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Endometrial MicroRNA Signature during the Window of Implantation Changed in Patients with Repeated Implantation Failure

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Chinese Medical Journal 2017年第5期130卷 566-573页

作者： cheng Shi huan Shen li-Juan Fan Jing Guan xin-Bang zheng xi Chen Rong liang xiao-Wei zhang Qing-hua Cui Kun-Kun Sun zhu-Ran Zhao Hong-Jing Han Reproductive Medical Center Peking University People's Hospital Beijing 100044 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Biomedical Informatics School of Basic Medical Sciences Peking University Beijing 100191 China Department of Pathology Peking University People's Hospital Beijing 100044 China Department of Paediatrics Peking University People's Hospital Beijing 100044 China

Background： At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA （miRNA） signatures for impaired endometrial receptivity by microarray analysis. Methods： A total of 12 repeated implantation failure （RIF） patients and I0 infertile patients, who conceived and delivered after one embryo transfer attempt, were recruited as RIF and control groups, respectively. Endometrial specimens from the window of implantation （WOI） were collected from these two groups. MiRNA microarray was conducted on seven and five samples from the RIF and control groups, respectively. Comparative, functional, and network analyses were performed for the microarray results. Quantitative real-time polymerase chain reaction （PCR） was performed on other samples to validate the expression of specific miRNAs. Results： Compared with those in the control group, the expression levels of 105 miRNAs in the RIF group were found to be significantly up- or down-regulated （at least 2-fold） by microarray analysis. The most relevant miRNA functional sets of these dysregulated miRNAs were miR-30 family, human embryonic stern cell regulation, epithelial-mesenchymal transition, and miRNA tumor suppressors by tool for annotations ofmicroRNA analysis. Network regulatory analysis found 176 miRNA-mRNA interactions, and the top 3 core miRNAs were has-miR-4668-5p, has-miR-429, and has-miR-5088. Expression levels of the 18 selected miRNAs in new samples by real-time PCR were found to be regulated with the same trend, as the result ofmicroarray analysis. Conclusions： There is a significant different expression of certain miRNAs in the WOI endometrium for RIF patients. These miRNAs may contribute to impaired endometrial receptivity.

关键词： Embryo Implantation Endometrial Receptivity MicroRNA Microarray Repeated Implantation Failure Window of Implantation

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Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study

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Chinese Medical Journal 2020年第24期133卷 2919-2927页

作者： Bin Su cheng Yao Qing-xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu yuan-yuan Chen li liu Hui Wang yun He yu-huang zheng ling-hua li Jin-feng Chen Jian-hua yu Biao zhu Min Zhao Yong-Tao Sun wen-Hui Lun Wei xia li-Jun Sun li-li Dai Tai-Yi Jiang mei-xia Wang Qing-Shan zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-hua Hu Hui xing Yi-Ming Shao Dong xie Tong zhang Fu-Jie zhang Hao Wu TALENT Study Team Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Frontier Biotechnologies Inc. NanjingJiangsu 211122China Department of Infectious Diseases Infectious Disease Hospital of Henan ProvinceZhengzhouHenan 450061China Infectious Disease Center Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510060China Institute of HIV/AIDS The First Hospital of ChangshaChangshaHunan 410005China Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of Infectious Diseases National Clinical Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518112China Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Infectious Diseases Xixi Hospital of HangzhouHangzhouZhejiang 310023China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310003China National Clinical Research Center for Infectious Diseases the Fifth Medical Center of PLA General HospitalBeijing 100039China Department of Infectious Diseases Tangdu HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710038China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Drug Clinical Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Beijing Co-CRO Medical Development Co. Ltd.Beijing 100711China State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China 不详

Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion *** present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral ***:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in *** on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 ***-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,*** 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for *** the per-protocol population,the superiority of albuvirtide over NRTI was *** frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride *** function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT ***:The TALENT study is the first phase 3 trial of an injectable long-acting HIV *** interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatme

关键词： HIV Fusion inhibitor Albuvirtide LPV/r Phase 3 clinical trial

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Advanced Space-based Solar Observatory(ASO-S):an overview

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Research in Astronomy and Astrophysics 2019年第11期19卷 3-10页

