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Food Science and Human Wellness 2024年

作者： Qi Yang Jingbo Liu Siwen Lyu Ting Li Xuanting Liu Zhiyang Du xiaomin Shang Ting Zhang Huifang Ge chunyu xi Jilin Provincial Key Laboratory of Nutrition and Functional Food， Jilin University College of Food Science and Engineering， Jilin University State Key Laboratory of Tea Plant Biology and Utilization， School of Tea and Food Sciences and Technology， Anhui Agricultural University

Bioactive peptides have various excellent biological activities and serve as functional foods to prevent chronic diseases in the human body. This article investigated the regulatory effect of egg white peptides (EPs) on the intestine barrier of young mice with colitis. The results showed that the intake of EPs could protect the intestines from inflammation damage. Besides， the expression of tight junction (TJ) proteins and mucin is upregulated. Markedly， the intake of EPs can increase the concentration of amino acids in the serum of young mice， which is crucial for nutritional supplementation during intestinal inflammation process. Proteomics analysis implied that EPs can regulate protein expression in the intestine， involving multiple inflammatory pathways including PI3K-AKT and MAPK signaling pathway. This demonstrated the health benefits of bioactive peptides and provides a theoretical basis for the development of animal derived proteins as functional foods.

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Graphene Supported Platinum Nanoparticles as Catalyst for Oxygen Reduction Reaction

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Chemical Research in Chinese Universities 2015年第6期31卷 1007-1011页

作者： ZHANG Wenyu WANG Zhixin SHEN Yan xi Muyao CHU Xuebin xi chunyu China-Japan Union Hospital Jilin University Changchun 130033 P. R. China Depertment of Food Science and Engineering Jilin University Changchun 130062 P. R. China Wuhan National Laboratory for Optoelectronics School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 P. R. China

Graphene supported Pt nanoparticles were fabricated via electrochemical reduction method and the appli- cation of them in oxygen reduction reaction was also investigated. The results of field emission scanning electron microscope（SEM）, X-ray photoelectron spectroscopy（XPS） and Raman spectroscopy reveal that the interaction be- tween Pt nanoparticles and graphene sheets can prevent graphene from agglomeration and improve the electronic conductivity of the composite. And the graphene supported Pt nanoparticles exhibit excellent electrocatalytic activity toward oxygen reduction reaction.

关键词： Graphene Pt nanoparticle Electrodeposition Oxygen reduction Electrocatalyst

Morphogenesis and Molecular Phylogeny of a Marine Urostylid Ciliate Apokeronopsis wrighti(Protista, Ciliophora, Hypotrichia)

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Journal of Ocean University of China 2024年第4期23卷 1067-1075页

作者： LIAN chunyu LI Ping ZHANG Tengteng SHAO Chen Department of Zoology College of Life SciencesShaanxi Normal UniversityXi’an 710119China Powerchina Northwest Engineering Corporation Limited Xi’an 710065China

Hypotrichs are one of the highly differentiated ciliated lineages which play important roles in ecological, environmental,evolutionary and basic biological studies. In the present study, we investigated the living characteristics, infraciliature, nuclear apparatus, ontogenesis and phylogenetic position of a marine hypotrichous ciliate, Apokeronopsis wrighti Long et al., 2008, which was isolated from coastal waters in Shenzhen, China. The new isolate resembles the type population in terms of morphological characteristics, morphometrics, and SSU rRNA gene sequence that is with a 99.7% similarity. Ontogenesis of A. wrighti is characterized by oral primordium for the proter as well as marginal and dorsal kineties anlagen in both filial products formed de novo, and the cirral row arranged along the paroral and endoral arises from several anterior frontoventral-transverse cirral streaks. Phylogenetic analyses based on SSU and concatenated gene data suggest that five species of Apokeronopsis form a monophyletic clade, and the genus Apokeronopsis is closely related to Thigmokeronopsis and Metaurostylopsis.

关键词： 18S rRNA gene Apokeronopsis ciliated protists multi-gene ontogenesis systematics Urostylida

Advanced rare earth tantalate RETaO_(4)(RE=Dy,Gd and Sm) with excellent oxygen/thermal barrier performance

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Journal of Rare Earths 2024年第8期42卷 1595-1603,I0007页

作者： Jun Wang Jianyu Li chunyu Jiang Jianbo Song xing Yang xiaolong Ma Kailiang Luo Peng Wu xiaoyu Chong Jing Feng Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming650093China Shanxi Tianxuan Coating Technology Co. LtdXi'an710000China

Thermal barrier coatings(TBCs) materials with lowered the rmal and oxygen ion conductivity can provide thermal and oxidative protection for high te mperature hot-end components in aero nautical engines and gas turbines,The rare-earth tantalate RETaO_(4)(RE=Dy,Gd and Sm) ceramics with monoclinic(m) phase were successfully synthesized via spark plasma *** vacancies responsible for the thermal and oxygen ion conductivities of RETaO_(4) were demonstrated by atomic-resolution energy dispersive Xray and X-ray photoelectron *** the three samples,DyTaO_(4) has excellent oxygen/thermal barrier *** to the current service thermal barrier coating material ZrO_(2)-8 wt% Y_(2)O_(3)(8 YSZ),DyTaO_(4) has an ultra-low oxygen ion conductivity benefiting from low oxygen vacancy concentration and strong stretching force *** intrinsic thermal conductivity of DyTaO_(4)is 68.2% less than that of 8 ***,the thermal expansion rate curves indicate that the phase transformation does not happen from room te mperature to 1200℃.The above results demonstrate that high-growth rate the rmally grown oxide can be retarded by creating dense DyTaO_(4) coating with lowered thermal and oxygen ion conductivity.

