the high dose subgroup of MI group,compared with the same dose subgroup of sham-operated ***+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup,and a higher ROSC rate than MI group in the high dose *** was no difference in blood K+ values of successful rats between MI group and MI+metoprolol *** rats with successful CPR had lower blood K+ values than rats with unsuccessful CPR in each of the three treatment ***:Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during *** increasing high blood K+ value would attenuate the rate of a successful CPR.

关键词： β-receptor blocker Cardiopulmonary resuscitation Return of spontaneous circulation Epinephrine Chemical examination