作者： Wei-Qun Gan cheng zhu yuan-Yong Deng Hui li Yang Su Hai-Ying zhang Bo Chen Zhe zhang Jian Wu Lei Deng yu huang Jian-feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin wen Chen cheng Fang Yi-hua Yan Jun lin Wei-Ming xiong Bin Chen Hai-Chao Bao Cai-xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen xin-yu li Ye zhang li feng Jiang-Tao Su Ying li Wei Chen You-Ping li Ying-Na Su Hai-Yan Wu mei Gu Lei huang Xue-Jun Tang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China Changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China yunnan Observatories Chinese Academy of SciencesKunming 650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Beijing Special Engineering and Design Institute Beijing 100028China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar *** scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(Hxi).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single ***-S is scheduled to be launched into a 720 km Sun-synchronous orbit in *** paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.

关键词： space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray,gamma-rays

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Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study

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Chinese Medical Journal 2018年第23期131卷 2776-2784页

作者： Wei Qiu De-Hui huang Shi-Fang Hou mei-Ni zhang Tao Jin Hui-Qing Dong hua Peng Chao-Dong zhang Gang Zhao Yi-Ning huang Dong Zhou Wei-Ping Wu Bao-Jun Wang Ji-mei li xing-Hu zhang Yan cheng Hai-feng li ling li Chuan-zhen Lu Xu zhang Bi-Tao Bu Wan-li Dong Dong-Sheng Fan Xue-Qiang Hu xian-Hao Xu Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510000China Department of Neurology Peking University First HospitalBeijing 100034China Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurology Baotou Central HospitalBaotouInner Mongolia 014040China Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijing 100000China Department of Neurology Beijing Tian Tan HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Tianjin Medical University General HospitalTianjin 300052China Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Neurology Hebei General HospitalShijiazhuangHebei 050051China Department of Neurology Hua Shah Hospital of the Shanghai Fudan University Medical CollegeShanghai 200040China Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Neurology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of Neurology Beijing HospitalNational Center of GerontologyBeijing 100083China Qilu Hospital of Shandong University JinanShandong 250012China Department of Neurology Beijing HospitalBeijing 100730China Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Neurology The First Hospital of Jilin UniversityChangchunJilin 130012China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology Shanghai Chang Zheng HospitalShanghai 200003China Department of Neurology The First Hospital of China Medical UniversityShenyang

Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in *** primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled *** subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,*** most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER *** has the potential to meet unmet medical needs for MS patients in China.

关键词： Chinese Patients Efficacy Phase 3 Relapsing Multiple Sclerosis Safety Teriflunomide TOWER

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Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy： A National Multicenter Study in China

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Chinese Medical Journal 2017年第22期130卷 2661-2665页

作者： hua Yang xiao-Chuan li Chen Yao Jing-He Lang Hang-mei Jin Ming-Rong xi Gang Wang Lu-wen Wang Min Hao Yan Ding Jie Chen Jian-Qing zhang Lu Han cheng-xiu Guo xiang Xue Yan li Jian-hua zheng Man-hua Cui huai-Fang li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-hua huang Qing liu Ya-li zhuang xiang-hua huang Gen-Hai zhu Ou-Ping huang li-Na Hu Mu-Jun li Hong-lin Zhou Jing-Hui Song Lan zhu Department of Obstetrics and Gynecology Peking Union Medical College Hospital Beijing 100730 China Department of Biostatistics Peking University Clinical Research Institute Peking University First Hospital Beijing 100871 China Department of Obstetrics and Gynecology Zhejiang University Affiliated Obstetrics and Gynecology Hospital Zhejiang Hangzhou 310006 China Department of Obstetrics and Gynecology West China Second Hospital of Sichuan University Cbengdu Sichuan 610041 China Department of Obstetrics and Gynecology The First People's Hospital of Foshan City Foshan Guangdong 528010 China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Henan Province Zhengzhou Henan 450052 China Department of Obstetrics and Gynecology The Second Hospital of Shanxi Medical University Datong Shanxi 030001 China Department of Obstetrics and Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumchi Xinjiang 830000 China Department of Obstetrics and Gynecology People's Hospital of Fujian Province Fuzhou Fujian 350000 China Department of Obstetrics and Gynecology Qinghai Red Cross Hospital Xining Qinghai 810000 China Department of Obstetrics and Gynecology Dalian Maternity Hospital Dalian Liaoning 116021 China Department of Obstetrics and Gynecology Tianjin Central Maternity Hospital Tianjin 300100 China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Obstetrics and Gynecology General Hospital of Ningxia Medical University Yinchuan Ningxia Hui Autonomous Region 750003 China Department of Obstetrics and Gynecology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150007 China Department of Obstetrics and Gynecology The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Obstetrics and Gynecology Shanghai Tongji Hospital Shanghai 200065 China Department of Obstetrics and Gynec

