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Benchmarking Algorithms for Gene Set Scoring of Single-cell ATAC-seq Data

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 27-42页

作者： xi Wang Qiwei Lian Haoyu Dong Shuo Xu yaru Su xiaohui Wu Pasteurien College Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China Department of Automation Xiamen UniversityXiamen 361005China College of Mathematics and Computer Science Fuzhou UniversityFuzhou 350116China

Gene set scoring(GSS)has been routinely conducted for gene expression analysis of bulk or single-cell RNA sequencing(RNA-seq)data,which helps to decipher single-cell heterogeneity and cell type-specific variability by incorporating prior knowledge from functional gene ***-cell assay for transposase accessible chromatin using sequencing(scATAC-seq)is a powerful technique for interrogating single-cell chromatin-based gene regulation,and genes or gene sets with dynamic regulatory potentials can be regarded as cell type-specific markers as if in single-cell RNA-seq(scRNA-seq).However,there are few GSS tools specifically designed for scATAC-seq,and the applicability and performance of RNA-seq GSS tools on scATAC-seq data remain to be ***,we systematically benchmarked ten GSS tools,including four bulk RNA-seq tools,five scRNA-seq tools,and one scATAC-seq ***,using matched scATAC-seq and scRNA-seq datasets,we found that the performance of GSS tools on scATAC-seq data was comparable to that on scRNA-seq,suggesting their applicability to ***,the performance of different GSS tools was extensively evaluated using up to ten scATAC-seq ***,we evaluated the impact of gene activity conversion,dropout imputation,and gene set collections on the results of *** show that dropout imputation can significantly promote the performance of almost all GSS tools,while the impact of gene activity conversion methods or gene set collections on GSS performance is more dependent on GSS tools or ***,we provided practical guidelines for choosing appropriate preprocessing methods and GSS tools in different application scenarios.

关键词： Single-cell ATAC-seq Gene set scoring Pathway analysis Single-cell RNA-seq Benchmark

Surface deterioration dependent on the crystal facets of spinel LiNi_(0.5)Mn_(1.5)O_(4) cathode active material

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Journal of Energy Chemistry 2024年第10期97卷 757-766,I0016页

作者： Qian Li Yan Zhao Jifu Zhu Wujiu Zhang Yi Liu yaru Cui Chao Shen Keyu xie School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsNorthwestern Polytechnical University and Shaanx joint Laboratory of Graphene(NPU)Xi'an 710072ShaanxiChina Shaanxi Union Research Center of University and Enterprise for Cathode Materials of LIBs Xi'an 710072ShaanxiChina CRRC Zhu Zhou Institute Co. Ltd.Zhuzhou 412000HunanChina

The spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode active materials(CAMs)are considered a promising alternative to commercially available cathodes such as layered and polyanion oxide cathodes,primarily due to their notable safety and high energy density,particularly in their single-crystal ***,the industrial application of the LNMO CAMs is severely inhibited due to the interfacial deterioration and corrosion under proton-rich and high-voltage *** study successfully designed and synthesized two typical types of crystal facets-exposed single-crystal LNMO *** tracking the electrochemical deterioration and chemical corrosion evolution,this study elucidates the surface degradation mechanisms and intrinsic instability of the LNMO,contingent upon their crystal ***(111)facet,due to its elevated surface energy,is found to be more susceptible to external attack compared to the(100)and(110)*** study highlights the electrochemical corrosion stability of crystal plane engineering for spinel LNMO CAMs.

关键词： LiNi_(0.5)Mn_(1.5)O_(4) Crystal facets Electrochemical degradation Chemical corrosion Surface energy

An Intelligent Bridge Multi-Dimension Deflection IoT Monitoring System Based on Laser Datum and Imaging

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Dan Zhao Huifeng Wang Hao Du Haoyi Cheng Lu Peng yaru Liang He Huang Yunmeng Li School of Electronic &Control Engineering， Chang'an University Research Institute of Highway Ministry of Transport State Key Laboratory of Traction Power， Southwest Jiaotong University

Aiming at the all-weather automatic monitoring of bridge structure health monitoring， an embedded bridge multi-dimensional (horizontal and vertical) deflection monitoring system based on dual laser references is proposed. The controller turns on the laser reference transmitter through instructions to emit the laser reference. The intelligent target system located in the middle of the span will calculate the multi-dimensional deflection and deformation information of the bridge structure according to the laser spot projected on the diffuse optical target， and pass this information through the wireless network communication unit transmits to the cloud platform to realize real-time monitoring of the bridge structure status and other parameters. Through the laboratory platform， it is found that the measurement error of this method is less than 300 μm， and the data update rate is less than 66 ms， which meets the requirements of bridge structural health monitoring. This method solves the problem of low efficiency of artificial bridge deflection monitoring， realizes all-weather online real-time monitoring of bridge deflection detection， and ensures the accuracy and efficiency of the measurement system.

