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艾迪注射液联合FOLFOX-4方案化疗治疗晚期结直肠癌的疗效及安全性分析

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中国肛肠病杂志 2024年第5期44卷 30-32页

作者：李欣夏春磊南阳医学高等专科学校第三附属医院药剂科河南南阳473000 南阳医学高等专科学校第三附属医院消化肿瘤内科河南南阳473000

目的:探讨艾迪注射液联合FOLFOX-4方案化疗治疗晚期结直肠癌的效果及安全性。方法:选择2022年1月至2023年8月我院收治的60例晚期结直肠癌患者,采用随机数字表法分为对照组和研究组,各30例。对照组采用FOLFOX-4方案化疗,研究组在FOLFOX-... 详细信息

目的:探讨艾迪注射液联合FOLFOX-4方案化疗治疗晚期结直肠癌的效果及安全性。方法:选择2022年1月至2023年8月我院收治的60例晚期结直肠癌患者,采用随机数字表法分为对照组和研究组,各30例。对照组采用FOLFOX-4方案化疗,研究组在FOLFOX-4方案化疗基础上予艾迪注射液静脉滴注。比较2组临床疗效、不良反应,以及治疗前后免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)和NK细胞)和血清肿瘤标志物癌胚抗原(CEA)、糖链抗原19-9(CA19-9)、糖链抗原242(CA242)水平。结果:研究组疾病控制率及疾病缓解率均高于对照组,P<0.05。治疗后研究组CD4^(+)、CD4^(+)/CD8^(+)、NK细胞比率均高于对照组,CD8^(+)低于对照组(P<0.05)。治疗后研究组CEA、CA19-9、CA242水平均低于对照组,P<0.05。研究组血液学毒性事件、消化系统反应、感觉性神经病变发生率均低于对照组,P<0.05。结论:艾迪注射液联合FOLFOX-4方案化疗治疗晚期结直肠癌可提高临床治疗效果,调节患者免疫功能,降低其血清肿瘤标志物水平及不良反应发生风险。

关键词：艾迪注射液 FOLFOX-4化疗方案结直肠癌效果安全性

汽车照明和光信号系列强制性法规修订动向及与UN法规的差异性分析

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汽车科技 2024年第2期 7-15页

作者：夏春雷汪洋罗翔那奇张弛岚图汽车科技有限公司武汉430000 襄阳达安汽车检测中心有限公司襄阳441058

本文对我国汽车照明和光信号装置系列强制性国家标准及其修订动向进行了分析,并结合UN系列法规进行了比较。分别对光信号投射功能、可变光强的前位灯、倒车灯路面照明、驾驶员辅助投射功能、发光车标、紧急制动信号、电力再生制动模式... 详细信息

本文对我国汽车照明和光信号装置系列强制性国家标准及其修订动向进行了分析,并结合UN系列法规进行了比较。分别对光信号投射功能、可变光强的前位灯、倒车灯路面照明、驾驶员辅助投射功能、发光车标、紧急制动信号、电力再生制动模式的制动灯、日间行车灯、顺序开启的转向灯、追尾警告信号等灯具的国标修订情况及其与UN法规的差异进行了详细的比较,对主机厂、零部件厂的灯具研发设计相关从业者及国内企业出口欧盟产品的研发认证人员具有一定的参考意义。

关键词：照明光信号灯具标准法规

Brain abscess from oral microbiota approached by metagenomic next-generation sequencing: A case report and review of literature

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World Journal of Clinical Cases 2024年第3期12卷 616-622页

作者： Xue-Min Zhu chun-xia Dong lei Xie Hao-Xin Liu Huai-Qiang Hu School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Neurology the 960th Hospital of People′s Liberation ArmyJinan 250031Shandong ProvinceChina

BACKGROUND Brain abscess is a serious and potentially fatal disease caused primarily by microbial infection.Although progress has been made in the diagnosis and treatment of brain abscesses,the diagnostic timeliness of pathogens needs to be improved.CASE SUMMARY We report the case of a 54-year-old male with a brain abscess caused by oral bacteria.The patient recovered well after receiving a combination of metagenomic next-generation sequencing(mNGS)-assisted guided medication and surgery.CONCLUSION Therefore,mNGS may be widely applied to identify the pathogenic microor-ganisms of brain abscesses and guide precision medicine.

