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富勒烯与β淀粉样肽低聚体结合的分子动力学模拟

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物理化学学报 2014年第8期30卷 1587-1596页

作者：周晓颖郗文辉韦广红应用表面物理国家重点实验室计算物质科学教育部重点实验室复旦大学物理系上海200433

本文通过分子动力学模拟研究富勒烯在Aβ42低聚体表面的结合过程.在结合过程中,C60在Aβ表面经历一系列尝试过程,最终找到某个稳定的结合位点.根据结合的残基不同,这些结合位点可以分为六类,其中核心疏水区域(CHC)位点(17LVFFA21)及Turn... 详细信息

本文通过分子动力学模拟研究富勒烯在Aβ42低聚体表面的结合过程.在结合过程中,C60在Aβ表面经历一系列尝试过程,最终找到某个稳定的结合位点.根据结合的残基不同,这些结合位点可以分为六类,其中核心疏水区域(CHC)位点(17LVFFA21)及Turn 27-31位点(27NKGAI31)具有最强的结合稳定性.二者的结合主要通过范德华作用稳定,而溶剂化效应则起相反作用.在这六类位点中的两个位点,观察到C60会对Aβ二级结构起破坏作用.其一位于核心疏水区域,C60有挤入多肽β片层中间的趋势;另外一位点位于N端,C60能够破坏外侧Aβ的3-5号残基的主链氢键,瓦解其末端的β片结构.这两个过程对理解富勒烯抑制Aβ聚集的微观机制提供了帮助.此外,在Turn 27-31位点以及Y10-H14位点,发现了富勒烯与Aβ纤维样聚集体结合的沟槽滚动机制,即富勒烯能够在淀粉样低聚体表面形成的特定沟槽内滚动.这一特征有助于预测富勒烯在其它淀粉样多肽表面的结合位点及结合行为.

关键词：多位点结合结合能二级结构破坏疏水口袋沟槽滚动机制

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

基于多层次灰色综合评价的口岸国际道路运输便利化测度

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科学技术与工程 2021年第14期21卷 5988-5996页

作者：杨圣文彭翀高璇习文辉杨敏西南林业大学机械与交通学院昆明650000 云南省交通科学研究院有限公司昆明650000

便利的国际道路运输对促进同周边国家经贸往来和沿边地区经济社会发展有重要的现实意义。从货物及人员跨境运输的双重视角,聚焦口岸跨境运输,基于国际道路运输流程的解构,构建了包含跨境手续、人员跨境运输、货物跨境运输、道路车辆入... 详细信息

便利的国际道路运输对促进同周边国家经贸往来和沿边地区经济社会发展有重要的现实意义。从货物及人员跨境运输的双重视角,聚焦口岸跨境运输,基于国际道路运输流程的解构,构建了包含跨境手续、人员跨境运输、货物跨境运输、道路车辆入境要求、商业交通权的交换、基础设施和标准、组织机构、其他因素8个一级指标和37个二级指标的国际道路运输便利化评价指标体系,提出了基于多层次灰色综合评价的国际道路运输便利化测度模型。以云南省国际道路运输为典型案例,验证测度方法体系的有效性,并提出了国际道路运输便利化的优化对策。结果显示:所建立的测度指标能够表征云南国际道路运输便利化发展水平;云南省基础设施和标准、法律法规、组织机构和商业通行权等方面便利程度较高;云南省在跨境手续的便利化、道路车辆入境要求的便利化以及货物、人员的跨境运输便利化方面仍然存在提升的空间。

关键词：交通经济运输便利化多层次灰色综合评价国际道路运输口岸

高效液相色谱的4种商品手性柱对38种手性化合物的拆分研究

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分析化学 2010年第2期38卷 181-186页

作者：张美奚文汇字敏彭雅谢生明袁黎明云南师范大学化学化工学院

采用纤维素-三(3,5-二甲基苯基氨基甲酸酯)涂敷型手性固定相(Chiralcel OD柱)、直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)涂敷型手性固定相(Chiralpak AD柱)、直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)键合型手性固定相(Chiralpak IA柱)和Pi... 详细信息

采用纤维素-三(3,5-二甲基苯基氨基甲酸酯)涂敷型手性固定相(Chiralcel OD柱)、直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)涂敷型手性固定相(Chiralpak AD柱)、直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)键合型手性固定相(Chiralpak IA柱)和Pirkle型的(S,S)-Whelk-01手性固定相对38种外消旋体化合物进行手性拆分。实验结果表明,4种固定相的手性识别能力为:OD>AD>IA>(S,S)-Whelk-01,OD固定相的手性识别率达到60%,并且它们之间的手性识别性能还具有一定的互补性。本研究对4种常用手性固定相的拆分能力进行了对比,为拆分手性化合物时有的放矢地选择手性固定相提供了参考。

关键词：纤维素直链淀粉高效液相色谱手性固定相手性拆分

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Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing xin-Ran Liu xing-Hua Wang hui Han Sha-Sha Liang xi-Meng Chen Dong-hui Wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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TRRE发动机关键技术分析及推进性能探索研究

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推进技术 2017年第2期38卷 298-305页

作者：韦宝禧凌文辉冮强魏祥庚秦飞何国强北京动力机械研究所高超声速冲压发动机技术重点实验室北京100074 西北工业大学燃烧热结构与内流场重点实验室陕西西安710072

对TRRE发动机关键技术难点及技术途径进行了初步分析,对北京动力机械研究所原理样机研制进展进行了简要介绍,并结合原理样机流道设计与数值仿真研究获得的性能数据,开展了TRRE发动机推进性能探索研究,初步验证了TRRE发动机在兼具加速、... 详细信息

对TRRE发动机关键技术难点及技术途径进行了初步分析,对北京动力机械研究所原理样机研制进展进行了简要介绍,并结合原理样机流道设计与数值仿真研究获得的性能数据,开展了TRRE发动机推进性能探索研究,初步验证了TRRE发动机在兼具加速、巡航、机动等方面的性能优势。研究结果表明,在适当兼顾低马赫数大推力需求和Ma=6纯冲压工况高比冲需求的情况下,发动机在宽马赫数工作范围具有较大范围、灵活便捷的推力调节能力,可满足高低速通道平稳接力需求,表现出极具优势的加速、机动飞行和高马赫数巡航的适应性。

关键词：临近空间及空天飞行器组合发动机性能分析

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui Li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： hui-Feng Wang wen-Jie Shi Yu-xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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