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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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Synergetic deformation mechanisms in an Mg-zn-Y-zr alloy with intragranular lPSO structures

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Journal of Magnesium and Alloys 2023年第5期11卷 1754-1768页

作者： z.z.Peng x.H.Shao z.M.liang D.l.Wang l.W.Wang x.l.Ma Hebei Key laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050018China Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Whenua RoadShenyang 110016China

Deformation kink is one of the important strengthening mechanisms of the long-period-stacking-ordered(lPSO)phase containing magnesium(Mg)alloys,while the deformation twin is generally *** optimize the mechanical properties of lPSO containing Mg alloy by simultaneously exciting kink and twin,we successfully prepared the Mg-zn-Y-zr alloy featuring intragranular lPSO phase and free grain boundary lPSO phase by *** unraveled the corresponding strengthening and toughening mechanisms through transmission electron microscopy characterization and theoretical *** high strength and good plasticity of the homogenized alloy benefit from the synergistic deformation mechanism of multiple kinking and twining in the *** the activation of kinking and twinning depends on the thicknesses of lPSO lamellae and their relative *** results may shed light on optimizing the design of Mg alloys regulating the microstructure of lPSO phases.

关键词： Mg alloy lPSO distribution Kink Twin Transmission electron microscopy

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Stability analyses of the mass abrasive projectile high-speed penetrating into a concrete target Part III: Terminal ballistic trajectory analyses

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Acta Mechanica Sinica 2015年第4期31卷 558-569页

作者： H.Wu x.W.Chen Q.Fang x.z.Kong l.l.He Institute of Systems Engineering China Academy of Engineering Physics State Key laboratory for Disaster Prevention & Mitigation of Explosion & Impact PLA University of Science and Technology

During the high-speed penetration of projectiles into concrete targets （the impact velocity ranges from 1.0 to 1.5 km/s）, important factors such as the incident oblique and attacking angles, as well as the asymmetric abrasions of the projectile nose induced by the target-projectile interactions, may lead to obvious deviation of the terminal ballistic tra- jectory and reduction of the penetration efficiency. Based on the engineering model for the mass loss and nose-blunting of ogive-nosed projectiles established, by using the Differ- ential Area Force law （DAFl） method and semi-empirical resistance function, a finite differential approach was pro- grammed （PENTRA2D） for predicting the terminal ballistic trajectory of mass abrasive high-speed projectiles penetrating into concrete targets. It accounts for the free-surface effects on the drag force acting on the projectile, which are attributed to the oblique and attacking angles, as well as the asymmetric nose abrasion of the projectile. Its validation on the prediction of curvilinear trajectories of non-normal high-speed pene- trators into concrete targets is verified by comparison with available test data. Relevant parametric influential analyses show that the most influential factor for the stability of ter- minal ballistic trajectories is the attacking angle, followed by the oblique angle, the discrepancy of asymmetric nose abrasion, and the location of mass center of projectile. The terminal ballistic trajectory deviations are aggravated as the above four parameters increase.

关键词： Projectile Penetration Concrete Massabrasion Terminal ballistic trajectory

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Simulations of deformation and damage processes of SiCp/Al composites during tension

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Journal of Materials Science & Technology 2018年第4期34卷 627-634页

作者： J.F.zhang x.x.zhang Q.z.wang B.l.xiao z.Y.Ma Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

The deformation, damage and failure behaviors of 17 vol.% SiCp/2009AI composite were studied by micro- scopic finite element （FE） models based on a representative volume element （RVE） and a unit cell. The RVE having a 3D realistic microstructure was constructed via computational modeling technique, in which an interface phase with an average thickness of 50 nm was generated for assessing the effects of interracial properties. Modeling results showed that the RVE based FE model was more accurate than the unit cell based one. Based on the RVE, the predicted stress-strain curve and the fracture morphology agreed well with the experimental results. Furthermore, lower interface strength resulted in lower flow stress and ductile damage of interface phase, thereby leading to decreased elongation. It was revealed that the stress concentration factor of SiC was -2.0： the average stress in SiC particles reached -1200 MPa, while that of the composite reached -600 MPa.

关键词： Metal matrix composites (MMCs) Fracture Finite element (FE) analysis Interfacial strength Tensile strength Representative volume element (RVE)

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Microstructure evolution and hot deformation behavior of carbon nanotube reinforced 2009Al composite with bimodal grain structure

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Journal of Materials Science & Technology 2021年第11期70卷 73-82页

作者： K.Ma z.Y.liu S.Bi x.x.zhang B.l.xiao z.Y.Ma Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of ScienceShenyang110016China School of Materials Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang110016China School of Materials Science and Engineering Guilin University of TechnologyGuilin541004China

The hot deformation behaviors of the bimodal carbon nanotube reinforced 2009Al(CNT/2009Al)composite were studied by establishing processing map and characterizing the microstructure *** results indicate that the grain size in the ultra-fine grained zones was stable during hot deformation,while the coarse grained zones were elongated with their long axis directions tending to be perpendicular to the compression *** temperature with high strain rate(lTHR),as well as high temperature with low strain rate(HTlR)could increase the length/width ratio of the coarse grained ***,lTHR and HTlR could cause the instable *** instable deformation at lTHR was induced by severe intragranular plastic deformation and the localized shear crack,while the instable deformation at HTlR resulted from the more deformation component at the coarse grained zones,and the micro-pore initiation due to CNT re-agglomeration at the boundaries between the coarse and the ultra-fine grained zones.

