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Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

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World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： Zhi-chang Ba Xi-qing Zhu Zhi-Guo Li Yuan-Zhou Li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

铈对AZ31镁合金显微组织和力学性能的影响

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金属热处理 2006年第11期31卷 46-49页

作者：吴安如夏长清董丽君湖南工程学院机械工程系中南大学材料科学与工程学院湖南长沙410083 中南大学材料科学与工程学院

在AZ31合金中添加0、0.2%、0.5%和1%(质量分数)的铈(Ce)制备了4种合金,研究不同Ce含量和合金变形状态对力学性能和显微组织的影响。试验表明,添加Ce元素后,形成的Al4Ce对合金有强化作用,但其铸态组织仍然粗大,经过轧制及退火后,合金的... 详细信息

在AZ31合金中添加0、0.2%、0.5%和1%(质量分数)的铈(Ce)制备了4种合金,研究不同Ce含量和合金变形状态对力学性能和显微组织的影响。试验表明,添加Ce元素后,形成的Al4Ce对合金有强化作用,但其铸态组织仍然粗大,经过轧制及退火后,合金的组织得到改善。力学性能测试结果表明,轧制态合金强度随Ce含量的增加而上升,伸长率亦有所提高,300℃退火1h后,强度比轧制态有所降低,伸长率提高较大。含0.5%铈的3号合金综合力学性能最好,屈服强度为168MPa,抗拉强度达到255MPa,伸长率为22%。

关键词： AZ31合金铈轧制退火组织与性能

Tong-xie-ning,a Chinese herbal formula,in treatment of diarrhea-predominant irritable bowel syndrome:a prospective,randomized,double-blind,placebo-controlled trial

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Chinese Medical Journal 2006年第24期119卷 2114-2119页

作者： WANG Gang LI Ting-qian WANG Lei xia qing chang Jing ZHANG Ying WAN Mei-hua GUO Jia CHENG Yan HUANG Xi ZHANG Rui-ming Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 China

Currently the main components of treatment for irritable bowel syndrome （IBS） include patienteducation and reassurance, dietary modification, symptomatic treatment, and psychological treatment, but little evidence exists that the current pharmaceutical agents routinely used in treating IBS patients are efficacious.1 Partly from lack of effective conventional therapeutics and in search of better treatment options, many patients with IBS in both the east and west have turned to complementary and alternative approaches, including traditional Chinese medicine （TCM）.

关键词： traditional Chinese medicine irritable bowel syndrome randomized controlled trial

Comprehensive evaluations of heat transfer performance with conjugate heat dissipation effect in high-speed rotating free-disk modeling of aero-engines

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Fundamental Research 2024年第3期4卷 611-623页

作者： Aqiang Lin Gaowen Liu Ran chang Yan Chen qing Feng School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China Shaanxi Key Laboratory of Thermal Science in Aero-engine System Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwester

Thermal boundary conditions of the turbine disk cavity system are of great importance in the design of secondary air systems in *** study aims to investigate the complex heat transfer mechanisms of a rotating turbine disk under high-speed conditions.A high-speed rotating free-disk model with Dorfman empirical solutions is developed to evaluate the heat transfer performance considering various ***,the influence of compressibility,variable properties,and heat dissipation is determined using theoretical and numerical *** particular,a novel combined solution method is proposed to simplify the complex heat transfer *** results indicate that the heat transfer performance of a free disk is primarily influenced by the rotating Mach number,rotating Reynolds number,Rossby number,and wall temperature *** heat transfer temperature and Nusselt number of the free disk are strongly correlated with the rotating Mach number and rotating Reynolds *** reveals that heat dissipation is a critical factor affecting the accurate evaluation of the heat transfer performance of the turbine ***,the combined solution method can serve as a reference for future investigations of flow and heat transfer in high-speed rotating turbine disk cavity systems in aero-engines.