关键词： Brain abscess Metagenomic next-generation sequencing Periodontitis Oral bacteria Precision medicine Case report

Effects of ultrasonic vibration on plastic deformation of AZ31 during the tensile process

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 70-76页

作者： Tong Wen Li Wei xia Chen chun-lei Pei College of Material Science and Engineering Chongqing University Chongqing 400044 China

An investigation on the plastic behavior of AZ31 magnesium alloy under ultrasonic vibration（with a frequency of 15 kHz and a maximum output of 2 kW） during the process of tension at room temperature was conducted to reveal the volume effect of the vibrated plastic deformation of AZ31.The characteristics of mechanical properties and microstructures of AZ31 under routine and vibrated tensile processes with different amplitudes were compared.It is found that ultrasonic vibration has a remarkable influence on the plastic behavior of AZ31 which can be summarized into two opposite aspects：the softening effect which reduces the flow resistance and improves the plasticity,and the hardening effect which decreases the formability.When a lower amplitude or vibration energy is applied to the tensile sample,the softening effect dominates,leading to a decrease of AZ31 deformation resistance with an increase of formability.Under the application of a high-vibrating amplitude,the hardening effect dominates,resulting in the decline of plasticity and brittle fracture of the samples.

关键词： ultrasonic effects tensile testing magnesium alloys plastic deformation

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie WANG Yu xia Qing-lei GAO Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor development.Tumor intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor progression.Accumulating evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse cytokines.These cytokines possess multifaced functions in the anti-tumor immune response.Thus,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor therapies.This manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these cytokines.We also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

Stepwise colloidal lithography toward scalable and various planar chiral metamaterials

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Rare Metals 2024年第2期43卷 723-735页

作者： Xiu Yang Yong Liu Fei-Liang Chen Qian-Qi Lin Rohit Chikkaraddy Shan-Shan Huang Shi-Lin xian Yi-Dong Hou Jing-lei Du Liang-Ping xia chun-lei Du School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Zhuhai Multiscale Optoelectronics Technology Co. Ltd.Zhuhai915060China Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of Twente7500 AEEnschedeThe Netherlands School of Physics and Astronomy University of BirminghamBirminghamB152TTUK College of Physics Sichuan UniversityChengdu610065China Key Laboratory of Micro Nano Optoelectronic Devices and Intelligent Perception Systems Yangtze Normal UniversityChongqing408100China

Chiral metamaterials(CMs)composed by artificial chiral resonators have attracted great attentions in the recent decades due to their strong chiroptical resonance and identifiable interaction with chiral materials,facilitating practical applications in chiral biosensing,chiral emission,and display technology.However,the complex geometry of CMs improves the fabrication difficulty and hinders their scalable fabrication for practical applications,especially in the visible and ultraviolet wavelengths.One potential strategy is the colloidal lithography that enables parallel fabrication for scalable and various planar structures.Here,we demonstrate a stepwise colloidal lithography technique that uses sequential deposition from multiple CMs and expand their variety and complexity.The geometry and optical chirality of building blocks from single deposition are systematically investigated,and their combination enables a significant extension of the range of chiral patterns by multiple-step depositions.This approach resulted in a myriad of complex designs with different characteristic sizes,compositions,and shapes,which are particularly beneficial for the development of nanophotonic materials.In addition,we designed a flexible chiral device based on PDMS,which exhibits a good CD value and excellent stability even after multiple inward and outward bendings.The excellent compatibility to various substrates makes the planar CMs more flexible in practical applications in microfluidic biosensing.