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社会文化理论中perezhivanie概念的解析——兼谈外语教育整体观的路径探索

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外语教学理论与实践 2024年第2期 11-19页

作者：孟亚茹张妍华郗佼西安交通大学外国语学院 710049 北京林业大学外语学院

体验(perezhivanie)是社会文化理论的核心概念之一,能有效捕捉个体心理发展过程中认知与情感、人格与社会环境的辩证统一。其倡导的整体视角契合外语教育目前的社会与情感转向,对解决该领域整体观缺乏的瓶颈具有理论和方法学的意义。但... 详细信息

体验(perezhivanie)是社会文化理论的核心概念之一,能有效捕捉个体心理发展过程中认知与情感、人格与社会环境的辩证统一。其倡导的整体视角契合外语教育目前的社会与情感转向,对解决该领域整体观缺乏的瓶颈具有理论和方法学的意义。但学界对该概念的内涵、应用和方法尚不明晰,相关研究寥若晨星。籍此,本文首先厘清该概念,并提出解析模型,进而探讨体验作为分析单位研究心理发展的方法,最后落脚到学习者外语能力和教师发展两方面,揭示其对外语教育整体观路径探索的作用。

关键词：社会文化理论体验认知与情感社会发展情境外语教育整体观

Portable Structure Surface Crack Detection System Based on Android Platform

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 154-164页

作者： WANG Huifeng PENG Haonan TANG Yu GUAN Yueyuan LIANG yaru WANG Lisha ZHAO Yu WANG xiaoyan GAO Rong HUANG He School of Electronics and Control Engineering Chang'an UniversityXi'an 710000ShaanxiChina Research Institute of Highway Ministry of Transport Beijing 100000China State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu 610000SichuanChina Highway School Chang'an UniversityXi'an 710000ShaanxiChina

Cracks,potholes,and other defects often occur on infrastructure such as bridges,among which cracks are one of the most frequent *** have diverse shapes and are difficult to *** manual inspection methods are inefficient and have low accuracy,while automated inspection machines are bulky and inconvenient to carry and *** on the shortcomings of existing detection technologies,this paper proposes a portable structural surface crack detection system based on the Android platform using a portable hand-held image acquisition *** system captures cracks on the structure's surface and obtains high-definition crack ***,these images are transmitted to portable smartphone terminals through ***,the image is pre-processed using weighted averaging,grayscale linear transformation,and adaptive median ***,the improved Canny edge detection algorithm is applied to identify crack information,and the edge segmentation algorithm is used to determine the crack ***,based on camera calibration,the pixels are converted into the length data required for actual *** results show that the system is easy to operate,and it not only has crack storage and tracking functions,but also can effectively measure the crack width on the surface of *** measurement accuracy of this system reaches the sub-pixel level,and in actual testing,compared with the crack width gauge,the maximum relative error does notexceed6.25%.

关键词： structural crack portable image processing detection accuracy crack parameter

功能性消化不良动物模型的中医证型及其评价指标研究进展

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药物评价研究 2024年第4期47卷 889-896页

作者：马玉朋袁亚茹邸志权姜溪胡金芳天津中医药大学天津301617 天津天诚新药评价有限公司天津300462 安徽医科大学安徽合肥230032 药物成药性评价与系统转化全国重点实验室天津300462 天津市药代动力学和药效动力学重点实验室天津300462 天津市新药非临床评价技术工程中心天津300462

功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型。FD动物模型的构建依据证型特定的发病机制来模拟人体... 详细信息

功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型。FD动物模型的构建依据证型特定的发病机制来模拟人体症状,检测指标常采用行为学、胃肠动力学及相关蛋白水平等评估模型与FD患者的相似度。符合病症的动物模型是开展药效研究和药效评价的前提和基础,对FD中医证型的造模方法及检测指标进行整理和分析,旨在完善和优化动物模型,为后续的药物研究提供支持。

关键词：功能性消化不良动物模型中医证型病证结合评价指标

基于多因素权重分析的农村居民清洁取暖接受度分类预测方法研究

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太阳能学报 2024年第8期45卷 249-255页

作者：朱可欣罗西刘晓君高雅儒西安建筑科技大学管理学院西安710055 西安建筑科技大学建筑设备科学与工程学院西安710055 绿色建筑全国重点实验室西安710055