Background： The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. Methods： A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected. We calculated the prevalence and recorded the clinical characteristics of the patients with malignancy after morcellation application. A total of 62 cases were finally pathologically confirmed as malignant postoperatively. Additionally, the medical records of the 62 patients were analyzed in details. Results： The proportion of postoperative malignancy after morcellation application was 0.18% （62/33,723） for patients who underwent laparoscopic myomectomy. Nearly 62.9% （39/62） of patients had demonstrated blood flow signals in the uterine fibroids before surgery. And, 23 （37.1%） patients showed rapid growth at the final preoperative ultrasound. With respect to the pathological types, 38 （61.3%） patients had detectable endometrial stromal sarcoma, 13 （21.0%） had detectable uterine leiomyosarcoma, only 3 （3.2%） had detectable carcinosarcoma, and 5 （8.1%） patients with leiomyoma had an undetermined malignant potential. Conclusions： The proportion of malignancy is low after using moreellation in patients who undergo laparoscopie myomectomy. Patients with fast-growing uterine fibroids and abnormal ultrasonic tumor blood flow should be considered for malignant potential, and morcellation should be avoided.

关键词： Laparoscopic Myomectomy Morcellation Sarcoma

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CD 147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2521-2535页

作者： Hong-Yong Cui Shi-Jie Wang Fei Song Xu cheng Gang Nan yu Zhao mei-Rui Qian xi Chen Jia-yue li Fen-ling liu yu-Meng zhu Ruo-Fei Tian Bin Wang Bin Wu Yang zhang xiu-Xuan Sun Ting Guo xiang-Min Yang Hai zhang ling li Jing Xu Hui-Jie Bian Jian-li Jiang Zhi-Nan Chen National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Urology Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina College of Chemistry and Materials Science Northwest UniversityXi'anChina National Facility for Protein Science Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Medical Research Center Southern University of Science and Technology HospitalShenzhenChina

Major gaps in understanding the molecular mechanisms of colorectal cancer(CRC)progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal *** factor 3(TFF3)has been reported to be involved in CRC progression and intestinal mucosal repair;however,how TFF3 drives tumors to become more aggressive or metastatic and how TFF3 promotes intestinal mucosal repair are still poorly ***,we found that the upregulated TFF3 in CRC predicted a worse overall survival ***3 deficiency impaired mucosal restitution and ***147,a membrane protein,was identified as a binding partner for *** binding to CD147,TFF3 enhanced CD147-CD44s interaction,resulting in signal transducer and activator of transcription 3(STAT3)activation and prostaglandin G/H synthase 2(PTGS2)expression,which were indispensable for TFF3-induced migration,proliferation,and ***2-derived PGE2 bound to prostaglandin E2 receptor EP4 subtype(PTGER4)and contributed to TFF3-stimulated CRC *** NMR studies of the TFF3-CD147 interaction revealed the key residues critical for TFF3 binding and the induction of PTGS2 *** ability of TFF3 to enhance mucosal restitution was weakened by a PTGS2 *** of TFF3-CD147 signaling using competitive inhibitory antibodies or a PTGS2 inhibitor reduced CRC lung metastasis in *** findings bring strong evidence that CD147 is a novel receptor for TFF3 and PTGS2 signaling is critical for TFF3-induced mucosal restitution and CRC progression,which widens and deepens the understanding of the molecular function of trefoil factors.