关键词： Thermal barrier coatings Rare earths Oxygen vacancies Thermal conductivity Oxygen ion conductivity

CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition

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Genes & Diseases 2024年第5期11卷 122-125页

作者： Miao Wang Lin Chen Yu Wang Tian Fan chunyu Zhu Zhixian Li Lei Mou Hong Yang Airong Qian Yu Li School of Life Sciences Northwestern Polytechnical UniversityXi’anShaanxi 710072China xi’an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Oncology Air Force Medical CenterPLABeijing 100142China Department of Obstetrics and Gynecology The First Affiliated Hospital of Air Force Medical UniversityXi’anShaanxi 710032China

Currently,the major therapy for patients with ovarian cancer includes post-cytoreductive surgery followed by chemotherapy of carboplatin or cisplatin plus *** rise of drug resistance is a substantial factor in cancer recurrence and mortality among ovarian cancer patients receiving cisplatin ***147 is widely expressed in a variety of cancer tissues1 and recognized as a drug target for its antibody drug Licartin which has been approved by China’s National Medicines and Pharmaceutical Administration.2 Even though many studies reported that CD147 is involved in the cisplatin resistance of varieties of cancers,3 its mechanism remains *** this investigation,we uncovered a distinctive mechanism by which CD147 regulates cisplatin resistance through the proteasomal degradation of the transcription factor FOXM1,which is associated with DNA damage repair,in ovarian cancer *** results suggest that targeting CD147 may have therapeutic implications for increasing cisplatin efficiency in the management of ovarian cancer.

关键词： FOXM1 cisplatin CD147

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考虑坠撞环境影响的民机应急撤离实验

航空学报 2024年第15期45卷 245-259页

作者：彭浩轩刘小川惠旭龙白春玉李肖成安昊牟让科强度与结构完整性全国重点实验室西安710065 中国飞机强度研究所结构冲击动力学航空科技重点实验室西安710065 陕西省飞行器振动冲击与噪声重点实验室西安710065

民机可生存坠撞事故中的环境因素对乘员撤离具有重要影响。本文基于典型民机可生存坠撞事故场景特点,提出了可模拟典型坠撞事故环境的乘员应急撤离实验方法,介绍了机体姿态、环境声/光、客舱障碍物、舷窗视效环境的模拟方法以及人员撤... 详细信息

民机可生存坠撞事故中的环境因素对乘员撤离具有重要影响。本文基于典型民机可生存坠撞事故场景特点,提出了可模拟典型坠撞事故环境的乘员应急撤离实验方法,介绍了机体姿态、环境声/光、客舱障碍物、舷窗视效环境的模拟方法以及人员撤离轨迹的高精度测量方法,并通过志愿者实验分别研究了机体倾斜姿态、事故声/光环境、过道障碍物等坠撞环境因素对民机乘员应急撤离的影响规律。结果表明:本文提出的考虑坠撞环境影响的应急撤离实验方法和坠撞环境模拟方案可行,获得了有效的实验数据;当机体姿态在俯仰角±5°以内变化时,对多乘员撤离的撤离总时间和撤离效率无显著影响,人群在过道区域上坡和下坡速度的差异随着俯仰角的增大而增大;坠撞事故声音和光照环境对乘员应急撤离有一定影响,事故背景声效会使撤离总时间减少,应急照明会使撤离总时间增加;客舱过道中存在障碍物时所需的撤离总时间总体增加,障碍物越靠近出口,撤离效率越低,而且相较于可移动型障碍物,固定型的障碍物会导致更低的撤离效率。

关键词：适坠性客舱安全坠撞事故应急撤离环境模拟定位测量疏散效率

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航空安全带织带拉伸力学特性研究

机械科学与技术 2024年第4期43卷 704-710页

作者：杨欢刘小川张宇惠旭龙白春玉中国飞机强度研究所西安710065 结构冲击动力学航空科技重点实验室西安710065

航空安全带是保障乘员安全的关键部件,为研究航空安全带织带的拉伸力学性能,利用电子万能实验机,开展了AM SAFE安全带织带在6.35 mm/min、30 mm/min、152.4 mm/min加载速率、160 mm、254 mm标距段尺寸、以及考虑二次加载影响下的拉伸性... 详细信息