提出一种基于多因素权重分析的分类模型(K-means-EWM-BP)来预测农村居民的清洁取暖接受度。首先,基于实地调研数据,选取农村居民家庭年总收入、性别、年龄、受教育程度作为聚类特征对农村居民分类;其次,在分类的基础上,对各类别农村居... 详细信息

提出一种基于多因素权重分析的分类模型(K-means-EWM-BP)来预测农村居民的清洁取暖接受度。首先,基于实地调研数据,选取农村居民家庭年总收入、性别、年龄、受教育程度作为聚类特征对农村居民分类;其次,在分类的基础上,对各类别农村居民的清洁取暖接受度影响因素进行多因素权重分析;最后,构建K-means-EWM-BP模型,实现对农村居民清洁取暖接受度的预测及验证。结果表明:1)受访农村居民可分为3类,其中清洁取暖接受度主要受教育程度影响的农村居民(类别1)占比31%,清洁取暖接受度主要受家庭年总收入影响的农村居民(类别2)占比43%,清洁取暖接受度主要受性别影响的农村居民(类别3)占比26%。2)类别1农村居民清洁取暖接受率预测值为95%,类别2农村居民清洁取暖接受率预测值为100%,类别3农村居民清洁取暖接受率预测值为72%。3)与EWM-BP模型和BP模型相比,K-means-EWM-BP模型预测准确性达到91.43%,高于准确性为87.14%的EWM-BP模型和准确性为80%的BP模型,同时标准误差(RMSE)与EWM-BP模型和BP模型相比分别降低0.01和0.06。

关键词：可再生能源农村地区预测多因素权重分析清洁取暖

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基于困难认知诊断的二语听力个性化学习路径反馈研究

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现代外语 2024年第2期47卷 270-282页

作者：孟亚茹王娅西安交通大学陕西省西安市710049

现有二语听力认知诊断评估主要基于正确作答,忽视了错误作答的重要诊断价值。“问题认知诊断模型”的出现有助于甄别学生的听力加工困难,并基于诊断结果刻画个性化的学习路径反馈。据此,本研究对6所大学1121名学生在听力理解多选题上的... 详细信息

现有二语听力认知诊断评估主要基于正确作答,忽视了错误作答的重要诊断价值。“问题认知诊断模型”的出现有助于甄别学生的听力加工困难,并基于诊断结果刻画个性化的学习路径反馈。据此,本研究对6所大学1121名学生在听力理解多选题上的错误作答进行认知诊断分析,获取他们的困难模式,并据此生成个性化的学习路径反馈。结果显示:1)困难主要来自隐含意义推理和词汇识别,而语音感知的难度最小;2)基于前十种高频困难模式所生成的三条个性化学习路径反馈有助于师生依此克服困难,循序渐进地提升听力理解水平。本研究对二语困难诊断、多选题开发、自适应考试发展以及个性化教学,均有重要启示。

关键词：二语听力多选题错误作答困难认知诊断个性化学习路径反馈

智慧教育对受教育权的变革及其在教育法典中的表达

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湖南师范大学教育科学学报 2024年第3期23卷 106-112,122页

作者：刘璞薛雅如西北政法大学行政法学院陕西西安710063 西北政法大学教育立法研究基地陕西西安710063

数字技术正在推动传统教育向智慧教育蜕变,以智慧教育为显著特征的全球教育发展新格局正在形成。受教育权被赋予新的内涵,受教育机会权兼有“入学机会”和“数字教育机会”,受教育条件权从获得“物理条件”向“虚拟资源”延伸,受教育结... 详细信息

数字技术正在推动传统教育向智慧教育蜕变,以智慧教育为显著特征的全球教育发展新格局正在形成。受教育权被赋予新的内涵,受教育机会权兼有“入学机会”和“数字教育机会”,受教育条件权从获得“物理条件”向“虚拟资源”延伸,受教育结果权的评价方式从“结果评价”变为“过程评价”。为适应权利保障诉求,教育立法价值取向应从保障“社会权为核心的受教育权”发展为追求“自由权为主的学习权”,兼顾“教育机会均等”与“公平优质教育”,从“教育管理法”向“国家教育管理权与个人受教育权的平衡法”发展。教育法典编纂应对智慧教育模式下受教育权新内涵做出回应,加大公平优质教育的制度供给;增加保障教育选择自由权的制度;确立数字教育保障制度和数字教育隐私保护制度;纳入非制度化教育与终身学习法律制度,保障教育活动中的自由权,实现人的全面发展。

关键词：智慧教育受教育权数字化教育法典公平优质教育价值取向