关键词： Aero-engine Rotating turbine disk Dimensional analysis Compressibility Heat dissipation Dorfman empirical solution

Biogenic volatile organic compounds dominated the near-surface ozone generation in Sichuan Basin,China,during fall and wintertime

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Journal of Environmental Sciences 2024年第7期141卷 215-224页

作者： Dasheng Huang qing Li Yan Han Shi-Yong xia Jiawei Zhou Hanxiong Che Keding Lu Fumo Yang Xin Long Yang Chen Research Center for Atmospheric Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China College of Resources and Environment Chongqing SchoolUniversity of the Chinese Academy of Sciences(UCAS Chongqing)Chongqing 400714China College of Environmental and Chemical Engineering Chongqing Three Gorges UniversityChongqing 404199China Key Laboratory for Urban Habitat Environmental Science and Technology School of Environment and EnergyPeking University Shenzhen Graduate SchoolLishui RoadNanshan DistrictShenzhen 518055China SKL-ESPC and BIC-ESAT College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China College of Architecture&Environment Sichuan UniversityChengdu 610065China

The complex air pollution driven by both Ozone(O_(3))and fine particulate matter(PM2.5)sig nificantly influences the air quality in the Sichuan Basin(SCB).Understanding the O_(3)for mation during autumn and winter is necessary to understand the atmospheric oxidative ***,continuous in-site field observations were carried out during the late summer,early autumn and winter of 2020 in a rural area of *** total volatile organic compounds(VOCs)concentration reported by a Proton-Transfer-Reaction Time-of Flight Mass Spectrometry(PTR-ToF-MS)were 13.66±9.75 ppb,5.50±2.64 ppb,and 9.41±5.11 ppb in late summer,early autumn and winter,*** anthropogenic VOCs(AVOCs)and biogenic VOCs(BVOCs)were 8.48±7.92 ppb and 5.18±2.99 ppb in late sum mer,3.31±1.89 ppb and 2.19±0.93 ppb in autumn,and 6.22±3.99 ppb and 3.20±1.27ppb in winter.A zero-dimensional atmospheric box model was employed to investigate the sensitivity of O_(3)-precursors by relative incremental reactivity(RIR).The RIR values of AV OCs,BVOCs,carbon monoxide(CO),and nitrogen oxides(NOx)were 0.31,0.71,0.09,and-0.36 for late summer,0.24,0.59,0.22,and-0.38 for early autumn,and 0.30,0.64,0.33 and-0.70 for winter,and the results showed that the O_(3)formation of sampling area was in the VOC-limited region,and O_(3)was most sensitive to BVOCs(with highest RIR values,>0.6)This study can be helpful in understanding O_(3)formation and interpreting the secondary formation of aerosols in the winter.

关键词： VOCs PTR-MS Model Ozone

One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

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Chinese Chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban Xi-Yang Yu Hai-Kuo Tian Zheng-qing Huang Chun-Ran chang Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e *** is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 *** work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired C_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

Dual modification of LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2) cathode materials by K^(+) doping and Li_(3)PO_(4) coating for lithium ions batteries

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Rare Metals 2024年第7期43卷 3007-3018页

作者： Wei xiao Jia-Le Wang Zhi-Cheng Yi Cheng-Jin Liu chang Miao Yu Xin Shu-qing Nie College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China

Li_(3)PO_(4)@Li_(0.99)K_(0.01)Ni_(0.83)Co_(0.11)Mn_(O.06)O_(2)(NCM-KP) cathode powders are synthesized via K^(+)doping in calcination processes and H_3PO_4 coating in sol-gel processes.K^(+) precisely enters into the lattice to widen the(003) plane to 0.4746 nm with a lower cationic disordered degree of 1.87%.Moreover,the surface residual lithium salts are treated by H_3PO_4 to generate a uniform Li_(3)PO_(4) coating layer of approximately 11.41 nm,which completely covers on the surface of secondary spherical particles to improve the interfacial *** 25℃,the NCM-KP electrode delivers a discharge specific capacity of 148.9 mAh·g^(-1) with a remarkable capacity retention ratio of 84.1% after 200 cycles at 1.0C and retains a high reversible specific capacity of 154.4 mAh·g^(-1) at *** at 1.0C and 60℃,it can maintain a reversible discharge specific capacity of 114.6 mAh·g^(-1) with 0.21% of capacity decay per cycle after 200 cycles,which is significantly lower than 0.40% for the pristine NCM ***,the charge transfer resistance of 238.89 Ω for the NCM-KP electrode is significantly lower than 947.41 Ω for the pristine NCM one by restricting the interfacial side ***,combining K+doping and Li_(3)PO_(4) coating is an effective strategy to enable the significant improvement of the electrochemical property of high-nickel cathode materials,which may be mainly attributed to the widened diffusion pathway and the formed Li_(3)PO_(4) protective layer,thus promoting Li~+diffusion rate and preventing the erosion of HF.