关键词： Carbon nanotube Bimodal Aluminum matrix composite Hot deformation Processing map

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MICROSTRUCTURE ANAlYSIS OF AN ION-NITRIDINGlAER ON A NO.45 STEEl

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Acta Metallurgica Sinica(English letters) 1998年第3期11卷 183-189页

作者： x.l.xu l.Wang z.W.Yu z.K.Hei Dalian Maritime Univ Dalian China

The cross-sectional microstructure of an ion-nitrided layer on a No.45 steel was studied by transmission electron microscopy (TEM). The results show that the columnar crystals constitute the compound layer. Most of them have the microstructure of alternating ε-Fe2-3N and γ-Fe4N and others are single ε-Fe2-3N phase. There are abnormal strip ferrites between the columnar crystals. The transition layer mainly consists of spherical γ-Fe4N and cementite (Fe3C) particles in the pearlite are dissolved in this layer. In diffusion layer, besides the equilibrium phase γ-Fe4N, there are α -Fe16N2 and the satellite spots around main spots of α-Fe16N2 demonstrate its modulation structure. A metastable ordered cluster zone of the nitropen atoms was found in the division layer.

关键词： ion nitriding microstructure No.45 steel

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Four late-type Galaxies with Double Radio lobes and Properties of Such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： z.S.Yuan x.Y.Gao z.l.Wen J.l.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO VlA Sky Survey and the Faint Images of the Radio Sky at Twenty-centimeter,we identify four late-type Galaxies with double Radio lobes(la GRls):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previously known la GRls,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)la GRls belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of la GRls are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

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Effect of grain size on fatigue cracking at twin boundaries in a CoCrFeMnNi high-entropy alloy

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Journal of Materials Science & Technology 2020年第4期39卷 1-6页

作者： A.G.Wang x.H.An J.Gu x.G.Wang l.l.li W.l.li M.Song Q.Q.Duan z.F.zhang x.z.l.ao School of Aerospace Mechanical&Mechatronic EngineeringThe University of Sydne0ySydneyAustralia State Key laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Materials Fatigue and Fracture Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Max-Planck-Institut für Eisenforschung Max-Planck-Stra?e 140237 DüsseldorfGermany

The fatigue cracking behavior at twin boundaries(TBs)in a Co Cr Fe Mn Ni high-entropy alloy with three different grain sizes was systematically investigated under low-cycle *** of grain size,the change from slip band cracking to TB cracking occurred with increasing the difference in the Schmid factors(DSF)between matrix and ***,the required critical DSF for the transition of the dominant cracking mode decreases with decreasing grain size due to the reduced slip band spacing that increases the impingement sites on the TBs and facilitates the coalescence of defects and voids to initiate TB cracks.

关键词： High-entropy alloy Fatigue cracking Twin boundary Slip band Grain size

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A fast numerical method of introducing the strengthening effect of residual stress and strain to tensile behavior of metal matrix composites

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Journal of Materials Science & Technology 2021年第28期87卷 167-175页

作者： J.F.zhang x.x.zhang H.Andrä Q.z.Wang B.l.xiao z.Y.Ma Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China Fraunhofer Institute for Industrial Mathematics Fraunhofer-Platz 1Kaiserslautern 67663Germany

Thermal residual stress and strain(TRSS)in particle reinforced metal matrix composites(PRMMCs)are believed to cause strengthening effects,according to previous ***,the representative volume element(RVE)based computational homogenization technique was used to study the tensile deformation of PRMMCs with different particle aspect ratios(AR).The influence of TRSS was assessed quantitatively via comparing simulations with or without the cooling *** was found that the strengthening effect of TRSS was affected by the particle *** the average strengthening effect of TRSS,a fast method of introducing the strengthening effect of TRSS to the tensile behavior of PRMMCs was *** new method has reduced the computational cost by a factor *** effect of TRSS on continuous fiber-reinforced metal matrix composite was found to have a softening-effect during the entire tensile deformation process because of the pre-yield effect caused by the cooling process.

关键词： Metal matrix composites(MMC) Finite element analysis(FEA) Representative volume element(RVE) Residual stress and strain Aspect ratio

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Effect of friction on corrosion behaviors of AISI 304 and Cr26Mo1 stainless steels in different solutions

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Journal of Iron and Steel Research International 2023年第12期30卷 2541-2556页

作者： z.x.Dai S.l.Jiang l.K.Ning x.D.xu S.li D.l.Duan Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026AnhuiChina liaoning Key laboratory of Aero-engine Materials Tribology Institute of Metal ResearchChinese Academy of SciencesShenyang110016LiaoningChina AnSteel lISCO Stainless Steel Co. Ltd.Guangzhou510760GuangdongChina

The corrosion and tribocorrosion behaviors of AISI 304 austenitic stainless steel and Cr26Mo1 ultrapure high chromium ferrite stainless steel in 3.5 wt.%NaCl and 0.5 mol/l H2SO4 solutions were *** electrochemical measurement technology was applied to identify electrochemistry behaviors during tribocorrosion tests in *** surface morphologies and compositions of the wear tracks were analyzed by scanning electron microscopy and Raman *** results showed that compositions of stainless steels,corrosive mediums and applied loads have great influence on tribocorrosion behaviors of stainless ***,the corrosion resistance in static state of stainless steels primarily dominates its tribocorrosion behavior;meanwhile,better mechanical properties are in favor of tribocorrosion ***,the corrosion rate is promoted significantly in 3.5%NaCl solution by friction,while the tendency is inconspicuous in 0.5 mol/l H2SO4 *** but not least,passive films on stainless steels can be wiped off by small friction *** the increase in applied load,the effect of friction converts to forming friction oxide film from removing passivation film,so that a critical load exists below which the friction force can promote the corrosion process extremely.

关键词： Tribocorrosion Stainless steel/PEEK friction pair Corrosive medium Applied load Microelectrode probe

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