关键词： TFF3 colorectal impaired

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The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis

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Molecular Plant 2020年第2期13卷 336-350页

作者： Jin liu Cong Shi cheng-cheng Shi Wei li Qun-Jie zhang yun zhang Kui li Hui-Fang Lu Chao Shi Si-Tao zhu Zai-yun xiao Hong Nan Yao yue Xun-Ge zhu yu Wu xiao-Ning Hong Guang-Yi Fan Yan Tong Dan zhang Chang-li Mao yun-Long liu Shi-Jie Hao Wei-Qing liu mei-Qi Lv Hai-Bin zhang yuan liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-huai Sun Shu-Bang Ni wen-Bin Chen xing-Cai zhang yuan-Nian Jiao Evan E.Eichler Guo-hua li xin liu li-Zhi Gao yunnan Institute of Tropical Crops Jinghong 666100China Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650204China University of Chinese Academy of Sciences Beijing 100049China BGI-Qingdao Qingdao 266555China lnstitution of Genomics and Bioinformatics South China Agricultural UniversityGuangzhou 510642China Asia-Pacific Tropical Forestry Germplasm Institution Southwest China Forestry UniversityKunming 650224China School of life Sciences Nanjing UniversityNanjing 210023China Novogene Bioinformatics Institute Beijing 100083China BGI-Shenzhen Shenzhen 518083China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA

The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw ***,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the～1.47-Gb genome assembly into 18 *** chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and *** show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by～65.88%(～970 Mbp)of the whole rubber tree genome since the divergence from *** identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains～15.7 million high-quality single-nucleotide *** identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber *** genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production.

关键词： rubber tree rubber biosynthesis chromosome evolution whole-genome duplication domestication

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Gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia

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World Journal of Gastroenterology 2013年第32期19卷 5357-5364页

作者： Jiao yu Shi liu xiu-Cai Fang Jun zhang Jun Gao Ying-lian xiao li-Ming zhu Fen-Rong Chen Zhao-Shen li Pin-Jin Hu mei-yun Ke xiao-hua Hou Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Division of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences Division of Gastroenterology Second Affiliated Hospital of Medical CollegeXi’an Jiaotong University Division of Gastroenterology Changhai HospitalSecond Military Medical University Division of Gastroenterology First Affiliated Hospital of Sun Yat-sen University

AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and xi’an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.RESULTS: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P linear regression analysis showed that sex (P xiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P line.CONCLUSION: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.

关键词： Functional dyspepsia Gastrointestinal symptoms Dyspeptic symptom score Helicobacter pylori infection Postprandial distress syndrome Epigastric pain syndrome Rome III criteria

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Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： yun-Dai CHEN Wei-Yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-yu GAO Jun-Bo GE Zuo-xiang HE Yong HUO Lang li Si-Jin li xi-lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU li YANG Bo yu mei zhang Jun-Jie YANG Shu-Yang zhang xiao-li zhang Shi-hua ZHAO Yang zhenG yu-Chi HAN Guang ZHI Chinese PLA General Hospital Beijing China Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guangxi Medical University Nanning China The First Affiliated Hospital of Shanxi Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of Jilin University Changchun China University of Pennsylvania United States

1 Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 2013 ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities

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舰船底部液舱结构在水下爆炸作用下的动态响应实验研究

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爆炸与冲击 2007年第5期27卷 431-437页

作者：张振华王乘黄玉盈朱锡李振环华中科技大学土木工程与力学学院湖北武汉430074 海军工程大学船舶与海洋工程系湖北武汉430033

实验研究了舰船底部液舱双层板结构在水下爆炸作用下的动态响应问题。对舰船底部液舱模型在空载、半载和满载状态下进行了水下爆炸实验,测量了底部液舱外板和内板的壁压、加速度和动态应变等参数。在此基础上,分析了船体底部液舱外板和... 详细信息

实验研究了舰船底部液舱双层板结构在水下爆炸作用下的动态响应问题。对舰船底部液舱模型在空载、半载和满载状态下进行了水下爆炸实验,测量了底部液舱外板和内板的壁压、加速度和动态应变等参数。在此基础上,分析了船体底部液舱外板和内板在水下爆炸作用下的响应特点,液舱满载时水下爆炸冲击波的透射作用和半载液舱飞溅载荷对内底的冲击作用等问题。

关键词：爆炸力学动态响应水下爆炸液舱结构舰艇

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