关键词： High-nickel cathode material Residual lithium K^(+)doping Li_(3)PO_(4)coating Lithium ions battery

Degradation behaviors of Nabumetone and its metabolite during UV/monochloramine process:Experimental and theoretical study

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Journal of Environmental Sciences 2024年第8期142卷 103-114页

作者： xiang Tu Yunsong Bai qing Fu Sheng chang Kunfeng Zhang Yang Pan Ruiyang xiao Yifu Fu Qi Zhang State Key Laboratory of Environmental Criteria and Risk Assessment State Environmental Protection Key Laboratory of Drinking Water Source ProtectionResearch Centre of Lake EnvironmentNational Engineering Laboratory for Lake Pollution Control and Ecological RestorationChinese Research Academy of Environmental SciencesBeijing 100012China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Institute of Environmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China School of Forestry Northeast Forestry UniversityHarbin 150040China

This study investigated degradation behaviors of a nonsteroidal anti-inflammatory drug Nabumetone(NMT)and its major metabolite 6-methoxy-2-naphthylacetic acid(MNA)in the coupling process of ultraviolet and monochloramine(UV/NH2Cl).The second-order rate constants of the contaminants reacting with reactive radicals(HO·,Cl·,Cl_(2)·-,and CO_(3)·^(-))were determined by laser flash photolysis ***·and Cl·contributed predominantly with 52.3%and 21.7%for NMT degradation and 60.8%and 22.3%for MNA *** presence of chlorides retarded the degradation of NMT,while promoted the destruction of MNA,which was ascribed to the photosensitization effects of MNA under UV *** functional theory(DFT)calculations revealed that radical adduct formation(RAF)was dominant pathway for both HO·and Cl·reacting with the contaminants,and hydrogen atom transfer(HAT)preferred to occur on side chains of NMT and *** reacted with NO_(2)·through single electron transfer(SET)with the second-order rate constant calculated to be 5.35×10^(7)(mol/L)^(-1)sec^(-1),and the contribution of NO_(2)·was predicted to be 13.0%of the total rate constant of NMT in pure water,which indicated that NO_(2)·played a nonnegligible role in the degradation of *** acute toxicity and developmental toxicity of NMT were enhanced after UV/NH_(2)Cl treatment,while those of MNA were *** transformation products of both NMT and MNA exhibited higher mutagenicity than their parent *** study provides a deep understanding of the mechanism of radical degradation of NMT and MNA in the treatment of UV/NH2Cl.

关键词： UV/NH_(2)Cl Reactive species Degradation kinetics Reaction mechanism Degradation products

Synergistic effect of carbon nanotube and encapsulated carbon layer enabling high-performance SnS_2-based anode for lithium storage

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Journal of Energy Chemistry 2024年第10期97卷 700-709,I0015页

作者： Chunwei Dong Yongjin xia Zhijiang Su Zhihua Han Yang Dong Jingyun Chen Fei Hao Qiyao Yu qing Jiang Jiaye Ye National Instituteof Clean-and-Low-Carbon Energy Beijing 102209China Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022JilinChina State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Tin disulfide(SnS_(2)),due to large interlayer spacing and high theoretical capacity,is regarded as a prospective anode material for lithium-ion ***,the poor electron conductivity of SnS_(2) and huge volumetric change during the lithiation/delithiation process lead to a rapid capacity decay of the battery,hindering its *** address these issues,herein,SnS_(2) is in-situ grown on the surface of carbon nanotubes(CNT)and then encapsulated with a layer of porous amorphous carbon(CNT/SnS_(2)@C)by simple solvothermal and further carbonization *** synergistic effect of CNT and porous carbon layer not only enhances the electrical co nductivity of SnS_(2) but also limits the huge volumetric change to avoid the pulverization and detachment of SnS_(2).Density functional theo ry calculations show that CNT/SnS_(2)@C has high Li^(+)adsorption and lithium storage capacity achieving high reaction ***,cells with the CNT/SnS_(2)@C anode exhibit a high lithium storage capacity of 837mAh/g after 100 cycles at 0.1 A/g and retaining a capacity of 529.8 mAh/g under 1.0 A/g after 1000 *** study provides a fundamental understanding of the electrochemical processes and beneficial guidance to design high-performance SnS_(2)-based anodes for LIBs.

关键词： Lithium-ion batteries Porous amorphous carbon Carbon nanotubes SnS_(2)-based anode Density functional theory calculations