关键词： Chiral metamaterials Colloidal lithography Nanophotonics Metasurfaces Plasmonics Nanofabrications Flexible devices

Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan Wang Kun Jiang Qiao xia xia Kang Shan Wang Ji-Hong Yu Wen-Feng Ni xiao-Qin Qi Ying-Na Zhang Jin-Bao Han Gang Liu lei Hou Zhi-chun Feng Liu-Ming Huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Senior Department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in neonates.We designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of neonates.Methods Using the 16S ribosomal DNA(rDNA)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time points.Results The beta diversities of the NP,NN,and NC groups were all similar.When comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-Shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of Streptococcus increased significantly at the E4 time point.Conclusions Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small intestine.The sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： Microbiota Necrotizing enterocolitis-Small intestine 16S rDNA

Prediction model on hydrolysis kinetics of phthalate monoester:A density functional theory study

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Journal of Environmental Sciences 2024年第1期135卷 51-58页

作者： Tong Xu Jingwen Chen Deming xia Weihao Tang Jiansheng Cui chun Liu Shuangjiang Li College of Environmental Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050000China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and ManagementInstitute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou 510650China

As primary degradation products of phthalate esters,phthalate monoesters(MPEs)have been widely detected in various aquatic environments and drawn growing toxicological concerns.Hydrolysis kinetics that is of importance for assessing environmental persistence of chemicals remain elusive for MPEs.Herein,kinetics of base-catalyzed and neutral hydrolysis for 18 MPEs with different leaving groups was investigated by density functional theory calculation.Results indicate that MPEs with leaving groups having p Kaof<10 prefer dissociative transition states.MPEs are more persistent than their parents,and their hydrolysis half-lives were calculated to vary from 3.4 min to 79.2 years(p H=7–9).A quantitative structure-activity relationship model was developed for predicting the hydrolysis kinetics parameters.It was found that p Kaof the leaving groups and electronegativity of the MPEs are key factors determining the hydrolysis kinetics.This work may lay a theoretical foundation for better understanding the chemical process that governs MPE persistence in aquatic environments.

关键词： Phthalate monoesters Phthalate esters Hydrolysis Density functional theory Quantitative structure-activity relationship

Sinomenine increases osteogenesis in mice with ovariectomyinduced bone loss by modulating autophagy

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World Journal of Stem Cells 2024年第5期16卷 486-498页

作者： Hai-xiang xiao lei Yu Yu xia Kai Chen Wen-Ming Li Gao-Ran Ge Wei Zhang Qing Zhang Hong-Tao Zhang De-chun Geng Department of Orthopedics The Fourth Affiliated Hospital of Soochow UniversitySuzhou Dushu Lake HospitalMedical Centre of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Jingjiang People’s Hospital Affiliated to Yangzhou UniversityJingjiang 214500Jiangsu ProvinceChina Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Hai’an People’s HospitalHai’an 226600Jiangsu ProvinceChina Department of Orthopedics The Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’an Second People’s HospitalXuzhou 223002Jiangsu ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of BMSCs is a potential therapeutic option to increase osteoblast viability and ameliorate osteoporosis.AIM To explore the effects of sinomenine(SIN)on the osteogenic differentiation of BMSCs and the underlying mechanisms.METHODS For in vitro experiments,BMSCs were extracted from sham-treated mice and ovariectomized mice,and the levels of autophagy markers and osteogenic differentiation were examined after treatment with the appropriate concen-trations of SIN and the autophagy inhibitor 3-methyladenine.In vivo,the therapeutic effect of SIN was verified by establishing an ovariectomy-induced mouse model and by morphological and histological assays of the mouse femur.RESULTS SIN reduced the levels of AKT and mammalian target of the rapamycin(mTOR)phosphorylation in the phosphatidylinositol 3-kinase(PI3K)/AKT/mTOR signaling pathway,inhibited mTOR activity,and increased autophagy ability of BMSCs,thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice in vivo.CONCLUSION The Chinese medicine SIN has potential for the treatment of various types of osteoporosis,bone homeostasis disorders,and autophagy-related diseases.

关键词： Sinomenine Osteogenesis Autophagy Ovariectomy Osteoporosis