航空安全带是保障乘员安全的关键部件,为研究航空安全带织带的拉伸力学性能,利用电子万能实验机,开展了AM SAFE安全带织带在6.35 mm/min、30 mm/min、152.4 mm/min加载速率、160 mm、254 mm标距段尺寸、以及考虑二次加载影响下的拉伸性能实验,并基于实验结果,采用区段式、有限元、混合式3种安全带建模方法,模拟并对比了安全带织带的拉伸过程。结果表明:安全带织带迟滞效应明显,耗能作用显著;其拉伸力学特性受加载速率影响很小,受标距段尺寸影响较大,与加载次数密切相关;3种建模方式均能较好地表征安全带织带的拉伸力学性能。

关键词：航空安全带力学特性尺寸效应二次加载数值仿真

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典型民用飞机全机坠撞实验研究

航空学报 2024年第5期45卷 377-397页

作者：刘小川惠旭龙张欣玥白春玉闫亚斌李肖成牟让科强度与结构完整性全国重点实验室西安710065 中国飞机强度研究所结构冲击动力学航空科技重点实验室西安710065 陕西省飞行器振动冲击与噪声重点实验室西安710065 西北工业大学航空学院西安710072 中航西飞民用飞机有限责任公司西安710089

民机全机坠撞实验是评价民用飞机适坠性的最直接手段,也是民机适坠性领域的世界性技术难题。提出全机坠撞实验高精度提升控制与高可靠投放方法,给出了结构响应、假人响应等关键物理量的测试方法,引入了分布式多目相机全场大变形连续测... 详细信息

民机全机坠撞实验是评价民用飞机适坠性的最直接手段,也是民机适坠性领域的世界性技术难题。提出全机坠撞实验高精度提升控制与高可靠投放方法,给出了结构响应、假人响应等关键物理量的测试方法,引入了分布式多目相机全场大变形连续测试方法。构建了全机坠撞动响应测试系统,使用统一时间基准触发,对坠撞后地面撞击载荷、结构加速度响应、假人响应以及飞机破坏变形进行了分析,获得了机体不同部位的响应分布规律;提出了修正的适坠性综合评估指数ICI。结果表明:全机坠撞实验测试数据完整可信,实验飞机在5.71 m/s垂直坠撞后,客舱地板下部结构变形严重,机翼的惯性效应导致中央翼区域机身上部结构产生明显变形;不同机身段的刚度差异造成该部位坠撞载荷和动响应的显著差异,刚度越大变形越小加速度响应越大;坠撞后乘员受载在安全范围内,客舱座椅结构完好,舱门可正常打开,乘员生存空间足够,乘员撤离通道畅通。实验飞机在给定状态下具有较好的适坠性,相比原始ICI指数,修正后的评估结果具有更好的工程适用性。

关键词：冲击动力学民用飞机全机坠撞全场测量结构吸能坠撞载荷适坠性评估

尿毒症血液透析患者行经导管主动脉瓣置换术1例

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中华心血管病杂志 2024年第1期52卷 85-88页

作者：肖喜娥戴欢子王红勇曾春雨王伟陆军军医大学大坪医院心血管内科重庆400042 陆军军医大学大坪医院肾脏内科重庆400042

目前经导管主动脉瓣置换术(TAVR)在国内外已逐渐成熟,但TAVR治疗主动脉瓣狭窄合并严重肾脏病的临床风险和获益尚无定论。该文报道1例主动脉瓣重度狭窄合并肾功能衰竭尿毒症期患者的介入治疗及围手术期管理,以期为临床相似病例的治疗提... 详细信息

目前经导管主动脉瓣置换术(TAVR)在国内外已逐渐成熟,但TAVR治疗主动脉瓣狭窄合并严重肾脏病的临床风险和获益尚无定论。该文报道1例主动脉瓣重度狭窄合并肾功能衰竭尿毒症期患者的介入治疗及围手术期管理,以期为临床相似病例的治疗提供参考。

关键词：主动脉瓣狭窄尿毒症经导管主动脉瓣置换术介入治疗

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食品科学“虚拟仿真”实践教学平台的建立

农产品加工 2022年第6期 112-115页

作者：张燕奚春宇郭娜张铁华吉林大学食品科学与工程学院吉林长春130062

目前,虚拟仿真技术已经逐渐应用于食品科学相关专业的实验课堂教学中,但仍然还处于探索的阶段。简要论述了我国食品科学相关专业虚拟仿真实验教学重要性、目前虚拟仿真实验教学中存在的一些问题和对虚拟仿真实验的实际应用发展现状,并... 详细信息

目前,虚拟仿真技术已经逐渐应用于食品科学相关专业的实验课堂教学中,但仍然还处于探索的阶段。简要论述了我国食品科学相关专业虚拟仿真实验教学重要性、目前虚拟仿真实验教学中存在的一些问题和对虚拟仿真实验的实际应用发展现状,并充分结合吉林大学食品科学工程学院近几年关于虚拟仿真实验教学的实际情况,探索其在食品科学相关专业实验教学中的应用和可行性,以期能够通过搭建科学化的虚拟仿真实验教学模型来实现虚拟仿真技术与食品生物科学课程实践教学的有机融合。

关键词：虚拟仿真食品科学实践教学教学改革